Details of the Drug

General Information of Drug (ID: DMMX75K)

Drug Name
LEE011
Synonyms
Ribociclib; LEE011; 1211441-98-3; LEE-011; Kisqali; Ribociclib(LEE011); UNII-TK8ERE8P56; LEE 011; 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; TK8ERE8P56; Ribociclib (LEE011); AK174906; 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo [2,3-d]pyrimidine-6-carboxylic acid dimethylamide; Ribociclib [USAN:INN]; LEE011A; Tube013
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 3 [1]
Solid tumour/cancer 2A00-2F9Z Phase 3 [2]
Affected Organisms
Humans and other mammals
ATC Code
L01EF02: LEE011
L01EF: Cyclin-dependent kinase (CDK) inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 434.5
Logarithm of the Partition Coefficient (xlogp) 2.2
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 7
ADMET Property
Half-life
The concentration or amount of drug in body reduced by one-half in 32.6 hours [3]
Chemical Identifiers
Formula
C23H30N8O
IUPAC Name
7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
Canonical SMILES
CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
InChI
InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
InChIKey
RHXHGRAEPCAFML-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
44631912
CAS Number
1211441-98-3
UNII
TK8ERE8P56
DrugBank ID
DB11730
TTD ID
D08MXP
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cyclin-dependent kinase 4 (CDK4) TT0PG8F CDK4_HUMAN Modulator [4]
Cyclin-dependent kinase 6 (CDK6) TTO0FDJ CDK6_HUMAN Modulator [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Protein Interaction/Cellular Processes [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Breast cancer
ICD Disease Classification 2C60-2C65
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cyclin-dependent kinase 4 (CDK4) DTT CDK4 3.30E-72 0.65 2.39
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 2.7369 4.9085 0.2331 1.5784
SK-ES-1 GDSC2 1.4117 6.4645 -1.3972 13.7704
ES1 GDSC2 1.4553 5.9513 -1.1071 11.9492
G-292 clone A141B1 GDSC2 1.5372 4.3829 -0.2673 6.5868
EW-3 GDSC2 1.5911 4.656 -0.3619 7.0417
MHH-ES-1 GDSC2 1.7779 4.3545 -0.0815 4.8879
ES6 GDSC2 1.7935 5.0423 -0.4041 6.8209
ES8 GDSC2 1.8789 4.5392 -0.1016 4.7937
EW-16 GDSC2 1.9321 4.6487 -0.1182 4.7829
MG-63 GDSC2 2.027 5.9203 -0.6657 7.8723
EW-7 GDSC2 2.06 4.874 -0.1409 4.6579
EW-12 GDSC2 2.0611 4.5605 0.0072 3.787
EW-22 GDSC2 2.107 4.5437 0.0437 3.4912
EW-1 GDSC2 2.1589 6.1258 -0.6732 7.6225
CADO-ES1 GDSC2 2.1763 4.0033 0.3283 1.8151
HOS GDSC2 2.2596 7.4054 -1.2233 10.616
NOS-1 [Human HNSCC] GDSC2 2.2861 4.4657 0.1852 2.4067
HuO-3N1 GDSC2 2.3216 4.7046 0.0987 2.8187
CHSA0011 GDSC2 2.3624 5.4602 -0.2228 4.5572
SJSA-1 GDSC2 2.4116 5.7629 -0.333 5.1012
EW-13 GDSC2 2.4361 5.0919 -0.0093 3.2261
CHSA8926 GDSC2 2.5322 4.4552 0.3205 1.4061
CAL-72 GDSC2 2.5822 4.1315 0.4748 0.7133
CAL-78 GDSC2 2.6347 4.6391 0.2947 1.411
EW-24 GDSC2 2.6505 4.4967 0.3607 1.1066
TC-71 GDSC2 2.7244 5.0049 0.1865 1.8105
ES5 GDSC2 2.8529 6.8166 -0.5475 5.5145
A-673 GDSC2 3.1788 4.6416 0.526 0.2486
HuO9 GDSC2 3.2474 5.6011 0.1937 1.244
U2OS GDSC2 3.3201 5.294 0.344 0.6567
SaOS-2 GDSC2 3.3932 5.1516 0.4254 0.3938
CHSA0108 GDSC2 3.4153 5.3106 0.3763 0.511
U-CH2 GDSC2 3.5276 5.1638 0.4715 0.2467
NY GDSC2 3.5632 5.6231 0.3202 0.592
SK-PN-DW GDSC2 3.6252 5.4628 0.4024 0.356
EW-18 GDSC2 3.7478 6.9821 -0.13 2.1214
EW-11 GDSC2 3.9074 6.4677 0.1452 0.9268
H-EMC-SS GDSC2 3.9116 6.1979 0.2475 0.6175
ES7 GDSC2 4.1573 6.5458 0.2171 0.5817
ES4 GDSC2 4.2624 6.6923 0.2049 0.5661
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 164 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 3.5783 5.0619 0.5246 0.1472
NB4 GDSC2 -1.0319 2.7177 -1.8425 24.7725
SUP-B8 GDSC2 -0.3749 2.2194 -0.9475 17.0071
TALL-1 [Human adult T-ALL] GDSC2 -0.2259 1.984 -0.693 14.9141
MV4-11 GDSC2 0.5288 4.6184 -1.2155 15.3472
JeKo-1 GDSC2 0.6833 4.7338 -1.137 14.3817
Kasumi-1 GDSC2 0.8848 4.9644 -1.079 13.4098
SUP-M2 GDSC2 0.9385 5.7187 -1.4108 15.2142
RCH-ACV GDSC2 0.9616 4.3457 -0.705 10.8827
OCI-Ly7 GDSC2 1.0067 3.4979 -0.2434 7.8513
697 GDSC2 1.0073 4.3118 -0.6499 10.405
SIG-M5 GDSC2 1.0757 3.9967 -0.4357 8.8655
KE-37 GDSC2 1.1178 3.7516 -0.2789 7.7586
CTB-1 GDSC2 1.1443 3.3259 -0.045 6.2082
MOLT-16 GDSC2 1.1616 2.8837 0.1892 4.6824
A4/Fukuda GDSC2 1.1723 5.5627 -1.1394 12.9281
SKM-1 GDSC2 1.2035 4.4089 -0.538 9.1481
OCI-Ly19 GDSC2 1.209 4.0556 -0.3573 8.0002
TUR GDSC2 1.2144 5.0598 -0.8541 11.0785
KY821 GDSC2 1.2607 5.4301 -1.0017 11.8493
A3/Kawakami GDSC2 1.3266 3.3474 0.0861 4.903
ST486 GDSC2 1.3502 5.0567 -0.7444 10.0302
JURL-MK1 GDSC2 1.3629 4.0073 -0.213 6.685
BALL-1 GDSC2 1.3776 4.0107 -0.2034 6.5873
SU-DHL-10 GDSC2 1.3844 3.4617 0.073 4.842
GR-ST GDSC2 1.411 4.8253 -0.5818 8.8627
P12-Ichikawa GDSC2 1.413 3.0969 0.2727 3.5341
Farage GDSC2 1.4134 3.2456 0.2003 3.9806
RPMI-8402 GDSC2 1.4203 4.0659 -0.1984 6.4476
MOLM-13 GDSC2 1.4385 4.8655 -0.5805 8.7827
MOLP-8 GDSC2 1.4786 4.1798 -0.2108 6.3798
Karpas-422 GDSC2 1.5012 6.9009 -1.5439 14.3607
HEL GDSC2 1.5277 3.2629 0.2724 3.2799
SR GDSC2 1.5289 4.7534 -0.4562 7.7806
GA-10 GDSC2 1.5395 6.1734 -1.152 11.9905
JVM-2 GDSC2 1.5478 6.1479 -1.1329 11.855
Karpas-45 GDSC2 1.5646 4.4633 -0.2866 6.64
OCI-AML-3 GDSC2 1.5905 3.4874 0.2074 3.5393
SCC-3 GDSC2 1.6147 4.6925 -0.3624 6.9877
SUP-T1 GDSC2 1.6171 6.5886 -1.2981 12.6419
ATN-1 GDSC2 1.618 6.3808 -1.1943 12.033
SU-DHL-4 GDSC2 1.6202 3.5667 0.1895 3.5842
Raji GDSC2 1.6314 5.9364 -0.9638 10.6267
NU-DUL-1 GDSC2 1.6355 5.2446 -0.6188 8.5178
MOLT-13 GDSC2 1.6825 5.4491 -0.6845 8.8033
EB2 GDSC2 1.734 5.315 -0.5805 8.0415
RC-K8 GDSC2 1.7341 4.0333 0.0429 4.2283
BC-1 GDSC2 1.7374 4.8632 -0.3569 6.6618
MY-M12 GDSC2 1.7423 4.0449 0.0429 4.2107
DoHH2 GDSC2 1.7591 3.3587 0.3772 2.2061
Karpas-620 GDSC2 1.7623 4.6415 -0.2312 5.8347
SU-DHL-6 GDSC2 1.7631 5.6663 -0.7318 8.8934
CRO-AP2 GDSC2 1.7803 6.3848 -1.073 10.8994
WIL2 NS GDSC2 1.8124 4.6767 -0.2132 5.6132
Ku812 GDSC2 1.8375 4.2737 -0.0025 4.2847
KM-H2 GDSC2 1.8417 5.797 -0.7383 8.7423
EoL-1 GDSC2 1.8441 4.7768 -0.2396 5.7037
JSC-1 GDSC2 1.8928 5.5574 -0.5843 7.689
HAL-01 GDSC2 1.8928 7.7675 -1.6716 14.0321
OCI-AML-5 GDSC2 1.9082 3.4495 0.4237 1.7047
LC4-1 GDSC2 1.9176 6.2374 -0.8989 9.5256
Karpas-1106P GDSC2 1.9249 3.8174 0.2672 2.5404
THP-1 GDSC2 1.9379 6.6733 -1.098 10.6557
BV-173 GDSC2 1.9426 4.6544 -0.1139 4.7355
HT GDSC2 1.9426 4.1736 0.1131 3.3931
KCL-22 GDSC2 1.9748 3.6816 0.358 1.9557
KMS-12-BM GDSC2 2.0011 4.9459 -0.214 5.2129
SU-DHL-5 GDSC2 2.0095 3.2273 0.5727 0.8341
