Details of the Drug

General Information of Drug (ID: DMC7W6R)

Drug Name
Selumetinib
Synonyms
Selumetinib; AZD-6244; ARRY142886; AZD6244; ARRY142886; AZD 6244; AZD-6244; 6UH91I579U; ARRY 142886; ARRY-142886; AZD6244 (Selumetinib); AZD6244(Selumetinib); CHEBI:90227; CHEMBL1614701; MEK inhibitors; Selumetinib (AZD6244); UNII-6UH91I579U
Indication
Disease Entry ICD 11 Status REF
Neurofibromatosis type 1 LD2D.10 Approved [1]
Melanoma 2C30 Phase 3 [2]
Thyroid cancer 2D10 Phase 3 [3]
Non-small-cell lung cancer 2C25.Y Phase 2 [4]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [5]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [5]
Solid tumour/cancer 2A00-2F9Z Investigative [6]
⏷ Show the Full List of Indication(s)
ATC Code
L01EE04: Selumetinib
L01EE: Mitogen-activated protein kinase (MEK) inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 457.7
Logarithm of the Partition Coefficient (xlogp) 3.6
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C17H15BrClFN4O3
IUPAC Name
6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
Canonical SMILES
CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
InChI
InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey
CYOHGALHFOKKQC-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
10127622
ChEBI ID
CHEBI:90227
CAS Number
606143-52-6
UNII
6UH91I579U
DrugBank ID
DB11689
TTD ID
D0T5DP
ACDINA ID
D01422
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ERK activator kinase 1 (MEK1) TTIDAPM MP2K1_HUMAN Inhibitor [3]
ERK activator kinase 2 (MEK2) TTTW2NY MP2K2_HUMAN Inhibitor [3]
MAPK/ERK kinase kinase (MAP3K) TTROQ37 NOUNIPROTAC Modulator [7]
HUMAN ERK activator kinase 1 (MEK1) TTAW3TO MP2K1_HUMAN Inhibitor [5]
HUMAN ERK activator kinase 2 (MEK2) TTWX403 MP2K2_HUMAN Inhibitor [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [8]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [9]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Post-Translational Modifications [8]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Gene/Protein Processing [8]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Gene/Protein Processing [8]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [10]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [10]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Post-Translational Modifications [8]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Skin
The Studied Disease Melanoma [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
ERK activator kinase 2 (MEK2) DTT MAP2K2 2.87E-01 0.91 0.61
ERK activator kinase 1 (MEK1) DTT MAP2K1 8.00E-01 -0.07 -0.15
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 5.2864 12.3608 0.3165 13.2342
H-EMC-SS GDSC1; GDSC2 -1.2597 9.5508 -4.1191 48.1216
ES1 GDSC1; GDSC2 4.2342 6.1866 2.5596 2.7298
CHSA0011 GDSC1; GDSC2 4.2491 10.9975 0.2268 16.185
U2OS GDSC1; GDSC2; CTRP2; CCLE 4.3218 11.1623 2.8611 27.046
CHSA8926 GDSC1; GDSC2 4.4809 7.1003 2.2891 3.8372
EW-24 GDSC1; GDSC2 4.4894 6.1003 2.7427 1.3626
ES7 GDSC1; GDSC2 4.984 7.0972 2.5735 1.5776
HuO9 GDSC1; GDSC2 5.1093 7.9889 2.2558 2.9928
ES8 GDSC1; GDSC2 5.2698 7.6169 2.4986 1.6044
EW-3 GDSC1; GDSC2 5.303 10.1563 1.381 7.4828
ES5 GDSC1; GDSC2 5.3115 8.9411 1.9462 4.3354
CAL-72 GDSC1; GDSC2 5.3626 10.5989 1.2111 8.3112
HuO-3N1 GDSC1; GDSC2 5.3882 7.6083 2.5582 1.2337
EW-7 GDSC1; GDSC2 5.4772 10.3169 1.4159 6.9631
CHSA0108 GDSC1; GDSC2 5.5005 14.0555 -0.3554 15.9708
EW-13 GDSC1; GDSC2 5.5299 7.5058 2.6608 0.7431
EW-12 GDSC2 5.6495 7.5537 2.6922 0.5735
CADO-ES1 GDSC1; GDSC2 5.6515 7.4527 2.7301 0.4664
EW-18 GDSC1; GDSC2 5.6659 7.6492 2.6633 0.651
U-CH2 GDSC2 5.7333 7.8208 2.6266 0.725
SK-PN-DW GDSC1; GDSC2 5.7698 7.6682 2.698 0.4956
EW-1 GDSC1; GDSC2 5.8697 8.2223 2.5313 0.9515
ES6 GDSC1; GDSC2 5.9797 8.2659 2.5611 0.7816
NY GDSC1; GDSC2 5.9814 8.8126 2.3495 1.5447
ES4 GDSC1; GDSC2 6.1464 12.2272 0.9452 8.2752
EW-16 GDSC1; GDSC2 6.1535 15.0687 -0.3921 14.7435
TC-71 GDSC1; GDSC2; CCLE 6.2023 7.6005 2.8774 0.0572
EW-22 GDSC1; GDSC2 6.2456 8.0877 2.7281 0.2535
EW-11 GDSC1; GDSC2 6.3328 8.5287 2.6049 0.4813
G-292 clone A141B1 GDSC1; GDSC2; CTRP2 6.8835 10.1849 5.9161 11.6703
SW1353 CTRP2; CCLE 6.9818 17.4161 2.466 22.1104
CAL-78 GDSC1; GDSC2; CTRP2; CCLE 7.3558 9.7352 6.5903 6.9977
MG-63 GDSC1; GDSC2; CTRP2; CCLE 7.4908 13.0615 5.0807 12.3375
NOS-1 [Human HNSCC] GDSC1; GDSC2 7.5537 19.243 -1.4483 16.3077
TC71 CTRP2 7.7866 13.3201 5.2096 12.5639
SJSA-1 GDSC1; GDSC2; CTRP2; CCLE 8.6889 21.249 1.9936 20.3057
Hs 822.T CTRP2 9.1195 13.7859 6.0377 6.7424
HOS GDSC1; GDSC2; CTRP2; CCLE 9.3076 14.4952 5.8265 6.5743
SK-N-MC CTRP2 9.549 10.4219 7.7966 0.0642
SK-ES-1 GDSC1; GDSC2; CTRP2; CCLE 10.2972 11.8866 7.5588 0.1964
SaOS-2 GDSC1; GDSC2; CTRP2; CCLE 10.3141 12.0947 7.4899 0.2972
Hs 888.T CTRP2 10.3157 18.6662 4.5121 10.8962
A-673 GDSC1; GDSC2; CTRP2; CCLE 10.9235 26.6454 1.045 19.2992
MHH-ES-1 GDSC1; GDSC2; CTRP2; CCLE 11.1101 22.0167 3.4443 12.3215
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 224 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 0.5988 15.7529 -2.9641 49.8865
MEC1 CTRP2 7.6597 9.7629 6.8651 5.9542
JM1 GDSC1; GDSC2; CTRP2 7.4775 11.3163 5.934 10.2217
Mino CTRP2; CCLE -12.7662 7.4819 -14.5101 78.2194
HuT 78 CTRP2; CCLE -4.3287 2.0766 -4.4103 70.8634
OCI-AML-2 GDSC1; GDSC2; CCLE -3.9304 0.0245 -3.9933 59.8155
OCI-AML-3 GDSC1; GDSC2; CTRP2; CTRP1 -3.7184 1.0347 -3.7368 75.6484
KMS-21-BM CTRP2 -3.228 1.4255 -3.2483 73.0642
SKM-1 GDSC1; GDSC2; CTRP2; CTRP1 -2.4509 5.3574 -2.8005 65.3835
Ku812 GDSC1; GDSC2; CTRP2; CCLE -2.0704 3.9192 -2.1991 59.6759
KMOE-2 GDSC1; GDSC2 -1.273 4.0779 -1.9177 47.0032
JURL-MK1 GDSC1; GDSC2; CTRP2 -1.0858 2.6651 -1.1016 60.6759
KMS-27 CTRP2 -0.8828 19.6414 -6.1974 53.671
SIG-M5 GDSC2; CTRP2; CCLE -0.7569 8.6864 -1.7368 52.1218
KO52 CTRP2; CCLE -0.6732 46.2178 -18.7 50.4507
KY821 GDSC1; GDSC2 -0.5809 13.7352 -5.411 46.0558
NCO2 CTRP2; CCLE 0.0658 5.1644 -0.0767 48.0219
NOMO-1 GDSC1; GDSC2; CTRP1 0.1109 13.5855 -2.5658 52.1777
