Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNLUKS)

• Drug Name: 1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane Drug Info
• Synonyms: CHEMBL1172206; 1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane; SCHEMBL4525293

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 11568942
  TTD Drug ID: DMNLUKS

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated potassium channel Kv11.1 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VESNARINONE	DMBKX3C	Cardiac failure	BD10-BD13	Approved	[2]
M100907	DM7ZFBA	Sleep-wake disorder	7A00-7B2Z	Phase 3	[3]
HP-184	DMNOMV2	Multiple sclerosis	8A40	Phase 2	[4]
NITD609	DMQHBSX	Malaria	1F40-1F45	Phase 2	[5]
ABT-229	DMN3S1B	Pain	MG30-MG3Z	Phase 2	[6]
ISOQUINE	DMR17YI	Malaria	1F40-1F45	Phase 1	[7]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1	DMC8935	N. A.	N. A.	Patented	[8]
Isoindoline derivative 5	DMIUTQW	N. A.	N. A.	Patented	[9]
Isoindoline derivative 3	DM2MYL9	N. A.	N. A.	Patented	[9]
Isoindoline derivative 4	DMP1NKI	N. A.	N. A.	Patented	[9]

Drug(s) Targeting 5-HT 2A receptor (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[10]
ZOTEPINE	DMF3VXA	Anxiety disorder	6B00-6B0Z	Approved	[11]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[12]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[13]
Lurasidone hydrochloride	DMCVPXO	Schizophrenia	6A20	Approved	[14]
Aniracetam	DMOIFW0	Cerebrovascular ischaemia	8B1Z	Approved	[15]
lumateperone tosylate	DMQ8HOJ	Schizophrenia	6A20	Approved	[16]
Sarpogrelate	DMGLP6S	Diabetic complication	5A2Y	Approved	[17]
Pimavanserin	DMR7IVC	Parkinson disease	8A00.0	Approved	[18]
Zicronapine	DMP8ESD	Schizophrenia	6A20	Phase 3	[19]

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[20]
Haloperidol	DM96SE0	Delirium		Approved	[21]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[22]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[23]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[24]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[25]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[26]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[27]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[28]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[12]

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[29]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[30]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[31]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[32]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[13]
Gepirone	DMGX5Q0	Major depressive disorder	6A70.3	Approved	[33]
TERTATOLOL	DM2L3D5	Hypertension	BA00-BA04	Approved	[34]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[35]
Treximet	DMU54QB	Migraine	8A80	Approved	[36]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[1]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Inhibitor	[1]
Voltage-gated potassium channel Kv11.1 (KCNH2)	TTQ6VDM	KCNH2_HUMAN	Inhibitor	[1]

References

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