Details of the Drug

General Information of Drug (ID: DM8QB1D)

• Drug Name: Olaparib
• Synonyms: AZD 2281; AZD2281; AZD-2281; Acylpiperazine analogue, 47; KU-0059436; KU-59436; Olaparib, KU-0059436, AZD2281,KU0059436, AZD2281; 4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one; 4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one

Indication

Disease Entry	ICD 11	Status	REF
Ovarian cancer	2C73	Approved	[1]
Pancreatic cancer	2C10	Phase 3	[2]
Prostate cancer	2C82.0	Phase 3	[2]

• Affected Organisms: Humans and other mammals
• ATC Code:
  L01XK01: Olaparib
  L01XK: Poly (ADP-ribose) polymerase (PARP) inhibitors
  L01X: OTHER ANTINEOPLASTIC AGENTS
  L01: ANTINEOPLASTIC AGENTS
  L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 434.5
  Logarithm of the Partition Coefficient (xlogp); 1.9
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 5
• ADMET Property:
  Absorption AUC: The area under the plot of plasma concentration (AUC) of drug is 25.8 mcgh/L [3]
  Absorption Cmax: The maximum plasma concentration (Cmax) of drug is 4.7 and 9.1 mg/L [3]
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 1-3 h [3]
  BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [4]
  Clearance: The total clearance of drug is 4.6 L/h [3]
  Elimination: Approximately 86% of the administered dose is recovered after 7 days from which 44% is found in the urine and 42% is obtained in feces [5]
  Half-life: The concentration or amount of drug in body reduced by one-half in 5 - 11 hours [3]
  Metabolism: The drug is metabolized via the liver []
  Vd: The volume of distribution (Vd) of drug is 40.3 L [3]
• Chemical Identifiers:
  Formula: C24H23FN4O3
  IUPAC Name: 4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one
  Canonical SMILES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
  InChI: InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
  InChIKey: FDLYAMZZIXQODN-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 23725625
  ChEBI ID: CHEBI:83766
  CAS Number: 763113-22-0
  UNII: WOH1JD9AR8
  DrugBank ID: DB09074
  TTD ID: D0J9HW
  VARIDT ID: DR00221
  INTEDE ID: DR1188
  ACDINA ID: D00485
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Poly [ADP-ribose] polymerase (PARP)	TTEBCY8	NOUNIPROTAC	Modulator	[6]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[7]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[9]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[10]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[10]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Drug Response	[11]
Breast cancer type 2 susceptibility protein (BRCA2)	OTF1XSV1	BRCA2_HUMAN	Drug Response	[11]
Bromodomain-containing protein 4 (BRD4)	OT2Y2TCW	BRD4_HUMAN	Drug Response	[9]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Post-Translational Modifications	[10]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[9]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Gene/Protein Processing	[10]
DNA mismatch repair protein Msh3 (MSH3)	OTD3YPVL	MSH3_HUMAN	Drug Response	[12]

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Bone Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
RPMI-3460/CS1	GDSC1; GDSC2	4.7968	10.045	1.096	10.1405
EW-12	GDSC2	1.0216	3.6098	0.7273	24.6351
ES1	GDSC1; GDSC2	1.3989	4.083	0.9754	21.5894
MHH-ES-1	GDSC1; GDSC2; CTRP2	1.4114	5.4103	1.2682	39.1282
ES8	GDSC1; GDSC2	1.4244	3.1001	1.3072	19.6524
EW-22	GDSC1; GDSC2	1.5655	3.6503	1.3064	19.0128
EW-3	GDSC1; GDSC2	1.7242	5.7704	0.6014	22.3175
ES7	GDSC1; GDSC2	1.9961	3.9829	1.6529	15.1887
TC-71	GDSC1; GDSC2	2.1252	3.9712	1.7951	13.8273
EW-1	GDSC1; GDSC2	2.1693	4.4021	1.6646	14.4087
ES5	GDSC1; GDSC2	2.1937	4.9435	1.4498	15.5905
SK-N-MC	CTRP2	2.5044	3.7539	2.5041	31.4456
EW-11	GDSC1; GDSC2	2.6235	6.1165	1.3071	14.8971
ES4	GDSC1; GDSC2	2.65	5.233	1.7616	12.019
A-673	GDSC1; GDSC2; CTRP2	2.7048	5.5164	2.6323	30.3527
SK-ES-1	GDSC1; GDSC2; CTRP2	2.758	4.7798	2.7438	29.8037
EW-16	GDSC1; GDSC2	2.9683	5.5881	1.8822	10.1952
EW-13	GDSC1; GDSC2	3.0151	6.2574	1.5913	11.8624
EW-7	GDSC1; GDSC2	3.1786	6.8442	1.44	12.2922
CADO-ES1	GDSC1; GDSC2	3.4182	5.1604	2.4816	5.047
EW-24	GDSC1; GDSC2	3.7749	5.4537	2.6059	3.374
SK-PN-DW	GDSC1; GDSC2	3.7791	5.9927	2.3457	4.9716
HuO9	GDSC1; GDSC2	3.8382	6.1012	2.3356	4.8942
CHSA0011	GDSC1; GDSC2	3.9111	5.7188	2.5718	3.2848
CAL-72	GDSC1; GDSC2	4.2129	6.7097	2.3006	4.2875
CAL-78	GDSC1; GDSC2; CTRP2	4.3699	9.0741	3.4649	22.3073
NY	GDSC1; GDSC2	4.7035	10.1222	0.9931	10.9331
NOS-1 [Human HNSCC]	GDSC1; GDSC2	4.88	8.7125	1.7881	5.9823
CHSA8926	GDSC1; GDSC2	4.8929	8.9702	1.6752	6.6087
CHSA0108	GDSC1; GDSC2	5.0512	9.9837	1.2985	8.4468
EW-18	GDSC1; GDSC2	5.1527	9.6632	1.5163	7.0112
TC71	CTRP2	5.2263	7.8242	4.856	14.6565
ES6	GDSC1; GDSC2	5.5782	7.7018	2.6063	0.8965
HuO-3N1	GDSC1; GDSC2	5.7027	12.1788	0.6858	10.46
H-EMC-SS	GDSC1; GDSC2	5.7146	8.0314	2.5379	1.0409
U2OS	GDSC1; GDSC2; CTRP2	5.8835	10.3916	4.4226	14.6459
U-CH2	GDSC2	6.3232	8.0925	2.7541	0.1922
HOS	GDSC1; GDSC2; CTRP2	6.9659	7.75	6.7263	2.6788
Hs 822.T	CTRP2	7.733	10.2924	6.0942	3.8761
Hs 888.T	CTRP2	7.985	12.88	5.006	7.9615
G-292 clone A141B1	GDSC1; GDSC2; CTRP2	8.3041	13.6399	4.8693	7.9964
SaOS-2	GDSC1; GDSC2; CTRP2	8.3489	13.7721	4.8373	8.0547
SJSA-1	GDSC1; GDSC2; CTRP2	8.5397	10.5269	6.5016	1.2691
SW1353	CTRP2	8.6128	15.4225	4.2204	10.0986
MG-63	GDSC1; GDSC2; CTRP2	9.0204	16.9223	3.782	11.142