PL21 CTRP2; CTRP1 0.1326 12.7612 -2.2057 51.6495
ML-2 GDSC1; GDSC2 0.1886 6.8045 -1.4206 37.6097
NB4 GDSC1; GDSC2 0.4254 8.6434 -2.0182 38.0146
F-36P CTRP2; CCLE 0.5645 17.796 -3.9017 47.5284
BDCM CCLE 0.6254 7.9727 -1.6642 30.1344
EoL-1 GDSC1; GDSC2; CTRP2 0.6334 4.9944 0.5421 49.562
MOLM-6 CTRP2 0.8868 7.6299 0.3476 48.1965
EM-2 GDSC1; GDSC2; CTRP2; CCLE 0.9155 9.9937 -0.3349 44.5196
MOLT-13 GDSC1; GDSC2 1.0061 10.0424 -2.1206 35.8695
HL-60 GDSC1; GDSC2; CTRP2 1.0287 13.8967 -1.725 48.2524
IM-9 GDSC1; GDSC2 1.0894 5.6387 0.0148 27.9974
AML-193 CTRP2 1.215 13.3228 -1.2908 47.4363
LAMA-84 GDSC1; GDSC2 1.2232 3.8548 0.8666 22.966
THP-1 GDSC1; GDSC2; CTRP2; CTRP1 1.2332 10.4112 -0.1381 46.817
H9 GDSC1; GDSC2 1.3043 13.2822 -3.4256 37.5278
MV4-11 GDSC1; GDSC2; CTRP2 1.487 7.3032 1.0806 44.5509
PL-21 GDSC1; GDSC2 1.4935 9.0509 -1.1797 31.2066
KMS-20 CTRP2 1.5713 10.5271 0.1843 45.1422
A4/Fukuda GDSC1; GDSC2; CTRP2 1.679 9.2502 0.7422 44.1077
MEG-01 GDSC1; GDSC2; CCLE 1.8476 7.1343 0.0812 20.7723
KG-1 GDSC1; GDSC2; CCLE 2.0489 6.2644 0.6904 17.2392
ME1 CTRP2 2.1501 29.6236 -7.9618 46.9255
NU-DHL-1 CTRP2 2.3524 11.7128 0.5638 41.6449
NKM-1 GDSC1; GDSC2 2.4809 9.2973 -0.3926 24.4813
OCI-Ly7 GDSC1; GDSC2 2.6432 3.4382 2.5465 7.3288
Kasumi-1 GDSC1; GDSC2; CTRP2 2.6565 9.5239 1.7114 38.5168
BONNA-12 GDSC2 2.8688 19.0271 -4.9114 35.5715
JVM-2 GDSC1; GDSC2; CTRP2 2.8907 9.1527 2.0905 36.7749
KYO-1 CTRP2 3.0779 7.9004 2.6685 34.5463
SUP-M2 GDSC1; GDSC2; CTRP2; CCLE 3.1078 7.1449 2.8771 30.4111
P31/FUJ GDSC1; GDSC2; CTRP2; CCLE 3.1528 14.1379 0.3637 36.2386
MOLM-13 GDSC1; GDSC2; CTRP2 3.371 7.6208 3.0582 32.3416
VL51 GDSC1; GDSC2 3.375 6.452 1.8009 9.4666
JSC-1 GDSC1; GDSC2 3.3786 8.7081 0.6759 16.2012
JM-1 CCLE 3.5084 5.2084 2.2854 2.7751
MY-M12 GDSC1; GDSC2 3.5371 5.4153 2.4487 4.9344
HD-MY-Z CTRP2; CCLE 3.6191 10.2033 2.5019 30.0133
OPM-2 GDSC1; GDSC2; CTRP2; CCLE 3.668 4.6455 3.668 26.3676
HAL-01 GDSC1; GDSC2 3.6751 11.6405 -0.5469 21.4343
KMS-28BM CTRP2 3.676 12.9432 1.4268 35.587
Sc-1 GDSC1 3.7815 5.0978 1.5696 0.3732
CMK-86 CCLE 3.7822 7.6933 1.269 7.5893
YT GDSC1; GDSC2 3.8144 6.5329 2.1061 6.3766
SCC-3 GDSC2 3.8386 6.2749 2.2507 5.4189
SU-DHL-1 GDSC2; CTRP2 3.9142 7.0338 3.7704 28.1912
MOLP-8 GDSC1; GDSC2; CTRP2; CCLE 3.9176 12.9265 1.6815 31.3424
MJ CCLE 3.9487 7.2691 1.595 5.5483
SU-DHL-16 GDSC1; GDSC2 4.0093 6.3519 2.3345 4.5131
LC4-1 GDSC1; GDSC2 4.027 7.3443 1.8638 7.3606
BC-3 GDSC2 4.0383 21.483 -5.1687 33.27
CESS GDSC1; GDSC2 4.3608 6.8666 2.3225 3.8673
Hs 445 GDSC1; GDSC2 4.3881 7.4878 2.0465 5.445
NK-92MI GDSC2 4.4262 6.2047 2.6635 1.8487
DG-75 GDSC1; GDSC2 4.4412 6.6896 2.4542 2.9664
MEC-1 CCLE 4.4695 8.3533 1.4266 5.4782
RC-K8 GDSC1; GDSC2 4.4915 6.1179 2.7363 1.3913
NU-DUL-1 GDSC1; GDSC2; CTRP2; CTRP1 4.5059 8.3622 4.0945 25.1096
MHH-CALL-4 GDSC2; CTRP2 4.537 15.5327 1.1036 33.7107
Farage GDSC1; GDSC2 4.6233 6.5578 2.6166 1.8152
TALL-1 [Human adult T-ALL] GDSC2; CTRP2 4.6682 18.1644 -0.0285 35.4889
MHH-CALL-2 GDSC1; GDSC2 4.6895 6.3906 2.7218 1.226
MOLT-4 GDSC1; GDSC2 4.7129 9.7916 1.1602 9.9631
SUP-B15 GDSC1; GDSC2; CTRP2 4.7187 10.6987 3.4698 26.7322
WSU-NHL GDSC1; GDSC2 4.777 8.1521 1.985 5.0423
BL-41 GDSC1; GDSC2; CCLE 4.7781 5.8722 2.9636 0.2177
NCI-H929 GDSC1; GDSC2; CTRP2 4.7795 9.7162 3.9278 24.9668
KOPN-8 GDSC1; GDSC2 4.8233 9.6115 1.3233 8.7847
MLMA GDSC1; GDSC2 4.8598 10.7795 0.784 11.7348
RPMI-8866 GDSC1; GDSC2 4.9233 8.0606 2.1168 4.036
ME1 GDSC1; GDSC2 4.9512 14.8484 -1.1462 20.5714
BV-173 GDSC1; GDSC2; CTRP2 5.0197 10.8099 3.7372 24.9434
Loucy GDSC1; GDSC2 5.0213 7.0137 2.6263 1.2994
CTV-1 GDSC1; GDSC2 5.0234 8.0522 2.1792 3.5307
ALL-PO GDSC1; GDSC2 5.0332 9.2977 1.6114 6.7007
NALM-6 GDSC1; GDSC2; CTRP2 5.0496 12.8496 2.861 27.7457
HH [Human lymphoma] GDSC1; GDSC2; CCLE 5.0858 7.5162 2.4483 1.7083
SET-2 CTRP2 5.086 11.9025 3.3275 26.1543
P30/OHK GDSC1; GDSC2 5.1149 7.0326 2.6627 1.0563
HC-1 GDSC1; GDSC2 5.1458 11.9864 0.3995 13.1254
ATN-1 GDSC1; GDSC2 5.1981 7.8899 2.347 2.4059
BC-1 GDSC1; GDSC2 5.201 8.2541 2.1898 3.2046
P32/ISH GDSC1; GDSC2 5.2126 6.4191 2.9326 0.1734
WIL2 NS GDSC1; GDSC2 5.2695 7.0074 2.7407 0.6493
DoHH2 GDSC1; GDSC2; CCLE 5.2716 6.586 2.8959 0.1884
KCL-22 GDSC1; GDSC2; CTRP2; CCLE 5.2784 11.8348 3.5529 22.4645
KMS-34 CCLE 5.3204 6.5917 2.5937 0.0893
CCRF-CEM GDSC1; GDSC2 5.3263 7.1746 2.7009 0.7453
KMS-18 CTRP2 5.3437 8.7531 4.8853 19.8248
Karpas-231 GDSC1; GDSC2 5.3861 6.4844 2.9714 0.0801
ARH-77 GDSC1; GDSC2 5.3904 7.4688 2.6146 1.0102
ST486 GDSC1; GDSC2; CTRP2 5.4262 9.7797 4.5902 20.6896
GDM-1 GDSC1; GDSC2; CTRP2; CTRP1 5.4563 9.4727 4.7435 20.0297
CML-T1 GDSC1; GDSC2; CTRP2 5.4737 10.3152 4.4192 21.1984
DND-41 GDSC1; GDSC2; CTRP2 5.4749 9.466 4.7659 19.893
OCI-Ly19 GDSC1; GDSC2; CTRP2 5.4787 16.4203 1.5819 30.1086
CRO-AP2 GDSC1; GDSC2 5.487 7.5006 2.6445 0.8277
Karpas-45 GDSC1; GDSC2 5.4882 7.7713 2.539 1.222
Ramos.2G6.4C10 GDSC1; GDSC2 5.4968 13.5509 -0.113 14.8629
SUP-B8 GDSC1; GDSC2 5.5073 8.0985 2.4155 1.7229
TK [Human B-cell lymphoma] GDSC1; GDSC2 5.5298 7.0845 2.816 0.3067
MN-60 GDSC1; GDSC2 5.5493 7.5696 2.6447 0.7842
TUR GDSC1; GDSC2 5.5687 7.7161 2.5967 0.938
SUP-T1 GDSC1; GDSC2; CCLE 5.5841 7.2887 2.7635 0.3419
BALL-1 GDSC1; GDSC2 5.6197 7.2818 2.7797 0.3556
MHH-PREB-1 GDSC1; GDSC2 5.6473 7.3295 2.7731 0.36
QIMR-WIL GDSC1; GDSC2 5.6847 16.3762 -1.3562 19.6863
Karpas-1106P GDSC1; GDSC2 5.6876 7.2066 2.8315 0.2229
Jiyoye GDSC1; GDSC2 5.7586 7.5639 2.7315 0.4142
P12-Ichikawa GDSC1; GDSC2; CTRP2; CCLE 5.8778 14.7464 2.7696 23.5405
BE-13 GDSC1; GDSC2 5.8841 7.6103 2.7625 0.2966
L-1236 GDSC1; GDSC2; CTRP2 5.9426 10.7038 4.7338 18.7437
OCI-AML-5 GDSC1; GDSC2; CTRP2; CCLE 5.9614 15.0216 2.7151 23.5182
MOLM-16 GDSC1; GDSC2; CTRP1 5.9945 19.6774 0.4507 31.73
EB2 GDSC1; GDSC2; CCLE 6.096 7.4543 2.89 0.0578
MHH-CALL-3 CTRP2 6.1286 21.9751 -0.556 32.9379
M-07e CTRP2 6.135 14.6631 3.0524 24.2951
U-698-M GDSC1; GDSC2 6.1507 7.9502 2.7414 0.2558
ROS-50 GDSC1; GDSC2 6.1743 12.3951 0.8847 8.5379
