Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ2SNL)

• Drug Name: 2-(carboxymethylamino)-2-oxoacetic acid Drug Info
• Synonyms: N-Oxalylglycine; 5262-39-5; Oxalylglycine; Oxaloglycine; 2-((Carboxymethyl)amino)-2-oxoacetic acid; UNII-VVW38EB8YS; N-(carboxycarbonyl)glycine; N-OXALYOLGLYCINE; VVW38EB8YS; 2-oxo-3-azaglutaric acid; CHEMBL90852; Glycine, N-(carboxycarbonyl)-; CHEBI:44482; OGA; C4H5NO5; 4idz; 4nrp; 2xml; 3hqr; N-oxalyl glycine, 1a; 2oq6; 1h2k; AC1MIVD0; Glycine,N-(carboxycarbonyl)-; SCHEMBL435820; BDBM26106; CTK8F0807; DTXSID20200601; MolPort-000-141-021; ZINC1534133; N-Oxalylglycine, > 4958AE

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3080614
  ChEBI ID: CHEMBL44482
  CAS Number: CAS 5262-39-5
  TTD Drug ID: DMQ2SNL

Molecule-Related Drug Atlas

Drug(s) Targeting HIF-prolyl hydroxylase 1 (HPH-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daprodustat	DMRNGD2	Anaemia	3A90	Approved	[3]
FG-4592	DM4XSQ2	Anaemia	3A90	Phase 3	[4]
BAY-85-3934	DM7NHLC	Anemia	3A00-3A9Z	Phase 2	[5]
Pyridine-2,4-dicarboxylic acid	DM4G8WX	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[6]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[10]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[13]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[14]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[15]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[10]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[17]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[22]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[10]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[24]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[29]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF-prolyl hydroxylase 1 (HPH-1)	TTMHFRY	EGLN2_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)	OT25JBA3	F263_HUMAN	Gene/Protein Processing	[2]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Gene/Protein Processing	[2]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Gene/Protein Processing	[2]

References

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