Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV5KR3)

• Drug Name: Ebrotidine Drug Info
• Synonyms: Ebrocit; FI-3542

Indication

Disease Entry	ICD 11	Status	REF
Duodenal ulcer	DA63	Withdrawn from market	[1]

• Cross-matching ID:
  PubChem CID: 65869
  ChEBI ID: CHEBI:135774
  CAS Number: CAS 100981-43-9
  TTD Drug ID: DMV5KR3

Molecule-Related Drug Atlas

Drug(s) Targeting Histamine H2 receptor (H2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[5]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[6]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[6]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[7]
Betazole	DMUFGAY	Gastric secretory disorder	DD90	Approved	[8]
Pibutidine	DMXSTRM	Ulcerative colitis	DD71	Discontinued in Phase 3	[9]
Osutidine	DMN7TL8	Duodenal ulcer	DA63	Discontinued in Phase 3	[10]
KU-1257	DMZMFX6	Duodenal ulcer	DA63	Discontinued in Phase 3	[11]
Lavoltidine	DMTY5VE	Gastroesophageal reflux disease	DA22.Z	Discontinued in Phase 2	[12]
IGN-2098	DMU4N1O	Duodenal ulcer	DA63	Discontinued in Phase 2	[13]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[14]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[3]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[15]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[18]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[19]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[20]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[21]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[22]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[23]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[24]
Methysergide	DM1EF73	Migraine	8A80	Approved	[4]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[29]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[30]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[3]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[33]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[34]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[35]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[36]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[37]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[38]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[39]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H2 receptor (H2R)	TTQHJ1K	HRH2_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[3]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Gene/Protein Processing	[3]
Phosphatidylcholine translocator ABCB4 (ABCB4)	OTE6PY83	MDR3_HUMAN	Gene/Protein Processing	[4]

References

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