SU-DHL-16 GDSC2 2.0298 3.6976 0.3819 1.7454
WSU-NHL GDSC2 2.047 5.6364 -0.5143 6.9179
NK-92MI GDSC2 2.0567 5.6264 -0.5028 6.8277
ROS-50 GDSC2 2.0689 6.8004 -1.0648 10.1458
MHH-CALL-2 GDSC2 2.07 4.2717 0.1466 2.9706
ML-2 GDSC2 2.1024 4.0011 0.2881 2.1354
DG-75 GDSC2 2.103 4.141 0.2257 2.4739
VAL GDSC2 2.1196 5.8464 -0.5655 7.0663
KMS-11 GDSC2 2.1199 7.5786 -1.4091 12.0036
NALM-6 GDSC2 2.1249 6.3497 -0.8052 8.4842
MC116 GDSC2 2.133 3.0905 0.6821 0.3133
EM-2 GDSC2 2.1384 3.7732 0.4078 1.4636
KOPN-8 GDSC2 2.1586 4.0031 0.3187 1.8902
BL-41 GDSC2 2.2148 3.481 0.5666 0.6629
LAMA-84 GDSC2 2.2192 4.1764 0.2759 2.0264
RS4;11 GDSC2 2.232 4.3173 0.2207 2.2992
BE-13 GDSC2 2.2385 4.657 0.0715 3.1045
RPMI-8866 GDSC2 2.2427 6.1429 -0.624 7.1491
MLMA GDSC2 2.2645 5.1961 -0.1612 4.383
CML-T1 GDSC2 2.2731 3.8022 0.4639 1.0396
CTV-1 GDSC2 2.287 4.0694 0.3587 1.5155
SU-DHL-8 GDSC2 2.3155 4.2096 0.3136 1.7015
BONNA-12 GDSC2 2.3725 5.0339 -0.0204 3.3921
Daudi GDSC2 2.3913 4.1409 0.3816 1.2835
MHH-CALL-4 GDSC2 2.4041 7.6365 -1.2334 10.3419
DB GDSC2 2.4135 4.291 0.3297 1.5005
Reh GDSC2 2.4199 3.8713 0.5047 0.7308
PL-21 GDSC2 2.4461 6.7472 -0.7761 7.6131
Jiyoye GDSC2 2.4566 4.9529 0.0649 2.7911
MM1.S GDSC2 2.5071 4.0998 0.4536 0.8571
DEL GDSC2 2.5187 10.2247 -2.416 16.2865
P32/ISH GDSC2 2.5334 4.1289 0.454 0.8324
Karpas-231 GDSC2 2.537 3.7243 0.61 0.3066
Loucy GDSC2 2.543 4.1331 0.4567 0.8137
RL GDSC2 2.5708 4.5608 0.2956 1.4773
L-540 GDSC2 2.5719 4.772 0.2069 1.8991
SUP-B15 GDSC2 2.5732 4.3323 0.3908 1.0539
OCI-M1 GDSC2 2.6035 3.8386 0.5944 0.3165
QIMR-WIL GDSC2 2.7141 14.0556 -4.1601 22.8858
DND-41 GDSC2 2.7281 4.8497 0.2533 1.4965
ME1 GDSC2 2.7621 3.9276 0.6229 0.1886
Jurkat GDSC2 2.7658 4.2078 0.5232 0.4323
YT GDSC2 2.8228 4.0203 0.6127 0.1896
Ramos.2G6.4C10 GDSC2 2.8562 4.1318 0.5858 0.2334
RPMI-6666 GDSC2 2.8883 4.3199 0.5307 0.3509
Hs 445 GDSC2 2.9228 4.4658 0.4909 0.4418
U-698-M GDSC2 2.9228 4.9514 0.3042 1.088
IM-9 GDSC2 2.9301 4.2731 0.5635 0.2554
NOMO-1 GDSC2 2.954 4.3245 0.5542 0.2672
WSU-DLCL2 GDSC2 2.9685 11.6413 -2.7826 16.9163
LP-1 GDSC2 2.9701 4.67 0.434 0.5857
Granta-519 GDSC2 2.9708 5.0587 0.2834 1.1289
U266B1 GDSC2 2.9746 4.638 0.4479 0.5399
L-363 GDSC2 2.9792 4.3318 0.5611 0.2432
RPMI-8226 GDSC2 2.9991 4.7467 0.4171 0.6216
ARH-77 GDSC2 3.0054 4.8749 0.3709 0.7725
P31/FUJ GDSC2 3.0194 4.1128 0.6508 0.0856
HL-60 GDSC2 3.0297 4.3742 0.5649 0.2187
OCI-AML-2 GDSC2 3.0598 4.2438 0.6206 0.117
BC-3 GDSC2 3.0971 4.5887 0.5142 0.3033
SU-DHL-1 GDSC2 3.1123 4.181 0.6597 0.063
JVM-3 GDSC2 3.1266 4.9227 0.4036 0.5869
K-562 GDSC2 3.1373 4.619 0.5186 0.2786
TK [Human B-cell lymphoma] GDSC2 3.1394 4.7839 0.4601 0.4188
HDLM-2 GDSC2 3.1807 5.1472 0.3413 0.7532
Karpas-299 GDSC2 3.2002 4.7717 0.4879 0.3237
OPM-2 GDSC2 3.2073 4.8319 0.4691 0.3656
HC-1 GDSC2 3.2248 4.8078 0.4844 0.3224
L-428 GDSC2 3.2365 4.985 0.4248 0.4667
MOLM-16 GDSC2 3.2453 4.6271 0.5553 0.1752
VL51 GDSC2 3.2523 5.0287 0.4151 0.4855
NCI-H929 GDSC2 3.2714 4.7963 0.5059 0.2591
MOLT-4 GDSC2 3.2764 4.6447 0.5604 0.1595
Namalwa GDSC2 3.2787 4.7613 0.5209 0.2274
P30/OHK GDSC2 3.2958 4.7716 0.5235 0.2174
GDM-1 GDSC2 3.3133 5.739 0.1689 1.2851
PF-382 GDSC2 3.3962 5.0951 0.4468 0.3422
CESS GDSC2 3.4244 4.9242 0.5171 0.1937
SK-MM-2 GDSC2 3.453 5.2071 0.4284 0.3626
KMOE-2 GDSC2 3.4833 5.6647 0.272 0.7849
L-1236 GDSC2 3.4984 5.4205 0.3689 0.4907
MHH-PREB-1 GDSC2 3.5043 4.9979 0.5204 0.1692
HH [Human lymphoma] GDSC2 3.5159 5.5209 0.339 0.5635
ALL-SIL GDSC2 3.5258 5.405 0.3851 0.4365
JJN-3 GDSC2 3.528 5.0393 0.5146 0.1727
MN-60 GDSC2 3.533 5.3034 0.4243 0.3414
H9 GDSC2 3.5749 5.2315 0.4651 0.2447
CCRF-CEM GDSC2 3.5816 4.9346 0.5686 0.0927
CA46 GDSC2 3.5854 5.5889 0.3416 0.5219
ALL-PO GDSC2 3.6052 6.1324 0.1445 1.14
EJM GDSC2 3.7673 5.5855 0.412 0.2879
NKM-1 GDSC2 3.7978 6.0258 0.2655 0.6249
KG-1 GDSC2 3.9442 5.577 0.4779 0.1405
Mono-Mac-6 GDSC2 4.1557 7.1337 -0.0039 1.2639
MEG-01 GDSC2 4.1795 6.1459 0.3669 0.2536
SUP-HD1 GDSC2 4.1803 5.942 0.4367 0.151
⏷ Show the Full List of 164 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACM5.1 C GDSC2 1.6381 4.115 -0.0631 5.0857
FLO-1 GDSC2 2.0063 4.4731 0.0133 3.8552
HCE-4 GDSC2 2.6069 5.7346 -0.2 3.9984
OACP4 C GDSC2 2.6554 4.965 0.1678 1.9849
SK-GT-4 GDSC2 2.7464 5.5631 -0.043 2.9316
KYSE-50 GDSC2 3.0823 4.7302 0.4572 0.4545
KYAE-1 GDSC2 3.1389 4.7314 0.4789 0.3706
ESO-51 GDSC2 3.246 5.4044 0.2704 0.9542
ESO-26 GDSC2 3.4098 5.1277 0.4404 0.3517
KYSE-220 GDSC2 3.7212 5.8087 0.3148 0.5287
TE-12 GDSC2 4.7716 7.3824 0.1518 0.4885
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 2.9319 4.9826 0.296 1.1131
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC2 1.0065 4.2802 -0.6346 10.3122
NB(TU)1 GDSC2 1.0487 3.4593 -0.1894 7.3889
CHP-212 GDSC2 1.3668 4.2819 -0.3462 7.5094
NH-12 GDSC2 1.6373 4.1304 -0.0711 5.1373
KP-N-YS GDSC2 1.8188 4.4216 -0.0859 4.8263
GI-ME-N GDSC2 1.8669 4.5204 -0.1007 4.8135
SJNB-14 GDSC2 1.8809 5.5012 -0.5654 7.6018
SK-N-BE(2)-M17 GDSC2 1.9515 4.6002 -0.0822 4.5277
SJNB-13 GDSC2 1.9697 5.5571 -0.5298 7.1833
SK-N-DZ GDSC2 2.0213 3.7787 0.3412 1.9743
SJNB-17 GDSC2 2.0455 11.3135 -3.3134 21.4155
IMR-5 GDSC2 2.3013 5.245 -0.1609 4.3137
MHH-NB-11 GDSC2 2.3663 4.7323 0.112 2.6769
SJNB-6 GDSC2 2.3753 4.9841 0.0039 3.2528
CHP-134 GDSC2 2.5646 4.0073 0.5153 0.5816
KP-N-RT-BM-1 GDSC2 2.6244 5.0069 0.1335 2.1952
CHP-126 GDSC2 2.6452 4.4783 0.3656 1.0909
SJNB-12 GDSC2 2.6719 5.9781 -0.2723 4.2903
GOTO GDSC2 2.7432 4.9015 0.2392 1.5438
SK-N-MC-IXC GDSC2 2.7441 3.8533 0.6422 0.1576
TGW GDSC2 2.7618 4.2704 0.4982 0.51
SiMa GDSC2 2.7964 5.056 0.2012 1.6582
SK-N-FI GDSC2 2.8394 4.257 0.5344 0.3637
LA-N-6 GDSC2 2.9149 4.6657 0.4125 0.6922
SK-N-AS GDSC2 2.9279 4.9486 0.3077 1.0697
SJNB-7 GDSC2 3.1847 4.6657 0.5197 0.2595
Kelly GDSC2 3.1956 4.3589 0.6288 0.0834
SK-N-SH GDSC2 3.235 8.9541 -1.3044 8.9882
SJNB-10 GDSC2 3.3621 5.88 0.135 1.3775
SJNB-5 GDSC2 3.5835 5.3148 0.4391 0.2924
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 2.2437 4.1637 0.2949 1.8928
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1937 GDSC2 2.0946 4.0756 0.2502 2.3527
UACC-812 GDSC2 2.5008 11.2951 -2.9565 18.7849
MDA-MB-330 GDSC2 2.6669 6.2256 -0.3888 4.9528
MCF-7 GDSC2 2.7692 5.5425 0.8217 4.9963
YMB-1-E GDSC2 2.898 5.0627 0.2479 1.3443
MDA-MB-453 GDSC2 2.9243 6.044 0.6868 5.4321
BT-549 GDSC2 2.9256 8.8452 -0.6852 12.8749
DU4475 GDSC2 3.0685 4.5354 1.4731 1.1192
Evsa-T GDSC2 3.1903 5.6322 1.0539 2.9862
BT-474 GDSC2 3.2204 6.1965 0.8108 4.2088