Cancer Drug Sensitivity Data Curated from 218 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JK1	CTRP2	2.2471	8.9571	1.2385	36.0448
MEC1	CTRP2	7.1158	9.4224	6.0365	5.2292
JM1	GDSC1; GDSC2	3.1105	4.8059	2.3971	6.5006
SUP-B15	GDSC1; GDSC2	0.509	3.2064	0.2829	29.3782
Kasumi-2	CTRP2	0.8571	5.481	0.6626	42.843
DoHH2	GDSC1; GDSC2; CTRP2	0.8952	4.5574	0.8222	42.3401
697	GDSC1; GDSC2; CTRP2	1.1036	3.1995	1.1005	40.7774
SU-DHL-5	GDSC1; GDSC2; CTRP1	1.4446	2.5428	1.4446	41.6159
SUP-M2	GDSC1; GDSC2; CTRP2	1.7113	4.9638	1.6417	36.9415
MY-M12	GDSC1; GDSC2	1.843	3.4241	1.6789	15.7113
KOPN-8	GDSC1; GDSC2	2.0087	4.0637	1.635	15.2384
NKM-1	GDSC1; GDSC2	2.0425	9.0529	-0.6691	27.2142
BV-173	GDSC1; GDSC2; CTRP2	2.1348	4.3008	2.1237	33.9411
MV4-11	GDSC1; GDSC2; CTRP2	2.1939	6.4791	1.9192	34.3801
OCI-Ly19	GDSC1; GDSC2; CTRP2	2.3147	5.1468	2.2589	32.8913
EoL-1	GDSC1; GDSC2; CTRP2	2.3422	5.9616	2.1808	33.0511
MHH-CALL-4	GDSC2; CTRP2	2.3711	8.7107	1.4598	35.0444
MOLT-3	CTRP2	2.5468	3.0558	2.5468	31.162
MOLT-16	GDSC1; GDSC2; CTRP2	2.59	4.156	2.5879	30.8819
NU-DHL-1	CTRP2	2.6454	8.8648	1.701	33.4445
NALM-6	GDSC1; GDSC2; CTRP2	2.6987	5.7242	2.5998	30.4816
GR-ST	GDSC1; GDSC2	2.9342	6.1005	1.5976	12.0809
MOLT-4	GDSC1; GDSC2	2.961	5.7896	1.7758	10.8844
JVM-2	GDSC1; GDSC2; CTRP2	2.976	6.6458	2.7328	29.1268
OCI-AML-2	GDSC1; GDSC2; CTRP2	3.0078	4.4	3.0061	28.0996
JVM-3	GDSC1; GDSC2; CTRP2	3.0358	6.1067	2.9032	28.3553
OCI-Ly3	CTRP2	3.0516	4.2736	3.051	27.8043
SCC-3	GDSC2	3.0701	4.9984	2.2655	7.4586
Granta-519	GDSC1; GDSC2; CTRP2	3.1149	5.5334	3.0637	27.5531
BALL-1	GDSC1; GDSC2	3.1316	4.5735	2.5312	5.5888
LC4-1	GDSC1; GDSC2	3.1347	5.9802	1.8337	9.9747
SU-DHL-8	GDSC1; GDSC2; CTRP2	3.148	4.3946	3.1471	27.1637
Farage	GDSC1; GDSC2	3.152	7.2875	1.1958	13.8605
CML-T1	GDSC1; GDSC2; CTRP2	3.1955	5.637	3.138	27.038
ML-2	GDSC1; GDSC2	3.254	7.3977	1.2272	13.362
P30/OHK	GDSC1; GDSC2	3.2885	5.2548	2.3275	6.3941
Hs 611.T	CTRP2	3.3213	8.374	2.6047	28.4559
IM-9	GDSC1; GDSC2	3.3319	4.973	2.5046	5.1458
NU-DUL-1	GDSC1; GDSC2; CTRP2; CTRP1	3.3515	5.4481	3.3192	25.9148
ALL-PO	GDSC1; GDSC2	3.3835	6.6233	1.7223	9.9338
RS4;11	GDSC1; GDSC2; CTRP2	3.4469	6.6729	3.2389	25.8833
CRO-AP2	GDSC1; GDSC2	3.492	6.353	1.9457	8.2262
SUP-B8	GDSC1; GDSC2	3.5455	5.3414	2.4919	4.6401
Reh	GDSC1; GDSC2; CTRP2	3.5717	5.7081	3.5275	24.4897
ARH-77	GDSC1; GDSC2	3.5775	6.0361	2.1715	6.5728
Karpas-231	GDSC1; GDSC2	3.6115	5.8241	2.3033	5.6549
WIL2 NS	GDSC1; GDSC2	3.6116	5.4421	2.4925	4.467
P32/ISH	GDSC1; GDSC2	3.6246	4.8303	2.8027	2.5052
CESS	GDSC1; GDSC2	3.6867	5.8862	2.3297	5.2982
P12-Ichikawa	GDSC1; GDSC2; CTRP2	3.6946	5.7116	3.6564	23.6511
WSU-NHL	GDSC1; GDSC2	3.7489	5.7325	2.4513	4.388
MOLM-13	GDSC1; GDSC2; CTRP2	3.7742	8.1845	3.1604	25.1493
KE-97	CTRP2; CTRP1	3.7769	7.2573	3.4538	24.098
SR	GDSC1; GDSC2; CTRP2	3.8	6.4442	3.6682	23.2713
OCI-Ly7	GDSC1; GDSC2	3.8193	5.3161	2.7027	2.6884
MHH-CALL-2	GDSC1; GDSC2	3.8255	6.1425	2.3062	5.1062
Karpas-1106P	GDSC1; GDSC2	3.8316	7.6027	1.59	9.5317
HC-1	GDSC1; GDSC2	3.8318	5.9678	2.3961	4.5354
VAL	GDSC1; GDSC2	3.9125	6.3911	2.2474	5.2655
Daudi	GDSC1; GDSC2; CTRP2	3.914	7.1798	3.6245	23.0691
KMS-34	CTRP2	3.9195	5.5592	3.902	22.0842
BONNA-12	GDSC2	3.9594	9.4329	0.7801	13.9813
SU-DHL-16	GDSC1; GDSC2	3.9731	8.0484	1.477	9.8584
SU-DHL-10	GDSC1; GDSC2	3.978	8.0731	1.4685	9.8978
CCRF-CEM	GDSC1; GDSC2	3.9959	7.2909	1.8672	7.414
SUP-T1	GDSC1; GDSC2; CTRP2	4.0068	6.4837	3.8843	21.8633
BC-3	GDSC2	4.0192	5.8151	2.5975	2.9112
RCH-ACV	GDSC1; GDSC2; CTRP2	4.0426	8.0804	3.4867	23.1764
NK-92MI	GDSC2	4.0919	6.146	2.4885	3.4132
EB2	GDSC1; GDSC2	4.1129	5.9417	2.5979	2.7301
ME1	GDSC1; GDSC2	4.1397	6.302	2.4459	3.5709
YT	GDSC1; GDSC2	4.159	6.5177	2.3562	4.0655
RC-K8	GDSC1; GDSC2	4.1662	5.8572	2.6696	2.225
Loucy	GDSC1; GDSC2	4.1736	6.3196	2.4595	3.4235
CTB-1	GDSC1; GDSC2	4.1916	8.776	1.2814	10.4845
VL51	GDSC1; GDSC2	4.2202	6.6796	2.3197	4.1592
L-540	GDSC1; GDSC2; CTRP2	4.2432	7.0961	4.0058	20.6965
SU-DHL-6	GDSC1; GDSC2; CTRP2	4.2996	6.7898	4.1404	20.0444
ATN-1	GDSC1; GDSC2	4.3565	7.4391	2.0486	5.4984
BE-13	GDSC1; GDSC2	4.4056	9.5802	1.0435	11.3483
Jiyoye	GDSC1; GDSC2	4.4203	6.7241	2.4257	3.1638
KY821	GDSC1; GDSC2	4.4238	8.3438	1.6594	7.6851
JSC-1	GDSC1; GDSC2	4.4371	7.4901	2.0778	5.1588
ALL-SIL	GDSC1; GDSC2; CTRP2	4.4571	7.3601	4.1671	19.4651
MHH-PREB-1	GDSC1; GDSC2	4.4696	8.6939	1.5219	8.4017
DND-41	GDSC1; GDSC2; CTRP2	4.504	7.1632	4.2728	18.9412
Sc-1	GDSC1	4.531	5.991	2.8096	1.1091
ROS-50	GDSC1; GDSC2	4.5376	8.7014	1.5655	7.9918
MLMA	GDSC1; GDSC2	4.548	7.9822	1.9173	5.8846
SUP-HD1	GDSC1; GDSC2; CTRP2	4.5502	7.9785	4.0712	19.5403
QIMR-WIL	GDSC1; GDSC2	4.5614	10.1024	0.901	11.7828
RPMI-6666	GDSC1; GDSC2; CTRP2	4.5693	8.0607	4.0631	19.5146
MN-60	GDSC1; GDSC2	4.5722	6.9839	2.3981	3.0587
TUR	GDSC1; GDSC2	4.5872	6.9827	2.4076	2.9816
U-698-M	GDSC1; GDSC2	4.591	6.4594	2.6419	1.7307
CTV-1	GDSC1; GDSC2	4.6194	8.8846	1.5335	8.0016
SKM-1	GDSC1; GDSC2; CTRP2; CTRP1	4.6447	11.1488	2.8471	23.7833
BL-41	GDSC1; GDSC2	4.6471	6.05	2.8405	0.7574
WSU-DLCL2	GDSC1; GDSC2; CTRP2; CTRP1	4.6584	8.5108	3.9929	19.5221
DG-75	GDSC1; GDSC2	4.66	6.7544	2.5508	2.1012
TALL-1 [Human adult T-ALL]	GDSC2; CTRP2	4.6921	10.2181	3.3144	21.9725
Karpas-45	GDSC1; GDSC2	4.6946	9.1215	1.471	8.2052
JURL-MK1	GDSC1; GDSC2; CTRP2	4.7105	8.2186	4.1585	18.752
Hs 445	GDSC1; GDSC2	4.7688	6.7474	2.6117	1.6517
HAL-01	GDSC1; GDSC2	4.7775	10.4347	0.8935	11.3202
SET-2	CTRP2	4.7812	8.1077	4.2749	18.113
BC-1	GDSC1; GDSC2	4.7961	7.1251	2.4629	2.3636
Ku812	GDSC1; GDSC2; CTRP2; CTRP1	4.8421	8.3684	4.2435	18.0581
Ramos.2G6.4C10	GDSC1; GDSC2	4.8498	6.5394	2.7379	0.9915
KE-37	GDSC1; GDSC2; CTRP2	4.8988	7.9213	4.4681	17.0522
MEG-01	GDSC1; GDSC2	4.9127	8.9903	1.6785	6.5504
OCI-AML-5	GDSC1; GDSC2; CTRP2	4.9211	9.7375	3.7606	19.6825
KMS-21-BM	CTRP2	4.9215	8.5594	4.2542	17.7945
MOLT-13	GDSC1; GDSC2; CTRP2	4.9539	8.5964	4.2739	17.6296
TK [Human B-cell lymphoma]	GDSC1; GDSC2	4.9906	6.5904	2.7813	0.7037
SU-DHL-1	GDSC2; CTRP2	5.0015	6.9207	4.8748	15.2613
MOLM-16	GDSC1; GDSC2; CTRP2; CTRP1	5.0139	9.8827	3.7916	19.3181
RPMI-8402	GDSC1; GDSC2; CTRP2	5.059	7.7017	4.7167	15.6614
OCI-AML-3	GDSC1; GDSC2; CTRP2; CTRP1	5.0606	9.7573	3.8948	18.7986
DB	GDSC1; GDSC2; CTRP2	5.0625	11.4072	3.1422	21.63
NB4	GDSC1; GDSC2; CTRP2	5.1366	8.4989	4.5064	16.2347
KG-1	GDSC1; GDSC2	5.2045	8.827	1.935	4.5708
MHH-CALL-3	CTRP2	5.2569	15.8603	1.1767	27.4118
Peer	CTRP2	5.2687	7.974	4.8483	14.5636
PL-21	GDSC1; GDSC2	5.2709	7.5138	2.5414	1.4156
L-1236	GDSC1; GDSC2	5.2958	7.729	2.4649	1.7278
Ki-JK	CTRP2	5.3102	8.3326	4.7563	14.7967
DEL	GDSC1; GDSC2; CTRP2	5.3506	10.3312	3.9277	17.9215
THP-1	GDSC1; GDSC2; CTRP2; CTRP1	5.3578	8.5581	4.7161	14.8204
SEM	CTRP2	5.3923	8.4874	4.7813	14.4745
Ri-1	CTRP2	5.442	10.0686	4.1397	16.8601
HH [Human lymphoma]	GDSC1; GDSC2	5.486	7.5948	2.6076	0.9606
KMOE-2	GDSC1; GDSC2	5.5028	7.826	2.5239	1.2696
Namalwa	GDSC1; GDSC2; CTRP2	5.5731	9.3762	4.5863	14.7607
EM-2	GDSC1; GDSC2; CTRP2	5.5797	9.4283	4.5696	14.8099
RPMI-8866	GDSC1; GDSC2	5.6062	13.7476	-0.1318	14.7121
MOLP-8	GDSC1; GDSC2; CTRP2	5.6599	9.3788	4.6731	14.1943
GA-10	GDSC1; GDSC2; CTRP2	5.7372	9.6231	4.6393	14.134
KM-H2	GDSC1; GDSC2; CTRP2	5.7895	9.5347	4.7321	13.6317
NCO2	CTRP2	5.9081	9.7968	4.7278	13.3563
HEL	GDSC1; GDSC2; CTRP2	5.9149	7.9553	5.5472	10.0892
CMK	GDSC1; CTRP2	5.917	9.7968	4.7364	13.2999
H9	GDSC1; GDSC2	5.9384	12.3376	0.7635	9.598
M-07e	CTRP2	5.9842	12.3732	3.5578	17.8278
KHM-1B	CTRP2	6.0107	9.5503	4.9441	12.2321
HD-MY-Z	CTRP2	6.0149	9.3309	5.0504	11.7927
Pfeiffer	CTRP2	6.02	10.3372	4.5801	13.6849
KMS-26	CTRP2	6.0487	8.9044	5.2799	10.7858
MM1.S	GDSC1; GDSC2; CTRP2	6.0608	8.6796	5.3934	10.3021
HuNS1	CTRP2	6.0921	9.1386	5.2161	10.9336
EB1	CTRP2	6.1564	13.3207	3.2487	18.605
KO52	CTRP2	6.1725	9.0097	5.3556	10.1719
MOLM-6	CTRP2	6.1797	10.1144	4.8398	12.252
BL-70	CTRP2; CTRP1	6.1887	9.7831	5.0072	11.5475
U-937	CTRP2; CTRP1	6.2001	10.0227	4.9033	11.9449
GDM-1	GDSC1; GDSC2; CTRP2; CTRP1	6.3195	9.9186	5.0672	10.9956
KMS-11	GDSC1; GDSC2; CTRP2; CTRP1	6.3705	11.3858	4.3978	13.6234
PF-382	GDSC1; GDSC2; CTRP2	6.3815	11.0645	4.5659	12.9127
LP-1	GDSC1; GDSC2; CTRP2; CTRP1	6.4024	9.4175	5.3874	9.4885
Jurkat	GDSC1; GDSC2; CTRP2	6.4593	10.9413	4.6978	12.1991
A3/Kawakami	GDSC1; GDSC2; CTRP2	6.4607	11.0028	4.6689	12.3151
SU-DHL-4	GDSC1; GDSC2; CTRP2; CTRP1	6.5461	10.2256	5.1293	10.2256
MC116	GDSC1; GDSC2; CTRP2; CTRP1	6.5509	9.9063	5.2902	9.5489
ME1	CTRP2	6.5585	9.6151	5.4396	8.9142
EHEB	GDSC1; CTRP2	6.5764	10.7532	4.8972	11.12
KMS-27	CTRP2	6.7008	11.0703	4.8521	11.0387
KMS-12-BM	GDSC1; GDSC2; CTRP2	6.7732	10.1326	5.3817	8.6814
KMS-18	CTRP2	6.7877	9.9271	5.4965	8.1719
U266B1	GDSC1; GDSC2; CTRP2	6.8078	10.8968	5.0331	10.061
HEL 92.1.7	CTRP2	6.8827	9.8098	5.6397	7.372
SIG-M5	GDSC2; CTRP2	6.9248	10.138	5.5137	7.8104
HPB-ALL	CTRP2	6.9479	10.2677	5.4694	7.9481
A4/Fukuda	GDSC1; GDSC2; CTRP2	6.9503	10.8556	5.1784	9.1599
NCI-H929	GDSC1; GDSC2; CTRP2	6.957	7.7544	6.7154	2.7445
JJN-3	GDSC1; GDSC2; CTRP2	7.0094	10.6061	5.354	8.3049
JeKo-1	GDSC1; GDSC2; CTRP2	7.0125	10.9028	5.2086	8.9073
L-363	GDSC1; GDSC2; CTRP2	7.0564	11.2352	5.0801	9.356
Mono-Mac-1	CTRP2	7.0853	12.0368	4.7042	10.8613
Karpas-299	GDSC1; GDSC2; CTRP2	7.1496	10.2276	5.6629	6.7298
Kasumi-1	GDSC1; GDSC2; CTRP2	7.1817	8.5358	6.5356	3.0032
Mono-Mac-6	GDSC1; GDSC2; CTRP2	7.2162	12.9043	4.3805	11.9331
P31/FUJ	GDSC1; GDSC2; CTRP2	7.247	11.6454	5.0356	9.1676
MOTN-1	CTRP2	7.278	11.332	5.218	8.3461
TF-1	CTRP2	7.3147	9.661	6.0835	4.6465
K-562	GDSC1; GDSC2; CTRP2	7.3177	10.4956	5.6688	6.3812
PL21	CTRP2; CTRP1	7.3431	11.9199	4.9778	9.2247
SUP-T11	CTRP2	7.3467	10.6744	5.6033	6.6016
KYO-1	CTRP2	7.3553	10.7475	5.5737	6.7097
KCL-22	GDSC1; GDSC2; CTRP2	7.3619	11.2075	5.3492	7.6382
SK-MM-2	GDSC1; GDSC2; CTRP2	7.3698	9.4049	6.2559	3.8217
CA46	GDSC1; GDSC2; CTRP2	7.4134	11.608	5.1911	8.2033
OPM-2	GDSC1; GDSC2; CTRP2	7.422	8.9011	6.5477	2.5088
AMO1	GDSC1; GDSC2; CTRP2; CTRP1	7.5494	9.9225	6.1389	3.9946
OCI-M1	GDSC1; GDSC2; CTRP2	7.6225	8.8873	6.7003	1.5651
RL	GDSC1; GDSC2; CTRP2	7.6354	11.3667	5.4882	6.5609
HuT 78	CTRP2	7.6557	10.0359	6.1632	3.7159
KMS-20	CTRP2	7.6826	21.6724	0.3816	24.3185
LAMA-84	GDSC1; GDSC2; CTRP2	7.7173	12.8809	4.7989	9.2791
HL-60	GDSC1; GDSC2; CTRP2	7.7458	9.9403	6.2761	3.1073
EJM	GDSC1; GDSC2; CTRP2; CTRP1	7.7685	11.778	5.3868	6.7526
Raji	GDSC1; GDSC2; CTRP2	7.7818	10.0974	6.2252	3.2605
AML-193	CTRP2	7.8093	10.7997	5.901	4.5513
ST486	GDSC1; GDSC2; CTRP2	7.8191	12.5995	5.0182	8.1943
RPMI-8226	GDSC1; GDSC2; CTRP2; CTRP1	7.8293	14.7083	3.977	12.3996
L-428	GDSC1; GDSC2; CTRP2	7.9468	10.9395	5.9325	4.2053
HT	GDSC1; GDSC2; CTRP2; CTRP1	7.9955	11.0537	5.9116	4.2166
NOMO-1	GDSC1; GDSC2; CTRP2; CTRP1	8.0017	9.7727	6.5288	1.7409
MOLP-2	CTRP2	8.1999	10.4864	6.3207	2.2974
HDLM-2	GDSC1; GDSC2; CTRP2	8.2421	12.2542	5.5024	5.5119
OCI-Ly10	CTRP2; CTRP1	8.3338	14.3924	4.521	9.3569
Ci-1	CTRP2	8.4336	9.284	6.9521	0.112
Karpas-422	GDSC1; GDSC2; CTRP2	8.4558	14.9705	4.3268	9.9329
F-36P	CTRP2	8.5155	19.9675	1.8974	18.542
Karpas-620	GDSC1; GDSC2; CTRP2	8.6085	11.2874	6.2014	2.2683
REC-1	CTRP2	8.6729	12.084	5.8733	3.4355
Toledo	CTRP2	8.8012	29.6267	-2.6883	28.6131
KMM-1	CTRP2	8.8214	17.6587	3.2743	13.35
P3HR-1	CTRP2; CTRP1	10.7959	22.4427	2.3503	13.5019

Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Oesophagus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TE15	CTRP2	7.9669	12.3409	5.2588	6.9492
TE8	CTRP2	8.3244	10.6342	6.3294	2.1138
KYSE-270	GDSC1; GDSC2	3.5319	5.3288	2.4877	4.7024
TE-8	GDSC1; GDSC2	4.1948	6.6164	2.333	4.1314
T.T	GDSC1; GDSC2	4.6434	6.9316	2.4631	2.5889
TE-15	GDSC1; GDSC2	4.688	6.6819	2.5974	1.8251
EC-GI-10	GDSC1; GDSC2; CTRP2	6.3395	10.8884	4.6137	12.8109
KYSE-510	GDSC1; GDSC2; CTRP2	6.7887	11.4695	4.7314	11.3533
TE-5	GDSC1; GDSC2; CTRP2	7.2094	9.4985	6.0778	4.8711
TE-10	GDSC1; GDSC2; CTRP2	7.5151	10.2622	5.9436	4.8695
KYSE-140	GDSC1; GDSC2; CTRP2; CTRP1	7.5288	10.6528	5.7599	5.6136
COLO 680N	GDSC1; GDSC2; CTRP2	7.5686	10.4831	5.8754	5.0608
TE-9	GDSC1; GDSC2; CTRP2	7.5692	11.7431	5.2487	7.6778
OE33	GDSC1; GDSC2; CTRP2	7.6231	11.6616	5.3319	7.2344
TE-4	GDSC1; GDSC2; CTRP2	7.6428	9.8797	6.2306	3.4579
TE-14	CTRP2	7.8474	10.9526	5.8539	4.6847
OE19	GDSC1; GDSC2; CTRP2	7.8559	9.4222	6.6003	1.6468
TE-6	GDSC1; GDSC2; CTRP2	7.8658	10.1073	6.2797	2.912
KYSE-450	GDSC1; GDSC2; CTRP2; CTRP1	7.9747	10.3993	6.2139	3.0202
KYSE-180	GDSC1; GDSC2; CTRP2	7.9879	11.269	5.8011	4.6804
KYSE-70	GDSC1; GDSC2; CTRP2	7.9969	11.0839	5.8978	4.2704
KYSE-150	GDSC1; GDSC2; CTRP2	8.0422	11.4583	5.7477	4.8154
KYSE-410	GDSC1; GDSC2; CTRP2; CTRP1	8.1547	10.9407	6.0763	3.3186
KYSE-520	GDSC1; GDSC2; CTRP2	8.2994	12.0253	5.6536	4.8126
TE-11	GDSC1; GDSC2; CTRP2	8.4187	13.4172	5.0615	7.035
KYSE-30	CTRP2	8.4907	13.0197	5.3057	5.9378
TE-1	GDSC1; GDSC2; CTRP2	8.4976	11.6018	5.9877	3.213
OE21	GDSC1; GDSC2; CTRP2	10.5613	20.5976	3.0763	11.4204

Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Pancreas Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
N2a-PK1	CTRP2	8.1659	11.3042	5.9093	3.9733
PL4	GDSC1; GDSC2	4.4429	6.0848	2.7249	1.5101
KP-1N	GDSC1; GDSC2	4.7725	6.8999	2.5483	1.9531
MZ-PC-1	GDSC1; GDSC2	5.5642	7.9089	2.5189	1.2313
Panc 03.27	GDSC1; GDSC2; CTRP2; CTRP1	6.8778	10.5871	5.2488	9.0153
SW1990	GDSC1; GDSC2; CTRP2	7.0887	12.0683	4.6914	10.9077
SUIT-2	GDSC1; GDSC2; CTRP2; CTRP1	7.198	11.5807	5.0271	9.298
HuP-T4	GDSC1; GDSC2; CTRP2; CTRP1	7.2667	10.7461	5.5016	7.1795
KP-4	GDSC1; GDSC2; CTRP2	7.5204	11.8857	5.1387	8.2251
L3.3	CTRP2	7.5782	10.0109	6.1171	4.0365
QGP-1	GDSC1; GDSC2; CTRP2; CTRP1	7.5862	9.9161	6.1702	3.8023
HPAF-II	GDSC1; GDSC2; CTRP2	7.6417	12.2997	5.0287	8.4631
HuP-T3	GDSC1; GDSC2; CTRP2	7.7225	13.01	4.7386	9.518
SNU-213	CTRP2	7.7798	11.142	5.7103	5.3897
BxPC-3	GDSC1; GDSC2; CTRP2	7.803	14.6534	3.9836	12.4213
Panc 10.05	GDSC1; GDSC2; CTRP2; CTRP1	7.8559	12.3154	5.1874	7.4308
DAN-G	GDSC1; GDSC2; CTRP2	7.869	10.754	5.9671	4.1839
Capan-1	GDSC1; GDSC2; CTRP2	8.0581	11.8209	5.5819	5.4707
PANC-1	CTRP2	8.1134	10.0638	6.4632	1.8563
KP-3	GDSC1; GDSC2; CTRP2; CTRP1	8.1298	12.4851	5.3085	6.48
PSN1	GDSC1; GDSC2; CTRP2	8.1827	14.5111	4.3488	10.3002
PK-59	CTRP2	8.2488	11.9687	5.6457	4.9189
Capan-2	GDSC1; GDSC2; CTRP2; CTRP1	8.3036	11.6484	5.8379	4.0644
MIA PaCa-2	GDSC1; GDSC2; CTRP2	8.35	11.9471	5.726	4.4475
YAPC	GDSC1; GDSC2; CTRP2	8.3538	10.0524	6.6077	1.0792
CFPAC-1	GDSC1; GDSC2; CTRP2; CTRP1	8.3641	12.778	5.334	6.0119
Panc 05.04	CTRP2	8.6066	10.2027	6.6727	0.6761
SNU-410	CTRP2	8.6545	14.7489	4.5806	8.6057
SU.86.86	GDSC1; GDSC2; CTRP2	8.6632	9.8223	6.846	0.2242
PaTu 8902	GDSC1; GDSC2; CTRP2; CTRP1	8.7022	10.0144	6.7901	0.3236
TCC-Pan2	CTRP2	8.9029	11.1383	6.4299	1.1946
PaTu 8988s	CTRP2	8.9302	10.8255	6.5729	0.7479
KP-2	GDSC1; GDSC2; CTRP2	8.9988	12.5706	5.8492	3.1388
Panc 08.13	GDSC1; GDSC2; CTRP2	9.1344	11.1213	6.5487	0.6904
Panc 04.03	GDSC1; GDSC2; CTRP2	9.1505	13.8096	5.3688	4.7847
HPAC	GDSC1; GDSC2; CTRP2; CTRP1	9.2226	13.2479	5.6739	3.538
PaTu 8988t	GDSC1; GDSC2; CTRP2	9.4332	10.5185	6.8836	0.0377
PK-45H	CTRP2	9.537	17.8195	3.7119	10.6156
Panc 02.03	GDSC1; GDSC2; CTRP2	9.5753	14.6345	5.2508	4.7145
AsPC-1	GDSC1; GDSC2; CTRP2	9.8233	16.4494	4.5599	7.0229
Hs 766T	GDSC1; GDSC2; CTRP2	10.3403	20.824	2.8171	12.6148