KE-37 GDSC1; GDSC2; CTRP2 6.1888 10.343 5.1451 16.5006
GR-ST GDSC1; GDSC2 6.2369 8.8699 2.4398 1.0118
CTB-1 GDSC1; GDSC2 6.2458 11.5554 1.3111 6.2122
VAL GDSC1; GDSC2 6.2874 8.0738 2.7478 0.2099
Mono-Mac-6 GDSC1; GDSC2; CTRP2 6.5223 12.9496 4.2486 19.154
SU-DHL-8 GDSC1; GDSC2; CTRP2; CCLE 6.5654 11.313 5.0746 14.24
K-562 GDSC1; GDSC2; CTRP2 6.5743 11.2809 5.0984 15.716
SU-DHL-5 GDSC1; GDSC2; CTRP1 6.6001 8.2012 6.4259 10.5502
SEM CTRP2 6.612 21.5052 0.1059 30.6846
Pfeiffer CTRP2; CCLE 6.6633 12.0924 4.7965 15.0361
Ki-JK CTRP2 6.8216 10.8096 5.5621 13.2526
U266B1 GDSC1; GDSC2; CTRP2 6.9095 21.9634 0.1382 29.9915
JJN-3 GDSC1; GDSC2; CTRP2 6.9822 9.7609 6.2099 10.2419
ALL-SIL GDSC1; GDSC2; CTRP2; CCLE 7.022 11.3142 5.5126 11.6692
HEL 92.1.7 CTRP2; CCLE 7.0578 14.392 4.0344 16.9361
Peer CTRP2 7.0892 11.424 5.5226 12.7849
U-937 CTRP2; CTRP1; CCLE 7.1262 12.8336 4.8662 13.8332
RCH-ACV GDSC1; GDSC2; CTRP2 7.1466 12.3959 5.1003 14.3733
PF-382 GDSC1; GDSC2; CTRP2 7.2513 11.3337 5.718 11.6154
Toledo CTRP2; CCLE 7.2606 12.8538 4.9781 13.1586
DB GDSC1; GDSC2; CTRP2 7.2709 11.6849 5.5638 12.2059
OCI-M1 GDSC1; GDSC2; CTRP2 7.2714 13.7563 4.5408 16.3204
697 GDSC1; GDSC2; CTRP2; CCLE 7.2925 15.427 3.7293 17.5195
Ri-1 CTRP2 7.3001 13.5039 4.6916 15.6671
REC-1 CTRP2 7.301 9.0973 6.8323 6.9439
Daudi GDSC1; GDSC2; CTRP2 7.3056 9.0518 6.8574 6.8322
RPMI-8402 GDSC1; GDSC2; CTRP2; CCLE 7.3481 10.3687 6.2786 8.1631
TF-1 CTRP2 7.3628 16.0569 3.4771 20.0396
MOTN-1 CTRP2 7.3685 9.0059 6.9417 6.3352
GA-10 GDSC1; GDSC2; CTRP2 7.4023 8.0873 7.3378 4.7149
WSU-DLCL2 GDSC1; GDSC2; CTRP2; CTRP1 7.4037 8.075 7.3427 4.6934
MOLT-16 GDSC1; GDSC2; CTRP2; CCLE 7.4142 9.8374 6.5977 6.8464
Karpas-299 GDSC1; GDSC2; CTRP2; CCLE 7.4519 14.9595 4.1017 15.9356
LP-1 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 7.5219 9.9322 6.654 6.4144
A3/Kawakami GDSC1; GDSC2; CTRP2 7.5317 8.2421 7.4297 3.9942
EHEB GDSC1; CTRP2 7.5432 17.6297 2.8487 21.732
AMO1 GDSC1; GDSC2; CTRP1; CCLE 7.5561 8.0935 7.5003 3.1869
EB1 CTRP2; CCLE 7.5667 9.5928 6.8608 5.5561
BL-70 CTRP2; CTRP1; CCLE 7.5861 8.0187 7.556 3.0281
Mono-Mac-1 CTRP2; CCLE 7.5952 21.2204 1.0994 24.5653
L-540 GDSC1; GDSC2; CTRP2 7.6715 8.6373 7.4142 3.6774
DEL GDSC1; GDSC2; CTRP2; CCLE 7.6742 8.1893 7.6022 2.6396
SU-DHL-6 GDSC1; GDSC2; CTRP2; CCLE 7.7015 12.7629 5.4141 10.7059
KMS-12-BM GDSC2; CTRP2; CCLE 7.7095 9.1547 7.2078 3.9765
OCI-Ly3 CTRP2 7.7346 11.6287 6.0082 9.3667
RL GDSC1; GDSC2; CTRP2 7.775 8.3949 7.6275 2.5631
SUP-T11 CTRP2 7.7988 9.927 6.9109 5.46
CA46 GDSC1; GDSC2; CTRP2 7.8623 9.0006 7.4259 3.1771
MOLT-3 CTRP2 7.8623 17.0961 3.3872 19.2982
JeKo-1 GDSC1; GDSC2; CTRP2 7.8724 10.1875 6.8466 5.574
Karpas-620 GDSC1; GDSC2; CTRP2; CCLE 7.9057 8.7273 7.5999 2.1196
HT GDSC1; GDSC2; CTRP2; CCLE 7.906 8.816 7.5567 2.2802
SU-DHL-10 GDSC1; GDSC2; CTRP2; CCLE 7.9251 8.5942 7.6829 1.7722
KE-97 CTRP2; CCLE 7.9315 9.0322 7.4732 2.5428
Reh GDSC1; GDSC2; CTRP2; CCLE 7.9474 8.7927 7.6061 2.014
RS4;11 GDSC1; GDSC2; CTRP2 7.9587 9.3157 7.3563 3.2613
JVM-3 GDSC1; GDSC2; CTRP2; CCLE 7.9621 24.0706 -0.0159 26.405
MM1.S GDSC1; GDSC2; CTRP2 7.9658 15.6362 4.2042 16.1558
OCI-Ly10 CTRP2; CTRP1; CCLE 7.9915 17.4114 3.3383 17.5046
KMS-11 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 8.034 16.5505 3.8042 15.8849
Raji GDSC1; GDSC2; CTRP2; CCLE 8.0615 9.1721 7.5164 2.1414
Namalwa GDSC1; GDSC2; CTRP2 8.0825 9.5248 7.3576 3.0095
L-363 GDSC1; GDSC2; CTRP2; CCLE 8.085 9.0245 7.6098 1.7481
L-428 GDSC1; GDSC2; CTRP2; CCLE 8.158 10.0065 7.1787 3.2508
KMM-1 CTRP2; CCLE 8.1822 16.5744 3.9155 15.2433
EJM GDSC1; GDSC2; CTRP2; CTRP1 8.1838 12.2259 6.0907 8.133
P3HR-1 CTRP2; CCLE 8.1971 10.5271 6.9504 4.0467
Granta-519 GDSC1; GDSC2; CTRP2; CCLE 8.2655 12.3868 6.077 7.2242
HPB-ALL CTRP2 8.3184 12.0244 6.3006 7.0046
SU-DHL-4 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 8.5533 10.0268 7.4647 1.6029
SR GDSC1; GDSC2; CTRP2 8.707 10.6392 7.2751 2.3277
Karpas-422 GDSC1; GDSC2; CTRP2; CCLE 8.8619 17.8284 3.8389 14.3495
SK-MM-2 GDSC1; GDSC2; CTRP2; CCLE 8.901 12.0504 6.728 3.8267
MC116 GDSC1; GDSC2; CTRP2; CCLE 9.0011 10.0049 7.7309 0.3393
Kasumi-2 CTRP2; CCLE 9.0225 25.4952 0.1426 24.2806
KMS-26 CTRP2; CCLE 9.0274 20.4675 2.6548 17.8424
Hs 611.T CTRP2 9.1123 13.2133 6.312 5.6345
Ci-1 CTRP2; CCLE 9.1231 9.7702 7.8685 0.0498
HEL GDSC1; GDSC2; CTRP2 9.1696 13.1603 6.3781 5.2797
KHM-1B CTRP2; CCLE 9.2052 30.7548 -2.3361 28.5712
MOLP-2 CTRP2 9.5566 26.9917 -0.1775 25.6946
SUP-HD1 GDSC1; GDSC2; CTRP2 9.8486 17.2628 4.8637 10.2818
Jurkat GDSC1; GDSC2; CTRP2; CCLE 10.5278 17.0833 5.4158 6.4747
HDLM-2 GDSC1; GDSC2; CTRP2 10.6391 12.4658 7.4817 0.2482
RPMI-6666 GDSC1; GDSC2; CTRP2 10.6973 20.82 3.735 13.0986
RPMI-8226 GDSC1; GDSC2; CTRP1 11.1435 23.0566 2.9493 15.1828
CMK GDSC1; CTRP2 11.2358 18.9173 5.0088 7.786
KM-H2 GDSC1; GDSC2; CTRP2 11.9184 22.4628 3.7783 11.2277
⏷ Show the Full List of 224 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 4.494 12.0591 2.6539 29.9669
TE15 CTRP2 7.5395 19.6811 1.8211 24.7443
KYSE-30 CTRP2; CCLE 2.8621 21.124 -3.1766 41.3439
TE-15 GDSC1; GDSC2; CCLE 3.7231 9.1314 0.7444 12.5152
OE21 GDSC1; GDSC2; CTRP2; CCLE 3.7535 11.6977 2.0431 30.8802
TE-8 GDSC1; GDSC2 4.1048 13.5003 -1.1304 22.6533
TE-4 GDSC1; GDSC2; CTRP2 4.3264 7.6356 4.0954 25.7542
T.T GDSC1; GDSC2 4.6964 9.515 1.2826 9.2962
KYSE-270 GDSC1; GDSC2 4.7865 9.4712 1.3656 8.3365
KYSE-140 GDSC1; GDSC2; CTRP2; CCLE 5.4879 10.7078 4.266 21.7307
TE-6 GDSC1; GDSC2; CTRP2 7.0272 11.66 5.3497 13.6322
TE-5 GDSC1; GDSC2; CTRP2; CCLE 7.1751 15.0521 3.8119 17.4682
KYSE-520 GDSC1; GDSC2; CTRP2; CCLE 7.696 19.3899 2.0999 21.7774
KYSE-180 GDSC1; GDSC2; CTRP2; CCLE 7.7061 12.7625 5.4183 10.6817
KYSE-70 GDSC1; GDSC2; CTRP2; CCLE 7.8887 17.7057 3.1047 18.4378
TE-11 GDSC1; GDSC2; CTRP2; CCLE 7.9517 22.4486 0.7865 24.6592
KYSE-410 GDSC1; GDSC2; CTRP2; CCLE 8.1632 18.8929 2.7406 19.0659
TE-1 GDSC1; GDSC2; CTRP2; CCLE 8.4242 18.3612 3.2212 17.1148
TE-10 GDSC1; GDSC2; CTRP2 8.7 17.5996 3.8242 16.1318