MDA-MB-415 GDSC2 3.2314 6.0779 0.8731 3.8605
MDA-MB-231 GDSC2 3.276 7.0462 0.4447 6.0736
HCC1428 GDSC2 3.3599 5.5507 1.1889 2.0704
HCC70 GDSC2 3.4062 5.5632 1.2088 1.9167
HCC1569 GDSC2 3.4188 6.4678 0.8086 3.8872
HCC2218 GDSC2 3.5321 6.0028 1.0852 2.3373
HCC38 GDSC2 3.545 6.4396 0.8973 3.2388
CAL-120 GDSC2 3.5609 5.5837 1.2811 1.4145
OCUB-M GDSC2 3.6204 6.4016 0.9579 2.831
BT-20 GDSC2 3.658 6.3574 0.9986 2.5833
CAMA-1 GDSC2 3.7001 6.194 1.093 2.0887
MDA-MB-436 GDSC2 3.7142 5.7596 1.2837 1.2498
HCC1143 GDSC2 3.7248 7.018 0.741 3.7544
ZR-75-30 GDSC2 3.7275 7.3696 0.5819 4.5593
HCC1419 GDSC2 3.7392 5.3262 1.4676 0.5677
MFM-223 GDSC2 3.7663 7.6936 0.4559 5.1455
EFM-19 GDSC2 3.7969 6.6698 0.938 2.6889
CAL-148 GDSC2 3.8621 5.1412 1.5847 0.2124
MDA-MB-175-VII GDSC2 3.9251 7.2895 0.735 3.4925
AU565 GDSC2 3.9373 7.5332 0.6325 3.9806
MRK-nu-1 GDSC2 3.9555 5.4134 1.5229 0.3095
COLO 824 GDSC2 3.9799 9.768 -0.3837 9.1064
MDA-MB-361 GDSC2 3.9803 6.0027 1.31 0.9235
EFM-192A GDSC2 4.0018 7.2879 0.7791 3.1739
Hs 578T GDSC2 4.0118 6.3811 1.1722 1.4153
HCC1187 GDSC2 4.0276 5.7302 1.4351 0.4982
HCC1395 GDSC2 4.0286 9.094 -0.0325 7.2208
HCC1599 GDSC2 4.1108 5.8804 1.413 0.5156
HCC1500 GDSC2 4.3191 6.22 1.3712 0.523
HCC1954 GDSC2 4.3831 6.284 1.3732 0.4868
MDA-MB-468 GDSC2 4.4161 7.5431 0.8889 2.1811
MDA-MB-157 GDSC2 4.4855 6.7397 1.2443 0.7951
JIMT-1 GDSC2 4.5001 6.2974 1.414 0.343
HCC1806 GDSC2 4.5045 7.1459 1.0941 1.2866
UACC-893 GDSC2 4.5836 7.3545 1.0471 1.3942
HDQ-P1 GDSC2 4.9192 6.7802 1.3995 0.2422
CAL-51 GDSC2 5.1108 6.5487 1.5436 0.0512
T-47D GDSC2 5.1992 11.4443 -0.3974 7.107
CAL-85-1 GDSC2 5.4631 7.4964 1.3477 0.1977
BT-483 GDSC2 5.5096 12.8785 -0.8672 8.7999
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DK-MG GDSC2 1.3181 3.3696 0.0687 5.0338
YH-13 GDSC2 1.4983 3.2854 0.2412 3.5344
LN-18 GDSC2 1.5773 2.7954 0.5256 1.6822
ONS-76 GDSC2 1.5992 3.1826 0.3585 2.6141
D-502MG GDSC2 1.6168 4.4094 -0.2219 6.1141
D-263MG GDSC2 1.6778 3.5456 0.2381 3.1725
H4 GDSC2 1.678 3.8116 0.1112 3.9345
D283 Med GDSC2 1.6806 4.6819 -0.3092 6.5019
Hs 683 GDSC2 1.7988 5.9073 -0.8239 9.3641
MOG-G-UVW GDSC2 1.8477 4.2343 0.0231 4.1108
LNZTA3WT4 GDSC2 1.8494 3.8987 0.1826 3.1644
U-87MG ATCC GDSC2 1.8661 4.027 0.1331 3.4224
SF539 GDSC2 2.1426 4.0032 0.3097 1.9602
D-245MG GDSC2 2.15 7.7427 -1.4676 12.2588
A-172 GDSC2 2.1655 7.3793 -1.2782 11.1513
D-542MG GDSC2 2.1834 3.8871 0.3825 1.5305
CAS-1 GDSC2 2.262 3.5632 0.5554 0.6665
42-MG-BA GDSC2 2.2895 5.1261 -0.113 4.0602
SK-MG-1 GDSC2 2.3769 4.2335 0.3353 1.5179
8-MG-BA GDSC2 2.442 4.1732 0.3931 1.1759
D-336MG GDSC2 2.4458 6.5004 -0.6587 6.9292
AM-38 GDSC2 2.5439 4.6337 0.2512 1.7185
KS-1 [Human Krukenberg tumour] GDSC2 2.6172 5.3869 -0.0373 3.0937
D-392MG GDSC2 2.6312 5.2082 0.0495 2.615
U-251MG GDSC2 2.6778 4.2619 0.4659 0.6737
SF295 GDSC2 2.743 4.0619 0.5677 0.3215
U-118MG GDSC2 2.7487 4.5394 0.3888 0.9048
SF268 GDSC2 2.7955 5.1043 0.1806 1.7547
YKG-1 GDSC2 2.861 4.5066 0.4503 0.6015
NMC-G1 GDSC2 2.9233 4.7854 0.3699 0.8366
MOG-G-CCM GDSC2 2.9824 5.1872 0.2372 1.3077
KINGS-1 GDSC2 3.0485 5.35 0.2023 1.3909
KNS-42 GDSC2 3.0902 4.6052 0.5056 0.3261
SW1783 GDSC2 3.1088 5.3809 0.2181 1.2692
SW1088 GDSC2 3.1234 5.2358 0.2822 1.0055
DBTRG-05MG GDSC2 3.1439 5.0973 0.3448 0.7663
D-566MG GDSC2 3.1818 4.8477 0.4534 0.4164
GaMG GDSC2 3.1844 4.8222 0.4637 0.3889
Onda 10 GDSC2 3.2048 4.9447 0.427 0.4764
SF126 GDSC2 3.2227 4.442 0.6103 0.1005
LN-405 GDSC2 3.343 4.8081 0.528 0.1964
KNS-81-FD GDSC2 3.4083 5.4193 0.3333 0.6384
M059J GDSC2 3.4292 5.267 0.3976 0.4478
Becker GDSC2 3.4417 4.9421 0.5172 0.1892
GI-1 GDSC2 3.525 5.4978 0.3511 0.5255
Onda 11 GDSC2 3.5425 5.5492 0.3392 0.5496
Daoy GDSC2 3.5452 5.2596 0.4444 0.2944
GB-1 GDSC2 3.5857 5.2004 0.4798 0.2154
SNB-75 GDSC2 3.7802 5.7719 0.3508 0.4139
LN-229 GDSC2 3.8047 5.5657 0.4324 0.2394
D-247MG GDSC2 3.8092 5.8896 0.3196 0.4769
T98G GDSC2 3.9981 5.6761 0.4632 0.1497
D-423MG GDSC2 4.0672 6.0039 0.3756 0.2684
KALS-1 GDSC2 4.6731 7.2442 0.1638 0.498
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC2 1.6346 3.5074 0.2276 3.3238
TGBC1TKB GDSC2 2.906 4.5393 0.4567 0.5534
TGBC24TKB GDSC2 3.8878 6.0063 0.3079 0.4723
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC2 1.7116 4.4778 -0.1875 5.6818
RL95-2 GDSC2 2.5454 4.1388 0.4555 0.8163
MFE-319 GDSC2 3.0054 4.4013 0.5463 0.2658
KLE GDSC2 3.3517 5.446 0.2997 0.7786
MFE-280 GDSC2 3.3906 6.8018 -0.2342 3.021
MFE-296 GDSC2 3.6396 5.5918 0.3617 0.4456
EN GDSC2 3.6798 5.0491 0.5638 0.0843
AN3-CA GDSC2 3.8496 5.8361 0.3542 0.38
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-13 GDSC2 1.2184 3.495 -0.0705 6.1685
KTCTL-195 GDSC2 1.5095 3.5945 0.0989 4.3834
Caki-1 GDSC2 1.5653 3.8162 0.0307 4.6754
RCC10RGB GDSC2 1.6064 3.5195 0.2028 3.5328
ACHN GDSC2 1.9268 4.1913 0.0948 3.5303
BFTC-909 GDSC2 2.048 3.9439 0.2825 2.2509
SW13 GDSC2 2.1469 4.0861 0.2755 2.1354
OS-RC-2 GDSC2 2.1579 4.2269 0.2188 2.4239
786-O GDSC2 2.1895 5.965 -0.5748 6.9707
KTCTL-26A GDSC2 2.1955 5.757 -0.4711 6.3413
769-P GDSC2 2.32 5.1823 -0.1202 4.0463
A-498 GDSC2 2.4619 4.9364 0.0752 2.728
LB996-RCC GDSC2 2.5823 4.5266 0.3156 1.3734
KTCTL-1M GDSC2 2.6671 5.0573 0.1344 2.1345
KTCTL-21 GDSC2 2.732 5.4782 -0.0136 2.7988
BB65-RCC GDSC2 2.9908 5.0097 0.3119 1
TK-10 GDSC2 3.0057 6.0743 -0.125 2.9877
CAL-54 GDSC2 3.014 8.5542 -1.2593 9.182
VMRC-RCZ GDSC2 3.0327 4.8786 0.3811 0.7185
A-704 GDSC2 3.063 5.0345 0.3342 0.8609
KMRC-1 GDSC2 3.1673 4.5898 0.54 0.2245
KMRC-20 GDSC2 3.1722 4.9525 0.4111 0.5387
SW156 GDSC2 3.1729 5.4069 0.237 1.1379
SN12C GDSC2 3.2098 5.1088 0.368 0.6478
NCC021 GDSC2 3.2241 7.4395 -0.6094 5.2198
HA7-RCC GDSC2 3.3077 5.1829 0.3804 0.5548
LB1047-RCC GDSC2 3.3953 5.6058 0.2572 0.8928
NCC010 GDSC2 3.4234 5.7308 0.2211 0.9996
VMRC-RCW GDSC2 3.5206 5.2778 0.4288 0.3361
LB2241-RCC GDSC2 3.5702 5.6397 0.3169 0.5979
KTCTL-140 GDSC2 3.6433 5.7396 0.3093 0.5815
UO-31 GDSC2 3.7179 5.506 0.4216 0.2845
RXF 393L GDSC2 4.29 6.7793 0.1841 0.6065
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 GDSC2 1.4006 6.0367 -1.1928 12.6069
LS1034 GDSC2 1.5992 3.2643 0.3199 2.8438
NCI-H508 GDSC2 1.6262 4.8678 -0.4401 7.4396
HT-29 GDSC2 1.6449 4.0695 -0.0361 4.9048
HT-55 GDSC2 1.6583 3.2398 0.3697 2.4335
GP5d GDSC2 1.7048 4.5578 -0.2312 5.9659
LoVo GDSC2 1.8952 6.8073 -1.1956 11.3321
SW48 GDSC2 1.9316 4.9612 -0.2683 5.6862
LS123 GDSC2 1.9442 5.6426 -0.5892 7.6004
CL-11 GDSC2 1.966 4.0692 0.1763 2.9853
LS513 GDSC2 2.0429 6.434 -0.9045 9.2618
