Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKZJ7T)

Drug Name

GINKGOLIDE A Drug Info

Synonyms

Ginkgolide A; 15291-75-5; CHEBI:5355; SCHEMBL340234; GTPL1861; LMPR0104540001; AB2000432; C07601

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9909368
CAS Number: CAS 15291-75-5
TTD Drug ID: DMKZJ7T

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Strychnine-binding glycine receptor (GLRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[4]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[5]
GINKOLIDE B	DMLIM7B	Sepsis	1G40-1G41	Terminated	[2]
3-demethoxy-3-D-lyxopyranosylaminothiocolchicine	DME8VPC	Discovery agent	N.A.	Investigative	[4]
3-demethoxy-3-D-xylopyranosylaminothiocolchicine	DMXFVD1	Discovery agent	N.A.	Investigative	[4]
3-demethoxy-3-L-fucopyranosylaminothiocolchicine	DM4ERYF	Discovery agent	N.A.	Investigative	[4]
3-demethoxy-3D-glucopyranosylaminothiocolchicine	DMID7TC	Discovery agent	N.A.	Investigative	[4]
3-demethoxy-3-D-mannopyranosylaminothiocolchicine	DMALMGH	Discovery agent	N.A.	Investigative	[4]
Ginkgolide J	DMUOMP1	Discovery agent	N.A.	Investigative	[2]
Ginkgolide C	DMVN374	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Glycine receptor (GlyR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[4]
ZD-9379	DM3KYO4	Cerebrovascular ischaemia	8B1Z	Phase 1	[6]
UK-240455	DMSCXB7	Nerve injury	ND56.4	Phase 1	[7]
MDL-27531	DMC60S8	Epilepsy	8A60-8A68	Phase 1	[8]
Gavestinel	DM8IL1U	Nerve injury	ND56.4	Discontinued in Phase 2	[9]
GV-196771	DMFN21T	Migraine	8A80	Discontinued in Phase 2	[10]
GW 468816	DMQ92WF	Tobacco dependence	6C4A.2	Discontinued in Phase 2	[11]
M-241247	DMIY51U	Cerebrovascular ischaemia	8B1Z	Terminated	[12]
GINKOLIDE B	DMLIM7B	Sepsis	1G40-1G41	Terminated	[2]
3-demethoxy-3-D-lyxopyranosylaminothiocolchicine	DME8VPC	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[13]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[13]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[14]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[15]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[16]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[13]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[13]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[13]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[17]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[18]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[19]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[20]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[21]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[22]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[23]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[24]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[25]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[26]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[27]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[25]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[30]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[31]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[33]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[34]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[35]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[36]
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Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[37]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[38]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[39]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[40]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[41]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[42]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[43]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[44]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[45]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[46]
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Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[47]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[48]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[49]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[53]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycine receptor (GlyR)	TTZ8EM9	GLRA1_HUMAN; GLRA2_HUMAN; GLRA3_HUMAN; GLRA4_HUMAN; GLRB_HUMAN	Inhibitor	[2]
Strychnine-binding glycine receptor (GLRA1)	TTF45NW	GLRA1_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Gene/Protein Processing	[3]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[3]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Gene/Protein Processing	[3]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Gene/Protein Processing	[3]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Gene/Protein Processing	[3]
UDP-glucuronosyltransferase 1A1	OTH1C8OJ	UD11_HUMAN	Gene/Protein Processing	[3]

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References

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