Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVFB93)

• Drug Name: NITRATE Drug Info
• Synonyms: nitrate; NITRATE ION; 14797-55-8; Nitrate(1-); UNII-T93E9Y2844; Nitrate(6CI,7CI,8CI,9CI); UN3218; CHEMBL186200; NO3-; Nitrates; CHEBI:17632; T93E9Y2844; NO3; trioxidonitrate; trioxonitrate; nitrooxidane; trioxonitrate(V); trioxonitrate(1-); trioxidonitrate(1-); AC1L1ADK; Nitrates, inorganic, n.o.s.; CTK0H4660; BDBM26988; NHNBFGGVMKEFGY-UHFFFAOYSA-N; 84145-82-4 (Parent); NO3(-); AKOS015904030; MCULE-5142506228; [NO3](-); Nitrates, inorganic, aqueous solution, n.o.s.; I14-18318; Nitrates, inorganic, n.o.s. [UN1447] [Oxidizer]; Nitrates, in

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 943
  ChEBI ID: CHEMBL17632
  TTD Drug ID: DMVFB93
  VARIDT Drug ID: DR00009

Molecule-Related Drug Atlas

Drug(s) Targeting Carbonic anhydrase I (CA-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[8]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[8]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[9]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[8]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[11]
CG-100649	DMIKMA9	Arthritis	FA20	Phase 3	[12]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[10]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[13]

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[14]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[15]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[16]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[17]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[17]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[18]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[19]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[20]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]

Drug(s) Transported By Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NAAG	DMFGOW0	Discovery agent	N.A.	Investigative	[21]

Drug(s) Transported By Anion exchange transporter (SLC26A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SULFATE	DMW0ZBF	Discovery agent	N.A.	Investigative	[2]
BICARBONATE	DMT5E36	Discovery agent	N.A.	Investigative	[22]
oxalate	DM40SEU	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Thyrotropin subunit beta (TSHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[25]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[26]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[27]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[28]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[29]
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[30]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[39]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Anion exchange transporter (SLC26A7)	DTOTME4	S26A7_HUMAN	Substrate	[2]
Sodium/iodide cotransporter (SLC5A5)	DTZAH46	SC5A5_HUMAN	Substrate	[3]
Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)	DTWLACT	S17A5_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Regulation of Drug Effects	[5]
Thyrotropin subunit beta (TSHB)	OTFDI39D	TSHB_HUMAN	Gene/Protein Processing	[6]

References

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