NCI-H747 GDSC2 2.0476 4.1948 0.1682 2.8869
COLO 678 GDSC2 2.0482 4.9702 -0.1942 4.9979
RCM-1 [Human ESC] GDSC2 2.0515 5.2786 -0.3392 5.8569
SNU-61 GDSC2 2.0849 4.3333 0.1272 3.0541
KM12 GDSC2 2.1441 4.1699 0.2364 2.3497
MDST8 GDSC2 2.1698 3.8855 0.376 1.581
C2BBe1 GDSC2 2.2216 5.877 -0.5109 6.5235
LS411N GDSC2 2.2435 3.7698 0.4628 1.0763
SNU-407 GDSC2 2.2574 4.8868 -0.0223 3.6003
SW1463 GDSC2 2.2748 10.3657 -2.6675 18.0619
SK-CO-1 GDSC2 2.2803 5.2792 -0.19 4.5206
SW620 GDSC2 2.2963 5.1021 -0.0977 3.9603
SNU-C5 GDSC2 2.3651 4.513 0.2084 2.169
SW1417 GDSC2 2.3809 4.6169 0.1714 2.3391
SW626 GDSC2 2.4998 5.0125 0.0628 2.7371
NCI-H716 GDSC2 2.5443 5.5612 -0.1583 3.8717
HT115 GDSC2 2.6828 4.1593 0.5073 0.5299
COLO205 GDSC2 2.7284 3.9201 0.613 0.2203
SNU-283 GDSC2 2.7634 4.1935 0.5275 0.421
RKO GDSC2 2.7652 4.9102 0.2464 1.4871
SNU-81 GDSC2 2.7652 4.5293 0.4001 0.8478
HCT 116 GDSC2 2.8107 4.4813 0.4386 0.6744
HCT 15 GDSC2 2.8365 4.6717 0.376 0.8817
LS180 GDSC2 3.1081 4.5064 0.5474 0.2285
CaR-1 GDSC2 3.2886 5.2127 0.3615 0.6216
COLO 320HSR GDSC2 3.4673 5.4128 0.3594 0.5315
SW837 GDSC2 3.4863 5.288 0.4121 0.3874
T84 GDSC2 3.4925 5.3827 0.3803 0.4636
SW1116 GDSC2 3.5135 5.1621 0.4669 0.2596
CW-2 GDSC2 3.5318 5.57 0.3273 0.5884
SW948 GDSC2 3.5983 5.1162 0.5132 0.1594
SNU-C1 GDSC2 3.6696 5.3473 0.4593 0.2288
SNU-C2B GDSC2 3.7072 5.9614 0.2529 0.7105
CCK-81 GDSC2 3.7315 5.9719 0.2588 0.6792
HCC2998 GDSC2 3.7744 5.5711 0.4196 0.2712
DiFi GDSC2 4.4668 6.4456 0.3662 0.1904
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 2.0824 3.9666 0.2921 2.1447
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-2 GDSC2 1.7632 4.2028 -0.0186 4.5385
SK-HEP-1 GDSC2 1.8697 3.7109 0.2825 2.5497
HuH-1 GDSC2 1.9991 6.8804 -1.1548 10.8391
JHH-6 GDSC2 2.2817 3.313 0.6596 0.2975
Huh-7 GDSC2 2.3114 4.7427 0.0756 2.9615
Hep-G2/C3A GDSC2 2.6181 3.9239 0.5689 0.3794
JHH-1 GDSC2 2.7852 4.2336 0.5214 0.427
SNU-423 GDSC2 3.2336 12.0326 -2.7838 16.3245
Hep 3B2.1-7 GDSC2 3.2877 4.8164 0.5049 0.2558
JHH-4 GDSC2 3.3105 5.2895 0.3417 0.6695
SNU-387 GDSC2 3.3281 5.3189 0.3379 0.6708
SNU-449 GDSC2 3.5939 5.4042 0.4114 0.3475
SNU-398 GDSC2 3.6885 5.619 0.3707 0.404
HLE GDSC2 3.9017 5.913 0.3465 0.378
JHH-7 GDSC2 4.0059 5.8119 0.4197 0.2102
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 184 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RERF-LC-MS GDSC2 -0.2955 6.3825 -2.8347 26.6175
BEN GDSC2 1.3402 3.7654 -0.1104 6.1004
NCI-H1581 GDSC2 1.3463 13.0723 -4.75 28.1677
PaCa-3 GDSC2 1.3619 7.5811 -1.994 17.2003
SBC-3 GDSC2 1.5076 4.2858 -0.2415 6.4991
NCI-H460 GDSC2 1.5176 4.1251 -0.155 5.9371
NCI-H3122 GDSC2 1.6049 4.5986 -0.3234 6.7703
NCI-H520 GDSC2 1.6431 6.731 -1.3488 12.8667
NCI-H838 GDSC2 1.7299 5.4734 -0.6614 8.5458
NCI-H1299 GDSC2 1.8308 4.7643 -0.2428 5.7519
NCI-H2122 GDSC2 1.8782 3.5247 0.3727 2.029
NCI-H1648 GDSC2 1.9067 5.9057 -0.7444 8.6248
SK-LU-1 GDSC2 1.9182 8.289 -1.9104 15.2503
RERF-LC-Sq1 GDSC2 1.9816 4.9241 -0.2166 5.2693
NCI-H2373 GDSC2 2.0196 8.906 -2.1388 16.1679
Lu-135 GDSC2 2.0235 4.6141 -0.0418 4.1456
LCLC-103H GDSC2 2.0554 4.0734 0.2283 2.5373
IA-LM GDSC2 2.1249 4.0581 0.2755 2.1687
DMS 114 GDSC2 2.1389 5.0679 -0.1811 4.7397
NCI-H1568 GDSC2 2.1654 4.2444 0.2153 2.4312
SBC-5 GDSC2 2.1786 3.5303 0.5299 0.8479
NCI-H211 GDSC2 2.1806 5.0778 -0.159 4.5288
NCI-H1869 GDSC2 2.2063 9.1758 -2.1313 15.6559
COR-L23 GDSC2 2.2533 3.841 0.438 1.1788
NCI-H292 GDSC2 2.3535 5.7616 -0.3695 5.4243
NCI-H345 GDSC2 2.3629 3.5595 0.6007 0.43
DMS 53 GDSC2 2.3685 4.5426 0.1973 2.2219
Lu-65 GDSC2 2.3862 4.3707 0.2815 1.7689
PC-14 GDSC2 2.3922 4.501 0.2284 2.0284
NCI-H2141 GDSC2 2.3953 4.2923 0.3198 1.5698
NCI-H1650 GDSC2 2.4131 4.5884 0.2016 2.1366
NCI-H1975 GDSC2 2.4362 4.3223 0.328 1.4814
NCI-H1915 GDSC2 2.4552 6.1658 -0.4942 5.9519
NCI-H2171 GDSC2 2.4646 4.0037 0.4725 0.8191
NCI-H2081 GDSC2 2.4741 4.8151 0.1357 2.3914
LB647-SCLC GDSC2 2.4959 4.9911 0.0701 2.7042
HARA [Human squamous cell lung carcinoma] GDSC2 2.499 5.0128 0.0623 2.7412
NCI-H290 GDSC2 2.5112 4.7529 0.183 2.0974
NCI-H810 GDSC2 2.5204 4.396 0.3393 1.3335
NCI-H322M GDSC2 2.5238 5.4841 -0.1354 3.7786
A-549 GDSC2 2.5283 5.7862 -0.2711 4.5331
SBC-1 GDSC2 2.5609 4.486 0.3219 1.3683
EMC-BAC-2 GDSC2 2.5774 4.9063 0.1519 2.1653
NCI-H1355 GDSC2 2.6141 6.063 -0.3462 4.8061
NCI-H720 GDSC2 2.6346 4.0453 0.5303 0.4863
NCI-H2196 GDSC2 2.635 4.3146 0.4264 0.8541
NCI-H2085 GDSC2 2.6431 4.8398 0.2147 1.7732
NCI-H748 GDSC2 2.6705 5.3604 0.0043 2.7941
KNS-62 GDSC2 2.6773 4.5863 0.3369 1.1812
EBC-1 GDSC2 2.6949 4.3572 0.4364 0.7679
NCI-H441 GDSC2 2.7158 6.3217 -0.4032 4.9474
NCI-H64 GDSC2 2.7174 3.726 0.6764 0.108
COR-L303 GDSC2 2.7175 4.1984 0.507 0.5093
NCI-H1435 GDSC2 2.737 4.2432 0.4982 0.5252
NCI-H2444 GDSC2 2.7436 3.8662 0.6375 0.1663
NCI-H1781 GDSC2 2.7498 4.0227 0.5845 0.2769
NCI-H1573 GDSC2 2.7573 4.8378 0.2724 1.38
LC-2/ad GDSC2 2.7664 5.0671 0.1816 1.784
IST-SL1 GDSC2 2.7957 4.927 0.2543 1.4199
NCI-H526 GDSC2 2.8073 4.0631 0.5919 0.2378
NCI-H196 GDSC2 2.8157 4.5897 0.3989 0.8127
NCI-H82 GDSC2 2.8163 4.1513 0.5638 0.2993
Lu-134-A GDSC2 2.8246 5.6954 -0.058 2.8975
Lu-165 GDSC2 2.8262 4.2538 0.5304 0.3809
NCI-H2066 GDSC2 2.8395 4.9589 0.2623 1.3404
Ms-1 GDSC2 2.845 4.4726 0.4565 0.5917
NCI-H1792 GDSC2 2.8624 4.9618 0.272 1.2764
SW1573 GDSC2 2.8726 5.5821 0.0171 2.4499
NCI-H358 GDSC2 2.8799 5.6616 -0.0134 2.5932
NCI-H2795 GDSC2 2.8897 4.9937 0.2719 1.2506
NCI-H841 GDSC2 2.9117 4.4951 0.4756 0.4923
COR-L279 GDSC2 2.9176 4.5071 0.4735 0.4951
NCI-H596 GDSC2 2.9221 4.6516 0.4209 0.659
NCI-H1155 GDSC2 2.9248 4.5538 0.459 0.535
NCI-H226 GDSC2 2.9436 13.6019 -3.7636 20.9492
NCI-H2030 GDSC2 2.9704 5.2584 0.2025 1.4672
NCI-H847 GDSC2 2.978 4.3224 0.5639 0.2376
LK-2 GDSC2 2.9949 4.6386 0.4559 0.5043
NCI-H510A GDSC2 3.0111 4.561 0.491 0.3977
NCI-H2347 GDSC2 3.0154 5.4372 0.1508 1.6476
DMS 79 GDSC2 3.0299 4.812 0.4053 0.6404
COR-L95 GDSC2 3.0319 4.6342 0.4724 0.4378
NCI-H740 GDSC2 3.0374 5.8792 -0.0238 2.4401
NCI-H1836 GDSC2 3.0395 4.5932 0.4904 0.3859
DMS 273 GDSC2 3.0433 8.3571 -1.1469 8.5048
NCI-H1105 GDSC2 3.0452 4.4563 0.5417 0.2615
NCI-H2023 GDSC2 3.0553 5.2834 0.2324 1.2593
Calu-3 GDSC2 3.0616 4.8161 0.4169 0.5842
NCI-H1993 GDSC2 3.0659 5.7856 0.0306 2.1438
NCI-H1770 GDSC2 3.0671 4.4511 0.5517 0.233
NCI-H2029 GDSC2 3.0823 4.3789 0.5824 0.1713
Lu-99A GDSC2 3.0833 5.4842 0.1643 1.5189
NCI-H2405 GDSC2 3.0874 5.3179 0.2334 1.2262
LXF 289 GDSC2 3.0994 5.0099 0.3593 0.7473
NCI-H1876 GDSC2 3.1025 4.8915 0.4054 0.5954