EC-GI-10 GDSC1; GDSC2; CTRP2 8.975 17.393 4.1445 14.464
TE-14 CTRP2 9.4227 25.6867 0.3668 24.7528
TE-9 GDSC1; GDSC2; CTRP2; CCLE 9.5153 15.9861 5.2475 8.3901
OE19 GDSC1; GDSC2; CTRP2 9.8058 10.9822 7.6952 0.1383
OE33 GDSC1; GDSC2; CTRP2; CCLE 10.6248 16.4513 5.7746 5.1264
KYSE-450 GDSC1; GDSC2; CTRP2; CCLE 11.8724 20.0139 4.8967 6.7111
KYSE-510 GDSC1; GDSC2; CTRP2; CCLE 13.3649 24.4458 3.767 8.6797
KYSE-150 GDSC1; GDSC2; CTRP2; CCLE 13.3925 22.9609 4.4591 6.5688
COLO 680N GDSC1; GDSC2; CTRP2 13.7513 25.8389 3.3613 10.3231
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 6.9362 17.1805 2.5426 23.9963
SNU-213 CTRP2 0.1672 9.939 -1.1271 51.8193
HuP-T4 GDSC1; GDSC2; CTRP2; CCLE 0.2866 5.8575 0.062 46.8355
KCI-MOH1 CCLE 1.336 7.7505 -0.8729 24.7208
PL45 CCLE 1.5884 8.8039 -1.1485 25.0331
Hs 766T GDSC1; GDSC2; CTRP2; CCLE 1.6738 14.6899 -1.3945 42.9242
BxPC-3 GDSC1; GDSC2; CTRP2; CCLE 1.7738 7.5133 1.3434 38.7491
MZ-PC-1 GDSC1; GDSC2 1.9006 7.6297 -0.1069 25.2587
HPAF-II GDSC1; GDSC2; CTRP2; CCLE 2.372 9.7127 1.3383 36.7219
PK-45H CTRP2; CCLE 2.4351 14.6554 -0.5981 39.7789
QGP-1 GDSC1; GDSC2; CTRP2; CCLE 2.7398 18.8345 -2.2089 40.7691
PL4 GDSC1; GDSC2 3.244 6.6546 1.5902 11.1661
Panc 05.04 CTRP2 3.259 16.1377 -0.4384 39.979
PK-1 CCLE 3.5345 12.2478 -1.1863 19.8448
AsPC-1 GDSC1; GDSC2; CTRP2; CCLE 3.5852 12.143 1.6793 32.265
Panc 02.03 GDSC1; GDSC2; CTRP2; CCLE 3.6321 11.6034 1.9556 31.4458
PaTu 8988s CTRP2 3.8044 12.1611 1.899 34.1074
HPAC GDSC1; GDSC2; CTRP2; CCLE 4.0632 14.3832 1.1713 32.1445
MIA PaCa-2 GDSC1; GDSC2; CTRP2; CCLE 4.0647 13.8305 1.4253 31.5612
SW1990 GDSC1; GDSC2; CTRP2; CCLE 4.1404 12.5442 2.0782 29.7358
KP-1NL CCLE 4.3086 9.4566 0.7866 9.0231
PSN1 GDSC1; GDSC2; CTRP2; CCLE 4.5375 14.4701 1.6025 29.9181
SUIT-2 GDSC1; GDSC2; CTRP2; CCLE 4.8217 14.9198 1.6707 29.0444
Capan-2 GDSC1; GDSC2; CTRP2; CCLE 4.8649 19.489 -0.4861 33.4299
PK-59 CTRP2; CCLE 5.1978 13.9951 2.4741 25.9789
HuP-T3 GDSC1; GDSC2; CTRP2; CCLE 5.6512 15.8007 2.045 26.1199
KP-3 GDSC1; GDSC2; CTRP2; CCLE 5.6897 13.8503 3.0205 23.1987
Capan-1 GDSC1; GDSC2; CTRP2 5.8515 10.1693 4.874 18.382
DAN-G GDSC1; GDSC2; CTRP2 6.4829 19.0467 1.2128 28.5818
Panc 10.05 GDSC1; GDSC2; CTRP2; CCLE 6.4982 19.9227 0.7918 27.4091
Panc 04.03 GDSC1; GDSC2; CTRP2; CCLE 6.5727 21.0916 0.2771 28.3797
Panc 08.13 GDSC1; GDSC2; CTRP2 6.5796 17.7804 1.927 26.4875
KP-1N GDSC1; GDSC2; CCLE 6.6306 13.1863 0.7983 6.9604
Panc 03.27 GDSC1; GDSC2; CTRP2; CCLE 6.631 17.1095 2.3054 23.2832
KP-2 GDSC1; GDSC2; CTRP2; CCLE 6.6996 23.6565 -0.8886 30.3703
CFPAC-1 GDSC1; GDSC2; CTRP2 7.8054 10.2075 6.7776 6.0026
PaTu 8902 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 8.1853 21.5002 1.4554 22.6104
KP-4 GDSC1; GDSC2; CTRP2; CCLE 8.2853 17.7736 3.4011 16.7781
SU.86.86 GDSC1; GDSC2; CTRP2; CCLE 8.3338 20.4639 2.0961 20.6357
PANC-1 CTRP2 8.5386 11.3708 6.797 4.5468
L3.3 CTRP2; CCLE 9.1918 18.4181 3.8035 13.9369
YAPC GDSC1; GDSC2; CTRP2 10.2241 11.4554 7.6823 0.08
SNU-410 CTRP2 10.3879 21.3873 3.2356 15.2556
PaTu 8988t GDSC1; GDSC2; CTRP2 13.2716 29.6655 1.2448 16.8483
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 79 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 -0.4583 7.9843 -1.2127 55.1061
CP50-MEL-B GDSC1; GDSC2 -3.8276 4.0125 -4.6796 62.8657
WM88 CTRP2; CCLE -3.8241 1.0054 -3.8436 69.8426
IPC-298 GDSC1; GDSC2; CTRP2; CCLE -3.7907 3.7248 -3.9972 67.1688
M14 GDSC1; GDSC2 -3.6628 3.446 -4.3349 62.7606
Mel Ho GDSC1; GDSC2; CTRP2; CCLE -2.8058 3.4697 -2.9295 63.3788
LB2518-MEL GDSC1; GDSC2 -2.5772 5.7251 -3.9015 55.2984
Malme-3M CTRP2; CCLE -2.5297 7.543 -3.3571 59.6069
SK-MEL-30 GDSC1; GDSC2; CTRP2; CCLE -1.8916 6.1669 -2.3464 57.7896
COLO 679 GDSC1; GDSC2; CCLE -1.712 5.3295 -2.8262 44.2131
G-mel GDSC1; GDSC2 -1.6964 3.5172 -2.2093 50.2812
IGR-37 GDSC1; GDSC2; CTRP2; CCLE -1.559 3.559 -1.6323 57.1991
SH-4 GDSC1; GDSC2 -1.5567 4.8031 -2.4693 49.2735
WM35 GDSC1; GDSC2 -1.3714 4.3357 -2.1088 47.8423
WM983B CTRP2; CCLE -1.3407 7.4392 -2.0339 54.9222
Hs 936.T CCLE -1.2977 2.8253 -1.6437 38.1458
HMV-II GDSC1; GDSC2 -1.2363 4.6464 -2.0682 46.8912
WT2-iPS GDSC1; GDSC2; CTRP2; CCLE -1.0643 2.729 -1.0816 54.5942
MMAc-SF GDSC1; GDSC2 -1.0393 9.9357 -4.0722 47.128
WM115 GDSC1; GDSC2; CTRP2; CCLE -0.6251 5.0662 -0.7991 51.8866
MZ-MEL-7 GDSC1; GDSC2 -0.5994 8.2279 -2.8559 44.154
HT-144 GDSC1; GDSC2; CTRP2; CCLE -0.5941 7.2332 -1.1697 51.5327
SK-MEL-1 GDSC1; GDSC2; CTRP2; CTRP1 -0.5341 4.0653 -0.6015 56.9019
UACC-257 GDSC1; GDSC2; CTRP2; CCLE -0.4775 6.068 -0.797 51.0278
CP66-MEL GDSC1; GDSC2 -0.4432 10.5888 -3.783 44.4129
COLO 792 GDSC1; GDSC2; CTRP2 -0.0066 6.593 -0.3885 53.0689
WM278 GDSC1; GDSC2 0.3001 12.2709 -3.8666 41.6552
UACC-62 GDSC1; GDSC2; CTRP2; CCLE 0.3021 6.902 -0.1185 46.9077
A-375 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 0.3607 7.1017 -0.0992 46.6239
G-361 GDSC1; GDSC2; CCLE 0.5538 5.6734 -0.5553 27.9423
Hs 944.T CTRP2; CCLE 0.6906 9.2089 -0.3193 45.3917
COLO 800 GDSC1; GDSC2; CTRP2 0.8056 5.7438 0.6354 48.5046
COLO 829 GDSC1; GDSC2; CTRP2 0.8408 7.9846 0.2049 48.4931
WM266-4 CTRP2; CCLE 0.9884 9.0377 0.0588 43.8228
GAK GDSC1; GDSC2 1.0054 4.3066 0.4701 26.0776
MZ-MEL-2 GDSC1; GDSC2 1.1253 9.244 -1.6226 34.0641
SK-MEL-24 GDSC1; GDSC2; CTRP2; CCLE 1.1498 10.0491 -0.1005 43.3867
Hs 938.T GDSC1; GDSC2; CCLE 1.1755 7.5404 -0.764 26.5717
WM1799 CTRP2; CCLE 1.2616 9.476 0.215 42.5802
LOX-IMVI GDSC1; GDSC2; CTRP2; CCLE 1.5414 8.7299 0.7561 40.7237
Hs 695T CCLE 2.1809 7.1949 0.1861 17.2456
451Lu GDSC1; GDSC2 2.4699 8.4827 0.0011 22.6759
COLO 783 GDSC1; GDSC2 2.6369 7.7166 0.5305 19.3565
SK-MEL-2 GDSC1; GDSC2; CTRP2; CCLE 2.677 8.8111 1.9681 34.2612
LB373-MEL-D GDSC1; GDSC2 2.7663 14.3823 -2.6779 31.3653
WM793 GDSC1; GDSC2; CTRP2; CCLE 2.9469 10.5287 1.6594 34.1818
MDA-MB-435S CTRP2; CCLE 3.0896 10.8214 1.6988 33.6569
RVH-421 GDSC1; GDSC2; CTRP2; CCLE 3.298 13.9924 0.5763 35.441
Mel JuSo GDSC1; GDSC2; CTRP2 3.9207 10.9733 2.5184 32.1231
