Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAN0DE)

Drug Name

Sorbitol Drug Info

Synonyms

D-Sorbitol; sorbitol; D-Glucitol; 50-70-4; glucitol; L-Gulitol; (-)-Sorbitol; Glucarine; Sorbilande; Diakarmon; Sorbostyl; Multitol; Nivitin; Karion; Esasorb; Neosorb; D-(-)-Sorbitol; Sorbol; Cholaxine; Sorbite; Sionit; Sionite; Siosan; Sionon; Karion instant; Sorbitol F; Sorbitol FP; Sorbex Rp; Sorbitol syrup C; Sorbex X; Sorbex R; Sorbex M; Sorbex S; Sionit K; D-Sorbol; Hexahydric alcohol; Sorbicolan; Sorvilande; Neosorb P 60; D-Sorbite; Foodol D 70; Neosorb 20/60DC; Neosorb 70/70; Neosorb 70/02; Neosorb P 20/60; d-Sorbit; Karion (carbohydrate)

Indication

Disease Entry	ICD 11	Status	REF
Constipation	DD91.1	Approved	[1]

Cross-matching ID

PubChem CID: 5780
ChEBI ID: CHEBI:17924
CAS Number: CAS 50-70-4
TTD Drug ID: DMAN0DE
INTEDE Drug ID: DR1933

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By Sorbitol dehydrogenase (SORD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[12]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[18]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[19]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[20]
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Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[22]
Fructose	DM43AN2	Vomiting	MD90	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[24]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[25]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[35]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[28]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[36]
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Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
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Drug(s) Affected By MAP kinase-activated protein kinase 2 (MAPKAPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Bortezomib	DMNO38U	Leukemia		Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[49]
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Drug(s) Affected By Mitogen-activated protein kinase 12 (MAPK12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[51]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[56]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[13]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[57]
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Drug(s) Affected By Mitogen-activated protein kinase 10 (MAPK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[60]
Dicumarol	DMFQCB1	Bleeding disorder	GA20-GA21	Approved	[6]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[63]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[6]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[64]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[68]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[73]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
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Drug(s) Affected By TAR DNA-binding protein 43 (TARDBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[80]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[81]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[82]
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Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[86]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[88]
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Drug(s) Affected By MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[5]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[49]
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[91]
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Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[95]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[96]
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Drug(s) Affected By Fragile X messenger ribonucleoprotein 1 (FMR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[97]
Bortezomib	DMNO38U	Leukemia		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[99]
M3541	DMG98QO	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[100]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sorbitol dehydrogenase (SORD)^{Main DME}	DEWU03P	DHSO_HUMAN	Substrate	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Regulation of Drug Effects	[3]
Fragile X messenger ribonucleoprotein 1 (FMR1)	OTWEV0T5	FMR1_HUMAN	Regulation of Drug Effects	[4]
MAP kinase-activated protein kinase 2 (MAPKAPK2)	OT460SBO	MAPK2_HUMAN	Gene/Protein Processing	[5]
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)	OTGBRJDQ	MKNK1_HUMAN	Gene/Protein Processing	[5]
Mitogen-activated protein kinase 10 (MAPK10)	OTC46VX1	MK10_HUMAN	Gene/Protein Processing	[6]
Mitogen-activated protein kinase 12 (MAPK12)	OTTCKE27	MK12_HUMAN	Post-Translational Modifications	[7]
Mitogen-activated protein kinase 14 (MAPK14)	OT5TCO3O	MK14_HUMAN	Post-Translational Modifications	[7]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Post-Translational Modifications	[8]
Mitogen-activated protein kinase 9 (MAPK9)	OTCEVJ9E	MK09_HUMAN	Post-Translational Modifications	[8]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Protein Interaction/Cellular Processes	[9]

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