COR-L321 GDSC2 3.1219 4.4844 0.5602 0.1999
A-427 GDSC2 3.1262 11.5357 -2.6182 15.8196
NCI-H727 GDSC2 3.1363 5.4895 0.1871 1.371
NCI-H1341 GDSC2 3.1385 4.7364 0.477 0.3757
NCI-H2228 GDSC2 3.1511 5.5226 0.1807 1.3836
CPC-N GDSC2 3.159 5.2989 0.2732 1.0108
NCI-H2135 GDSC2 3.1873 4.5581 0.5583 0.1851
NCI-H1437 GDSC2 3.1884 5.1383 0.3479 0.726
NCI-H2869 GDSC2 3.1889 6.9939 -0.4291 4.3084
NCI-H2009 GDSC2 3.2101 5.5973 0.1781 1.3399
NCI-H146 GDSC2 3.2129 5.3425 0.28 0.9444
NCI-H2731 GDSC2 3.2139 5.463 0.2333 1.118
NCI-H513 GDSC2 3.2318 4.9395 0.4396 0.4295
NCI-H2369 GDSC2 3.2342 4.729 0.5158 0.2511
NCI-H250 GDSC2 3.2347 4.998 0.4193 0.4825
NCI-H1563 GDSC2 3.2507 6.2622 -0.0767 2.4321
NCI-H1666 GDSC2 3.2532 7.4756 -0.6086 5.168
Lu-139 GDSC2 3.2534 5.0695 0.4005 0.5259
NCI-H647 GDSC2 3.2578 5.1877 0.3582 0.6496
NCI-H2087 GDSC2 3.2628 5.4949 0.2425 1.0436
NCI-H2170 GDSC2 3.2747 4.9882 0.4386 0.4123
NCI-H524 GDSC2 3.2937 5.3483 0.3125 0.7745
NCI-H1755 GDSC2 3.2966 5.2681 0.344 0.6708
LOU-NH91 GDSC2 3.3143 4.9913 0.4528 0.3606
COR-L32 GDSC2 3.318 5.6221 0.2172 1.0947
NCI-H1092 GDSC2 3.325 5.1936 0.3834 0.5371
HCC33 GDSC2 3.3266 5.0058 0.4523 0.3569
COLO 668 GDSC2 3.3297 5.3557 0.3247 0.7117
COR-L88 GDSC2 3.3574 4.8817 0.5076 0.229
NCI-H2722 GDSC2 3.3609 5.0939 0.4338 0.387
HOP-62 GDSC2 3.3683 5.1637 0.4114 0.4399
NCI-H1048 GDSC2 3.3694 5.1238 0.4263 0.4018
ABC-1 GDSC2 3.3735 5.7232 0.2022 1.1069
NCI-H1694 GDSC2 3.3821 4.812 0.5406 0.1658
NCI-H1963 GDSC2 3.387 5.1388 0.4277 0.391
NCI-H209 GDSC2 3.4075 5.6413 0.2488 0.9133
SHP-77 GDSC2 3.4116 4.9003 0.5208 0.1908
NCI-H661 GDSC2 3.4137 5.4233 0.334 0.6332
COR-L311 GDSC2 3.416 5.4831 0.3125 0.6975
NCI-H2818 GDSC2 3.4178 5.176 0.4261 0.382
NCI-H2291 GDSC2 3.4307 5.2587 0.4013 0.4378
NCI-H2227 GDSC2 3.431 5.3207 0.3788 0.4965
NCI-H3255 GDSC2 3.4735 5.2053 0.4368 0.3357
NCI-H446 GDSC2 3.482 5.4619 0.3472 0.5579
SK-MES-1 GDSC2 3.4982 5.1432 0.4679 0.2625
NCI-H650 GDSC2 3.5156 5.2781 0.4268 0.3423
UMC-11 GDSC2 3.5294 5.2872 0.4287 0.333
LCLC-97TM1 GDSC2 3.5318 5.7351 0.2656 0.7751
NCI-H1436 GDSC2 3.5509 4.9108 0.566 0.0999
NCI-H2803 GDSC2 3.5528 5.5173 0.3549 0.5019
NCI-H2810 GDSC2 3.5566 5.4681 0.3743 0.4503
NCI-H1693 GDSC2 3.5735 5.3033 0.4395 0.295
NCI-H1793 GDSC2 3.5837 5.307 0.442 0.2867
NCI-H1688 GDSC2 3.5913 5.3755 0.4206 0.3284
NCI-H23 GDSC2 3.5927 5.6177 0.334 0.5389
IST-SL2 GDSC2 3.5953 5.4744 0.3869 0.4031
NCI-H2804 GDSC2 3.6246 6.2571 0.1044 1.2743
VMRC-LCD GDSC2 3.6653 5.0393 0.5622 0.0878
NCI-H522 GDSC2 3.6809 5.4872 0.4146 0.3104
HCC366 GDSC2 3.6924 5.4992 0.4146 0.3065
NCI-H1734 GDSC2 3.7057 5.3968 0.4552 0.2263
HCC827 GDSC2 3.7199 5.2257 0.5185 0.1287
EKVX GDSC2 3.7202 6.0268 0.2338 0.7611
NCI-H69 GDSC2 3.7584 5.7959 0.3339 0.4634
CAL-12T GDSC2 3.7815 5.7342 0.3648 0.3817
NCI-H2342 GDSC2 3.7938 5.6361 0.404 0.2953
NCI-H2172 GDSC2 3.7994 5.2094 0.5511 0.0816
EPLC-272H GDSC2 3.8025 5.9338 0.301 0.5269
Calu-6 GDSC2 3.8504 5.7658 0.3793 0.3264
NCI-H2461 GDSC2 3.8722 15.4834 -4.01 19.8032
NCI-H1651 GDSC2 3.8876 5.6698 0.4263 0.2282
RERF-LC-KJ GDSC2 3.8935 5.4286 0.5102 0.1106
ChaGo-K-1 GDSC2 3.907 5.4947 0.4927 0.1287
LC-1/sq GDSC2 3.9094 6.2099 0.2422 0.6332
HCC44 GDSC2 3.9548 5.9077 0.3681 0.3154
NCI-H1703 GDSC2 3.9627 6.4383 0.1791 0.7871
COR-L105 GDSC2 3.9667 6.0341 0.3279 0.395
HCC78 GDSC2 4.0761 5.9477 0.3981 0.2279
HCC15 GDSC2 4.0834 5.935 0.4051 0.215
NCI-H2591 GDSC2 4.0907 6.289 0.284 0.4471
NCI-H1838 GDSC2 4.1308 5.7429 0.4863 0.1025
SW1271 GDSC2 4.1597 6.0623 0.3886 0.2232
NCI-H1944 GDSC2 4.1615 6.1388 0.363 0.2651
NCI-H835 GDSC2 4.1684 6.021 0.4058 0.1952
NCI-H2110 GDSC2 4.2515 6.4173 0.2987 0.3587
NCI-H1623 GDSC2 4.2962 6.0638 0.4357 0.133
EMC-BAC-1 GDSC2 4.4066 6.9974 0.1503 0.6405
NCI-H2595 GDSC2 4.5059 6.4381 0.3824 0.1623
HOP-92 GDSC2 4.7078 6.8672 0.3076 0.2241
⏷ Show the Full List of 184 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 3.7597 5.835 0.3202 0.4971
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-5 GDSC2 1.7601 3.8294 0.1576 3.4863
TE-8 GDSC2 2.2388 5.2128 -0.1852 4.5706
OE33 GDSC2 2.39 4.6855 0.1461 2.459
OE21 GDSC2 2.6014 5.4318 -0.0665 3.275
KYSE-450 GDSC2 2.6763 4.2499 0.4699 0.6605
KYSE-140 GDSC2 2.7297 4.9898 0.1955 1.7616
OE19 GDSC2 2.7728 4.2429 0.513 0.4586
KYSE-180 GDSC2 3.0726 5.219 0.266 1.1096
TE-10 GDSC2 3.0915 4.8855 0.4031 0.6092
COLO 680N GDSC2 3.1082 4.9158 0.3986 0.6132
KYSE-150 GDSC2 3.1757 4.7549 0.4846 0.3413
TE-4 GDSC2 3.1788 4.9495 0.4149 0.5242
KYSE-510 GDSC2 3.1907 10.7381 -2.1863 13.6374
EC-GI-10 GDSC2 3.2402 5.1357 0.3705 0.6222
TE-9 GDSC2 3.3051 4.856 0.4974 0.2654
KYSE-520 GDSC2 3.3726 5.5417 0.2721 0.8573
KYSE-410 GDSC2 3.6104 5.7643 0.2869 0.6631
KYSE-70 GDSC2 3.6187 5.3666 0.4339 0.2915
T.T GDSC2 3.625 5.6009 0.3527 0.4744
TE-15 GDSC2 3.7128 5.9939 0.243 0.7369
TE-6 GDSC2 3.7251 5.5242 0.4179 0.2895
TE-1 GDSC2 3.9041 5.6705 0.432 0.2148
KYSE-270 GDSC2 4.0182 5.9485 0.377 0.2795
TE-11 GDSC2 4.0598 6.1784 0.3117 0.3968
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DOV13 GDSC2 1.5612 5.22 -0.6625 8.9733
OVTOKO GDSC2 1.6808 4.336 -0.1403 5.4626
RMG-I GDSC2 1.8664 4.4298 -0.0577 4.5559
TOV-112D GDSC2 2.1488 5.3131 -0.2907 5.3668
JHOS-4 GDSC2 2.1913 4.186 0.2561 2.1719
EFO-27 GDSC2 2.2577 4.2863 0.2488 2.1122
OAW42 GDSC2 2.2729 3.4564 0.6019 0.4862
OV56 GDSC2 2.3415 3.8556 0.4748 0.9227
OV-90 GDSC2 2.431 5.0709 -0.0027 3.1985
TOV-21G GDSC2 2.4362 4.0736 0.4311 1.0161
A2780 GDSC2 2.4498 6.7944 -0.7962 7.7227
OVKATE GDSC2 2.4781 9.7933 -2.2339 15.5007
OC 314 GDSC2 2.5878 4.6363 0.2725 1.5652
OVCAR-5 GDSC2 2.6639 6.3098 -0.4296 5.1889
IGROV-1 GDSC2 2.7641 4.8987 0.2506 1.4695
OVCAR-4 GDSC2 2.7704 4.556 0.392 0.8747
JHOS-2 GDSC2 2.7713 5.1207 0.1614 1.8734
Caov-3 GDSC2 2.8084 4.4714 0.4415 0.6663
OVISE GDSC2 2.9902 4.0507 0.6615 0.0778
ES-2 GDSC2 2.998 4.554 0.4883 0.411
OVCAR-8 GDSC2 3.0828 6.4528 -0.2486 3.5167
Kuramochi GDSC2 3.1104 5.1934 0.293 0.9752
OVK18 GDSC2 3.1268 4.9915 0.3778 0.668
TYK-nu GDSC2 3.1461 4.9187 0.4131 0.5472
FU-OV-1 GDSC2 3.1707 4.8952 0.4317 0.4806
EFO-21 GDSC2 3.2955 4.7208 0.541 0.1864
OVCAR-3 GDSC2 3.3625 4.8511 0.5201 0.2049
SK-OV-3 GDSC2 3.4485 5.3483 0.3756 0.4966
Caov-4 GDSC2 4.2156 6.4569 0.2714 0.4285
OAW28 GDSC2 4.8143 6.6229 0.4255 0.0799
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
QGP-1 GDSC2 1.8415 5.6481 -0.6655 8.302
PaTu 8902 GDSC2 2.0023 3.9207 0.2662 2.4146
PaTu 8988t GDSC2 2.143 3.9263 0.3438 1.7816
MIA PaCa-2 GDSC2 2.6865 4.358 0.4323 0.7894