COLO 741 CTRP2; CCLE 3.9253 12.2279 1.9951 30.5321
A-431 GDSC1; GDSC2 4.218 12.7629 -0.6741 20.4931
A-388 GDSC1; GDSC2 4.4992 10.6415 0.5909 13.6389
SK-MEL-5 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 4.5857 15.095 1.3575 30.3857
WM1552C GDSC1; GDSC2 4.6117 13.3502 -0.662 19.4258
MeWo GDSC1; GDSC2; CTRP2; CCLE 4.636 13.2346 2.2706 27.9311
IGR-1 GDSC1; GDSC2; CTRP2 4.6511 11.5665 3.0305 28.3612
K029AX CTRP2; CCLE 4.6734 17.7849 0.1595 32.7076
Hs 294T CTRP2; CCLE 4.8778 14.3144 2.0105 28.0322
SF8657 CCLE 5.125 13.4564 -0.5805 13.8578
CHL-1 GDSC1; GDSC2; CCLE 5.2375 9.3472 1.7166 4.7865
IST-MEL1 GDSC1; GDSC2 5.2409 15.2134 -1.1102 19.7459
VMRC-MELG GDSC1; GDSC2 5.3386 6.8223 2.837 0.3336
DJM-1 GDSC1; GDSC2 5.9252 13.0184 0.4338 11.3043
Hs 852.T CTRP2; CTRP1; CCLE 6.0749 18.25 1.2387 27.2461
RPMI-7951 GDSC1; GDSC2; CTRP2; CCLE 6.0996 14.5975 3.051 22.1874
SK-MEL-28 GDSC1; GDSC2; CTRP2; CTRP1 6.8808 25.9696 -1.8848 33.4827
SK-MEL-31 GDSC1; GDSC2; CTRP2; CCLE 7.0165 15.9462 3.227 19.7141
A101D GDSC1; GDSC2; CTRP2 7.1595 20.5577 1.0564 27.4709
Hs 940.T GDSC1; GDSC2; CTRP2 7.2132 11.9483 5.3814 13.0818
Hs 895.T CTRP2; CCLE 7.4476 13.7534 4.6985 13.8188
HMCB CTRP2; CCLE 8.0511 12.0737 6.0569 7.6653
IGR-39 CTRP2; CCLE 8.0766 14.6579 4.7861 12.35
A2058 GDSC2; CTRP2; CCLE 9.1175 20.3554 2.7818 17.3134
Hs 934.T CTRP2 9.2562 14.5646 5.7556 7.6755
Hs 688(A).T CTRP2 9.3007 15.3306 5.4124 8.9893
CJM [Human melanoma] CTRP2 10.4514 21.9739 2.9942 15.9355
SK-MEL-3 GDSC1; GDSC2; CTRP2 10.6388 40.2653 -5.9353 32.5372
Hs 839.T CTRP2 10.8796 20.5812 3.9783 11.9847
EquiPSC Line K2 GDSC1; GDSC2 -0.5753 11.9934 -4.5742 45.5466
⏷ Show the Full List of 79 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-51 GDSC1; GDSC2 2.4346 9.2757 -0.4233 24.7769
OACP4 C GDSC1; GDSC2 3.7283 12.6488 -1.0074 23.2025
TE-12 GDSC1; GDSC2 4.2992 12.9246 -0.6913 20.3526
KYSE-220 GDSC1; GDSC2 4.5259 13.0851 -0.5962 19.3584
SK-GT-4 GDSC1; GDSC2 4.6234 15.2739 -1.6071 23.0825
FLO-1 GDSC1; GDSC2 4.805 16.175 -1.9143 23.6907
KYSE-50 GDSC1; GDSC2 5.2173 7.223 2.6337 1.0821
HCE-4 GDSC1; GDSC2 5.5532 8.7421 2.1678 2.8322
ESO-26 GDSC1; GDSC2 5.6129 7.6107 2.6558 0.7063
OACM5.1 C GDSC1; GDSC2 5.6338 7.7654 2.6057 0.8593
KYAE-1 GDSC1; GDSC2 5.902 7.6762 2.7459 0.3252
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 5.1775 8.7973 1.9325 4.6301
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC1; GDSC2; CTRP2; CCLE -3.7231 5.8197 -4.2622 64.9811
NB69 GDSC1; GDSC2 -0.243 6.1868 -1.6028 40.2592
SK-N-BE(2) CTRP2; CCLE 0.0665 9.8816 -1.217 48.4653
LA-N-6 GDSC1; GDSC2 1.3984 9.5598 -1.5161 32.6747
SJNB-5 GDSC1; GDSC2 1.6244 6.5406 0.1456 25.1082
SK-N-AS GDSC1; GDSC2; CTRP2; CCLE 2.1654 13.8104 -0.5065 40.4639
NB(TU)1 GDSC1; GDSC2 2.8796 6.4394 1.3808 13.5941
KP-N-SI9s CTRP2; CCLE 3.3937 11.9925 1.5436 33.1325
NH-12 GDSC1; GDSC2 3.4614 8.9694 0.6136 16.3037
SK-N-FI GDSC1; GDSC2; CTRP2; CCLE 3.4878 11.2817 1.9367 31.9036
SK-N-BE(2)-M17 GDSC1; GDSC2 3.5137 8.4278 0.927 14.3771
SJNB-6 GDSC1; GDSC2 3.659 5.6646 2.4182 4.8133
SJNB-10 GDSC1; GDSC2 3.7186 11.5521 -0.4675 20.9594
SiMa GDSC1; GDSC2; CTRP2; CCLE 3.9718 9.2599 3.226 26.8769
KP-N-RT-BM-1 GDSC2 3.9735 9.7371 0.6399 14.7233
MHH-NB-11 GDSC1; GDSC2; CTRP2 4.3071 11.6088 2.6566 30.5223
SJNB-14 GDSC1; GDSC2 4.3787 6.2683 2.6084 2.2153
SJNB-12 GDSC1; GDSC2 4.5441 7.3334 2.2202 4.1179
CHP-134 GDSC1; GDSC2 4.7667 7.9904 2.0537 4.667
SK-N-MC-IXC GDSC1; GDSC2 4.9774 6.0198 2.9859 0.143
IMR-5 GDSC1; GDSC2 5.0073 6.8178 2.6991 1.0058
TGW GDSC1; GDSC2 5.3353 8.3617 2.2162 2.8795
SJNB-17 GDSC1; GDSC2 5.3794 7.321 2.6674 0.8246
CHP-126 GDSC1; GDSC2 5.4905 7.0865 2.8003 0.3592
SJNB-13 GDSC1; GDSC2 5.6331 7.3575 2.7575 0.4039
GOTO GDSC1; GDSC2 5.8068 7.7043 2.6994 0.4745
KP-N-YS GDSC1; GDSC2 5.8311 7.9637 2.6133 0.7078
NB1 GDSC1; GDSC2; CTRP2 5.9115 8.9581 5.4257 16.1684
GI-ME-N GDSC1; GDSC2 5.9301 21.3471 -3.6201 26.0762
SJNB-7 GDSC1; GDSC2 6.122 7.5536 2.8659 0.0883
KP-N-YN GDSC1; GDSC2; CTRP2 6.2337 10.703 5.0289 16.8414
Kelly GDSC1; GDSC2; CTRP2; CCLE 6.7903 14.2123 3.8805 18.0059
IMR-32 CTRP2; CCLE 7.0975 12.8396 4.837 13.9969
SK-N-SH GDSC1; GDSC2; CTRP2; CCLE 7.5139 13.1063 5.0788 12.3006
NH-6 CTRP2 7.8475 15.3015 4.2716 16.1404
SK-N-DZ GDSC1; GDSC2; CTRP2; CCLE 7.9581 13.003 5.5141 9.8678
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 -1.5716 10.2343 -3.112 58.5125
SNU-478 CTRP2 -0.092 9.7507 -1.3455 52.9901
SNU-245 CTRP2 2.7576 8.009 2.2901 36.763
HuCC-T1 GDSC1; GDSC2; CTRP2; CCLE 5.1981 16.8202 1.1233 29.4626
SNU-869 CTRP2 6.671 18.246 1.7779 26.7448
SNU-1196 CTRP2 6.8431 10.2908 5.8269 12.1299
SNU-308 CTRP2 7.0527 18.8692 1.8051 25.8243
HuH-28 CTRP2 7.1354 10.2078 6.1522 10.1011
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 90 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 GDSC1; GDSC2; CTRP2 -3.351 -1.522 -3.351 75.9871
HMC-1-8 CTRP2; CCLE 0.376 12.979 -2.0345 47.547
UACC-893 GDSC1; GDSC2 2.8456 7.9699 0.5899 18.3375
CAL-85-1 GDSC1; GDSC2; CTRP2; CCLE 3.8872 12.6933 1.7532 31.2486
MDA-MB-175-VII GDSC1; GDSC2; CCLE 4.1417 6.9667 2.1293 4.5586
HCC2157 GDSC1; GDSC2 4.4888 7.5546 2.0811 5.0357
HCC1569 GDSC1; GDSC2; CCLE 4.4991 6.8411 2.4197 2.5496
COLO 824 GDSC1; GDSC2 4.8184 7.1235 2.4758 2.2657
MDA-MB-436 GDSC1; GDSC2; CCLE 4.9289 8.7188 1.8162 4.7819
MRK-nu-1 GDSC1; GDSC2 4.9784 6.5921 2.7753 0.7347
MDA-MB-415 GDSC1; GDSC2; CCLE 5.0663 8.5587 1.9749 3.8229
MDA-MB-231 GDSC1; GDSC2; CTRP2 5.098 14.0835 2.3349 29.1515
Evsa-T GDSC1; GDSC2 5.1274 6.5188 2.865 0.3569
Hs 739.T CCLE 5.2107 7.9181 2.0475 1.6275
HCC1143 GDSC1; GDSC2; CTRP2 5.213 12.0283 3.3994 25.5607
MFM-223 GDSC1; GDSC2 5.2701 7.3092 2.6235 1.0764
EFM-19 GDSC1; GDSC2; CCLE 5.394 7.6894 2.5283 1.1256
OCUB-M GDSC1; GDSC2 5.5094 8.599 2.2062 2.6997
HCC1954 GDSC1; GDSC2; CTRP2; CCLE 5.5188 14.8438 2.3809 25.4915
HCC1599 GDSC2 5.5362 7.8637 2.5242 1.2391
YMB-1-E GDSC2 5.5743 13.0293 0.1929 13.2241
HCC1187 GDSC1; GDSC2; CCLE 5.7344 11.772 0.8985 7.8593
