Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP204G)

• Drug Name: METHYLENEDIOXYAMPHETAMINE Drug Info
• Synonyms: Tenamfetamine; 3,4-methylenedioxyamphetamine; Methylenedioxyamphetamine; 4764-17-4; 3,4-Methylenedioxy-amphetamine; MDA (pharmaceutical); Tenamfetamine [INN]; Tenamfetaminum [Latin]; Tenamfetamina [Spanish]; 1-(1,3-benzodioxol-5-yl)propan-2-amine; BRN 0150196; DEA No. 7400; AI3-24882; alpha-Methyl-1,3-benzodioxole-5-ethanamine; 1,3-Benzodioxole-5-ethanamine, alpha-methyl-; CHEMBL6731; ALPHA-METHYL-3,4-(METHYLENEDIOXY)PHENETHYLAMINE; NGBBVGZWCFBOGO-UHFFFAOYSA-N; 5-19-08-00417 (Beilstein Handbook Reference); Phenethylamine, alp

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 1614
  ChEBI ID: CHEMBL6731
  CAS Number: CAS 4764-17-4
  TTD Drug ID: DMP204G
  VARIDT Drug ID: DR00861

Molecule-Related Drug Atlas

Drug(s) Targeting Norepinephrine transporter (NET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[4]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[5]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[6]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[4]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[7]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[8]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[9]
Venlafaxine	DMR6QH0	Anxiety disorder	6B00-6B0Z	Approved	[8]
Trimipramine	DM1SC8M	Major depressive disorder	6A70.3	Approved	[10]
Duloxetine	DM9BI7M	Depression	6A70-6A7Z	Approved	[11]

Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[4]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[5]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[12]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[13]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[14]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[7]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[8]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[12]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[12]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[12]

Drug(s) Targeting Dopamine transporter (DAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[7]
Dasotraline	DMLDQFV	Attention deficit hyperactivity disorder	6A05.Z	Approved	[15]
Methylphenidate	DM7SJD6	Attention deficit hyperactivity disorder	6A05.Z	Approved	[16]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[12]
Phenmetrazine	DMXYTN9	Obesity	5B81	Approved	[17]
Ioflupane i-123	DMNARJT	Parkinson disease	8A00.0	Approved	[18]
DEXMETHYLPHENIDATE HYDROCHLORIDE	DM8WBAH	Attention deficit hyperactivity disorder	6A05.Z	Approved	[19]
Altropane	DMO9WDS	Attention deficit hyperactivity disorder	6A05.Z	Approved	[20]
Amitifadine	DMS1X67	Obesity	5B81	Phase 3	[21]
NAV5001	DMRSI1M	Dementia	6D80-6D86	Phase 3	[20]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[22]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[3]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[23]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[24]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[25]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[26]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[27]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[28]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[29]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[27]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Inhibitor	[1]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[3]

References

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