Cancer Drug Sensitivity Data Curated from 76 Cell Line(s) in Skin Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SH4	CTRP2	11.8887	28.2251	0.3148	17.7981
IST-MEL1	GDSC1; GDSC2	3.7896	5.7554	2.4695	4.1797
A-431	GDSC1; GDSC2	3.8452	6.0962	2.3431	4.8315
M14	GDSC1; GDSC2	3.8919	6.48	2.1891	5.6743
DJM-1	GDSC1; GDSC2	4.0864	8.1308	1.5211	9.3088
VMRC-MELG	GDSC1; GDSC2	4.1028	5.5085	2.7905	1.6599
GAK	GDSC1; GDSC2	4.3026	5.7032	2.8151	1.2443
CHL-1	GDSC1; GDSC2	4.3087	6.8526	2.2957	4.1253
WM1552C	GDSC1; GDSC2	4.4115	6.4726	2.5353	2.5633
SH-4	GDSC1; GDSC2	4.4595	6.1275	2.7153	1.5366
MZ-MEL-2	GDSC1; GDSC2	4.6461	8.7129	1.6341	7.3526
A-388	GDSC1; GDSC2	4.6481	8.4085	1.7808	6.4847
HMV-II	GDSC1; GDSC2	4.6968	8.272	1.8775	5.8198
WM35	GDSC1; GDSC2	4.7296	8.1305	1.9651	5.2465
COLO 679	GDSC1; GDSC2	4.7353	6.5331	2.6851	1.3435
LB373-MEL-D	GDSC1; GDSC2	4.8151	6.8482	2.5927	1.6864
LB2518-MEL	GDSC1; GDSC2	4.9132	6.5503	2.7627	0.8351
Hs 938.T	GDSC1; GDSC2	4.9337	7.235	2.4892	2.0435
WM278	GDSC1; GDSC2	4.992	7.6997	2.3183	2.8365
MMAc-SF	GDSC1; GDSC2	5.0007	6.8211	2.6948	1.0295
MZ-MEL-7	GDSC1; GDSC2	5.1626	6.6124	2.8446	0.3948
CP66-MEL	GDSC1; GDSC2	5.1909	6.6586	2.8389	0.3964
CP50-MEL-B	GDSC1; GDSC2	5.2954	6.9029	2.7906	0.4787
COLO 783	GDSC1; GDSC2	5.337	6.6884	2.8841	0.2288
451Lu	GDSC1; GDSC2	5.4852	7.3637	2.696	0.6572
G-mel	GDSC1; GDSC2	5.6045	7.7023	2.6174	0.8394
Hs 852.T	CTRP2; CTRP1	6.0351	9.1474	5.1553	11.3201
WM266-4	CTRP2	6.4868	7.1673	6.4349	5.1185
WM88	CTRP2	6.5629	10.0745	5.2189	9.8172
COLO 792	GDSC1; GDSC2; CTRP2	6.5646	8.8462	5.8167	7.3487
CJM [Human melanoma]	CTRP2	6.6741	16.0864	2.3297	20.7117
G-361	GDSC1; GDSC2; CTRP2; CTRP1	6.6902	8.5295	6.089	5.9375
Hs 944.T	CTRP2; CTRP1	6.7022	8.9573	5.8942	6.7098
A2058	GDSC1; GDSC2; CTRP2	6.7499	11.989	4.4387	12.6383
HMCB	CTRP2	6.83	7.4142	6.7318	3.0112
WM115	GDSC1; GDSC2; CTRP2	6.8732	10.5274	5.2746	8.9173
LOX-IMVI	GDSC1; GDSC2; CTRP2	7.0974	12.7093	4.3783	12.1763
SK-MEL-1	GDSC1; GDSC2; CTRP2; CTRP1	7.2031	8.2836	6.6798	2.3555
SK-MEL-5	GDSC1; GDSC2; CTRP2; CTRP1	7.2284	8.1095	6.7881	1.8515
RPMI-7951	GDSC1; GDSC2; CTRP2	7.2299	9.4854	6.1014	4.7323
WT2-iPS	GDSC1; GDSC2; CTRP2	7.2337	8.2501	6.7222	2.1178
COLO 741	CTRP1	7.2434	9.497	4.4302	1.8874
UACC-62	GDSC1; GDSC2; CTRP2	7.2851	8.4379	6.6705	2.2383
SK-MEL-28	GDSC1; GDSC2; CTRP2; CTRP1	7.2969	8.1221	6.8375	1.5165
RVH-421	GDSC1; GDSC2; CTRP2	7.4439	8.8134	6.6078	2.2213
Hs 940.T	GDSC1; GDSC2; CTRP2	7.5783	11.8073	5.2239	7.7646
SK-MEL-31	GDSC1; GDSC2; CTRP2	7.7356	10.1456	6.1682	3.5668
WM983B	CTRP2	7.7446	10.1368	6.1791	3.5077
Hs 839.T	CTRP2	7.8717	11.5006	5.6022	5.686
IGR-37	GDSC1; GDSC2; CTRP2	7.889	10.0157	6.3398	2.636
SK-MEL-24	GDSC1; GDSC2; CTRP2	7.9054	13.0348	4.8686	8.6622
MeWo	GDSC1; GDSC2; CTRP2	7.9221	10.0664	6.3379	2.5965
WM793	GDSC1; GDSC2; CTRP2	8.0867	11.1396	5.934	3.989
HT-144	GDSC1; GDSC2; CTRP2	8.0912	12.6281	5.2098	6.9474
MDA-MB-435S	CTRP2	8.1179	10.3241	6.3445	2.3082
Mel JuSo	GDSC1; GDSC2; CTRP2	8.1626	10.7273	6.1832	2.8829
Hs 688(A).T	CTRP2	8.1703	10.1945	6.4378	1.8848
WM1799	CTRP2	8.1909	12.0851	5.5483	5.4025
A-375	GDSC1; GDSC2; CTRP2; CTRP1	8.2035	13.9022	4.6655	8.9886
IGR-1	GDSC1; GDSC2; CTRP2	8.2236	10.0702	6.5266	1.494
Mel Ho	GDSC1; GDSC2; CTRP2	8.2773	10.4592	6.3813	1.9731
SK-MEL-2	GDSC1; GDSC2; CTRP2	8.2798	9.2507	6.9025	0.2607
IGR-39	CTRP2	8.399	11.5326	5.9566	3.4624
Hs 934.T	CTRP2	8.6478	20.3945	1.7879	18.6488
K029AX	CTRP2	8.7424	12.7203	5.6188	4.3375
COLO 800	GDSC1; GDSC2; CTRP2	8.8312	14.9186	4.6236	8.1638
Hs 936.T	CTRP2; CTRP1	8.8434	12.2694	5.8932	3.1531
SK-MEL-30	GDSC1; GDSC2; CTRP2	8.9417	10.1429	6.8381	0.1552
IPC-298	GDSC1; GDSC2; CTRP2	8.9461	10.1194	6.8481	0.1398
Hs 895.T	CTRP2	9.0304	15.0982	4.6755	7.6643
SK-MEL-3	GDSC1; GDSC2; CTRP2	9.1023	10.2612	6.8557	0.0992
A101D	GDSC1; GDSC2; CTRP2	9.1221	10.2577	6.864	0.0871
UACC-257	GDSC1; GDSC2; CTRP2	9.2534	14.6235	5.052	5.8798
COLO 829	GDSC1; GDSC2; CTRP2	10.2582	17.8207	4.1945	7.827
Hs 294T	CTRP2	10.5386	18.3512	4.1245	7.729
EquiPSC Line K2	GDSC1; GDSC2	5.366	10.4605	1.2785	7.9316

Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HCE-4	GDSC1; GDSC2	3.9861	6.3782	2.3056	4.7404
KYSE-220	GDSC1; GDSC2	4.0437	5.8731	2.586	2.9316
KYSE-50	GDSC1; GDSC2	4.6226	6.5209	2.6322	1.7377
FLO-1	GDSC1; GDSC2	4.6981	7.812	2.0939	4.5622
KYAE-1	GDSC1; GDSC2	5.0158	8.3804	2.0261	4.3841
OACP4 C	GDSC1; GDSC2	5.1575	7.5922	2.4529	1.9415
SK-GT-4	GDSC1; GDSC2	5.2059	7.8739	2.358	2.3411
ESO-51	GDSC1; GDSC2	5.2298	7.3555	2.5862	1.2651
ESO-26	GDSC1; GDSC2	5.3235	7.8241	2.4391	1.8147
OACM5.1 C	GDSC1; GDSC2	5.3873	7.5077	2.5978	1.077
TE-12	GDSC1; GDSC2	6.4647	11.8292	1.3139	5.8583

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
COLO 684	GDSC1; GDSC2; CTRP2	8.3846	16.9123	3.3133	13.9476

Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Autonomic Ganglia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SK-N-MC-IXC	GDSC1; GDSC2	1.4575	3.1595	1.3292	19.3796
IMR-32	CTRP2	1.8001	4.5409	1.7684	36.2343
KP-N-RT-BM-1	GDSC2	2.3935	4.5122	1.8464	12.4456
SJNB-10	GDSC1; GDSC2	2.871	5.0814	2.043	9.5102
NB69	GDSC1; GDSC2	2.9583	6.2268	1.5564	12.2592
SJNB-14	GDSC1; GDSC2	3.0186	5.757	1.8432	10.2777
MHH-NB-11	GDSC1; GDSC2; CTRP2	3.1856	4.9316	3.1759	26.9427
IMR-5	GDSC1; GDSC2	3.2146	6.0486	1.8682	9.515
GOTO	GDSC1; GDSC2	3.4248	6.5393	1.7981	9.3416
CHP-134	GDSC2	3.4802	5.7737	2.2253	6.4961
SiMa	GDSC1; GDSC2	3.7184	5.4699	2.5577	3.8004
CHP-126	GDSC1; GDSC2; CTRP2	3.7572	6.0275	3.6878	23.3406
SJNB-7	GDSC1; GDSC2	3.7759	5.4919	2.588	3.4812
SJNB-17	GDSC1; GDSC2	3.9022	5.7008	2.5744	3.288
NH-12	GDSC1; GDSC2	3.9603	7.1225	1.9239	7.1505
GI-ME-N	GDSC1; GDSC2	3.9853	8.7802	1.124	11.9354
TGW	GDSC1; GDSC2	4.0492	5.5493	2.7402	2.0285
SJNB-6	GDSC1; GDSC2	4.1524	6.139	2.5307	3.0469
SK-N-FI	GDSC1; GDSC2	4.289	6.3073	2.5375	2.7591
SJNB-13	GDSC1; GDSC2	4.3156	6.1103	2.643	2.1266
KP-N-YS	GDSC1; GDSC2	4.4349	7.3054	2.1638	4.6552
SJNB-12	GDSC1; GDSC2	4.5956	10.1071	0.9234	11.5761
SJNB-5	GDSC1; GDSC2	4.6798	8.7392	1.6443	7.2222
CHP-212	GDSC1; GDSC2; CTRP2	4.7501	9.1577	3.8309	19.8786
SK-N-BE(2)-M17	GDSC1; GDSC2	5.1198	6.871	2.7288	0.7972
LA-N-6	GDSC1; GDSC2	5.1687	6.9625	2.7146	0.8115
NB(TU)1	GDSC1; GDSC2	5.4287	14.4392	-0.5937	17.1844
SK-N-BE(2)	CTRP2	5.6216	10.1124	4.2979	15.7842
Kelly	GDSC1; GDSC2; CTRP2	5.8228	10.143	4.4814	14.5562
NH-6	CTRP2	5.9291	10.1323	4.5899	13.8619
SK-N-SH	GDSC1; GDSC2; CTRP2	6.1587	10.4445	4.6607	13.032
SK-N-DZ	GDSC1; GDSC2; CTRP2	6.4395	11.32	4.4932	13.082
NB1	GDSC1; GDSC2; CTRP2	6.5794	10.7224	4.9151	11.0389
KP-N-SI9s	CTRP2	6.7603	11.742	4.5708	12.0751
SK-N-AS	GDSC1; GDSC2; CTRP2	8.623	13.7102	5.0636	6.7171
KP-N-YN	GDSC1; GDSC2; CTRP2	8.6453	13.5912	5.1368	6.3902

Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SNU-1079	CTRP2	3.6024	7.4248	3.216	25.477
SNU-478	CTRP2	7.0562	11.6457	4.875	10.2111
HuH-28	CTRP2	7.0751	9.2212	6.1018	5.0379
HuCC-T1	GDSC1; GDSC2; CTRP2	7.1913	11.1604	5.2316	8.4564
SNU-1196	CTRP2	7.732	10.3124	6.0836	3.9214
SNU-308	CTRP2	7.9052	10.4123	6.1594	3.3421
SNU-869	CTRP2	7.9251	11.777	5.5057	5.9977

Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Breast Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MDA-MB-157	GDSC1; GDSC2; CTRP2	3.5737	8.6836	2.7658	27.1322
DU4475	GDSC1; GDSC2; CTRP2	3.7938	9.5828	2.651	26.8605
HCC1599	GDSC2	3.9676	6.1004	2.427	4.0272
Evsa-T	GDSC1; GDSC2	4.022	6.1411	2.4445	3.8059
OCUB-M	GDSC1; GDSC2	4.0837	6.547	2.2916	4.596
UACC-893	GDSC1; GDSC2	4.1032	8.1444	1.5268	9.2013
YMB-1-E	GDSC2	4.2997	7.2427	2.1043	5.2832
UACC-812	GDSC2	4.3552	7.4436	2.0456	5.4996
MDA-MB-436	GDSC1; GDSC2	4.3565	7.7571	1.8961	6.3913
MRK-nu-1	GDSC1; GDSC2	4.4358	6.3359	2.6108	2.1062
HCC70	GDSC1; GDSC2	4.519	6.3823	2.6366	1.8498
MFM-223	GDSC1; GDSC2	4.8533	6.9447	2.5714	1.7363
MDA-MB-175-VII	GDSC1; GDSC2	4.8803	6.8343	2.6316	1.4218
HCC1569	GDSC1; GDSC2	4.8949	7.1742	2.4948	2.0586
HCC2157	GDSC1; GDSC2	5.1308	6.845	2.7437	0.7324
CAL-148	GDSC2; CTRP2	5.1368	10.3503	3.7053	19.3281
EFM-19	GDSC1; GDSC2	5.2439	9.2149	1.7814	5.3353
BT-483	GDSC1; GDSC2	5.3183	7.3524	2.6281	1.0139
MDA-MB-468	GDSC1; GDSC2; CTRP2	5.3643	9.3866	4.3691	16.1572
COLO 824	GDSC1; GDSC2	5.4101	7.4869	2.6163	0.9844
HCC2218	GDSC1; GDSC2; CTRP2	5.465	9.6048	4.374	15.8775
MDA-MB-330	GDSC1; GDSC2	5.7686	7.9789	2.5814	0.8469
CAL-51	GDSC1; GDSC2; CTRP2	5.8568	10.6631	4.2673	15.3338
MDA-MB-453	GDSC1; GDSC2; CTRP2	6.2442	8.9624	5.4486	9.6196
HMC-1-8	CTRP2	6.6661	8.6799	5.9939	6.3838
AU565	GDSC1; GDSC2; CTRP2	6.7185	11.3067	4.7504	11.4222
HCC1187	GDSC1; GDSC2	6.7275	14.0609	0.4555	9.6778
HCC1395	GDSC1; GDSC2; CTRP2	6.7786	12.9257	3.997	14.3636
SK-BR-3	CTRP2	6.8533	10.8543	5.0944	9.7106
ZR-75-30	GDSC1; GDSC2; CTRP2	6.9442	9.7818	5.708	6.9573
HCC1500	GDSC1; GDSC2; CTRP2	7.2258	9.6948	5.9933	5.1941
BT-474	GDSC1; GDSC2; CTRP2	7.2333	8.8311	6.4314	3.3399
HCC1419	GDSC1; GDSC2; CTRP2	7.3008	10.5063	5.6496	6.4938
BT-20	GDSC1; GDSC2; CTRP2	7.4181	11.0114	5.4928	6.9321
MDA-MB-361	GDSC1; GDSC2; CTRP2	7.4521	12.4619	4.796	10.5477
CAMA-1	GDSC1; GDSC2; CTRP2	7.4811	9.0975	6.4955	2.6258
CAL-85-1	GDSC1; GDSC2; CTRP2	7.528	13.7236	4.2273	11.9575
HDQ-P1	GDSC1; GDSC2; CTRP2	7.6111	12.1107	5.0987	8.2272
HCC38	GDSC1; GDSC2; CTRP2	7.6893	9.4882	6.4561	2.4575
HCC1954	GDSC1; GDSC2; CTRP2	7.7362	12.0082	5.2477	7.3868
MCF-7	GDSC1; GDSC2; CTRP2; CTRP1	7.7387	11.7195	5.393	6.7782
EFM-192A	GDSC1; GDSC2; CTRP2	7.7716	11.3301	5.6111	5.8153
HCC202	GDSC1; CTRP2	7.7781	12.8448	4.8645	8.9008
ZR-75-1	CTRP2	7.8234	10.1528	6.2278	3.1862
CAL-120	GDSC1; GDSC2; CTRP2	7.8481	9.2732	6.6651	1.4056
HCC1428	GDSC1; GDSC2; CTRP2	7.9635	11.5446	5.6484	5.3465
HCC1937	GDSC1; GDSC2; CTRP2	7.9846	11.812	5.5325	5.7906
T-47D	GDSC1; GDSC2; CTRP2	8.0085	13.5619	4.6863	9.2324
JIMT-1	GDSC1; GDSC2; CTRP2	8.0762	10.0121	6.4641	1.898
KPL-1	CTRP2	8.0931	8.7295	7.0208	0.0951
Hs 578T	GDSC1; GDSC2; CTRP2	8.1619	14.2417	4.4664	9.8633
Hs 578Bst	CTRP2	8.2974	17.4361	2.9861	15.2879
HCC1143	GDSC1; GDSC2; CTRP2	8.4452	11.5057	5.9992	3.235
MDA-MB-415	GDSC1; GDSC2; CTRP2	8.4486	12.4251	5.5635	4.96
MDA-MB-231	GDSC1; GDSC2; CTRP2	8.6907	13.1711	5.37	5.3921
BT-549	GDSC1; GDSC2; CTRP2	9.3134	16.8602	4.0203	9.7887
HCC1806	GDSC1; GDSC2; CTRP2	9.6017	17.6162	3.855	9.9881
BT 145	CTRP2	4.1016	7.2161	3.8194	21.7975
BT164	CTRP2	4.4248	6.5545	4.3229	19.0107
BT 286	CTRP2	5.4238	12.3865	3.0255	21.1474
BT 112	CTRP2	5.4354	10.3395	4.0081	17.3933
BT 428	CTRP2	6.2016	10.9677	4.4469	13.8038
BT 416	CTRP2	6.5006	12.2029	4.1115	14.496
BT 131	CTRP2	6.6284	11.1517	4.747	11.628
BT 271	CTRP2	6.8467	11.5795	4.7274	11.2492
BT 245	CTRP2	6.9139	10.7823	5.1832	9.2145
BT 248	CTRP2	6.9873	11.158	5.0595	9.5808
BT147	CTRP2	7.434	14.3255	3.85	13.6361
BT 172	CTRP2	7.5044	11.9221	5.1077	8.3832
BT 231	CTRP2	7.5203	11.8484	5.1572	8.1479
BT 232	CTRP2	7.6762	16.3844	3.0183	16.3109
BT 422	CTRP2	7.7152	12.3369	5.068	8.1697
BT 216	CTRP2	7.7586	11.9336	5.3021	7.1219
BT 239	CTRP2	7.849	16.6077	3.0457	15.8874
BT 330	CTRP2	7.851	12.3803	5.1515	7.588
BT 498	CTRP2	7.9615	9.9465	6.4213	2.2111
BT 320	CTRP2	8.1219	12.159	5.4626	5.8601
BT 482	CTRP2	8.1558	13.0897	5.0304	7.5786
BT 444	CTRP2	8.2353	11.471	5.8766	4.0056
BT 333	CTRP2	8.4274	13.523	5.0161	7.2059
BT 179	CTRP2	8.781	12.1047	5.931	3.0837
BT 224	CTRP2	8.7883	12.3851	5.8055	3.5538
BT 340	CTRP2	8.9791	15.1206	4.6293	7.9216
BT 159	CTRP2	9.0344	13.5757	5.4044	4.7949
BT 504	CTRP2	9.0788	16.0614	4.2432	9.2836
BT 359	CTRP2	9.6608	17.2053	4.0929	9.0103
BT 139	CTRP2	9.8364	17.8146	3.9197	9.412
BT 328	CTRP2	9.8446	16.44	4.5781	6.9263
BT 187	CTRP2	9.9963	19.0244	3.4477	10.9105
BT 228	CTRP2	10.3658	19.8203	3.3165	10.8559
BT 440	CTRP2	12.5643	23.4194	3.0296	9.0845

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
YD-38	CTRP2	8.2217	11.6324	5.7895	4.3764

Cancer Drug Sensitivity Data Curated from 69 Cell Line(s) in Central Nervous System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
D-566MG	GDSC1; GDSC2	1.867	5.8023	0.7291	21.0475
H4	GDSC1; GDSC2	2.752	7.5286	0.7266	17.8803
D283 Med	GDSC1; GDSC2; CTRP2	3.4986	6.5724	3.3165	25.4502
MOG-G-UVW	GDSC1; GDSC2	3.6435	8.2176	1.1366	12.7804
GI-1	GDSC1; GDSC2	3.8992	7.0886	1.8954	7.4763
D-502MG	GDSC1; GDSC2	3.9742	5.6717	2.636	2.7724
M059J	GDSC1; GDSC2	3.9924	7.0694	1.9733	6.769
LNZTA3WT4	GDSC1; GDSC2	4.0317	5.6559	2.6801	2.4046
Onda 10	GDSC1; GDSC2	4.0535	5.6424	2.6999	2.2506
D-423MG	GDSC1; GDSC2	4.063	7.588	1.7705	7.8465
D-263MG	GDSC1; GDSC2	4.0832	6.1927	2.4607	3.5961
KNS-81-FD	GDSC1; GDSC2	4.1269	6.1267	2.5202	3.157
LN-405	GDSC1; GDSC2	4.1452	6.0432	2.5709	2.8265
D-247MG	GDSC1; GDSC2	4.1583	9.1449	1.0747	11.7797
MOG-G-CCM	GDSC1; GDSC2	4.5002	7.1526	2.2768	3.8726
KS-1 [Human Krukenberg tumour]	GDSC1; GDSC2	4.5056	7.7742	1.9882	5.5513
SK-MG-1	GDSC1; GDSC2	4.6136	7.2016	2.3236	3.4056
PFSK-1	GDSC1; GDSC2	4.7377	10.2967	0.9324	11.1947
D-245MG	GDSC2	4.9002	8.5342	1.8843	5.3916
D-336MG	GDSC1; GDSC2	5.0084	7.2249	2.5321	1.7429
AM-38	GDSC1; GDSC2	5.1731	9.9581	1.3906	7.681
D-542MG	GDSC1; GDSC2	5.4787	6.8305	2.8863	0.1827
KINGS-1	GDSC1; GDSC2	5.5306	7.5376	2.649	0.7824
Onda 11	GDSC1; GDSC2	5.5566	8.2371	2.3824	1.8179
SF126	GDSC1; GDSC2; CTRP2	6.1111	8.7507	5.4125	10.0971
D-392MG	GDSC1; GDSC2	6.2456	13.3808	0.4703	10.5042
42-MG-BA	GDSC1; GDSC2; CTRP2	6.2863	13.8821	3.0874	18.91
TM-31	CTRP2	6.5367	10.9137	4.782	11.6824
T98G	GDSC1; GDSC2; CTRP2	6.5622	10.3289	5.0934	10.3388
8-MG-BA	GDSC1; GDSC2; CTRP2	6.5863	11.405	4.5838	12.391
SNU-738	CTRP2	6.7231	11.2124	4.8013	11.2015
ONS-76	GDSC1; GDSC2; CTRP2	6.8631	14.2892	3.3894	16.5503
SF539	GDSC1; GDSC2; CTRP2	7.3037	14.4194	3.6957	14.4904
YH-13	GDSC1; GDSC2; CTRP2	7.3482	11.7977	5.0431	8.9432
SF268	GDSC1; GDSC2; CTRP2	7.3644	12.597	4.6568	10.5149
SF295	GDSC1; GDSC2; CTRP2; CTRP1	7.3708	12.8968	4.5122	11.0968
CAS-1	GDSC1; GDSC2; CTRP2	7.4045	9.8762	6.0485	4.6279
Hs 683	GDSC1; GDSC2; CTRP2	7.417	10.8562	5.5694	6.6131
LN-18	GDSC1; GDSC2; CTRP2	7.5303	9.2196	6.4722	2.6411
SNU-201	CTRP2	7.5394	11.9141	5.1397	8.1859
Daoy	GDSC1; GDSC2; CTRP2	7.6239	13.314	4.5089	10.6377
SNU-466	CTRP2	7.6618	17.1412	2.6287	17.7113
SW1783	GDSC1; GDSC2; CTRP2	7.6895	10.5822	5.9189	4.6739
KNS-42	GDSC1; GDSC2; CTRP2	7.7329	10.2632	6.1085	3.8173
U-251MG	GDSC1; GDSC2; CTRP2	7.7711	13.4418	4.5618	10.1555
SNU-626	CTRP2	7.823	10.3817	6.116	3.6446
M059K	CTRP2	7.8741	12.8711	4.9258	8.4808
SNU-489	CTRP2	7.8897	10.1692	6.2663	2.9311
U-87MG ATCC	GDSC1; GDSC2; CTRP2	7.9064	9.6277	6.5361	1.8324
Becker	GDSC1; GDSC2; CTRP2	7.9467	11.9826	5.4205	6.3145
NMC-G1	GDSC1; GDSC2; CTRP2	8.0038	11.3845	5.7561	4.8405
SNB-75	GDSC1; GDSC2; CTRP2	8.0284	13.0912	4.9344	8.1829
KNS-60	CTRP2	8.0462	9.9789	6.4606	1.9482
GB-1	GDSC1; GDSC2; CTRP2	8.2337	13.9436	4.6677	8.9297
SW1088	GDSC1; GDSC2; CTRP2	8.3912	12.6616	5.4096	5.6648
U-118MG	GDSC1; GDSC2; CTRP2	8.6335	14.6556	4.6111	8.5165
KNS-81	CTRP2	8.6377	9.8387	6.8296	0.2663
GMS-10	CTRP2	8.816	12.5975	5.7238	3.8341
A-172	GDSC1; GDSC2; CTRP2	8.8171	15.4045	4.3771	9.1596
KALS-1	GDSC1; GDSC2; CTRP2	8.8717	13.9093	5.1387	6.0585
DBTRG-05MG	GDSC1; GDSC2; CTRP2	9.0745	13.7058	5.369	4.8808
SNU-1105	CTRP2	9.2122	14.8015	4.9405	6.3691
GaMG	GDSC1; GDSC2; CTRP2; CTRP1	9.2515	13.5542	5.5507	3.9669
LN-229	GDSC1; GDSC2; CTRP2; CTRP1	9.4776	16.62	4.2494	8.6758
DK-MG	GDSC1; GDSC2; CTRP2	9.7388	16.3127	4.5696	7.0962
KG-1-C	CTRP2	10.4665	44.8194	-8.9411	33.7353
GOS-3	CTRP2	10.641	18.9957	3.8878	8.4555
YKG-1	GDSC1; GDSC2; CTRP2	11.2537	18.8572	4.3278	6.17
CCF-STTG1	CTRP2	11.7345	21.4717	3.4202	8.7506

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TGBC1TKB	GDSC1; GDSC2	4.4807	6.303	2.6503	1.8393
ETK-1	GDSC1; GDSC2	5.3207	11.0774	0.9568	9.7916
TGBC24TKB	GDSC1; GDSC2	5.3483	7.7104	2.4981	1.5248

Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JHUEM-2	CTRP2; CTRP1	-1.0746	6.0155	-1.5328	54.3226
MFE-280	GDSC1; GDSC2	5.0767	7.4181	2.4853	1.884
JHUEM-1	CTRP2	5.4908	11.5654	3.4839	19.2831
HEC-50B	CTRP2	5.6741	7.9751	5.2827	11.7711
KLE	GDSC1; GDSC2; CTRP2; CTRP1	6.1393	9.1893	5.2393	10.7233
HEC-265	CTRP2; CTRP1	6.1944	7.1728	6.1147	7.1617
ESS-1	GDSC1; GDSC2; CTRP2	6.297	10.3231	4.85	11.939
HEC-151	CTRP2; CTRP1	6.4054	9.2034	5.4927	9.0505
MFE-319	GDSC1; GDSC2; CTRP2; CTRP1	6.6017	12.4466	4.0805	14.403
HEC-251	CTRP2; CTRP1	6.7162	8.6892	6.0372	6.0887
RL95-2	GDSC1; GDSC2; CTRP2	6.7272	11.706	4.5596	12.1903
HEC-6	CTRP2; CTRP1	6.8179	10.3986	5.2897	8.9701
HEC-1-A	CTRP2	6.8764	9.9136	5.5825	7.6244
MFE-296	GDSC1; GDSC2; CTRP2	6.883	12.6955	4.2022	13.3242
HEC-59	CTRP2; CTRP1	7.2641	8.5567	6.594	2.5984
HEC-1-B	CTRP2	7.2753	8.9029	6.4302	3.265
JHUEM-3	CTRP2	7.4828	18.0312	2.0378	20.0152
HEC-108	CTRP2; CTRP1	8.0393	11.5657	5.6931	5.0435
JHUEM-7	CTRP2	8.1069	15.6697	3.716	12.9185
EN	GDSC1; GDSC2; CTRP2	8.975	12.7054	5.7728	3.4536
AN3-CA	GDSC1; GDSC2; CTRP2	9.4848	18.5303	3.33	12.0917
Ishikawa (Heraklio) 02 ER-	CTRP2; CTRP1	6.9234	7.4519	6.8162	2.4289

Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Kidney Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
KTCTL-140	GDSC1; GDSC2	3.6313	8.1857	1.1428	12.7778
HA7-RCC	GDSC1; GDSC2	4.1299	6.3536	2.415	3.7736
A-498	GDSC1; GDSC2	4.1614	7.5621	1.8542	7.1033
LB2241-RCC	GDSC1; GDSC2	4.413	6.2058	2.6557	1.909
A-704	GDSC1; GDSC2	4.4738	6.8131	2.4173	3.1184
KTCTL-21	GDSC1; GDSC2	4.5875	7.65	2.0997	4.7354
SW156	GDSC1; GDSC2	4.6357	6.9831	2.4356	2.7494
SN12C	GDSC1; GDSC2	4.7111	7.1821	2.3898	2.8798
KTCTL-195	GDSC1; GDSC2	4.7237	7.4822	2.2614	3.5667
LB996-RCC	GDSC1; GDSC2	4.7892	12.2364	0.0205	15.8578
BB65-RCC	GDSC1; GDSC2	4.91	6.6626	2.7164	1.0246
SW13	GDSC1; GDSC2	5.0871	6.4715	2.8664	0.3727
NCC021	GDSC1; GDSC2	5.1958	8.158	2.2293	3.0067
KTCTL-13	GDSC1; GDSC2	5.3997	7.5065	2.6039	1.0432
NCC010	GDSC1; GDSC2	5.4033	7.7814	2.4954	1.4816
KTCTL-1M	GDSC1; GDSC2	5.627	8.2646	2.4049	1.6473
KTCTL-26A	GDSC1; GDSC2	5.6509	7.4502	2.7308	0.4649
RXF 393L	GDSC1; GDSC2	6.2245	10.0138	1.9734	2.9393
TK-10	GDSC1; GDSC2	6.4713	8.4607	2.6805	0.2761
UO-31	GDSC1; GDSC2; CTRP2	6.6064	11.7185	4.4463	12.9112
LB1047-RCC	GDSC1; GDSC2	6.7674	8.9438	2.6202	0.302
KMRC-20	GDSC1; GDSC2; CTRP2	6.9711	8.8253	6.2068	4.8162
TUHR4TKB	CTRP2	7.191	10.0667	5.7782	6.1649
SNU-1272	CTRP2	7.2846	8.7213	6.5286	2.8345
CAL-54	GDSC1; GDSC2; CTRP2	7.2958	12.4253	4.6862	10.5247
RCC10RGB	GDSC1; GDSC2; CTRP2; CTRP1	7.5651	9.1879	6.5134	2.4147
ACHN	GDSC1; GDSC2; CTRP2	7.6016	10.168	6.0571	4.2466
786-O	GDSC1; GDSC2; CTRP2	7.6763	12.8619	4.7759	9.447
TUHR14TKB	CTRP2	7.7755	13.5688	4.5021	20.3857
TUHR10TKB	CTRP2	7.8525	10.0299	6.3078	2.8177
BFTC-909	GDSC1; GDSC2; CTRP2	7.9137	11.0267	5.866	4.5296
Caki-2	CTRP2	8.2687	11.0398	6.1046	3.0517
VMRC-RCW	GDSC1; GDSC2; CTRP2; CTRP1	8.3528	11.5646	5.9109	3.7049
OS-RC-2	GDSC1; GDSC2; CTRP2	8.3752	12.0137	5.7112	4.4716
VMRC-RCZ	GDSC1; GDSC2; CTRP2	8.7345	13.4926	5.2456	5.8264
769-P	GDSC1; GDSC2; CTRP2	8.8845	15.095	4.5755	8.2743
KMRC-2	CTRP2	9.5075	14.6095	5.2205	4.9104
KMRC-1	GDSC1; GDSC2; CTRP2	10.311	17.0893	4.5692	6.3792
Caki-1	GDSC1; GDSC2; CTRP2	11.8768	22.2165	3.1634	9.4401