MDA-MB-330 GDSC1; GDSC2 5.853 8.2781 2.5026 1.0649
UACC-812 GDSC2; CCLE 5.9003 18.5552 -2.2673 20.079
BT-483 GDSC1; GDSC2 5.9509 12.5717 0.6615 10.0998
Hs 578T GDSC1; GDSC2; CCLE 6.2729 15.8628 -0.6922 13.8207
HCC70 GDSC1; GDSC2; CCLE 6.2841 19.5348 -2.468 19.9899
MDA-MB-157 GDSC1; GDSC2; CTRP2; CCLE 6.4588 10.0968 4.9934 9.2757
HCC1500 GDSC1; GDSC2; CTRP2 7.4435 12.5165 5.3094 12.8731
HDQ-P1 GDSC1; GDSC2; CTRP2; CCLE 7.6358 20.6615 1.4133 23.7132
MDA-MB-468 GDSC1; GDSC2; CTRP2; CCLE 7.6533 14.1985 4.6562 13.5854
EFM-192A GDSC1; GDSC2; CTRP2 7.825 11.3615 6.2201 8.2953
HCC2218 GDSC1; GDSC2; CTRP2 8.035 21.7815 1.1896 25.3684
HCC1419 GDSC1; GDSC2; CTRP2 8.0501 10.7767 6.7046 5.8141
JIMT-1 GDSC1; GDSC2; CTRP2 8.056 9.1799 7.5078 2.4301
ZR-75-30 GDSC1; GDSC2; CTRP2; CCLE 8.1438 9.457 7.4418 2.2826
HCC1395 GDSC1; GDSC2; CTRP2; CCLE 8.2247 13.5614 5.4568 9.6191
HCC38 GDSC1; GDSC2; CTRP2 8.2269 9.9544 7.26 3.1515
HCC1428 GDSC1; GDSC2; CTRP2 8.329 10.4 7.1181 3.5654
Hs 578Bst CTRP2 8.368 11.2653 6.7183 5.1675
SK-BR-3 CTRP2; CCLE 8.3781 10.6945 7.0098 3.5338
BT-474 GDSC1; GDSC2; CTRP2; CCLE 8.4775 10.1524 7.3511 2.1174
CAL-120 GDSC1; GDSC2; CTRP2 8.5953 17.7368 3.6718 16.8694
KPL-1 CTRP2 8.873 9.7734 7.7644 0.3652
HCC1806 GDSC1; GDSC2; CTRP2; CCLE 8.9977 24.3338 0.7024 23.0644
BT-20 GDSC1; GDSC2; CTRP2; CCLE 9.0031 14.9574 5.3746 8.6757
MDA-MB-453 GDSC1; GDSC2; CTRP2; CCLE 9.0546 14.0904 5.8408 6.8808
MCF-7 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 9.2668 16.9183 4.6044 11.0587
AU565 GDSC1; GDSC2; CTRP2; CCLE 9.6866 13.0231 6.7817 3.0024
CAL-148 GDSC2; CTRP2 9.6988 11.2158 7.5661 0.4189
CAMA-1 GDSC1; GDSC2; CTRP2; CCLE 9.9195 19.138 3.9967 12.1833
HCC1937 GDSC1; GDSC2; CTRP2 9.9925 19.345 3.9486 13.4083
MDA-MB-361 GDSC1; GDSC2; CTRP2 10.129 21.787 2.8478 16.9192
ZR-75-1 CTRP2; CCLE 10.1768 11.1613 7.7642 0.0246
HCC202 GDSC1; CTRP2 10.3041 20.4866 3.616 14.1131
CAL-51 GDSC1; GDSC2; CTRP2 10.7306 18.7385 4.7625 9.3666
BT-549 GDSC1; GDSC2; CTRP2; CCLE 11.0404 20.0815 4.3285 9.553
T-47D GDSC1; GDSC2; CTRP2; CCLE 11.8073 22.8101 3.5392 11.1347
BT 286 CTRP2 -1.1182 5.555 -1.399 59.3887
BT 482 CTRP2 1.6664 8.1121 1.0713 43.7374
BT 428 CTRP2 2.0654 7.5746 1.6464 41.0106
BT 440 CTRP2 2.1532 7.0832 1.8539 40.1985
BT 239 CTRP2 2.2135 15.0469 -0.9978 43.8048
BT 444 CTRP2 4.3332 11.6009 2.687 30.354
BT 231 CTRP2 5.0382 15.8815 1.4228 31.6372
BT 159 CTRP2 5.7114 13.4024 3.2546 24.7074
BT 330 CTRP2 5.764 12.5049 3.7292 22.9461
BT147 CTRP2 5.9352 16.6531 1.8951 28.1713
BT 232 CTRP2 5.973 12.2415 4.058 21.2214
BT 228 CTRP2 5.9944 9.7279 5.2095 16.7654
BT 340 CTRP2 6.0061 12.0194 4.1946 20.6306
BT 504 CTRP2 6.1008 16.1499 2.2947 26.6739
BT164 CTRP2 6.271 16.7049 2.1787 26.5893
BT 245 CTRP2 6.3057 11.4619 4.7502 17.7521
BT 139 CTRP2 6.7849 11.3778 5.2561 14.5772
BT 172 CTRP2 7.0467 16.998 2.7311 23.1757
BT 271 CTRP2 7.1774 16.8248 2.9324 22.2541
BT 498 CTRP2 7.4293 18.7467 2.1931 23.9439
BT 187 CTRP2 7.4598 13.5992 4.7859 14.9504
BT 131 CTRP2 7.8654 13.8474 5.0135 13.1989
BT 179 CTRP2 8.0431 19.2468 2.4637 21.888
BT 112 CTRP2 8.2366 13.813 5.3408 11.1424
BT 333 CTRP2 8.3383 16.4707 4.0958 15.8271
BT 328 CTRP2 9.2082 17.9191 4.0638 14.3481
BT 248 CTRP2 9.6004 16.8624 4.88 10.6101
BT 422 CTRP2 9.8123 16.181 5.3641 8.3892
BT 216 CTRP2 9.9073 17.8838 4.6025 11.1847
BT 224 CTRP2 10.1479 15.6532 5.8444 6.0341
BT 320 CTRP2 11.8149 24.6526 2.6595 14.9351
BT 359 CTRP2 11.877 30.9177 -0.3521 22.4856
⏷ Show the Full List of 90 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 68 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ONS-76 GDSC1; GDSC2; CTRP2; CCLE -0.412 6.7217 -0.8556 50.6597
D-263MG GDSC1; GDSC2 1.6997 18.588 -5.7018 39.5869
D-245MG GDSC2 3.7905 8.1661 1.2784 11.5335
SW1783 GDSC1; GDSC2 3.9572 6.5605 2.1967 5.4747
D-336MG GDSC1; GDSC2 4.1586 14.1944 -1.4337 23.6483
LNZTA3WT4 GDSC1; GDSC2 4.2198 7.2172 2.0623 5.7073
CAS-1 GDSC1; GDSC2; CCLE 4.4314 9.4818 1.1106 9.1677
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 4.4542 16.4011 -2.2997 25.7707
D-502MG GDSC1; GDSC2 4.5645 17.6672 -2.8433 27.0663
DBTRG-05MG GDSC1; GDSC2; CTRP2; CCLE 4.6029 17.4447 0.256 32.69
1321N1 CCLE 4.6893 9.1205 1.2071 6.2048
D-247MG GDSC1; GDSC2 4.7016 11.4058 0.3642 14.3426
KNS-81-FD GDSC1; GDSC2 4.7508 11.2445 0.4792 13.6246
MOG-G-UVW GDSC1; GDSC2 4.9043 12.1224 0.1606 14.8919
LN-229 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 5.2446 13.9496 2.5413 25.6741
SK-MG-1 GDSC1; GDSC2 5.2545 6.911 2.7709 0.5614
M059J GDSC1; GDSC2; CCLE 5.2568 9.8734 1.4841 6.7843
D-542MG GDSC1; GDSC2 5.2744 6.9465 2.7657 0.5657
D-566MG GDSC1; GDSC2 5.3028 10.4227 1.2555 8.1822
AM-38 GDSC1; GDSC2; CTRP2 5.3341 14.075 2.5693 27.842
H4 GDSC1; GDSC2; CCLE 5.4384 12.9188 0.1523 11.7794
KINGS-1 GDSC1; GDSC2 5.615 14.3488 -0.417 15.9942
LN-405 GDSC1; GDSC2 5.7403 7.5811 2.7182 0.4563
D-423MG GDSC1; GDSC2 5.7445 13.7404 -0.0328 13.9503
Onda 11 GDSC1; GDSC2 5.7793 12.5669 0.552 10.9967
SNU-1105 CTRP2 5.9568 9.6065 5.2201 16.8267
Onda 10 GDSC1; GDSC2 6.0502 15.2868 -0.5677 15.7233
SF539 GDSC1; GDSC2; CTRP2 6.2073 14.4713 3.2135 23.5918
PFSK-1 GDSC1; GDSC2 6.2588 8.0733 2.7378 0.2332
GI-1 GDSC1; GDSC2; CCLE 6.3152 14.5218 -0.023 11.0061
KALS-1 GDSC1; GDSC2; CTRP2; CCLE 6.3395 15.5951 2.7871 22.4805
KNS-60 CTRP2; CCLE 6.6876 13.7374 4.0192 17.7404
SNU-201 CTRP2 6.9702 9.4887 6.3212 9.8266
YKG-1 GDSC1; GDSC2; CTRP2; CCLE 7.1499 13.2998 4.6577 14.5438
Hs 683 GDSC1; GDSC2; CTRP2; CCLE 7.1845 9.8754 6.3572 8.2205
GaMG CTRP1; CCLE; GDSC1; GDSC2; CTRP2 7.3033 10.0316 6.3982 7.8152
D-392MG GDSC1; GDSC2 7.3085 20.0362 -1.9915 18.6584
KG-1-C CTRP2 7.3361 33.975 -5.4946 36.7786
YH-13 GDSC1; GDSC2; CTRP2 7.4071 11.8844 5.5896 11.8001
SNU-489 CTRP2 7.4219 8.715 7.1246 5.4718
SNU-738 CTRP2 7.4233 11.1816 5.951 10.27
DK-MG GDSC1; GDSC2; CTRP2; CCLE 7.4558 19.6864 1.7468 23.1872
TM-31 CTRP2 7.486 15.9415 3.6419 19.2002
A-172 GDSC1; GDSC2; CTRP2; CCLE 7.549 13.9357 4.6967 13.6335
D283 Med GDSC1; GDSC2; CTRP2 7.5987 8.642 7.3382 4.1664
