Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJQDUC)

• Drug Name: Aminoguanidine Drug Info
• Synonyms: aminoguanidine; Pimagedine; Hydrazinecarboximidamide; Guanyl hydrazine; Monoaminoguanidine; 2-aminoguanidine; 79-17-4; Imino semicarbazide; Aminate base; 2-azanylguanidine; Pimagedine [INN]; GUANIDINE, AMINO-; 1-aminoguanidine; UNII-SCQ4EZQ113; Hydrazinecarboximidamide(9CI); CCRIS 3511; EINECS 201-183-1; Aminoguanidine, Hemisulfate; SCQ4EZQ113; CHEMBL225304; CHEBI:40618; HAMNKKUPIHEESI-UHFFFAOYSA-N; guanylhydrazine; GER-11; AGU; amino guanidine; 1-amino-guanidine; Aminoguanidine (AG); Tocris-0787; Carbonohydrazonic diamide; INCB3284

Indication

Disease Entry	ICD 11	Status	REF
Diabetic retinopathy	9B71.0	Phase 1	[1]
Insulin-resistant disorder	5A44	Discontinued in Phase 2	[2]
Rheumatoid arthritis	FA20	Discontinued in Phase 2	[2]

• Cross-matching ID:
  PubChem CID: 2146
  ChEBI ID: CHEMBL225304
  CAS Number: CAS 79-17-4
  TTD Drug ID: DMJQDUC

Molecule-Related Drug Atlas

Drug(s) Targeting Nitric-oxide synthase inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
SD-6010	DM9DEYL	Osteoarthritis	FA00-FA05	Phase 3	[7]
MPL-S	DMNDCFY	Endotoxic shock	1G41	Phase 3	[8]
Pimagedine HCl	DMPWH30	Diabetic kidney disease	GB61.Z	Phase 2/3	[9]
GW274150	DMZMCB1	Asthma	CA23	Phase 2	[10]
BXT-51072	DMD8GNB	Cardiovascular disease	BA00-BE2Z	Phase 2	[11]
HP-228	DMNZ35F	Postoperative pain	MG30-MG3Z	Phase 2	[12]
CR-3294	DMHJEZS	Diarrhea	ME05.1	Phase 2	[13]
KD-7040	DME1WV2	Pain	MG30-MG3Z	Phase 2	[14]
LT-1951	DM5N04G	Coronary artery disease	BA80	Phase 1/2	[15]

Drug(s) Targeting C-C chemokine receptor type 2 (CCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cenicriviroc	DM4V8WF	Human immunodeficiency virus infection	1C62	Phase 2	[16]
MLN1202	DM24SOL	Metastatic cancer	2D50-2E2Z	Phase 2	[17]
BMS-813160	DMKY638	Diabetic nephropathy	GB61.Z	Phase 2	[18]
CCX-140	DMJ9XCO	Diabetic nephropathy	GB61.Z	Phase 2	[19]
AZD-2423	DMF34UY	Chronic obstructive pulmonary disease	CA22	Phase 2	[20]
CCX872	DMPVAUT	Pancreatic tumour	2C10	Phase 2	[21]
MK-0812	DMRT8K4	Multiple sclerosis	8A40	Phase 2	[22]
TAK-202	DMVYEFZ	Melanoma	2C30	Phase 1	[23]
OPL-CCL2-LPM	DM3HOUX	Arthritis	FA20	Phase 1	[24]
CNTX-6970	DMCOJM7	Inflammatory pain	MG30.42	Phase 1	[25]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[29]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[32]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 2 (CCR2)	TTFZYTO	CCR2_HUMAN	Antagonist	[3]
Nitric-oxide synthase inducible (NOS2)	TTF10I9	NOS2_HUMAN	Inhibitor	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Gene/Protein Processing	[5]

References

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• [2] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018258)
• [3] Incyte Announces Second Quarter 2005 Financial Results; Reports Positive Phase IIb Results for Reverset in Treatment-Experienced HIV Patients. Incyte Corporation. 2005.
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• [8] Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, gamma interferon, and interleukin-10 mRNA production in murine macrophages. Infect Immun. 1997 Aug;65(8):3239-47.
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• [14] WO patent application no. 2014,0214,08, Method for treating cancer by anticancer agent co-administration.
• [15] Critical role of L-arginine in endothelial cell survival during oxidative stress. Circulation. 2003 May 27;107(20):2607-14.
• [16] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [17] Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
• [18] A dual CCR2/CCR5 chemokine antagonist, BMS-813160. Expert Opin Ther Pat. 2011 Dec;21(12):1919-24.
• [19] Present and future in the treatment of diabetic kidney disease. J Diabetes Res. 2015;2015:801348.
• [20] CA patent application no. 841416, Method of selecting therapeutic indications.
• [21] Therapeutic use of a clinical stage CCR2 inhibitor, CCX872, in obesity-associated steatohepatitis. The Lancet Volume 383, Supplement 1, 26 February 2014, Pages S78.
• [22] Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist. J Immunol Methods. 2010 Jan 31;352(1-2):101-10.
• [23] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [24] Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis. Clin Exp Immunol. 2009 February; 155(2): 295-303.
• [25] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [26] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [27] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [28] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [29] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [30] Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
• [31] Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
• [32] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [33] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [34] Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
• [35] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.