Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUH012)

Drug Name

PMID26911565-peptide-P9 Drug Info

Synonyms

PMID26911565-P9

Indication

Disease Entry	ICD 11	Status	REF
Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[1]
Severe acute respiratory syndrome (SARS)	1D65	Preclinical	[1]

Therapeutic Class

Antiviral Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting SARS-CoV spike glycoprotein (S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Griffithsin	DMNZA4L	Human immunodeficiency virus infection	1C62	Preclinical	[2]
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Drug(s) Targeting MERS-CoV spike glycoprotein (S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nafamostat	DMU1XOD	Pancreatitis	DC31-DC34	Approved	[3]
REGN 3048	DMW08TD	Middle East Respiratory Syndrome (MERS)	1D64	Discontinue in Phase 1 Trial	[4]
REGN 3051	DMLH28J	Middle East Respiratory Syndrome (MERS)	1D64	Discontinue in Phase 1 Trial	[4]
MERS-five-helix bundle	DMG5YRP	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[5]
Alpha-Helical lipopeptides LLS	DM3WVM4	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[6]
Peptide P21S10	DMMWQTI	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[7]
Alpha-Helical lipopeptides IIS	DM1MGBX	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[6]
Alpha-Helical lipopeptides IIK	DMVSKQF	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[6]
Alpha-Helical lipopeptides FFS	DMATQB7	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MERS-CoV spike glycoprotein (S)	TT85VHW	A0A140AYZ5_9BETC	Inhibitor	[1]
SARS-CoV spike glycoprotein (S)	TTTL19V	SPIKE_CVHSA	Inhibitor	[1]

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References

1	A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses. Sci Rep. 2016 Feb 25;6:22008.
2	Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
3	Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay Antimicrob Agents Chemother. 2016 Oct 21;60(11):6532-6539.
4	Pre- And Postexposure Efficacy of Fully Human Antibodies Against Spike Protein in a Novel Humanized Mouse Model of MERS-CoV Infection. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43. doi: 10.1073/pnas.1510830112.
5	Identification of a Novel Inhibitor against Middle East Respiratory Syndrome Coronavirus. Viruses. 2017 Sep 14;9(9). pii: E255.
6	De Novo Design of -Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745.
7	Discovery of Hydrocarbon-Stapled Short -Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors. J Med Chem. 2018 Mar 8;61(5):2018-2026.