Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAN0DE)

Drug Name
Sorbitol Drug Info
Synonyms
D-Sorbitol; sorbitol; D-Glucitol; 50-70-4; glucitol; L-Gulitol; (-)-Sorbitol; Glucarine; Sorbilande; Diakarmon; Sorbostyl; Multitol; Nivitin; Karion; Esasorb; Neosorb; D-(-)-Sorbitol; Sorbol; Cholaxine; Sorbite; Sionit; Sionite; Siosan; Sionon; Karion instant; Sorbitol F; Sorbitol FP; Sorbex Rp; Sorbitol syrup C; Sorbex X; Sorbex R; Sorbex M; Sorbex S; Sionit K; D-Sorbol; Hexahydric alcohol; Sorbicolan; Sorvilande; Neosorb P 60; D-Sorbite; Foodol D 70; Neosorb 20/60DC; Neosorb 70/70; Neosorb 70/02; Neosorb P 20/60; d-Sorbit; Karion (carbohydrate)
Indication
Disease Entry ICD 11 Status REF
Constipation DD91.1 Approved [1]
Cross-matching ID
PubChem CID
5780
ChEBI ID
CHEMBL17924
CAS Number
CAS 50-70-4
TTD Drug ID
DMAN0DE
INTEDE Drug ID
DR1933

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Sorbitol dehydrogenase (SORD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [10]
Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [11]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [12]
Fructose DM43AN2 Vomiting MD90 Approved [13]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [15]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [16]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Gefitinib DM15F0X Colon adenocarcinoma Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [25]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [26]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [19]
Ethacrynic acid DM60QMR Edema MG29 Approved [27]
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Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
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Drug(s) Affected By Mitogen-activated protein kinase 12 (MAPK12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [36]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [41]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [42]
Amsacrine DMZKYIV Acute lymphoblastic leukaemia 2A85 Approved [40]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [43]
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Drug(s) Affected By Mitogen-activated protein kinase 10 (MAPK10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Panobinostat DM58WKG Chronic graft versus host disease Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Ethanol DMDRQZU Chronic pain MG30 Approved [46]
Dicumarol DMFQCB1 Bleeding disorder GA20-GA21 Approved [6]
Menthol DMG2KW7 Back pain ME84.Z Approved [47]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [48]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [49]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [6]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [50]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [59]
Testosterone DM7HUNW Hot flushes GA30 Approved [60]
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Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [65]
Ethacrynic acid DM60QMR Edema MG29 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [67]
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Drug(s) Affected By MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [5]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [69]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [70]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [71]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
Phosphate DMUXQG7 Constipation DD91.1 Approved [73]
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Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [79]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [48]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [78]
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Drug(s) Affected By Fragile X messenger ribonucleoprotein 1 (FMR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [79]
Folic Acid DMEMBJC Colorectal carcinoma Approved [80]
Bortezomib DMNO38U Leukemia Approved [81]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [69]
Urethane DM7NSI0 N. A. N. A. Phase 4 [82]
M3541 DMG98QO Solid tumour/cancer 2A00-2F9Z Phase 1 [4]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [83]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Sorbitol dehydrogenase (SORD) Main DME DEWU03P DHSO_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Regulation of Drug Effects [3]
Fragile X messenger ribonucleoprotein 1 (FMR1) OTWEV0T5 FMR1_HUMAN Regulation of Drug Effects [4]
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) OTGBRJDQ MKNK1_HUMAN Gene/Protein Processing [5]
Mitogen-activated protein kinase 10 (MAPK10) OTC46VX1 MK10_HUMAN Gene/Protein Processing [6]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Post-Translational Modifications [7]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Post-Translational Modifications [7]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Post-Translational Modifications [8]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Post-Translational Modifications [8]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Protein Interaction/Cellular Processes [9]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Post-Translational Modifications [8]

References

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