Panc 02.03 GDSC2 2.7327 6.4912 -0.4711 5.2994
Capan-2 GDSC2 2.7669 5.2168 0.1183 2.0865
Hs 766T GDSC2 2.7692 5.0751 0.1796 1.7901
SU.86.86 GDSC2 2.7695 4.3369 0.4763 0.5754
Panc 03.27 GDSC2 2.7708 4.5642 0.3889 0.8859
PL4 GDSC2 2.8524 4.5243 0.44 0.6414
KP-1N GDSC2 2.8696 5.1529 0.1971 1.5965
CFPAC-1 GDSC2 2.8832 4.6546 0.4031 0.7471
DAN-G GDSC2 2.969 4.6853 0.4278 0.6062
SUIT-2 GDSC2 2.971 4.6574 0.4392 0.5689
YAPC GDSC2 2.9826 4.181 0.6148 0.1425
KP-4 GDSC2 3.0942 4.5362 0.5317 0.2655
KP-2 GDSC2 3.1781 4.4199 0.6023 0.119
Capan-1 GDSC2 3.2831 5.0299 0.4268 0.4392
AsPC-1 GDSC2 3.2896 5.3409 0.3135 0.7737
HuP-T4 GDSC2 3.2912 6.2598 -0.0551 2.2822
HuP-T3 GDSC2 3.3641 5.2021 0.3958 0.4831
HPAC GDSC2 3.56 5.1198 0.4984 0.1909
Panc 08.13 GDSC2 3.7787 5.5882 0.4152 0.2783
HPAF-II GDSC2 3.822 5.5061 0.4591 0.1912
Panc 10.05 GDSC2 3.9449 5.9566 0.3472 0.3612
MZ-PC-1 GDSC2 4.0011 6.262 0.2593 0.5442
PSN1 GDSC2 4.0177 5.8101 0.4245 0.2001
Panc 04.03 GDSC2 4.029 5.9169 0.3919 0.2502
KP-3 GDSC2 4.1593 6.507 0.232 0.5434
BxPC-3 GDSC2 4.1642 5.9009 0.445 0.1435
SW1990 GDSC2 4.2216 6.1753 0.3719 0.2351
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC2 2.1101 4.0823 0.2562 2.296
NCI-H2052 GDSC2 2.1523 4.9137 -0.1001 4.2392
NCI-H28 GDSC2 2.1536 4.1612 0.2458 2.2843
MPP 89 GDSC2 3.2279 5.1543 0.3584 0.6672
MSTO-211H GDSC2 3.239 5.1826 0.3524 0.6795
NCI-H2452 GDSC2 4.3323 6.3118 0.3645 0.2211
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 GDSC2 1.8176 5.3385 -0.5314 7.5426
LNCaP clone FGC GDSC2 1.9864 5.5134 -0.4969 6.9473
VCaP GDSC2 2.5259 4.7908 0.1744 2.1207
NCI-H660 GDSC2 2.5554 3.8635 0.5659 0.4227
PC-3 GDSC2 3.3294 5.3605 0.3228 0.7178
DU145 GDSC2 3.7595 5.4455 0.4577 0.2083
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 3.7462 5.7718 0.3378 0.4589
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-7951 GDSC2 1.5682 4.2003 -0.1548 5.8145
SK-MEL-3 GDSC2 1.5849 4.0136 -0.0516 5.137
COLO 792 GDSC2 1.6423 3.566 0.2048 3.4452
LOX-IMVI GDSC2 1.6826 5.9723 -0.9427 10.3693
GAK GDSC2 1.7763 3.4482 0.3465 2.3509
Hs 938.T GDSC2 1.7863 3.5411 0.3096 2.5442
SK-MEL-24 GDSC2 1.858 3.485 0.3788 2.0282
SH-4 GDSC2 1.8734 5.1522 -0.4009 6.6191
A101D GDSC2 1.8832 3.6707 0.3092 2.3752
UACC-62 GDSC2 1.9453 5.4648 -0.5021 7.0706
WM793 GDSC2 1.9609 4.2247 0.1008 3.4306
SK-MEL-2 GDSC2 2.0315 3.0449 0.6563 0.4697
LB2518-MEL GDSC2 2.0404 4.2099 0.1569 2.9636
SK-MEL-28 GDSC2 2.0446 10.0774 -2.7002 18.7986
A-431 GDSC2 2.1233 4.836 -0.0822 4.1901
Hs 940.T GDSC2 2.1613 5.5826 -0.4107 6.054
MZ-MEL-7 GDSC2 2.1657 4.5632 0.0707 3.2333
IST-MEL1 GDSC2 2.1979 4.4554 0.139 2.7969
Mel JuSo GDSC2 2.203 3.7856 0.436 1.2465
A2058 GDSC2 2.2321 3.3962 0.6075 0.4958
SK-MEL-31 GDSC2 2.2325 15.4679 -5.2342 27.2765
IGR-37 GDSC2 2.4026 3.8027 0.524 0.6712
UACC-257 GDSC2 2.5085 4.1491 0.4345 0.933
COLO 783 GDSC2 2.5321 4.1269 0.4542 0.8327
MeWo GDSC2 2.5686 6.7632 -0.7026 6.9362
G-mel GDSC2 2.5947 4.8006 0.2065 1.8723
CP66-MEL GDSC2 2.6038 4.1942 0.4599 0.7519
WM35 GDSC2 2.6706 4.8168 0.2384 1.6289
M14 GDSC2 2.6751 4.7193 0.2813 1.4277
G-361 GDSC2 2.7132 4.3675 0.4404 0.7389
COLO 679 GDSC2 2.7165 4.5942 0.3522 1.0798
HMV-II GDSC2 2.735 6.1585 -0.3169 4.4315
WT2-iPS GDSC2 2.7409 3.7731 0.6686 0.1145
SK-MEL-30 GDSC2 2.7927 4.0811 0.5799 0.2704
IGR-1 GDSC2 2.8617 4.5428 0.4368 0.6457
RVH-421 GDSC2 2.8803 4.5994 0.4231 0.6796
SK-MEL-1 GDSC2 2.895 4.2654 0.5529 0.2929
MMAc-SF GDSC2 2.9276 4.1736 0.5976 0.1869
A-375 GDSC2 2.9386 4.3601 0.5356 0.3165
SK-MEL-5 GDSC2 2.9503 4.4927 0.492 0.4247
WM115 GDSC2 2.9672 4.4005 0.532 0.3133
IPC-298 GDSC2 2.9902 15.2667 -4.5502 23.5242
LB373-MEL-D GDSC2 3.0347 4.6331 0.4739 0.4322
451Lu GDSC2 3.1253 4.9553 0.3909 0.6273
Mel Ho GDSC2 3.1727 4.6578 0.5181 0.2671
VMRC-MELG GDSC2 3.1958 4.7095 0.5084 0.2797
COLO 829 GDSC2 3.2094 5.4204 0.248 1.0656
DJM-1 GDSC2 3.2862 5.9588 0.0674 1.7336
CP50-MEL-B GDSC2 3.3152 5.0235 0.4416 0.3873
HT-144 GDSC2 3.3673 4.9455 0.4889 0.2622
WM1552C GDSC2 3.3863 5.1498 0.4234 0.4017
MZ-MEL-2 GDSC2 3.4206 13.7085 -3.4672 18.753
CHL-1 GDSC2 3.4621 5.3448 0.3822 0.4726
COLO 800 GDSC2 3.6635 5.4293 0.4285 0.288
WM278 GDSC2 3.9661 15.2105 -3.8108 18.8931
A-388 GDSC2 4.0464 5.9666 0.381 0.2645
EquiPSC Line K2 GDSC2 4.5901 7.0075 0.2166 0.4145
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 1.6584 6.671 -1.3072 12.5861
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 GDSC2 1.4407 9.2363 -2.7569 20.6892
A-204 GDSC2 1.6494 5.2278 -0.6001 8.3684
RKN GDSC2 1.8012 3.4038 0.382 2.1058
KYM-1 GDSC2 1.8506 6.0515 -0.8567 9.435
Rh41 GDSC2 1.9567 4.1344 0.1402 3.2096
SW982 GDSC2 2.02 4.0969 0.1964 2.7755
MES-SA GDSC2 2.036 3.5051 0.4691 1.292
SW684 GDSC2 2.4464 4.0656 0.4392 0.972
STS-0421 GDSC2 2.4492 5.6003 -0.2339 4.4629
VA-ES-BJ GDSC2 2.7368 4.2179 0.5076 0.4956
G-402 GDSC2 2.9033 10.6625 -2.3516 15.0759
Hs 633.T GDSC2 2.9089 4.2122 0.5771 0.2336
HT-1080 GDSC2 2.9658 4.1933 0.6046 0.1637
SW872 GDSC2 2.9936 4.7667 0.4073 0.6571
SK-LMS-1 GDSC2 3.0122 4.992 0.3284 0.9207
TE 441.T GDSC2 3.0178 4.2263 0.6118 0.139
MFH-ino GDSC2 3.2186 5.2193 0.3299 0.7661
Rh30 GDSC2 3.2641 4.8441 0.4863 0.3033
GCT GDSC2 3.3327 4.8635 0.505 0.2415
SK-UT-1 GDSC2 3.4886 5.3368 0.3954 0.427
EW-8 GDSC2 3.4904 5.0057 0.5127 0.1846
RD GDSC2 4.4243 6.4329 0.3556 0.2141
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 GDSC2 1.5252 4.2865 -0.2287 6.3764
MKN45 GDSC2 1.5786 3.2147 0.3298 2.8265
HGC-27 GDSC2 1.5952 3.7887 0.0651 4.3963
Hs 746.T GDSC2 1.7036 4.1363 -0.0276 4.7219
NCI-N87 GDSC2 1.9095 4.8358 -0.2231 5.4612
RERF-GC-1B GDSC2 1.9131 4.771 -0.1895 5.2509
AGS GDSC2 2.0283 3.8801 0.2998 2.1876
SNU-1 GDSC2 2.0317 3.9856 0.2542 2.4328
SNU-5 GDSC2 2.1187 3.9587 0.3161 1.9616
NUGC-3 GDSC2 2.1445 4.6668 0.0099 3.6173
ECC12 GDSC2 2.4957 3.6615 0.6166 0.3086
Fu97 GDSC2 2.6636 5.2871 0.0327 2.6564
23132/87 GDSC2 2.8168 4.5165 0.4277 0.7081
SCH GDSC2 2.9015 4.3723 0.5167 0.3812
IM95 GDSC2 2.9254 6.0914 -0.1767 3.3705
ECC10 GDSC2 2.9793 4.6294 0.453 0.5216
OCUM-1 GDSC2 3.0268 4.8862 0.3757 0.7409
HSC-39 GDSC2 3.0966 4.5695 0.5208 0.2885
KATO III GDSC2 3.1473 4.9716 0.3938 0.6048
RF-48 GDSC2 3.1873 4.9219 0.4285 0.4811
NUGC-4 GDSC2 3.2241 5.1571 0.3558 0.6778
GCIY GDSC2 3.3876 5.3419 0.3536 0.5894
MKN1 GDSC2 3.4346 5.0166 0.4888 0.2416
TMK-1 GDSC2 3.6121 5.2819 0.4611 0.2414
TGBC11TKB GDSC2 3.6521 5.4195 0.4277 0.2932
SK-GT-2 GDSC2 3.7382 5.7202 0.3533 0.4248
MKN7 GDSC2 3.85 5.5892 0.4406 0.214
MKN28 GDSC2 4.1211 6.0596 0.3757 0.2538