Cancer Drug Sensitivity Data Curated from 61 Cell Line(s) in Large Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SK-CO-1	GDSC1; GDSC2; CTRP2; CTRP1	3.6821	6.2641	3.5725	23.9789
SW1463	GDSC1; GDSC2	4.1224	6.6072	2.289	4.5296
HCC2998	GDSC1; GDSC2	4.2716	7.7554	1.8381	6.9265
SW837	GDSC1; GDSC2	4.6783	7.4089	2.2677	3.5962
CaR-1	GDSC1; GDSC2	4.8109	8.6701	1.7636	6.2371
SW1116	GDSC1; GDSC2	4.8617	6.9629	2.568	1.7424
SNU-283	GDSC2	4.9761	6.5604	2.7867	0.6953
SW626	GDSC1; GDSC2	5.1091	7.2526	2.5706	1.4537
GP5d	GDSC1; GDSC2	5.1531	8.6141	2.0013	4.277
DiFi	GDSC1; GDSC2	5.1599	7.5195	2.4847	1.7827
COLO 320HSR	GDSC1; GDSC2	5.254	9.1725	1.807	5.1765
SW480	CTRP1	5.2641	10.0743	3.9502	35.6005
SW620	GDSC1; GDSC2; CTRP2; CTRP1	5.6588	8.0559	5.2353	11.995
SNU-C2B	GDSC1; GDSC2	5.8688	12.4851	0.6492	10.2907
SNU-81	GDSC1; GDSC2; CTRP2; CTRP1	5.8805	13.3324	2.9915	20.18
GP2d	CTRP2; CTRP1	5.984	10.0606	4.6773	13.3765
SW48	GDSC1; GDSC2; CTRP2; CTRP1	5.9933	9.9328	4.7469	13.0725
SNU-175	GDSC2; CTRP1	6.1537	11.1278	4.3133	15.4834
CCK-81	GDSC1; GDSC2; CTRP2	6.3085	8.1378	5.8855	7.7101
NCI-H747	GDSC1; GDSC2; CTRP2	6.3154	9.7291	5.1546	10.6463
RKO	GDSC1; GDSC2; CTRP2; CTRP1	6.4873	9.3088	5.5208	8.7428
LS123	GDSC1; GDSC2; CTRP2; CTRP1	6.496	11.2602	4.574	12.6273
HT115	GDSC1; GDSC2; CTRP2; CTRP1	6.6024	9.9506	5.3161	9.3267
LS180	GDSC1; GDSC2; CTRP2; CTRP1	6.8166	12.1181	4.4327	12.5242
SNU-407	GDSC1; GDSC2; CTRP2	6.9335	10.914	5.1347	9.377
SW403	CTRP1	7.0699	10.866	3.7402	7.0895
SNU-C4	CTRP2; CTRP1	7.1124	9.2605	6.1144	4.9095
SNU-C5	GDSC1; GDSC2; CTRP2; CTRP1	7.1697	11.4473	5.0701	9.1738
COLO205	GDSC1; GDSC2; CTRP2; CTRP1	7.229	11.0191	5.3338	7.9555
LoVo	GDSC1; GDSC2; CTRP2; CTRP1	7.245	11.3304	5.1915	8.5203
HCT 116	GDSC1; GDSC2; CTRP2; CTRP1	7.2973	12.558	4.621	10.7905
SW1417	GDSC1; GDSC2; CTRP2	7.4405	10.6146	5.709	5.9854
SNU-C1	GDSC1; GDSC2; CTRP2	7.4483	11.0277	5.5091	6.8086
OUMS-23	CTRP2	7.459	8.4642	6.7909	1.4398
SNU-C2A	CTRP2; CTRP1	7.4695	13.2273	4.4277	11.2553
T84	GDSC1; GDSC2; CTRP2	7.6514	10.7577	5.803	5.2205
CW-2	GDSC1; GDSC2; CTRP2; CTRP1	7.7299	11.286	5.6011	5.9271
SW948	GDSC1; GDSC2; CTRP2; CTRP1	7.792	11.2194	5.6812	5.4899
CL-40	CTRP1	7.8383	12.5039	5.0663	16.0422
RCM-1 [Human ESC]	GDSC1; GDSC2; CTRP2; CTRP1	7.8383	10.1809	6.2247	3.1766
HCT 8	CTRP2; CTRP1	7.8419	9.0932	6.7445	1.1116
SNU-1040	GDSC1; GDSC2; CTRP1	7.8447	12.6221	5.0126	8.7117
HT-55	GDSC1; GDSC2; CTRP2; CTRP1	7.9018	9.8969	6.4053	2.3554
CL-34	CTRP1	7.9101	12.5131	5.1165	15.407
COLO 320	CTRP2; CTRP1	7.9138	12.5788	5.1011	7.6896
C2BBe1	GDSC1; GDSC2; CTRP2; CTRP1	7.9512	10.7369	6.0343	3.7827
SNU-61	GDSC1; GDSC2; CTRP2; CTRP1	8.0298	10.4266	6.2381	2.8457
DLD-1	CTRP2; CTRP1	8.2477	9.3895	6.8333	0.4555
NCI-H716	GDSC1; GDSC2; CTRP2	8.2543	15.9125	3.7092	12.6862
NCI-H508	GDSC1; GDSC2; CTRP2; CTRP1	8.3114	9.9985	6.6081	1.1165
LS411N	GDSC1; GDSC2; CTRP2; CTRP1	8.3728	9.6957	6.7681	0.5586
COLO 678	GDSC1; GDSC2; CTRP2; CTRP1	8.4056	14.8925	4.328	10.0107
HCT 15	GDSC1; GDSC2; CTRP2	8.411	10.081	6.6257	0.9689
CL-11	GDSC1; GDSC2; CTRP2	8.5258	13.3621	5.1643	6.4563
MDST8	GDSC1; GDSC2; CTRP2; CTRP1	8.591	13.644	5.0733	6.726
COLO201	CTRP2	8.7507	12.7274	5.6208	4.3186
HT-29	GDSC1; GDSC2; CTRP2; CTRP1	8.8361	10.1483	6.7949	0.2608
LS1034	GDSC1; GDSC2; CTRP2	9.0457	10.6506	6.6928	0.3882
LS513	GDSC1; GDSC2; CTRP2; CTRP1	9.0804	15.9074	4.319	8.9869
KM12	GDSC1; GDSC2; CTRP2; CTRP1	9.1296	13.2588	5.6122	3.8784
SNU-503	CTRP2	10.1772	18.2778	3.926	8.9214

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MO-T	GDSC1; GDSC2	4.4892	8.4937	1.6324	7.7018

Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Liver Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
Huh-7	GDSC1; GDSC2	4.1601	7.5325	1.8677	7.0238
Hep-G2/C3A	GDSC1; GDSC2	4.2198	6.1728	2.5571	2.77
JHH-7	GDSC1; GDSC2	4.386	6.1266	2.6757	1.8435
HLE	GDSC1; GDSC2	5.1719	7.4934	2.5016	1.6971
SNU-886	CTRP2	5.9148	10.9433	4.1883	15.5123
HuH-6	CTRP2	6.1787	9.8329	4.9738	11.7072
SNU-182	CTRP2	6.2196	9.7009	5.0763	11.1924
JHH-2	GDSC1; GDSC2; CTRP2	6.6578	9.5205	5.5781	8.1173
SNU-878	CTRP2	6.6667	8.9309	5.8735	6.8767
JHH-5	CTRP2	6.6931	9.122	5.8056	7.0967
Li-7	CTRP2	6.765	9.7293	5.5737	7.8996
PLC/PRF/5	CTRP2	6.8641	13.0312	4.0184	14.1012
SNU-398	GDSC1; GDSC2; CTRP2; CTRP1	7.0939	12.0031	4.7283	10.7445
JHH-4	GDSC1; GDSC2; CTRP2	7.1452	9.0788	6.2333	4.3445
SK-HEP-1	GDSC1; GDSC2; CTRP2	7.1643	12.9261	4.3263	12.2555
Hep 3B2.1-7	GDSC1; GDSC2; CTRP2	7.5004	9.1719	6.4733	2.6857
Hep-G2	CTRP2; CTRP1	7.5815	9.1146	6.5612	2.1921
HuH-1	GDSC1; GDSC2; CTRP2	7.5962	10.3052	5.9851	4.556
SNU-761	CTRP2	7.6511	9.8189	6.2666	3.2957
JHH-6	GDSC1; GDSC2; CTRP2; CTRP1	7.841	8.6394	6.9447	0.4116
SNU-423	GDSC1; GDSC2; CTRP2	7.9879	13.2566	4.8218	8.7131
SNU-475	CTRP2	8.4046	12.7215	5.3899	5.7246
SNU-387	GDSC1; GDSC2; CTRP2	9.1316	14.8745	4.8519	6.827
HLF	CTRP2	9.4122	15.6384	4.6749	7.1298
JHH-1	GDSC1; GDSC2; CTRP2	9.5079	15.8189	4.6524	7.0867
SNU-449	GDSC1; GDSC2; CTRP2; CTRP1	10.3554	15.5764	5.2827	3.7508