8-MG-BA GDSC1; GDSC2; CTRP2; CCLE 7.6338 11.0192 6.2218 7.8069
U-118MG GDSC1; GDSC2; CTRP2; CCLE 7.6675 14.1571 4.6892 13.4396
NMC-G1 GDSC1; GDSC2; CTRP2 7.6719 12.941 5.2996 12.4316
MOG-G-CCM GDSC1; GDSC2; CCLE 7.7062 17.5381 -0.5494 10.9634
GMS-10 CTRP2; CCLE 7.7729 11.3195 6.1957 7.6427
SNB-75 GDSC1; GDSC2; CTRP2 7.8228 17.6399 3.0819 20.3991
GB-1 GDSC1; GDSC2; CTRP2; CCLE 7.9853 16.3563 3.8606 15.7807
T98G GDSC1; GDSC2; CTRP2; CCLE 8.1064 11.8418 6.2189 6.9589
SF126 GDSC1; GDSC2; CTRP2; CCLE 8.1811 13.6515 5.3759 9.9951
CCF-STTG1 CTRP2 8.274 10.3175 7.1163 3.6692
SF268 GDSC1; GDSC2; CTRP2 8.3044 12.347 6.1283 7.7511
SW1088 GDSC1; GDSC2; CTRP2; CCLE 8.5568 14.3871 5.3122 9.6053
KNS-42 GDSC1; GDSC2; CTRP2; CCLE 8.6886 12.782 6.2126 6.0422
SNU-626 CTRP2 8.9881 11.5126 7.0461 2.854
LN-18 GDSC1; GDSC2; CTRP2; CCLE 9.4494 10.5377 7.7182 0.1799
Daoy GDSC1; GDSC2; CTRP2; CCLE 10.3102 19.0232 4.3348 10.4898
GOS-3 CTRP2 10.5434 17.3921 5.2796 7.6789
Becker GDSC1; GDSC2; CTRP2 10.6232 24.4709 1.8931 18.9461
U-87MG ATCC GDSC1; GDSC2; CTRP2; CCLE 11.459 24.1044 2.6768 14.1779
KNS-81 CTRP2; CCLE 11.6508 23.0853 3.3017 12.0621
U-251MG GDSC1; GDSC2; CTRP2 12.1404 30.6125 -0.0101 21.34
42-MG-BA GDSC1; GDSC2; CTRP2; CCLE 12.2177 25.8141 2.3769 14.0539
SF295 GDSC1; GDSC2; CTRP2; CCLE 12.5258 25.4183 2.7748 12.5451
⏷ Show the Full List of 68 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1; GDSC2 4.2351 10.5264 0.4496 14.6124
TGBC1TKB GDSC1; GDSC2 5.4169 13.0919 0.0535 14.2459
ETK-1 GDSC1; GDSC2 5.6252 7.7326 2.6146 0.8346
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1; GDSC2; CTRP2; CCLE -0.8938 8.3628 -1.7927 52.7658
HEC-151 CTRP2; CTRP1; CCLE 2.8323 10.0697 1.7076 34.419
JHUEM-3 CTRP2 4.2541 9.1871 3.5565 27.8427
MFE-280 GDSC1; GDSC2; CCLE 4.493 6.9001 2.389 2.7023
TEN CCLE 4.9648 7.1054 2.2619 1.0454
KLE CTRP1; CCLE; GDSC1; GDSC2; CTRP2 5.1289 9.4679 4.3958 20.0136
HEC-1-B CTRP2; CCLE 5.9076 27.3342 -3.4144 35.4418
JHUEM-2 CTRP2; CTRP1; CCLE 6.1234 9.937 5.2553 14.5977
JHUEM-1 CTRP2 6.6316 9.8653 5.8088 12.7339
JHUEM-7 CTRP2 6.9717 14.1752 4.0639 18.8008
AN3-CA GDSC1; GDSC2; CTRP2; CCLE 7.5176 14.6078 4.3343 14.9931
ESS-1 GDSC1; GDSC2; CTRP2; CCLE 7.8151 13.1253 5.3313 10.8065
MFE-296 GDSC1; GDSC2; CTRP2; CCLE 7.9502 12.3864 5.8156 8.7508
HEC-1-A CTRP2; CCLE 8.4598 17.2228 3.8189 15.09
HEC-265 CTRP2; CCLE 9.2291 13.2635 6.3696 4.6974
MFE-319 GDSC1; GDSC2; CTRP2; CCLE 9.3375 17.8137 4.2149 12.3116
EFE-184 CTRP2; CCLE 9.3408 21.5401 2.3673 18.1746
HEC-59 CTRP2; CTRP1; CCLE 9.4217 19.4141 3.4863 14.6198
EN GDSC1; GDSC2; CTRP2; CCLE 11.1179 18.116 5.3086 6.1639
HEC-6 CTRP2; CCLE 11.1324 19.968 4.4444 9.0529
HEC-251 CTRP2; CCLE 11.2688 30.72 -0.7071 22.7002
HEC-50B CTRP2 11.968 20.4853 4.7377 7.8605
HEC-108 CTRP2; CTRP1 15.2224 34.2092 0.3781 16.6084
Ishikawa (Heraklio) 02 ER- CTRP2; CTRP1; CCLE 11.3637 17.334 5.8156 4.232
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-140 GDSC1; GDSC2 0.6949 11.4829 -3.1118 39.1028
LB2241-RCC GDSC1; GDSC2 1.2246 7.671 -0.7774 30.8239
BB65-RCC GDSC1; GDSC2 2.9528 13.4511 -2.0534 29.0842
NCC021 GDSC1; GDSC2 3.6206 5.7733 2.3354 5.4298
A-498 GDSC1; GDSC2; CTRP2 3.7749 8.8017 3.1657 30.6545
UO-31 GDSC1; GDSC2; CTRP2 3.7857 9.3503 2.9931 31.1621
KTCTL-13 GDSC1; GDSC2 3.9417 6.2113 2.3555 4.5345
TK-10 GDSC1; GDSC2 4.0938 11.2989 -0.0429 17.9411
SW13 GDSC1; GDSC2 4.1921 9.273 1.0368 11.9141
A-704 GDSC1; GDSC2 4.2478 7.1683 2.1049 5.3897
SN12C GDSC1; GDSC2 4.5905 13.6975 -0.8503 19.7778
NCC010 GDSC1; GDSC2 4.7635 7.8196 2.1307 4.2337
LB1047-RCC GDSC1; GDSC2 4.7812 10.1328 1.0426 10.4771
KTCTL-1M GDSC1; GDSC2 4.8454 14.1323 -0.8721 19.7298
KTCTL-21 GDSC1; GDSC2 4.9527 12.1691 0.1728 14.7169
RXF 393L GDSC1; GDSC2 5.0435 15.3053 -1.3025 20.95
SW156 GDSC1; GDSC2 5.3695 13.266 -0.0643 14.9154
HA7-RCC GDSC1; GDSC2 5.4018 8.7996 2.0607 3.5866
LB996-RCC GDSC1; GDSC2 5.5746 10.5673 1.3602 6.8604
KTCTL-26A GDSC1; GDSC2 5.6865 12.8991 0.3318 12.2992
KTCTL-195 GDSC1; GDSC2 5.8392 12.1918 0.7684 9.7623
TUHR14TKB CTRP2 6.0046 13.5853 3.4499 23.3015
KMRC-2 CTRP2; CCLE 6.3743 13.9731 3.6124 19.7806
CAL-54 GDSC1; GDSC2; CTRP2 6.8824 17.9208 2.1272 25.2541
TUHR10TKB CTRP2 7.1765 8.5848 6.9206 6.9283
KMRC-3 CTRP2 7.3943 13.245 4.904 14.6199
TUHR4TKB CTRP2 7.4804 8.4161 7.3097 4.5942
786-O GDSC1; GDSC2; CTRP2; CCLE 7.5329 15.264 4.0205 16.0642
VMRC-RCW GDSC2; CTRP2; CCLE 7.7441 11.8314 5.9155 8.7493
769-P GDSC1; GDSC2; CTRP2; CCLE 8.2161 20.4813 1.9903 21.1362
BFTC-909 GDSC1; GDSC2; CTRP2; CCLE 8.7075 21.8731 1.6969 21.0757
Caki-2 CTRP2; CCLE 8.7918 16.8435 4.2741 12.9699
KMRC-1 GDSC1; GDSC2; CTRP2; CCLE 9.8427 19.8968 3.5662 13.7174
KMRC-20 GDSC1; GDSC2; CTRP2 10.357 19.476 4.1476 12.1641
VMRC-RCZ GDSC1; GDSC2; CTRP2; CCLE 10.5804 20.4561 3.8292 11.8046
OS-RC-2 GDSC1; GDSC2; CTRP2 11.75 22.1484 3.8164 11.3238
SNU-1272 CTRP2 12.3655 23.8346 3.4214 11.8129
RCC10RGB GDSC1; GDSC2; CTRP2; CTRP1 14.9569 34.1951 0.2104 17.2946
ACHN GDSC1; GDSC2; CTRP2; CCLE 15.0874 29.2307 2.6141 10.2139
Caki-1 GDSC1; GDSC2; CTRP2 15.6818 30.5216 2.3804 11.0512
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 63 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO201 CCLE -3.2502 0.6729 -3.3549 53.4043
SW403 CCLE -2.9836 3.5397 -3.6851 51.0459
CL-34 CTRP1 -1.7205 5.7116 -2.0766 85.0011
NCI-H747 GDSC1; GDSC2; CTRP2; CCLE -1.4971 7.6389 -2.2552 55.5273
HCC2998 GDSC1; GDSC2 -1.4038 6.3721 -2.8999 48.4367
COLO205 GDSC1; GDSC2; CTRP2; CCLE -1.3399 7.7791 -2.1201 54.8197
LS513 GDSC1; GDSC2; CTRP2; CCLE -0.4916 3.6294 -0.5302 51.2161
SW48 GDSC1; GDSC2; CTRP2; CCLE -0.2773 8.6688 -1.2085 49.9711
CL-40 CTRP1 0.0431 7.4005 -0.5184 77.7288
CL-11 GDSC1; GDSC2; CTRP2 0.1638 7.5239 -0.4145 52.1541
SNU-C1 GDSC1; GDSC2; CTRP2 0.3369 8.8933 -0.6063 51.1303
SW620 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 0.5178 13.9192 -2.2689 47.1513
SK-CO-1 GDSC1; GDSC2; CTRP2; CCLE 0.5873 6.1859 0.331 45.1761
LS411N GDSC1; GDSC2; CTRP2; CCLE 0.9751 9.5405 -0.1175 44.0706