SNG-M GDSC2 2.6553 7.0308 -0.7727 7.1665
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC2 1.871 5.4596 -0.5522 7.5448
8305C GDSC2 1.8774 3.83 0.2322 2.824
B-CPAP GDSC2 2.1968 4.3961 0.1652 2.6545
CAL-62 GDSC2 2.3266 3.7707 0.5022 0.8227
TT GDSC2 2.3309 9.0764 -1.9898 14.6265
IHH-4 GDSC2 2.4279 4.1934 0.3778 1.26
TT2609-C02 GDSC2 2.6161 4.5447 0.3246 1.297
WRO GDSC2 2.8573 4.6095 0.4093 0.7438
ML-1 [Human leukemia] GDSC2 2.9048 5.498 0.0699 2.1502
CGTH-W-1 GDSC2 3.0692 4.512 0.531 0.2761
BHT-101 GDSC2 3.2071 4.5224 0.5776 0.1486
FTC-133 GDSC2 3.2934 4.7684 0.5237 0.2177
KMH-2 GDSC2 3.365 5.1246 0.4243 0.4087
ASH-3 GDSC2 3.4675 4.8347 0.5628 0.1173
HTC-C3 GDSC2 3.6229 5.8911 0.2446 0.7856
8505C GDSC2 3.8375 5.7575 0.3775 0.3345
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHU-011 GDSC2 1.6639 7.0121 -1.4723 13.5184
PCI-15A GDSC2 1.7347 4.1549 -0.0151 4.5782
HSC-2 GDSC2 1.9679 3.5536 0.4111 1.6827
KON GDSC2 2.2477 4.448 0.1713 2.5405
Ca9-22 GDSC2 2.2686 4.4457 0.1843 2.4386
KOSC-2 GDSC2 2.4705 5.21 -0.0425 3.3528
UPCI-SCC-090 GDSC2 2.4774 5.0987 0.0116 3.0463
BICR 22 GDSC2 2.7172 3.9629 0.5935 0.2688
PCI-06A GDSC2 2.7675 4.8985 0.2524 1.4583
FaDu GDSC2 2.8382 4.3025 0.5173 0.4112
CAL-33 GDSC2 2.9112 5.0252 0.2693 1.2411
Detroit 562 GDSC2 2.9206 4.6343 0.4268 0.6401
BICR 10 GDSC2 2.9629 5.1314 0.2506 1.2704
SCC-4 GDSC2 3.0754 5.0095 0.3492 0.7987
CAL-27 GDSC2 3.0916 4.2511 0.6292 0.0997
SAS GDSC2 3.1233 5.5031 0.1756 1.4316
SAT [Human HNSCC] GDSC2 3.1392 5.9473 -0.0004 2.2031
HSC-3 GDSC2 3.1658 4.4762 0.5788 0.1564
BHY GDSC2 3.2518 4.9651 0.4381 0.4242
SKN-3 GDSC2 3.3151 5.3111 0.3355 0.6864
HSC-4 GDSC2 3.3437 4.85 0.5137 0.2217
HO-1-u-1 GDSC2 3.373 5.3143 0.358 0.5847
SCC-15 GDSC2 3.3974 5.4425 0.3201 0.685
OSC-19 GDSC2 3.4209 4.9349 0.5122 0.203
PCI-30 GDSC2 3.427 5.2284 0.4108 0.4155
SCC-25 GDSC2 3.5077 5.1618 0.4649 0.2654
BICR 78 GDSC2 3.5337 5.3036 0.4245 0.3407
LB771-HNC GDSC2 3.5785 5.5444 0.3551 0.4895
OSC-20 GDSC2 3.662 5.3194 0.4662 0.2189
SCC-9 GDSC2 3.6678 5.8719 0.2702 0.6809
HO-1-N-1 GDSC2 3.7029 5.5676 0.3944 0.3453
PCI-04B GDSC2 3.7059 5.6476 0.367 0.4056
PE/CA-PJ15 GDSC2 3.7207 5.457 0.4397 0.2496
JHU-029 GDSC2 3.7411 6.1437 0.1984 0.86
BICR 31 GDSC2 3.8134 5.6597 0.4029 0.2913
NCI-H3118 GDSC2 3.8892 6.0534 0.2914 0.5126
JHU-022 GDSC2 4.0427 6.3061 0.2595 0.5254
BB30-HNC GDSC2 4.0553 5.7833 0.4468 0.1605
DOK GDSC2 4.2884 6.5089 0.2802 0.3843
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 GDSC2 1.6496 3.5991 0.1939 3.4955
RT-112 GDSC2 1.8677 3.686 0.2928 2.495
UM-UC-3 GDSC2 2.0744 3.7667 0.3761 1.7115
639V GDSC2 2.1925 3.4432 0.5714 0.6631
KU-19-19 GDSC2 2.2723 3.5772 0.5545 0.6615
RT-4 GDSC2 2.3419 4.6321 0.1428 2.5488
CAL-29 GDSC2 2.4679 4.1711 0.4065 1.0907
647V GDSC2 2.828 4.2774 0.5224 0.4019
HT-1376 GDSC2 2.9665 5.4718 0.1124 1.8761
TCCSUP GDSC2 3.228 4.9497 0.4344 0.4451
SW1710 GDSC2 3.3505 5.2785 0.3621 0.5847
SW780 GDSC2 3.451 5.0202 0.4935 0.2279
5637 GDSC2 3.8636 5.801 0.3718 0.3374
J82 GDSC2 3.8992 5.7815 0.3918 0.2866
T24 GDSC2 4.3743 6.1181 0.4442 0.1126
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC2 0.677 6.0827 -1.8153 18.3011
CAL-39 GDSC2 1.2213 4.4371 -0.5378 9.098
KGN GDSC2 1.5656 8.008 -2.0445 16.894
NEC8 GDSC2 2.048 4.3092 0.1158 3.1844
SiHa GDSC2 2.0484 3.7253 0.38 1.7283
OVCA420 GDSC2 2.0875 3.9329 0.31 2.0405
HEC-1 GDSC2 2.1871 4.0912 0.2956 1.9694
HeLa GDSC2 2.2688 3.3444 0.6427 0.3548
DSH1 GDSC2 2.2952 6.4743 -0.7475 7.7659
LB831-BLC GDSC2 2.5012 5.9815 -0.3785 5.1957
PEO1 GDSC2 2.5864 4.8404 0.1851 1.9876
SW954 GDSC2 2.6228 5.23 0.0353 2.701
OVCA433 GDSC2 2.6654 13.0128 -3.6813 21.2975
C-33 A GDSC2 2.6889 5.1179 0.1198 2.1788
JAR GDSC2 2.7445 4.3258 0.47 0.6127
HEY GDSC2 2.7529 5.0627 0.1766 1.8235
PWR-1E GDSC2 2.7674 4.3637 0.4652 0.6134
MS751 GDSC2 2.8614 4.7113 0.3715 0.8787
SKG-IIIa GDSC2 2.8652 4.9514 0.2775 1.2504
SW756 GDSC2 2.903 4.497 0.4713 0.51
BPH-1 GDSC2 2.9524 5.5136 0.0876 2.0081
NCC-IT GDSC2 3.1326 5.0799 0.3466 0.7676
SW962 GDSC2 3.1867 4.9028 0.4353 0.4627
NT2-D1 GDSC2 3.3218 5.1144 0.4112 0.4622
C-4-I GDSC2 3.3241 4.8686 0.5 0.2539
DoTc2 4510 GDSC2 3.3678 5.1245 0.4254 0.4047
Ca Ski GDSC2 3.4638 6.2368 0.0387 1.6805
OVMIU GDSC2 3.5445 6.0073 0.1666 1.1055
SiSo GDSC2 3.5659 5.4949 0.3682 0.4615
JEG-3 GDSC2 3.6434 4.9574 0.5819 0.0718
OMC-1 [Human cervical carcinoma] GDSC2 3.792 5.6336 0.4042 0.2954
HT-3 GDSC2 3.8011 5.8204 0.3415 0.4275
JHOS-3 GDSC2 3.8086 6.0363 0.266 0.6183
TC-YIK GDSC2 4.0083 5.9873 0.3599 0.3147
ACC-OV7 GDSC2 4.0375 6.3686 0.2348 0.5911
SKN GDSC2 4.0457 5.9919 0.3719 0.2809
OV17R GDSC2 4.1266 6.1428 0.3489 0.3001
ME-180 GDSC2 4.1579 6.4371 0.2566 0.4843
UWB1.289 GDSC2 4.6081 7.03 0.2153 0.4112
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as LEE011
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Larotrectinib DM26CQR Moderate Decreased clearance of LEE011 due to the transporter inhibition by Larotrectinib. Solid tumour/cancer [2A00-2F9Z] [6]
Coadministration of a Drug Treating the Disease Different from LEE011 (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Increased risk of hepatotoxicity by the combination of LEE011 and Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [6]
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of LEE011 and Ivosidenib. Acute myeloid leukaemia [2A60] [7]
Arn-509 DMT81LZ Major Increased metabolism of LEE011 caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [8]
Gilteritinib DMTI0ZO Major Increased risk of prolong QT interval by the combination of LEE011 and Gilteritinib. Acute myeloid leukaemia [2A60] [9]
Levalbuterol DM5YBO1 Major Increased risk of prolong QT interval by the combination of LEE011 and Levalbuterol. Asthma [CA23] [9]
Troleandomycin DMUZNIG Major Decreased metabolism of LEE011 caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [10]
Pexidartinib DMS2J0Z Major Increased risk of hepatotoxicity by the combination of LEE011 and Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [11]
Talazoparib DM1KS78 Moderate Decreased clearance of LEE011 due to the transporter inhibition by Talazoparib. Breast cancer [2C60-2C6Y] [12]
HKI-272 DM6QOVN Major Decreased metabolism of LEE011 caused by HKI-272 mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [13]
LY2835219 DM93VBZ Moderate Decreased metabolism of LEE011 caused by LY2835219 mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [14]
