Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYW3ZG)

• Drug Name: Cephalosporin C Drug Info
• Synonyms: cephalosporin C; 7-(5-Amino-5-carboxyvaleramido)cephalosporanic acid; 61-24-5; UNII-3XIY7HJT5L; CHEBI:15776; EINECS 200-501-6; 3XIY7HJT5L; BRN 0065348; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-((5-amino-5-carboxy-1-oxopentyl)amino)-8-oxo-, (6R-(6alpha,7beta(R*)))-; (6R,7R)-3-[(acetyloxy)methyl]-7-{[(5R)-5-amino-5-carboxypentanoyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(5-amino-5-carboxyvaleramid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 65536
  ChEBI ID: CHEBI:15776
  CAS Number: CAS 61-24-5
  TTD Drug ID: DMYW3ZG

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Penicillin binding protein 3 (Bact mrcA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aztreonam	DMDNJHG	Bacterial infection	1A00-1C4Z	Approved	[4]
Cefmetazole	DM42W1B	Bacterial infection	1A00-1C4Z	Approved	[5]
Cefotiam	DMF5HU6	Respiratory tract infection	CA45	Approved	[6]
Latamoxef	DMANL0D	Bacterial infection	1A00-1C4Z	Approved	[5]
Mezlocillin	DMY5JEP	Acute gonococcal cervicitis		Approved	[7]
Moxalactam Disodium	DMYKUNR	Bacterial infection	1A00-1C4Z	Approved	[8]
Cefmenoxime	DMPLY7B	Bacterial infection	1A00-1C4Z	Approved	[9]
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[10]
LYS228	DM23Y6K	Urinary tract infection	GC08	Phase 2	[11]
PCNOTAXIME GROUP	DMGS6YH	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting Bacterial DD-carboxypeptidase (Bact vanYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cefalotin	DMVYSLE	Bacteremia	1A73	Approved	[13]
B-Lactams	DMR8YD6	Bacterial infection	1A00-1C4Z	Approved	[14]
Cephalosporin	DM79XDW	Bacterial infection	1A00-1C4Z	Approved	[15]
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[16]
TD-1792	DMGKBZH	Skin infection	1F28-1G0Z	Phase 3	[17]
Phenyl Boronic acid	DMFZH49	Discovery agent	N.A.	Investigative	[18]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[19]
D-Alanine	DMVIDQL	Discovery agent	N.A.	Investigative	[19]
3-boronobenzoic acid	DMRCJW0	Discovery agent	N.A.	Investigative	[18]
NITROCEFIN	DM7M5VY	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting Bacterial Penicillin-binding protein 1B (Bact mrcB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
N-BENZOYL-D-ALANINE	DMX0Y79	Discovery agent	N.A.	Investigative	[12]

Drug(s) Affected By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[22]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[23]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[24]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[24]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[3]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[3]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[25]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[26]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[29]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial DD-carboxypeptidase (Bact vanYB)	TTLP6GN	VANY_ENTFA	Inhibitor	[1]
Bacterial Penicillin binding protein 3 (Bact mrcA)	TT85JMW	FTSI_ECOLI	Antagonist	[1]
Bacterial Penicillin-binding protein 1B (Bact mrcB)	TT329FH	PBPB_ECOLI	Antagonist	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Regulation of Drug Effects	[2]
Organic anion transporter 3 (SLC22A8)	OT8BY933	S22A8_HUMAN	Regulation of Drug Effects	[3]

References

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