Cancer Drug Sensitivity Data Curated from 226 Cell Line(s) in Lung Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NCI-H209	GDSC1; GDSC2	0.8101	3.8866	0.408	27.3001
NCI-H1876	GDSC1; GDSC2; CTRP1	2.0953	6.0226	1.9017	37.5395
COR-L279	GDSC1; GDSC2; CTRP2; CTRP1	2.3934	4.7926	2.3677	32.2684
IST-SL2	GDSC1; GDSC2	3.2075	5.1947	2.2885	6.8833
SBC-3	GDSC1; GDSC2	3.3047	6.733	1.602	10.9134
NCI-H1651	GDSC1; GDSC2; CTRP2	3.4179	10.3846	1.9252	30.3058
NCI-H526	GDSC1; GDSC2; CTRP2	3.4854	6.9326	3.2204	25.8262
Lu-134-A	GDSC1; GDSC2	3.5542	7.7524	1.2972	12.068
NCI-H596	GDSC1; GDSC2; CTRP1	3.6062	7.2206	3.2741	27.247
NCI-H2227	GDSC1; GDSC2	3.6144	5.699	2.3675	5.2441
NCI-H1048	GDSC1; GDSC2; CTRP1	3.6472	7.3641	2.6583	17.9215
Lu-99	CTRP2; CTRP1	3.6926	8.4267	2.987	26.0062
Lu-99A	GDSC1; GDSC2	3.7103	6.6723	1.9583	7.5621
LK-2	GDSC1; GDSC2	3.782	5.4559	2.6098	3.3338
EMC-BAC-2	GDSC1; GDSC2	3.8163	7.2678	1.7443	8.6204
NCI-H748	GDSC2	3.8495	8.6427	1.0874	12.5088
NCI-H847	GDSC1; GDSC2	3.8641	5.6186	2.588	3.2872
NCI-H187	GDSC1	3.8692	5.7117	2.5466	3.9056
NCI-H2373	GDSC1; GDSC2	3.9312	6.339	2.2861	4.9839
NCI-H2795	GDSC1; GDSC2	4.0469	9.0588	1.033	12.3065
NCI-H740	GDSC2	4.0604	8.5415	1.2991	10.7069
CPC-N	GDSC1; GDSC2	4.0764	5.9656	2.5635	3.0001
Lu-135	GDSC1; GDSC2	4.0912	6.534	2.303	4.5273
IST-SL1	GDSC1; GDSC2	4.1994	6.366	2.4543	3.4045
NCI-H1734	GDSC1; GDSC2; CTRP2	4.2324	8.2927	3.617	22.1428
NCI-H2722	GDSC1; GDSC2	4.2367	6.4893	2.4202	3.5328
NCI-H2369	GDSC1; GDSC2	4.2654	6.8153	2.2851	4.2743
LC-2/ad	GDSC1; GDSC2	4.291	7.0648	2.1834	4.8277
Lu-165	GDSC1; GDSC2	4.2949	5.6819	2.8202	1.2289
NCI-H2461	GDSC1; GDSC2	4.3019	7.4913	1.9866	5.9868
NCI-H345	GDSC1; GDSC2	4.3234	5.4192	2.9438	0.6306
COR-L303	GDSC2	4.3256	6.2452	2.5878	2.4144
COR-L311	GDSC2	4.3294	9.7891	0.8848	12.438
NCI-H2135	GDSC1; GDSC2	4.3325	6.4282	2.5084	2.8483
NCI-H290	GDSC1; GDSC2	4.334	7.3317	2.0848	5.3284
NCI-H446	GDSC1; GDSC2; CTRP2	4.3659	6.9932	4.1654	19.7496
A-427	GDSC1; GDSC2	4.3691	10.2399	0.6921	13.4113
NCI-H835	GDSC1; GDSC2	4.3836	7.8853	1.853	6.6137
NCI-H1770	GDSC1; GDSC2	4.4688	6.9756	2.3394	3.5696
NCI-H513	GDSC1; GDSC2	4.4812	6.4968	2.5649	2.291
COLO 668	GDSC1; GDSC2; CTRP2; CTRP1	4.5224	7.1723	4.2905	18.8216
NCI-H146	GDSC1; GDSC2	4.5509	10.8101	0.5462	13.752
NCI-H1105	GDSC1; GDSC2; CTRP2; CTRP1	4.5653	10.5676	3.0297	23.3509
NCI-H1648	GDSC1; GDSC2	4.5858	6.8315	2.4749	2.6148
IA-LM	GDSC1; GDSC2	4.6103	6.4424	2.6595	1.6176
NCI-H1436	GDSC1; GDSC2	4.6733	6.1699	2.8045	0.8808
Ms-1	GDSC1; GDSC2	4.7076	9.0167	1.5301	7.8321
NCI-H250	GDSC2	4.7311	7.1628	2.4098	2.7405
ABC-1	GDSC1; GDSC2	4.7624	7.1721	2.4234	2.6205
NCI-H2347	GDSC1; GDSC2	4.7951	8.2477	1.9518	5.2
SBC-1	GDSC1; GDSC2	4.8523	10.4548	0.9364	10.9118
NCI-H2810	GDSC1; GDSC2	4.8689	7.7901	2.2075	3.6242
COR-L32	GDSC1; GDSC2	4.8729	7.5454	2.3198	3.0063
NCI-H1184	CTRP2	4.8863	9.3279	3.9015	19.2381
UMC-11	GDSC1; GDSC2	4.8892	7.17	2.4937	2.0792
NCI-H2731	GDSC1; GDSC2	4.8953	7.2245	2.4733	2.1733
PaCa-3	GDSC1; GDSC2	4.8976	7.5536	2.3301	2.9137
NCI-H1930	CTRP1	4.9135	9.757	2.6846	22.5417
NCI-H2804	GDSC1; GDSC2	4.9559	9.0857	1.6614	6.5644
NCI-H64	GDSC1; GDSC2	4.9585	6.2254	2.9056	0.3291
NCI-H2869	GDSC1; GDSC2	4.9618	7.5655	2.3606	2.6588
EMC-BAC-1	GDSC1; GDSC2	4.9642	8.4532	1.9615	4.8363
Lu-139	GDSC1; GDSC2	4.9707	9.9899	1.2417	8.9366
LB647-SCLC	GDSC1; GDSC2	5.0103	10.2238	1.1565	9.3347
NCI-H1688	GDSC1; GDSC2	5.0369	6.4111	2.8686	0.392
COR-L321	GDSC1; GDSC2	5.1336	11.1051	0.8171	10.9458
NCI-H1694	GDSC1; GDSC2; CTRP2; CTRP1	5.141	9.0398	4.2887	17.0617
NCI-H211	GDSC1; GDSC2; CTRP2	5.1466	10.8394	3.4899	20.1225
NCI-H2066	GDSC1; GDSC2	5.155	7.0058	2.6916	0.9085
NCI-H2591	GDSC1; GDSC2	5.1742	7.4894	2.5044	1.6817
HCC44	GDSC1; GDSC2; CTRP2; CTRP1	5.2127	10.3834	3.7661	18.899
NCI-H1963	GDSC1; GDSC2; CTRP1	5.2184	8.409	4.6223	16.741
NCI-H3122	GDSC1; GDSC2	5.2392	7.1764	2.6621	0.9524
RERF-LC-Sq1	GDSC1; GDSC2	5.362	8.0749	2.3531	2.1714
NCI-H1304	GDSC1	5.3738	6.8961	2.824	0.3883
NCI-H1155	GDSC1; GDSC2; CTRP2	5.4012	10.828	3.7464	18.4982
NCI-H1993	GDSC1; GDSC2	5.4118	7.4495	2.6317	0.9294
DMS 454	CTRP2	5.4813	11.3901	3.5584	19.0223
NCI-H82	GDSC1; GDSC2; CTRP1	5.5416	8.7904	3.6877	7.3213
DV-90	CTRP2; CTRP1	5.5612	11.2177	3.7177	18.2143
LC-1/sq	GDSC1; GDSC2	5.6008	12.769	0.3361	12.4571
NCI-H2595	GDSC1; GDSC2	5.7037	11.4395	1.0349	8.6131
LCLC-97TM1	GDSC1; GDSC2; CTRP2; CTRP1	5.7041	9.8091	4.5204	14.6919
NCI-H1581	GDSC1; GDSC2; CTRP2	5.7796	9.2826	4.8373	13.236
HCC366	GDSC1; GDSC2; CTRP2	5.9145	8.8425	5.1719	11.5587
NCI-H2087	GDSC1; GDSC2; CTRP2	5.941	9.2114	5.0318	12.0512
NCI-H2818	GDSC1; GDSC2	5.9449	13.9057	0.0241	13.2634
NCI-H720	GDSC1; GDSC2	5.9565	12.8685	0.5252	10.7828
NCI-H2009	GDSC1; GDSC2; CTRP2; CTRP1	6.0008	10.4851	4.4907	14.0922
NCI-H2803	GDSC1; GDSC2	6.0214	8.0135	2.6707	0.4518
DMS 79	GDSC1; GDSC2; CTRP2	6.0456	11.4605	4.0609	15.7158
SW1573	GDSC1; GDSC2; CTRP2	6.0638	10.8996	4.3507	14.5106
COR-L95	GDSC1; GDSC2; CTRP2	6.065	11.2646	4.1745	15.2168
DMS 273	GDSC1; GDSC2; CTRP2; CTRP1	6.1445	11.8348	3.9697	15.8523
NCI-H322M	GDSC1; GDSC2	6.1774	12.5684	0.8063	8.9348
RERF-LC-KJ	GDSC1; GDSC2; CTRP1	6.21	8.2592	4.4158	2.3149
NCI-H2286	CTRP2; CTRP1	6.2423	9.9378	4.9845	11.5141
NCI-H23	GDSC1; GDSC2; CTRP2; CTRP1	6.2481	11.3433	4.3063	14.2681
SK-MES-1	GDSC1; GDSC2; CTRP2	6.2842	9.6601	5.1579	10.7063
NCI-H1092	GDSC1; GDSC2; CTRP2	6.2868	9.8194	5.0839	11.003
NCI-H1437	GDSC1; GDSC2; CTRP1	6.2929	8.828	4.2037	3.2124
EKVX	GDSC1; GDSC2; CTRP2	6.3934	11.4133	4.4052	13.5425
NCI-H2405	GDSC1; GDSC2; CTRP2; CTRP1	6.4441	10.4136	4.943	11.2228
COR-L88	GDSC1; GDSC2; CTRP1	6.523	10.5105	3.5576	6.0423
SBC-5	GDSC1; GDSC2; CTRP2	6.5307	7.2235	6.4684	4.8642
HCC33	GDSC2; CTRP1	6.5344	9.9401	3.8362	4.6322
KNS-62	GDSC1; GDSC2; CTRP2; CTRP1	6.5632	7.9221	6.2417	5.6376
NCI-H2081	GDSC1; GDSC2; CTRP2; CTRP1	6.5763	13.3476	3.61	16.3109
NCI-H1755	GDSC1; GDSC2; CTRP2; CTRP1	6.6498	9.1386	5.7569	7.3964
NCI-H1573	GDSC1; GDSC2; CTRP1	6.6799	8.3339	4.6361	0.8422
NCI-H2106	CTRP2	6.722	11.8036	4.5065	12.4194
EPLC-272H	GDSC1; GDSC2; CTRP2; CTRP1	6.7379	10.2025	5.3153	9.0339
NCI-H2073	CTRP1	6.7924	13.7464	3.5872	29.0937
RERF-LC-MS	GDSC1; GDSC2; CTRP2	6.8029	12.2323	4.3639	12.8333
NCI-H69	GDSC1; GDSC2; CTRP2	6.847	12.6136	4.212	13.3588
SK-LU-1	GDSC1; GDSC2; CTRP2; CTRP1	6.8545	11.6468	4.7007	11.3433
COR-L47	CTRP2	6.8683	13.3285	3.8736	14.6674
NCI-H1975	GDSC1; GDSC2; CTRP1	6.8827	9.068	4.4317	1.4308
NCI-H524	GDSC1; GDSC2; CTRP2	6.8861	13.7046	3.701	15.3073
DMS 53	GDSC1; GDSC2; CTRP2	6.8966	12.0739	4.5241	11.9843
Lu-65	GDSC1; GDSC2; CTRP2; CTRP1	6.9343	9.8167	5.682	7.0866
LXF 289	GDSC1; GDSC2; CTRP2; CTRP1	6.9771	10.2448	5.5062	7.7339
NCI-H358	GDSC1; GDSC2; CTRP2; CTRP1	6.9789	10.3245	5.4681	7.8899
NCI-H1339	CTRP2	7.0286	11.3324	5.0079	9.7129
NCI-H3255	GDSC1; GDSC2; CTRP1	7.0316	10.4285	5.4494	8.3946
NCI-H1341	GDSC1; GDSC2; CTRP2	7.0965	11.1615	5.1512	8.9793
SHP-77	GDSC1; GDSC2; CTRP2; CTRP1	7.1721	9.7899	5.9007	5.6875
NCI-H810	GDSC1; GDSC2; CTRP2; CTRP1	7.1883	11.6277	4.9955	9.4485
NCI-H2342	GDSC1; GDSC2; CTRP2; CTRP1	7.212	11.3749	5.1418	8.792
VMRC-LCD	GDSC1; GDSC2; CTRP2; CTRP1	7.2148	8.9426	6.3602	3.6745
NCI-H2029	GDSC1; GDSC2; CTRP2; CTRP1	7.2349	9.6295	6.0335	5.0079
MOR/CPR	CTRP2	7.2607	8.0592	6.8399	1.573
HCC4006	CTRP2; CTRP1	7.2702	10.702	5.5266	7.0679
Calu-3	GDSC1; GDSC2; CTRP2; CTRP1	7.2744	10.9243	5.4189	7.5117
NCI-H520	GDSC1; GDSC2; CTRP2	7.278	11.7079	5.0301	9.1309
NCI-H2110	GDSC1; GDSC2; CTRP2; CTRP1	7.321	12.9875	4.4259	11.5448
NCI-H661	GDSC1; GDSC2; CTRP2; CTRP1	7.3353	11.4746	5.194	8.3377
NCI-H1568	GDSC1; GDSC2; CTRP2; CTRP1	7.3354	11.1586	5.352	7.6762
NCI-H727	GDSC1; GDSC2; CTRP2; CTRP1	7.3392	12.3383	4.7655	10.1138
NCI-H1944	GDSC1; GDSC2; CTRP2; CTRP1	7.3482	13.2948	4.2948	12.0258
NCI-H1836	GDSC1; GDSC2; CTRP1	7.402	9.6249	6.1582	4.4001
HCC1359	CTRP1	7.4431	8.4971	6.7484	3.2824
NCI-H1793	GDSC1; GDSC2; CTRP2; CTRP1	7.4708	10.686	5.6976	5.9782
PC-14	GDSC1; GDSC2; CTRP2	7.4813	8.7836	6.6505	1.9829
COLO 699	CTRP2; CTRP1	7.5067	10.9182	5.6103	6.2788
HCC2279	CTRP2	7.5142	15.9442	3.1067	16.2999
Calu-6	GDSC1; GDSC2; CTRP2; CTRP1	7.5276	9.6223	6.2711	3.4813
DMS 114	GDSC1; GDSC2; CTRP2	7.5375	13.62	4.2867	11.6999
CAL-12T	GDSC1; GDSC2; CTRP2; CTRP1	7.5487	10.8725	5.6662	5.97
NCI-H1355	GDSC1; GDSC2; CTRP2; CTRP1	7.5584	10.4373	5.8903	5.0167
NCI-H2196	GDSC2; CTRP2	7.5649	11.3468	5.4428	6.875
RERF-LC-A1	CTRP2	7.5684	12.2395	5.0005	8.7125
NCI-H2085	GDSC1; GDSC2; CTRP2	7.574	10.7076	5.768	5.5
Sq-1	CTRP2; CTRP1	7.6453	9.8052	6.2691	3.295
NCI-H838	GDSC1; GDSC2; CTRP2	7.6474	11.1969	5.5819	6.1487
NCI-H1838	GDSC1; GDSC2; CTRP2	7.6593	10.4477	5.9625	4.543
NCI-H1299	GDSC1; GDSC2; CTRP2; CTRP1	7.6623	12.1039	5.1424	7.9542
NCI-H2228	GDSC1; GDSC2; CTRP2	7.6746	10.4448	5.9756	4.4631
HCC15	GDSC1; GDSC2; CTRP2; CTRP1	7.68	13.9509	4.236	11.6408
HCC95	CTRP2	7.7236	10.5666	5.9522	4.4789
LCLC-103H	GDSC1; GDSC2; CTRP2; CTRP1	7.7338	8.9008	6.7669	1.1548
NCI-H510A	GDSC1; GDSC2; CTRP2	7.7851	15.5776	3.5085	14.2926
NCI-H292	GDSC1; GDSC2; CTRP2	7.7899	12.1714	5.2081	7.4579
NCI-H2172	GDSC1; GDSC2; CTRP2; CTRP1	7.8146	10.1693	6.2135	3.2579
NCI-H441	GDSC1; GDSC2; CTRP2; CTRP1	7.8333	10.7709	5.9328	4.3815
RERF-LC-Ad1	CTRP2	7.8453	9.0535	6.7647	1.0325
NCI-H2171	GDSC2; CTRP2	7.8545	14.712	3.995	12.2829
SCLC-21H	CTRP1	7.874	14.3222	4.1906	21.6113
LUDLU-1	CTRP2	7.8743	11.1874	5.7583	5.0362
COR-L51	CTRP2; CTRP1	7.8994	12.8686	4.9464	8.3521
NCI-H1623	GDSC1; GDSC2; CTRP2	7.9338	12.4278	5.1909	7.2849
NCI-H1703	GDSC1; GDSC2; CTRP2	7.9672	12.074	5.3907	6.4041
NCI-H2023	GDSC1; GDSC2; CTRP2; CTRP1	7.9996	11.1501	5.8675	4.3907
NCI-H2291	GDSC1; GDSC2; CTRP2	8.0229	10.9654	5.9738	3.9215
COR-L23	GDSC1; GDSC2; CTRP1	8.0245	13.9838	4.4753	10.7617
EBC-1	GDSC1; GDSC2; CTRP2; CTRP1	8.0304	13.529	4.7193	9.0603
HOP-92	GDSC1; GDSC2; CTRP2	8.0353	14.5759	4.2038	12.0095
NCI-H2122	GDSC1; GDSC2; CTRP2; CTRP1	8.0841	11.791	5.6153	5.293
BEN	GDSC1; GDSC2; CTRP2; CTRP1	8.0958	9.0254	6.9091	0.3413
NCI-H841	GDSC1; GDSC2; CTRP2; CTRP1	8.1297	12.3506	5.3744	6.2097
NCI-H2444	GDSC1; GDSC2; CTRP2	8.1449	9.3256	6.8096	0.5975
HOP-62	GDSC1; GDSC2; CTRP2	8.1495	16.6081	3.2826	14.4749
NCI-H1915	GDSC1; GDSC2; CTRP2; CTRP1	8.1545	11.8223	5.6504	5.0414
NCI-H1563	GDSC1; GDSC2; CTRP2	8.1594	12.2262	5.4568	5.825
NCI-H1693	GDSC1; GDSC2; CTRP2	8.1676	14.8717	4.1588	11.0834
NCI-H650	GDSC1; GDSC2; CTRP2; CTRP1	8.1683	11.5597	5.7875	4.4626
SW1271	GDSC1; GDSC2; CTRP2	8.1798	10.5524	6.2769	2.4924
NCI-H1869	GDSC1; GDSC2; CTRP2	8.196	11.3861	5.8906	4.0057
NCI-H889	CTRP2	8.1967	10.183	6.4592	1.7735
HCC2108	CTRP2; CTRP1	8.1991	14.8799	4.1788	10.9498
HCC1833	CTRP2; CTRP1	8.2495	17.9945	2.6711	16.4777
LOU-NH91	GDSC1; GDSC2; CTRP2	8.2763	12.4388	5.4368	5.7269
NCI-H2141	GDSC1; GDSC2; CTRP2; CTRP1	8.2862	18.8492	2.2608	17.7097
NCI-H196	GDSC1; GDSC2; CTRP2	8.3379	12.5616	5.4206	5.6997
NCI-H2126	CTRP2; CTRP1	8.346	9.5228	6.8253	0.4173
HCC78	GDSC1; GDSC2; CTRP2; CTRP1	8.3604	12.3707	5.5289	5.2273
NCI-H1373	CTRP2; CTRP1	8.396	12.297	5.5891	4.9325
NCI-H1650	GDSC1; GDSC2; CTRP2	8.4018	11.5093	5.9694	3.4083
NCI-H647	GDSC1; GDSC2; CTRP2	8.4265	14.906	4.3369	9.9407
COR-L105	GDSC1; GDSC2; CTRP2	8.4673	15.5695	4.0403	11.0428
NCI-H1781	GDSC1; GDSC2; CTRP1	8.5033	13.0692	5.2752	6.433
HARA [Human squamous cell lung carcinoma]	GDSC1; GDSC2; CTRP2; CTRP1	8.5105	14.5675	4.5651	8.8942
ChaGo-K-1	GDSC1; GDSC2; CTRP2; CTRP1	8.5367	11.5192	6.0509	2.9199
HCC1195	CTRP2; CTRP1	8.5815	13.7618	5.0094	6.9973
HCC1438	CTRP2	8.6021	15.0815	4.3798	9.4865
NCI-H1435	GDSC1; GDSC2; CTRP2; CTRP1	8.6071	13.6709	5.0716	6.7088
NCI-H1395	CTRP2	8.6904	11.4973	6.1546	2.3509
NCI-H226	GDSC1; GDSC2; CTRP2	8.7207	10.0729	6.7756	0.3476
A-549	GDSC1; GDSC2; CTRP2; CTRP1	8.7637	14.7923	4.6373	8.2118
NCI-H460	GDSC1; GDSC2; CTRP2; CTRP1	8.8289	14.1731	4.9827	6.7393
LK2	CTRP2	8.8616	13.2064	5.4667	4.7772
HCC827	GDSC1; GDSC2; CTRP2; CTRP1	8.8668	18.1158	3.0828	13.9657
HCC1588	CTRP2	8.9476	16.3295	4.0192	10.3506
NCI-H2170	GDSC1; GDSC2; CTRP2	9.0139	13.8821	5.2463	5.4391
NCI-H322	CTRP2	9.0556	13.1606	5.6119	3.9687
T3M-10	CTRP2; CTRP1	9.0963	15.3403	4.6042	7.8489
NCI-H1666	GDSC1; GDSC2; CTRP2; CTRP1	9.1171	15.3821	4.5983	7.842
NCI-H522	GDSC1; GDSC2; CTRP2; CTRP1	9.2758	15.5509	4.6253	7.5109
NCI-H1792	GDSC1; GDSC2; CTRP2; CTRP1	9.2786	14.3286	5.2072	5.2457
HCC2935	CTRP2; CTRP1	9.4648	15.824	4.6214	7.2646
LC-1/sq-SF	CTRP2; CTRP1	9.6076	19.3177	3.0339	12.9565
NCI-H2030	GDSC1; GDSC2; CTRP2; CTRP1	10.5156	18.7979	3.9004	8.5702
HCC1171	CTRP2	10.6562	21.7074	2.6084	12.8612
Calu-1	CTRP2	10.9067	21.8856	2.6925	12.237
RERF-LC-Ad2	CTRP2	12.4625	23.2655	3.0386	9.1697
Hs 888.Lu	CTRP2	7.8869	14.5704	4.091	11.8448

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CBTCi002-A	GDSC1; GDSC2	5.0588	6.985	2.6558	1.1364

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SYO-1	CTRP2	2.7276	8.4257	1.9444	32.4655
P-STS	CTRP2	5.5999	9.5267	4.5456	14.8538

Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
Yamato-SS	CTRP2	6.7778	12.5733	4.172	13.6638
Aska-SS	CTRP2	8.4135	14.7841	4.3872	9.7618
EW-8	GDSC1; GDSC2	3.5336	4.9988	2.6527	3.6605
STS-0421	GDSC1; GDSC2	4.3339	8.911	1.3194	9.9154
SW872	GDSC1; GDSC2	4.4598	6.0898	2.7317	1.454
Rh30	GDSC1; GDSC2	4.4671	6.622	2.5004	2.6656
MFH-ino	GDSC1; GDSC2	4.5223	12.2478	-0.1844	17.5014
SW684	GDSC1; GDSC2	4.5308	5.8938	2.8493	0.8291
VA-ES-BJ	GDSC1; GDSC2	4.6816	8.3403	1.8353	6.0972
Hs 633.T	GDSC1; GDSC2	4.7635	10.574	0.8158	11.7818
Rh41	GDSC1; GDSC2; CTRP2	5.0592	10.3097	3.6457	19.7566
KYM-1	GDSC1; GDSC2; CTRP2	5.5295	11.5379	3.5342	18.9967
G-401	GDSC1; GDSC2; CTRP2; CTRP1	5.8044	13.3024	2.9363	20.5562
TTC-709	CTRP2	5.8852	17.6073	0.8813	26.7317
A-204	GDSC1; GDSC2; CTRP2	5.941	12.3083	3.5496	17.9592
G-402	GDSC1; GDSC2; CTRP2	6.2624	13.4356	3.2873	18.2232
TE 617.T	CTRP2	6.2911	13.8227	3.1212	18.7754
RKN	GDSC1; GDSC2; CTRP2; CTRP1	6.852	10.754	5.1431	9.5103
HT-1080	GDSC1; GDSC2; CTRP2; CTRP1	6.9896	13.2967	3.9933	13.9447
TE 441.T	GDSC2; CTRP2	7.0644	12.5005	4.4548	11.9296
SK-UT-1	GDSC1; GDSC2; CTRP2	7.2715	11.3126	5.2224	8.3403
BT-16	CTRP2	7.4237	11.3266	5.3399	7.562
SK-LMS-1	GDSC1; GDSC2; CTRP2	7.8799	13.1934	4.7703	9.1104
BT-12	CTRP2	7.9428	8.7613	6.9442	0.3402
GCT	GDSC1; GDSC2; CTRP2	8.1059	16.2961	3.4038	14.1031
MES-SA	GDSC1; GDSC2; CTRP2	8.3472	11.7296	5.8284	4.0414
SW982	GDSC1; GDSC2; CTRP2	8.3891	15.8098	3.8628	11.8639
Tm87-16	CTRP2	8.4563	13.7104	4.9453	7.4478
Hs 729.T	CTRP2	8.55	16.322	3.7308	12.0996
Rh18	GDSC1; CTRP2	9.133	15.9298	4.3449	8.8078
RD	GDSC1; GDSC2; CTRP2	9.3112	16.0309	4.419	8.2613

Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Ovary Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
2004	CTRP2	6.9924	19.7767	0.7568	24.7021
TOV-21G	GDSC1; GDSC2	2.1802	7.7969	0.0739	23.3434
OVCAR-3	GDSC1; GDSC2	4.1495	6.2564	2.4738	3.3867
ES-2	GDSC1; GDSC2	4.373	5.8796	2.7763	1.3453
A2780	GDSC1; GDSC2; CTRP2; CTRP1	4.8149	10.2963	3.4046	21.3088
TYK-nu	GDSC1; GDSC2; CTRP2; CTRP1	5.286	10.6243	3.7279	18.8593
Caov-4	GDSC1; GDSC2	5.3682	7.362	2.6466	0.9081
OVKATE	GDSC1; GDSC2; CTRP1	6.0436	10.1221	4.6955	14.1322
Caov-3	GDSC2; CTRP2; CTRP1	6.1421	10.4191	4.6572	13.0847
OVCAR-8	GDSC1; GDSC2; CTRP2; CTRP1	6.3088	11.7845	4.1452	14.7817
COV362	CTRP2; CTRP1	6.339	16.4563	1.8541	36.736
MCAS	CTRP2	6.4055	8.6303	5.7626	7.9534
OC 314	GDSC1; GDSC2; CTRP2	6.4816	10.9108	4.7333	12.0041
JHOS-4	GDSC1; GDSC2; CTRP1	6.6004	9.5397	4.0645	3.4162
OVK18	GDSC1; GDSC2; CTRP2; CTRP1	6.7424	11.5263	4.6623	11.7355
FU-OV-1	GDSC1; GDSC2; CTRP2	6.859	11.5785	4.7386	11.1772
RMUG-S	CTRP1	6.9245	14.2365	3.4557	29.0976
COV318	CTRP1	6.951	7.817	4.9339	0.0675
Kuramochi	GDSC1; GDSC2; CTRP2	7.052	11.4681	4.9601	9.8654
OV-90	GDSC1; GDSC2; CTRP2; CTRP1	7.0904	11.1531	5.1502	8.9956
IGROV-1	GDSC1; GDSC2; CTRP2; CTRP1	7.4845	13.0347	4.5361	10.7846
JHOM-1	CTRP2; CTRP1	7.4913	11.1233	5.4958	6.7858
SNU-119	CTRP2	7.4964	10.9274	5.5975	6.3508
OAW28	GDSC1; GDSC2; CTRP2	7.5112	11.323	5.412	7.1004
COV434	CTRP2; CTRP1	7.583	19.3366	1.4675	21.5651
SNU-8	CTRP2	7.5898	9.0429	6.6022	2.0117
OVSAHO	CTRP2	7.695	11.8803	5.2792	7.3274
DOV13	GDSC1; GDSC2; CTRP2	7.7337	11.6263	5.4354	6.6104
OAW42	GDSC1; GDSC2; CTRP2; CTRP1	7.8258	9.7735	6.4131	2.431
ES2	CTRP2	7.8907	11.0498	5.838	4.6812
OVCAR-4	GDSC1; GDSC2; CTRP2; CTRP1	7.9803	13.9556	4.4693	10.1628
ONCO-DG-1	CTRP2	8.0431	11.1521	5.8974	4.2026
TOV-112D	GDSC1; GDSC2; CTRP2	8.063	13.53	4.7436	8.9059
SK-OV-3	GDSC1; GDSC2; CTRP2; CTRP1	8.4174	10.8463	6.2884	2.1602
OVTOKO	GDSC1; GDSC2; CTRP2	8.4384	14.1415	4.7214	8.3808
RMG-I	GDSC1; GDSC2; CTRP2; CTRP1	8.5433	13.256	5.2279	6.1736
COV644	CTRP2; CTRP1	8.5656	12.2547	5.7236	4.1597
EFO-27	GDSC1; GDSC2; CTRP2; CTRP1	8.6758	12.9012	5.489	4.9393
EFO-21	GDSC1; GDSC2; CTRP2; CTRP1	8.7085	13.4365	5.2548	5.8264
OVMANA	CTRP1	8.7437	15.6281	2.5676	11.0263
HEY A8	CTRP2; CTRP1	8.8257	13.6278	5.2424	5.7111
SNU-840	CTRP2; CTRP1	8.8585	12.9342	5.593	4.2874
JHOS-2	GDSC1; GDSC2; CTRP2	8.8771	15.7711	4.2412	9.5995
OV56	GDSC1; GDSC2; CTRP2	9.035	14.2803	5.071	6.0996
OVISE	GDSC1; GDSC2; CTRP2	9.2437	16.4638	4.1636	9.3444
OV7	CTRP2; CTRP1	9.493	23.5	0.8945	19.8127
OVCAR-5	GDSC1; GDSC2; CTRP2	10.948	20.5912	3.3347	10.0122
JHOC-5	CTRP2; CTRP1	11.1468	18.1497	4.5846	5.387

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
U-CH1	CTRP2	8.0773	10.0311	6.4559	1.9281

Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MSTO-211H	GDSC1; GDSC2; CTRP2; CTRP1	3.4024	7.3162	3.0287	26.7541
MPP 89	GDSC1; GDSC2; CTRP2	7.2234	10.802	5.4377	7.5309
NCI-H2052	GDSC1; GDSC2; CTRP2; CTRP1	7.3441	10.6195	5.6286	6.5004
NCI-H28	GDSC1; GDSC2; CTRP2; CTRP1	7.9235	12.4564	5.169	7.3926
NCI-H2452	GDSC1; GDSC2; CTRP2	8.0819	11.2562	5.8742	4.239
ACC-MESO-1	CTRP2	8.6008	13.8373	4.9864	7.0608
JL-1	CTRP2	8.6516	12.34	5.7394	3.9836
IST-Mes1	GDSC1; GDSC2; CTRP2	9.9052	16.3902	4.6403	6.6141

Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
PC-3	GDSC1; GDSC2	5.2721	7.8065	2.4207	1.9583
22Rv1	GDSC1; GDSC2; CTRP2	6.2158	10.3167	4.7765	12.4267
LNCaP clone FGC	GDSC1; GDSC2; CTRP2	6.3568	12.7607	3.7063	16.4136
DU145	GDSC1; GDSC2; CTRP2	7.4836	13.0619	4.5218	10.8445
VCaP	GDSC1; GDSC2; CTRP2	7.9164	9.804	6.4593	2.1213
NCI-H660	GDSC2; CTRP2	8.2828	10.4804	6.3749	1.9908
PaCa-3	CTRP2; CTRP1	8.3366	12.8218	5.2932	6.2197

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
YD-15	CTRP2	5.8481	9.2354	4.9277	12.7018
A-253	GDSC1; GDSC2; CTRP2	7.3282	9.219	6.3153	3.649

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HuTu 80	GDSC1; GDSC2	2.6538	5.8927	1.4447	13.9552

Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Stomach Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SCH	GDSC1; GDSC2	3.6701	5.9752	2.2731	5.6939
OCUM-1	GDSC1; GDSC2	4.2749	7.9881	1.7274	7.6124
HGC-27	GDSC1; GDSC2; CTRP2	4.3401	9.9272	3.0788	23.7966
GCIY	GDSC1; GDSC2	4.3868	6.2949	2.6011	2.242
HSC-39	GDSC1; GDSC2	4.4966	8.1567	1.7996	6.6904
RERF-GC-1B	GDSC1; GDSC2	4.6988	10.6356	0.7394	12.352
SK-GT-2	GDSC1; GDSC2	4.7059	7.5453	2.2218	3.8194
GSS	CTRP2	4.912	8.0535	4.4354	17.1361
RF-48	GDSC1; GDSC2	5.0298	11.1416	0.7277	11.6575
TMK-1	GDSC1; GDSC2	5.2789	8.2689	2.226	2.9067
MKN28	GDSC1; GDSC2	5.2829	8.2273	2.2463	2.7979
ECC10	GDSC1; GDSC2; CTRP2	5.3912	8.6091	4.7303	14.675
SNU-1	GDSC1; GDSC2; CTRP2	5.6637	12.1284	3.3776	19.266
TGBC11TKB	GDSC1; GDSC2	5.8034	7.5915	2.7388	0.3782
Fu97	GDSC1; GDSC2; CTRP2; CTRP1	5.9312	7.9312	5.5739	9.9414
SNU-5	GDSC1; GDSC2; CTRP2	6.0347	8.3841	5.4963	9.9627
SNU-16	GDSC1; GDSC2; CTRP2	6.0456	10.7872	4.3879	14.4027
23132/87	GDSC1; GDSC2; CTRP2	6.3607	9.4309	5.3411	9.7764
SNU-601	CTRP2	6.5437	11.7164	4.3913	13.2705
SNU-620	CTRP2	6.6209	8.827	5.88	6.9567
SH-10-TC	CTRP2; CTRP1	6.8815	7.4808	6.7603	2.7596
MKN45	GDSC1; GDSC2; CTRP2	7.0143	7.4658	6.9048	1.8401
SNU-668	CTRP2	7.1794	9.6143	5.9947	5.2785
AGS	GDSC1; GDSC2; CTRP2; CTRP1	7.1941	9.271	6.1787	4.4772
ECC12	GDSC2; CTRP2	7.2564	10.7722	5.4801	7.2894
NCI-N87	GDSC1; GDSC2; CTRP2	7.5349	10.8633	5.6599	6.021
NCC-StC-K140	CTRP2	7.5651	16.5612	2.8398	17.1601
MKN7	GDSC1; GDSC2; CTRP2; CTRP1	7.6203	11.9395	5.1912	7.8257
GSU	CTRP2	7.6219	8.6015	6.8359	1.0283
NUGC-4	GDSC1; GDSC2; CTRP2; CTRP1	7.6431	11.0461	5.6535	5.858
NUGC-3	GDSC1; GDSC2; CTRP2	7.6454	11.528	5.4158	6.8451
MKN1	GDSC1; GDSC2; CTRP2	7.6629	9.618	6.3738	2.8351
MKN74	CTRP2; CTRP1	7.6928	10.6962	5.865	4.8924
SNU-216	CTRP2	7.7917	17.4497	2.5796	17.6334
Hs 746.T	GDSC1; GDSC2; CTRP2	7.8538	14.7825	3.9593	12.4248
HuG1-N	CTRP2	7.896	11.1405	5.7973	4.8406
KATO III	GDSC1; GDSC2; CTRP2	8.0987	11.5201	5.7578	4.6876
KE-39	CTRP2	8.274	15.379	3.9886	11.5705
LMSU	CTRP2	8.9569	15.1205	4.6139	8.0149
IM95	GDSC1; GDSC2; CTRP2	9.8527	11.5992	6.6633	0.1914
SNU-719	CTRP2	10.2559	18.4645	3.8891	8.9514
SNU-685	CTRP2	7.3206	11.9808	4.9289	9.4711
SNU-1077	CTRP2	7.4124	12.0202	4.9843	9.0673
SNG-M	GDSC1; GDSC2; CTRP2; CTRP1	7.624	12.9349	4.698	9.8624

Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
IHH-4	GDSC1; GDSC2	3.6753	7.3304	1.6041	9.8581
KMH-2	GDSC1; GDSC2	4.334	6.2741	2.5796	2.4457
HTC-C3	GDSC1; GDSC2	4.4264	6.7761	2.4055	3.2681
WRO	GDSC1; GDSC2	4.6065	7.7039	2.0866	4.7754
ASH-3	GDSC1; GDSC2	4.8193	6.6119	2.6938	1.2119
K5	GDSC1; GDSC2	5.5195	12.8849	0.2248	13.1843
BHT-101	GDSC1; GDSC2; CTRP2	6.0345	10.1137	4.7009	13.1605
ML-1 [Human leukemia]	GDSC1; GDSC2; CTRP2	6.7257	10.5034	5.1554	9.7258
CGTH-W-1	GDSC1; GDSC2; CTRP2	6.9647	10.8328	5.2023	9.0308
B-CPAP	GDSC1; GDSC2; CTRP2	6.982	11.7707	4.749	10.8829
SW579	CTRP2	7.009	11.7362	4.7894	10.6608
TT2609-C02	GDSC1; GDSC2; CTRP2	7.0257	11.5532	4.8951	10.1883
8505C	GDSC1; GDSC2; CTRP2	7.3383	13.7261	4.071	12.9452
FTC-133	GDSC1; GDSC2; CTRP2	7.5916	11.7868	5.2446	7.6545
FTC-238	CTRP2	7.6118	12.2812	5.0142	8.5772
CAL-62	GDSC1; GDSC2; CTRP2	7.7691	12.118	5.2186	7.4503
TT	GDSC1; GDSC2; CTRP2	8.0515	13.1331	4.9311	8.1577
8305C	GDSC1; GDSC2; CTRP2	8.1218	13.3835	4.8603	8.3306

Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Upper Aerodigestive Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
BB30-HNC	GDSC1; GDSC2	3.5634	5.7928	2.2815	5.9178
BB49-HNC	GDSC1; GDSC2	3.5978	5.8838	2.263	5.9434
OSC-19	GDSC1; GDSC2	3.9565	7.7518	1.611	9.0843
SAS	GDSC1; GDSC2	4.0511	7.5529	1.7791	7.8227
KOSC-2	GDSC1; GDSC2	4.0527	6.4566	2.3139	4.5442
OSC-20	GDSC1; GDSC2	4.19	6.5047	2.3828	3.8447
PCI-04B	GDSC1; GDSC2	4.2907	8.4054	1.5354	8.732
PCI-06A	GDSC1; GDSC2	4.3602	9.4613	1.0686	11.3143
PCI-15A	GDSC1; GDSC2	4.3871	5.9814	2.7398	1.5099
Ca9-22	GDSC1; GDSC2	4.5532	8.2168	1.809	6.5153
UPCI-SCC-090	GDSC1; GDSC2	4.6139	6.8345	2.4897	2.4915
SCC-15	GDSC1; GDSC2	4.6208	8.7257	1.6109	7.5436
HO-1-N-1	GDSC1; GDSC2	4.6453	8.1729	1.8908	5.8444
BICR 78	GDSC1; GDSC2	4.6509	8.7456	1.6218	7.4152
BICR 10	GDSC1; GDSC2	4.714	8.8571	1.6108	7.3466
KON	GDSC1; GDSC2	4.7375	9.9631	1.0943	10.2835
NCI-H3118	GDSC1; GDSC2	4.7453	8.4361	1.8315	5.9926
DOK	GDSC1; GDSC2	4.8111	9.3757	1.4281	8.2056
PCI-38	GDSC1	4.9134	8.4297	1.9411	5.5728
JHU-029	GDSC1; GDSC2	4.9602	12.3277	0.1007	15.0564
LB771-HNC	GDSC1; GDSC2	4.9996	7.3044	2.4939	1.9368
HO-1-u-1	GDSC1; GDSC2	5.0787	11.0075	0.8264	11.0152
SKN-3	GDSC1; GDSC2	5.3961	12.8686	0.1472	13.8353
JHU-011	GDSC1; GDSC2	5.4141	12.8321	0.1774	13.6474
PCI-30	GDSC1; GDSC2	5.5508	11.1037	1.0947	8.5828
JHU-022	GDSC1; GDSC2	5.9181	12.3072	0.7648	9.6298
SNU-1214	CTRP2	5.9821	10.7149	4.3624	14.6545
SCC-25	GDSC1; GDSC2; CTRP2	6.0402	9.748	4.88	12.4202
HSC-4	GDSC1; GDSC2; CTRP2	6.089	8.0093	5.7101	8.9828
CAL-27	GDSC1; GDSC2; CTRP2	6.1807	12.1594	3.8435	16.269
SAT [Human HNSCC]	GDSC1; GDSC2	6.3815	16.3863	-0.8697	16.3087
HSC-2	GDSC1; GDSC2; CTRP2; CTRP1	6.3838	9.8867	5.1435	10.5339
HSC-3	GDSC1; GDSC2; CTRP2	6.6631	7.396	6.5589	4.139
SCC-4	GDSC1; GDSC2; CTRP2	6.6696	11.2918	4.7143	11.675
YD-10B	CTRP2	6.7438	10.3202	5.2624	9.2413
SNU-1076	CTRP2	6.8454	12.2322	4.4008	12.5946
FaDu	GDSC1; GDSC2; CTRP2	6.9063	9.5897	5.7699	6.7781
CAL-33	GDSC1; GDSC2; CTRP2	7.3918	11.647	5.1541	8.3983
Detroit 562	GDSC1; GDSC2; CTRP2	7.4254	9.7376	6.1343	4.2309
BICR 22	GDSC1; GDSC2; CTRP2	7.4266	13.7839	4.1146	12.6015
BHY	GDSC1; GDSC2; CTRP2	7.5742	11.7611	5.2437	7.6897
SNU-1066	CTRP2	7.9392	11.7862	5.5117	5.95
BICR 18	CTRP2	7.9758	13.5708	4.6568	9.409
YD-8	CTRP2	8.081	11.6976	5.6587	5.1197
BICR 31	GDSC2; CTRP2	8.1381	14.3958	4.372	10.2833
BICR 16	CTRP2	8.1542	11.1935	5.9546	3.8075
PE/CA-PJ49	CTRP2	8.1578	13.092	5.0308	7.5736
PE/CA-PJ34 (clone C12)	CTRP2	8.2725	15.6282	3.8641	12.058
SNU-46	CTRP2	8.3284	13.2385	5.0838	7.0851
SNU-1041	CTRP2	8.3616	11.3831	6.0029	3.3296
BICR 6	CTRP2	8.3776	11.8331	5.7993	4.1153
SNU-899	CTRP2	8.4499	12.2001	5.6724	4.5216
SCC-9	GDSC1; GDSC2; CTRP2; CTRP1	8.5008	13.7438	4.961	7.3156
PE/CA-PJ15	GDSC1; GDSC2; CTRP2	8.5476	15.2388	4.2627	10.0374
BICR 56	CTRP2	9.4552	16.8609	4.1182	9.2081
PE/CA-PJ41 (clone D2)	CTRP2	10.396	19.2733	3.5975	9.8176

Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Urinary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SW780	GDSC1; GDSC2	4.5054	7.7695	1.9903	5.5393
SW1710	GDSC1; GDSC2	4.9572	6.7116	2.7186	0.9721
647V	GDSC1; GDSC2; CTRP2	5.3235	8.9697	4.5082	15.7204
253J	CTRP2	5.3954	8.6533	4.7164	14.7174
UM-UC-3	GDSC1; GDSC2; CTRP2; CTRP1	5.5553	7.3641	5.3638	11.8125
JMSU-1	CTRP2	5.6172	9.4469	4.5991	14.5971
5637	GDSC1; GDSC2; CTRP2; CTRP1	6.5628	12.2117	4.1627	14.1561
SCaBER	CTRP2	6.8084	7.9413	6.4815	4.0555
KU-19-19	GDSC1; GDSC2; CTRP2	7.0304	7.6484	6.8372	2.0719
BC-3C	CTRP2	7.1113	13.4833	4.0032	13.6611
253J-BV	CTRP2	7.1512	9.3745	6.0906	4.9314
HT-1197	GDSC1; GDSC2; CTRP2	7.2153	13.0783	4.2928	12.2914
J82	GDSC1; GDSC2; CTRP2	7.4924	10.3691	5.8726	5.2067
U-BLC1	CTRP2	7.593	11.5826	5.3475	7.223
BFTC-905	GDSC1; GDSC2; CTRP2	7.6685	8.9061	6.7222	1.4141
KMBC-2	CTRP2; CTRP1	7.7871	12.2308	5.1765	7.594
639V	GDSC1; GDSC2; CTRP2	7.8162	9.8789	6.3556	2.677
RT-112	GDSC1; GDSC2; CTRP2	7.8878	11.43	5.6489	5.4665
HT-1376	GDSC1; GDSC2; CTRP2; CTRP1	7.8882	10.0424	6.3264	2.6908
CAL-29	GDSC1; GDSC2; CTRP2	7.9574	11.8376	5.4998	5.9693
RT-4	GDSC1; GDSC2; CTRP2; CTRP1	8.0159	12.0932	5.4173	6.2149
UM-UC-1	CTRP2	8.1721	14.6468	4.2736	10.6192
TCCSUP	GDSC1; GDSC2; CTRP2	8.2849	12.0183	5.6468	4.8611
T24	GDSC1; GDSC2; CTRP2	8.4596	13.6612	4.9717	7.3359
VM-CUB-1	CTRP2	8.7307	14.2253	4.8894	7.2557

Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NT2-D1	GDSC1; GDSC2	0.7253	4.7727	-0.0074	29.7615
PA-1	GDSC1; GDSC2	2.9822	7.3313	1.0275	15.3929
JEG-3	GDSC1; GDSC2	3.4092	6.0261	2.0419	7.8519
TC-YIK	GDSC1; GDSC2	3.6439	5.9225	2.2792	5.7224
C-33 A	GDSC1; GDSC2	3.679	5.4482	2.5397	4.0064
HT-3	GDSC1; GDSC2	3.823	5.4206	2.6551	2.9684
KGN	GDSC1; GDSC2	3.8616	6.4726	2.1706	5.8609
SiHa	GDSC1; GDSC2	3.8781	5.0656	2.8585	1.6571
SiSo	GDSC1; GDSC2	4.0167	6.3293	2.3504	4.4001
C-4-I	GDSC1; GDSC2	4.0882	5.9182	2.5933	2.8035
SKG-IIIa	GDSC1; GDSC2	4.0978	5.6882	2.7059	2.1384
ACC-OV7	GDSC1; GDSC2	4.1502	9.3082	0.9879	12.3019
BPH-1	GDSC1; GDSC2	4.198	8.7512	1.2983	10.3687
ME-180	GDSC1; GDSC2	4.2031	6.7803	2.2605	4.5478
PWR-1E	GDSC1; GDSC2	4.2764	8.3332	1.5603	8.6158
SW756	GDSC1; GDSC2	4.2899	6.2861	2.5478	2.699
UWB1.289	GDSC1; GDSC2	4.3096	7.9359	1.7773	7.2328
MS751	GDSC1; GDSC2	4.4143	7.8487	1.8915	6.3168
SW954	GDSC1; GDSC2	4.4658	7.7939	1.9524	5.8451
LB831-BLC	GDSC1; GDSC2	4.5079	6.7989	2.4441	2.9102
SKN	GDSC1; GDSC2	4.5294	7.4753	2.1446	4.5844
DoTc2 4510	GDSC1; GDSC2	4.5995	8.7555	1.5821	7.7591
HEY	GDSC1; GDSC2	4.6427	8.6717	1.6516	7.257
PEO1	GDSC1; GDSC2	4.6431	6.8989	2.4775	2.5121
CAL-39	GDSC1; GDSC2	4.7239	6.8685	2.5357	2.0895
NEC8	GDSC1; GDSC2	4.7587	8.8067	1.6647	6.9394
Ca Ski	GDSC1; GDSC2	4.7863	7.3396	2.3623	2.9111
OVCA420	GDSC1; GDSC2	4.7953	6.8015	2.6023	1.6642
OMC-1 [Human cervical carcinoma]	GDSC1; GDSC2	4.8787	6.6681	2.6994	1.1269
SW962	GDSC1; GDSC2	4.894	7.0528	2.5464	1.813
DSH1	GDSC1; GDSC2	4.9905	7.1045	2.5736	1.5697
OV17R	GDSC1; GDSC2	5.1242	7.9006	2.3027	2.7288
OVMIU	GDSC1; GDSC2	5.228	7.8087	2.3973	2.1222
JAR	GDSC1; GDSC2	5.2295	6.7897	2.806	0.4695
HEC-1	GDSC1; GDSC2	5.3231	9.6115	1.6471	5.9608
NCC-IT	GDSC2	5.408	7.275	2.6972	0.7024
OVCA433	GDSC1; GDSC2	5.4236	7.2929	2.697	0.693
JHOS-3	GDSC1; GDSC2	5.7121	7.5563	2.7162	0.4747
HeLa	GDSC1; GDSC2; CTRP2	7.4074	8.474	6.748	1.6998

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Olaparib

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Rucaparib	DM9PVX8	Moderate	Decreased metabolism of Olaparib caused by Rucaparib mediated inhibition of CYP450 enzyme.	Ovarian cancer [2C73]	[13]

Coadministration of a Drug Treating the Disease Different from Olaparib (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Ivosidenib	DM8S6T7	Moderate	Increased metabolism of Olaparib caused by Ivosidenib mediated induction of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[14]
Arn-509	DMT81LZ	Major	Increased metabolism of Olaparib caused by Arn-509 mediated induction of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[14]
Oliceridine	DM6MDCF	Moderate	Decreased metabolism of Olaparib caused by Oliceridine mediated inhibition of CYP450 enzyme.	Acute pain [MG31]	[14]
Troleandomycin	DMUZNIG	Major	Decreased metabolism of Olaparib caused by Troleandomycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[14]
Pexidartinib	DMS2J0Z	Major	Increased metabolism of Olaparib caused by Pexidartinib mediated induction of CYP450 enzyme.	Bone/articular cartilage neoplasm [2F7B]	[14]
Tucatinib	DMBESUA	Major	Decreased metabolism of Olaparib caused by Tucatinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[14]
Revefenacin	DMMP5SI	Moderate	Decreased clearance of Olaparib due to the transporter inhibition by Revefenacin.	Chronic obstructive pulmonary disease [CA22]	[15]
Lumacaftor	DMCLWDJ	Major	Increased metabolism of Olaparib caused by Lumacaftor mediated induction of CYP450 enzyme.	Cystic fibrosis [CA25]	[14]
MK-8228	DMOB58Q	Major	Decreased metabolism of Olaparib caused by MK-8228 mediated inhibition of CYP450 enzyme.	Cytomegaloviral disease [1D82]	[14]
Oestradiol valerate and dienogest	DMZK0FQ	Moderate	Increased metabolism of Olaparib caused by Oestradiol valerate and dienogest mediated induction of CYP450 enzyme.	Endometriosis [GA10]	[16]
Stiripentol	DMMSDOY	Major	Decreased metabolism of Olaparib caused by Stiripentol mediated inhibition of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[14]
Eslicarbazepine	DMZREFQ	Moderate	Increased metabolism of Olaparib caused by Eslicarbazepine mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[14]
Tazemetostat	DMWP1BH	Moderate	Increased metabolism of Olaparib caused by Tazemetostat mediated induction of CYP450 enzyme.	Follicular lymphoma [2A80]	[14]
Ripretinib	DM958QB	Moderate	Decreased clearance of Olaparib due to the transporter inhibition by Ripretinib.	Gastrointestinal stromal tumour [2B5B]	[14]
GS-9857	DMYU6P5	Moderate	Decreased clearance of Olaparib due to the transporter inhibition by GS-9857.	Hepatitis virus infection [1E50-1E51]	[17]
Berotralstat	DMWA2DZ	Major	Decreased metabolism of Olaparib caused by Berotralstat mediated inhibition of CYP450 enzyme.	Innate/adaptive immunodeficiency [4A00]	[14]
Eluxadoline	DMYZ0P1	Moderate	Decreased clearance of Olaparib due to the transporter inhibition by Eluxadoline.	Irritable bowel syndrome [DD91]	[14]
Lurbinectedin	DMEFRTZ	Moderate	Decreased metabolism of Olaparib caused by Lurbinectedin mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[18]
PF-06463922	DMKM7EW	Major	Increased metabolism of Olaparib caused by PF-06463922 mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[14]
Capmatinib	DMYCXKL	Moderate	Decreased clearance of Olaparib due to the transporter inhibition by Capmatinib.	Lung cancer [2C25]	[19]
Selpercatinib	DMZR15V	Moderate	Decreased metabolism of Olaparib caused by Selpercatinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[13]
Artesunate	DMR27C8	Moderate	Decreased clearance of Olaparib due to the transporter inhibition by Artesunate.	Malaria [1F40-1F45]	[14]
Arry-162	DM1P6FR	Moderate	Decreased metabolism of Olaparib caused by Arry-162 mediated inhibition of UGT.	Melanoma [2C30]	[14]
Ubrogepant	DM749I3	Moderate	Decreased clearance of Olaparib due to the transporter inhibition by Ubrogepant.	Migraine [8A80]	[20]
Rimegepant	DMHOAUG	Moderate	Decreased clearance of Olaparib due to the transporter inhibition by Rimegepant.	Migraine [8A80]	[21]
Siponimod	DM2R86O	Major	Additive immunosuppressive effects by the combination of Olaparib and Siponimod.	Multiple sclerosis [8A40]	[14]
Ocrelizumab	DMEZ2KH	Moderate	Additive immunosuppressive effects by the combination of Olaparib and Ocrelizumab.	Multiple sclerosis [8A40]	[22]
Fedratinib	DM4ZBK6	Moderate	Decreased metabolism of Olaparib caused by Fedratinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[14]
Entrectinib	DMMPTLH	Moderate	Decreased metabolism of Olaparib caused by Entrectinib mediated inhibition of CYP450 enzyme.	Non-small cell lung cancer [2C25]	[13]
S-297995	DM26IH8	Moderate	Decreased metabolism of Olaparib caused by S-297995 mediated inhibition of CYP450 enzyme.	Opioid use disorder [6C43]	[14]
Abametapir	DM2RX0I	Moderate	Decreased metabolism of Olaparib caused by Abametapir mediated inhibition of CYP450 enzyme.	Pediculosis [1G00]	[23]
Lefamulin	DME6G97	Moderate	Decreased metabolism of Olaparib caused by Lefamulin mediated inhibition of CYP450 enzyme.	Pneumonia [CA40]	[24]
Relugolix	DMK7IWL	Moderate	Decreased clearance of Olaparib due to the transporter inhibition by Relugolix.	Prostate cancer [2C82]	[14]
Anthrax vaccine	DM9GSWY	Moderate	Antagonize the effect of Olaparib when combined with Anthrax vaccine.	Sepsis [1G40-1G41]	[25]
Voxelotor	DMCS6M5	Moderate	Decreased metabolism of Olaparib caused by Voxelotor mediated inhibition of CYP450 enzyme.	Sickle-cell disorder [3A51]	[14]
Telotristat ethyl	DMDIYFZ	Moderate	Increased metabolism of Olaparib caused by Telotristat ethyl mediated induction of CYP450 enzyme.	Small intestine developmental anomaly [DA90]	[16]
Larotrectinib	DM26CQR	Moderate	Decreased metabolism of Olaparib caused by Larotrectinib mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[13]
LEE011	DMMX75K	Major	Decreased metabolism of Olaparib caused by LEE011 mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[14]
Fostamatinib	DM6AUHV	Moderate	Decreased metabolism of Olaparib caused by Fostamatinib mediated inhibition of CYP450 enzyme.	Thrombocytopenia [3B64]	[26]
Lusutrombopag	DMH6IKO	Moderate	Decreased clearance of Olaparib due to the transporter inhibition by Lusutrombopag.	Thrombocytopenia [3B64]	[14]
Elagolix	DMB2C0E	Moderate	Increased metabolism of Olaparib caused by Elagolix mediated induction of CYP450 enzyme.	Uterine fibroid [2E86]	[14]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Isopropyl alcohol	E00070	3776	Antimicrobial preservative; Solvent
Mannitol	E00103	6251	Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Potassium acetate	E00430	517044	Film/membrane-forming agent
Sodium stearyl fumarate	E00545	23665634	lubricant
Ammonia	E00007	222	Alkalizing agent
Butyl alcohol	E00011	263	Flavoring agent; Solvent
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Ferrosoferric oxide	E00231	14789	Colorant
Polyethylene glycol 400	E00653	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Propylene glycol	E00040	1030	Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Titanium dioxide	E00322	26042	Coating agent; Colorant; Opacifying agent
Water	E00035	962	Solvent

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Olaparib 100 mg tablet	100 mg	Oral Tablet	Oral
Olaparib 150 mg tablet	150 mg	Oral Tablet	Oral
Olaparib 50 mg capsule	50 mg	Oral Capsule	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7519).
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Nivolumab and Olaparib. Hosp Pharm. 2015 May;50(5):356-66. doi: 10.1310/hpj5005-356.
• [4] BDDCS predictions, self-correcting aspects of BDDCS assignments, BDDCS assignment corrections, and classification for more than 175 additional drugs
• [5] Olaparib New Zealand Data Sheet
• [6] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [7] Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer. Transl Oncol. 2019 May 7;12(7):871-878.
• [8] Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiother Oncol. 2015 Sep;116(3):358-65.
• [9] The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer. Gynecol Oncol. 2018 Jun;149(3):575-584. doi: 10.1016/j.ygyno.2018.03.049. Epub 2018 Mar 20.
• [10] PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma. PLoS One. 2014 Dec 22;9(12):e114583. doi: 10.1371/journal.pone.0114583. eCollection 2014.
• [11] Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest. 2011 Jul;121(7):2750-67. doi: 10.1172/JCI45014.
• [12] MSH3 mediates sensitization of colorectal cancer cells to cisplatin, oxaliplatin, and a poly(ADP-ribose) polymerase inhibitor. J Biol Chem. 2011 Apr 8;286(14):12157-65. doi: 10.1074/jbc.M110.198804. Epub 2011 Feb 1.
• [13] Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
• [14] Cerner Multum, Inc. "Australian Product Information.".
• [15] Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
• [16] Cerner Multum, Inc. "UK Summary of Product Characteristics.".
• [17] Product Information. Vosevi (sofosbuvir/velpatasvir/voxilaprevir). Gilead Sciences, Foster City, CA.
• [18] Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
• [19] Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
• [20] Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
• [21] Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
• [22] Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
• [23] Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
• [24] Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
• [25] CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
• [26] Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.