Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ3DS5)

• Drug Name: Aryl piperazine derivative 6 Drug Info
• Synonyms: PMID30124346-Compound-III-2
• Cross-matching ID: TTD Drug ID: DMZ3DS5

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D3 receptor (D3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cariprazine	DMJYDVK	Bipolar disorder	6A60	Approved	[2]
Pramipexole	DMNMW9R	Parkinson disease	8A00.0	Approved	[3]
Ropinirole	DMA6S1D	Parkinson disease	8A00.0	Approved	[3]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[4]
P2B-001	DM9PVHX	Parkinson disease	8A00.0	Phase 3	[5]
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[6]
ONC201	DMM5SCF	Endometrial cancer	2C76	Phase 2	[7]
TAK-906	DMBQD9H	Diabetic gastroparesis	DA41.00	Phase 2	[8]
GSK598809	DMGU05N	Drug abuse	6C4G.1Z	Phase 2	[9]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[9]

Drug(s) Targeting 5-HT 2A receptor (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[10]
ZOTEPINE	DMF3VXA	Anxiety disorder	6B00-6B0Z	Approved	[11]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[12]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[2]
Lurasidone hydrochloride	DMCVPXO	Schizophrenia	6A20	Approved	[13]
Aniracetam	DMOIFW0	Cerebrovascular ischaemia	8B1Z	Approved	[14]
lumateperone tosylate	DMQ8HOJ	Schizophrenia	6A20	Approved	[15]
Sarpogrelate	DMGLP6S	Diabetic complication	5A2Y	Approved	[16]
Pimavanserin	DMR7IVC	Parkinson disease	8A00.0	Approved	[17]
Zicronapine	DMP8ESD	Schizophrenia	6A20	Phase 3	[18]

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[19]
Haloperidol	DM96SE0	Delirium		Approved	[20]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[21]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[22]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[23]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[24]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[25]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[26]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[27]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[12]

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[3]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[28]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[29]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[30]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[2]
Gepirone	DMGX5Q0	Major depressive disorder	6A70.3	Approved	[31]
TERTATOLOL	DM2L3D5	Hypertension	BA00-BA04	Approved	[32]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[33]
Treximet	DMU54QB	Migraine	8A80	Approved	[9]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Ligand	[1]
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Ligand	[1]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Ligand	[1]
Dopamine D3 receptor (D3R)	TT4C8EA	DRD3_HUMAN	Ligand	[1]

References

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