PF-04449913 DMSB068 Major Increased risk of prolong QT interval by the combination of LEE011 and PF-04449913. Chronic myelomonocytic leukaemia [2A40] [9]
Osilodrostat DMIJC9X Major Increased risk of prolong QT interval by the combination of LEE011 and Osilodrostat. Cushing syndrome [5A70] [9]
MK-8228 DMOB58Q Moderate Decreased metabolism of LEE011 caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [6]
Polatuzumab vedotin DMF6Y0L Moderate Decreased metabolism of LEE011 caused by Polatuzumab vedotin mediated inhibition of CYP450 enzyme. Diffuse large B-cell lymphoma [2A81] [15]
Deutetrabenazine DMUPFLI Major Increased risk of prolong QT interval by the combination of LEE011 and Deutetrabenazine. Dystonic disorder [8A02] [9]
Ingrezza DMVPLNC Major Increased risk of prolong QT interval by the combination of LEE011 and Ingrezza. Dystonic disorder [8A02] [9]
Eslicarbazepine DMZREFQ Moderate Increased metabolism of LEE011 caused by Eslicarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [6]
Bay 80-6946 DMLOS5R Moderate Decreased metabolism of LEE011 caused by Bay 80-6946 mediated inhibition of CYP450 enzyme. Follicular lymphoma [2A80] [16]
Tazemetostat DMWP1BH Major Decreased metabolism of LEE011 caused by Tazemetostat mediated inhibition of CYP450 enzyme. Follicular lymphoma [2A80] [17]
Ripretinib DM958QB Moderate Decreased metabolism of LEE011 caused by Ripretinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [6]
Avapritinib DMK2GZX Major Decreased metabolism of LEE011 caused by Avapritinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [10]
MK-1439 DM215WE Minor Decreased metabolism of LEE011 caused by MK-1439 mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [18]
Fostemsavir DM50ILT Major Increased risk of prolong QT interval by the combination of LEE011 and Fostemsavir. Human immunodeficiency virus disease [1C60-1C62] [9]
Berotralstat DMWA2DZ Moderate Decreased metabolism of LEE011 caused by Berotralstat mediated inhibition of CYP450 enzyme. Innate/adaptive immunodeficiency [4A00] [19]
Pemigatinib DM819JF Major Decreased metabolism of LEE011 caused by Pemigatinib mediated inhibition of CYP450 enzyme. Liver cancer [2C12] [10]
Brigatinib DM7W94S Major Decreased metabolism of LEE011 caused by Brigatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [6]
Lurbinectedin DMEFRTZ Major Decreased metabolism of LEE011 caused by Lurbinectedin mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [20]
PF-06463922 DMKM7EW Moderate Increased metabolism of LEE011 caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [6]
Pralsetinib DMWU0I2 Moderate Decreased metabolism of LEE011 caused by Pralsetinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [21]
Capmatinib DMYCXKL Moderate Decreased metabolism of LEE011 caused by Capmatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [22]
Selpercatinib DMZR15V Major Decreased metabolism of LEE011 caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [10]
IPI-145 DMWA24P Moderate Decreased metabolism of LEE011 caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [23]
Arry-162 DM1P6FR Moderate Decreased clearance of LEE011 due to the transporter inhibition by Arry-162. Melanoma [2C30] [6]
Ubrogepant DM749I3 Moderate Decreased metabolism of LEE011 caused by Ubrogepant mediated inhibition of CYP450 enzyme. Migraine [8A80] [24]
Rimegepant DMHOAUG Moderate Decreased metabolism of LEE011 caused by Rimegepant mediated inhibition of CYP450 enzyme. Migraine [8A80] [25]
Siponimod DM2R86O Major Increased risk of ventricular arrhythmias by the combination of LEE011 and Siponimod. Multiple sclerosis [8A40] [6]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of LEE011 and Ocrelizumab. Multiple sclerosis [8A40] [26]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of LEE011 and Ozanimod. Multiple sclerosis [8A40] [10]
Fedratinib DM4ZBK6 Minor Decreased metabolism of LEE011 caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [6]
Entrectinib DMMPTLH Major Decreased metabolism of LEE011 caused by Entrectinib mediated inhibition of CYP450 enzyme. Non-small cell lung cancer [2C25] [6]
Rucaparib DM9PVX8 Major Increased risk of prolong QT interval by the combination of LEE011 and Rucaparib. Ovarian cancer [2C73] [9]
Abametapir DM2RX0I Moderate Decreased metabolism of LEE011 caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [27]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of LEE011 and Macimorelin. Pituitary gland disorder [5A60-5A61] [28]
Lefamulin DME6G97 Major Increased risk of prolong QT interval by the combination of LEE011 and Lefamulin. Pneumonia [CA40] [29]
Relugolix DMK7IWL Major Increased risk of prolong QT interval by the combination of LEE011 and Relugolix. Prostate cancer [2C82] [9]
Darolutamide DMV7YFT Minor Decreased metabolism of LEE011 caused by Darolutamide mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [30]
Voxelotor DMCS6M5 Moderate Decreased metabolism of LEE011 caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [31]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of LEE011 caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [6]
Fostamatinib DM6AUHV Moderate Decreased metabolism of LEE011 caused by Fostamatinib mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [32]
Elagolix DMB2C0E Moderate Increased metabolism of LEE011 caused by Elagolix mediated induction of CYP450 enzyme. Uterine fibroid [2E86] [6]
Fluticasone DMGCSVF Moderate Decreased metabolism of LEE011 caused by Fluticasone mediated inhibition of CYP450 enzyme. Vasomotor/allergic rhinitis [CA08] [6]
⏷ Show the Full List of 51 DDI Information of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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21 Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
22 Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
23 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
24 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
25 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
26 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
27 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
28 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
29 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
30 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
31 DSouza DL, Levasseur LM, Nezamis J, Robbins DK, Simms L, Koch KM "Effect of alosetron on the pharmacokinetics of alprazolam." J Clin Pharmacol 41 (2001): 452-4. [PMID: 11304902]
32 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.