General Information of Drug (ID: DMN0ZQ5)

Drug Name
OTSGC-A24 Drug Info
Synonyms Peptide vaccine (gastric cancer), OncoTherapy
Indication
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DMN0ZQ5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fruquintinib DMHOSCQ Colorectal cancer 2B91.Z Approved [3]
Tivozanib DMUKC5L Renal cell carcinoma 2C90 Approved [4]
E-3810 DM42PFT Solid tumour/cancer 2A00-2F9Z Phase 3 [5]
Sulfatinib DMPOTM4 Neuroendocrine cancer 2B72.1 Phase 3 [6]
Famitinib DMSFWT7 Solid tumour/cancer 2A00-2F9Z Phase 2 [7]
X-82 DMW1NKO Age-related macular degeneration 9B75.0 Phase 2 [8]
OCV-101 DMT9QI2 Pancreatic cancer 2C10 Phase 2 [9]
LY3012212 DMRVEHY Arteriosclerosis BD40 Phase 2 [10]
CEP-11981 DMYDTJ6 Solid tumour/cancer 2A00-2F9Z Phase 1 [11]
EW-A-401 DM3VC6T Peripheral vascular disease BD4Z Phase 1 [12]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [13]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [14]
Regorafenib DMHSY1I Gastrointestinal stromal tumour 2B5B Approved [15]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [16]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [17]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [18]
Pazopanib HCl DM6U9CQ Renal cell carcinoma 2C90 Approved [19]
Fruquintinib DMHOSCQ Colorectal cancer 2B91.Z Approved [3]
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [20]
Tivozanib DMUKC5L Renal cell carcinoma 2C90 Approved [4]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Vascular endothelial growth factor receptor 1 (FLT-1) TT2Q6G1 VGFR1_HUMAN Not Available [2]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT01227772) Study of OTSGC-A24 Vaccine in Advanced Gastric Cancer. U.S. National Institutes of Health.
2 J Clin Oncol 33, 2015 (suppl 3; abstr 65).
3 Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy. Cancer Biol Ther. 2014;15(12):1635-45.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services
5 E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71(4):1396-405.
6 Clinical pipeline report, company report or official report of Hutchison Medi Pharma.
7 Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706.
8 National Cancer Institute Drug Dictionary (drug id 695817).
9 Phase I trial of OTS11101, an anti-angiogenic vaccine targeting vascular endothelial growth factor receptor 1 in solid tumor.Cancer Sci.2013 Jan;104(1):98-104.
10 Icrucumab, a fully human monoclonal antibody against the vascular endothelial growth factor receptor-1, in the treatment of patients with advanced solid malignancies: a Phase 1 study. Invest New Drugs. 2014 Apr;32(2):303-11.
11 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8189).
12 DOI: http://dx.doi.org/10.1016/j.tips.2014.09.007
13 Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling.Mol Cancer Ther.2008 Oct;7(10):3129-40.
14 Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem. 2002 Dec 19;45(26):5687-93.
15 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
16 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
17 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
18 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
19 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
20 Clinical pipeline report, company report or official report of Exelixis (2011).