Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV8AH6)

• Drug Name: A192621 Drug Info
• Synonyms: A-192621; A 192621

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5310991
  CAS Number: CAS 195529-54-5
  TTD Drug ID: DMV8AH6

Molecule-Related Drug Atlas

Drug(s) Targeting Endothelin B receptor (EDNRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[4]
Macitentan	DMP79A1	Cardiovascular disease	BA00-BE2Z	Approved	[5]
BQ788	DM6KRLW	Acute kidney injury	GB60	Phase 3	[6]
PD-145065	DMWVBTQ	Hypertension	BA00-BA04	Phase 2	[7]
SPI-1620	DMNPRMC	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
ENB003	DMK2B3S	Melanoma	2C30	Phase 1/2	[9]
J-104132	DM5E6MK	Pulmonary arterial hypertension	BB01.0	Discontinued in Phase 2	[10]
ENRASENTAN	DM05F1Z	Pulmonary arterial hypertension	BB01.0	Discontinued in Phase 2	[11]
SB-209670	DMJYW80	Arrhythmia	BC9Z	Discontinued in Phase 2	[12]
ET-1	DMA85ND	N. A.	N. A.	Phase 0	[13]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[14]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[14]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[20]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[22]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[28]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[29]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[22]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[23]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[22]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[39]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[23]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[17]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[42]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]

Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[45]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[47]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[22]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Endothelin B receptor (EDNRB)	TT3ZTGU	EDNRB_HUMAN	Antagonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Gene/Protein Processing	[3]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Gene/Protein Processing	[3]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Gene/Protein Processing	[3]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Gene/Protein Processing	[3]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Gene/Protein Processing	[3]

References

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