LoVo GDSC1; GDSC2; CTRP2; CTRP1 1.3971 10.0178 0.1778 45.8891
HCT 116 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 1.4713 5.0963 1.4122 39.6621
SW1463 GDSC1; GDSC2; CTRP2 1.4789 7.898 0.9244 44.7892
SNU-81 GDSC1; GDSC2; CTRP2; CTRP1 1.6039 8.1114 1.0032 44.1132
NCI-H508 GDSC1; GDSC2; CTRP2; CTRP1 1.6529 11.9971 -0.2903 45.21
LS180 GDSC1; GDSC2; CTRP2; CTRP1 1.7827 11.0699 0.2088 44.257
RCM-1 [Human ESC] GDSC1; GDSC2; CTRP2; CTRP1 1.8078 9.0926 0.9331 43.3072
MDST8 GDSC1; GDSC2; CTRP2; CTRP1 1.9404 9.573 0.9189 42.7671
HT-55 GDSC1; GDSC2; CTRP2; CTRP1 2.0231 9.0955 1.1663 42.0516
COLO 678 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 2.2306 12.9123 -0.0569 39.6516
SW1417 GDSC1; GDSC2; CTRP2; CCLE 2.3398 10.6148 0.9771 37.5651
SNU-1033 CTRP2 2.3923 14.8727 -0.738 42.9935
SNU-61 GDSC1; GDSC2; CTRP2; CTRP1 2.5445 9.449 1.6157 39.144
SNU-175 GDSC2; CTRP1 2.5864 10.9512 1.1067 40.5443
GP2d CTRP2 2.638 25.2096 -5.3578 45.1817
LS1034 GDSC1; GDSC2; CTRP2 2.6885 6.8158 2.4864 36.48
SNU-283 GDSC2 2.7537 15.8143 -3.4039 33.1023
HCC-56 CTRP2; CCLE 2.8048 29.0704 -7.0828 43.8227
T84 GDSC1; GDSC2; CTRP2; CCLE 2.8245 6.6579 2.6605 31.8995
SW626 GDSC1; GDSC2 2.8299 9.8905 -0.3809 23.2666
SW948 GDSC1; GDSC2; CTRP2; CTRP1 2.9935 8.2102 2.4922 35.3511
DiFi GDSC1; GDSC2 3.0082 6.2461 1.5908 11.887
CCK-81 GDSC1; GDSC2; CCLE 3.1713 10.6184 -0.4526 19.4154
SNU-1040 GDSC1; GDSC2; CTRP1 3.1878 6.9924 2.9915 33.7784
SW837 GDSC1; GDSC2 3.2915 11.8599 -0.9724 24.3292
SW1116 GDSC1; GDSC2 3.33 14.5841 -2.3024 28.731
SNU-407 GDSC1; GDSC2; CTRP2 3.7202 14.3433 0.8456 36.6038
NCI-H716 GDSC1; GDSC2; CTRP2 3.95 12.5734 1.8702 33.7175
SNU-C2B GDSC1; GDSC2; CCLE 4.1679 13.1048 -0.8836 21.0262
GP5d GDSC1; GDSC2 4.1857 16.6487 -2.636 27.4187
SNU-503 CTRP2 4.508 15.8951 0.904 34.2021
SNU-C2A CTRP2; CCLE 4.524 16.7263 0.5243 32.3518
KM12 GDSC1; GDSC2; CTRP2; CTRP1 4.6001 9.7251 3.7327 26.184
C2BBe1 GDSC1; GDSC2; CTRP2; CCLE 4.7292 15.3195 1.3917 29.9509
HT115 GDSC1; GDSC2; CTRP1 4.8067 7.2372 4.6955 22.5085
LS123 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 4.9134 12.6356 2.8222 25.65
RKO CTRP1; CCLE; GDSC1; GDSC2; CTRP2 5.1191 12.3093 3.1775 24.0542
SNU-C4 CTRP2; CTRP1 5.4692 13.3547 3.041 26.0384
COLO 320HSR GDSC1; GDSC2 5.8629 7.3125 2.8576 0.1392
HT-29 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 5.9289 10.9964 4.5886 17.4034
CaR-1 GDSC1; GDSC2 6.3438 16.8106 -1.1003 17.3067
SNU-C5 GDSC1; GDSC2; CTRP2; CTRP1 6.5426 17.0765 2.2421 25.7718
HCT 8 CTRP2; CTRP1 6.8697 9.8275 6.0667 11.0991
SW480 CTRP1; CCLE 7.1568 27.6648 -2.5056 32.0615
HCT 15 GDSC1; GDSC2; CTRP2; CCLE 7.8573 14.8718 4.4947 13.7936
CW-2 GDSC1; GDSC2; CTRP2; CTRP1 8.0219 17.1572 3.4908 18.6187
DLD-1 CTRP2 8.0741 9.6581 7.2839 3.335
OUMS-23 CTRP2 8.4028 10.6069 7.0721 3.6306
COLO 320 CTRP2; CTRP1; CCLE 10.3905 12.5275 7.3586 0.5155
⏷ Show the Full List of 63 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 5.244 7.0423 2.7164 0.7493
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep-G2 CTRP1; CCLE -0.3899 9.7021 -1.6575 50.4205
SNU-878 CTRP2 0.8498 6.6402 0.5304 48.3092
SNU-761 CTRP2 1.0185 4.8609 0.9578 47.06
SNU-886 CTRP2 1.624 9.6128 0.5624 44.5494
JHH-5 CTRP2; CCLE 1.9763 5.6301 1.8935 36.719
JHH-7 GDSC1; GDSC2; CCLE 2.1298 5.1006 1.3141 13.8736
Hep 3B2.1-7 GDSC1; GDSC2; CTRP2; CCLE 2.4337 4.8217 2.4217 33.7848
Li-7 CTRP2 2.8362 9.8931 1.7758 37.7064
Hep-G2/C3A GDSC1; GDSC2; CCLE 3.3256 8.6281 0.6719 13.8232
JHH-2 GDSC1; GDSC2; CTRP2; CCLE 3.4124 8.2115 2.949 29.303
JHH-4 GDSC1; GDSC2; CTRP2; CCLE 3.7606 5.96 3.7341 25.8932
SNU-182 CTRP2; CCLE 3.9379 14.9491 0.7859 33.2965
Huh-7 GDSC1; GDSC2 4.2762 7.5198 1.9552 6.2322
HLE GDSC1; GDSC2; CCLE 5.3165 10.7423 1.1133 7.537
JHH-1 GDSC1; GDSC2; CTRP2 5.6102 16.6571 1.5904 29.7545
SNU-387 GDSC1; GDSC2; CTRP2; CCLE 5.8629 14.723 2.7668 23.5823
SNU-423 GDSC1; GDSC2; CTRP2; CCLE 6.6897 10.4064 5.6211 11.9864
SNU-398 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 7.3555 16.0898 3.4544 18.3126
HuH-1 GDSC1; GDSC2; CTRP2; CCLE 7.474 8.415 7.3034 4.1657
HLF CTRP2; CCLE 7.6657 13.0586 5.2356 11.4363
HuH-6 CTRP2 7.8213 10.98 6.4071 7.5202
PLC/PRF/5 CTRP2; CCLE 8.0699 11.9513 6.1338 7.343
JHH-6 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 8.158 8.8639 7.7487 1.1043
SNU-449 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 8.4675 15.0485 4.9109 11.2272
SNU-475 CTRP2; CCLE 9.0304 13.4517 6.1368 5.8228
SK-HEP-1 GDSC1; GDSC2; CTRP2; CCLE 13.397 28.5982 1.8394 14.0804
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 229 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1588 CTRP2 -2.7176 2.6528 -2.776 69.3868
NCI-H1666 GDSC1; GDSC2; CTRP2; CCLE -1.1731 11.7218 -3.2043 53.2527
NCI-H2087 GDSC1; GDSC2; CTRP2; CCLE -0.2369 9.0765 -1.2877 49.7894
NCI-H2291 GDSC1; GDSC2 0.0815 8.2329 -2.1706 39.8782
EBC-1 GDSC1; GDSC2; CTRP2; CCLE 0.1972 4.3888 0.1368 47.1968
DV-90 CTRP2; CCLE 0.5175 8.4782 -0.2859 46.0817
NCI-H2122 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 0.5723 4.4605 0.5221 44.9749
NCI-H727 GDSC1; GDSC2; CTRP2; CCLE 1.1717 13.9307 -1.5901 44.6493
NCI-H2795 GDSC1; GDSC2 1.2365 3.5957 0.9658 22.3643
A-549 GDSC1; GDSC2; CTRP2; CCLE 1.3929 7.9343 0.8209 41.165
NCI-H358 GDSC1; GDSC2; CTRP2; CCLE 1.4602 12.4961 -0.6944 42.9291
NCI-H1437 GDSC1; GDSC2 1.6154 10.8912 -1.9645 32.4495
Lu-65 GDSC1; GDSC2; CTRP2 1.7866 10.6025 0.3881 44.0551
NCI-H2009 GDSC1; GDSC2; CTRP2; CCLE 2.053 8.1219 1.4905 37.4534
Calu-6 GDSC1; GDSC2; CTRP2; CCLE 2.0616 6.823 1.8072 36.6653
HCC1171 CTRP2 2.0795 17.0856 -2.0519 44.9686
HCC1833 CTRP2; CTRP1 2.0897 19.6604 -3.2342 45.5648
COLO 677 CCLE 2.0921 9.0339 -0.8034 22.0931
NCI-H2347 GDSC1; GDSC2 2.1308 19.0496 -5.5553 38.3151
HCC44 GDSC1; GDSC2; CTRP2; CCLE 2.1322 9.6205 1.1106 37.9903
SW1271 GDSC1; GDSC2; CTRP2; CCLE 2.3178 8.2643 1.7396 35.9843
Lu-99 CTRP2; CCLE 2.482 9.1781 1.6383 35.6903
Lu-99A GDSC1; GDSC2 2.7154 5.8423 1.5264 12.7903
NCI-H2405 GDSC1; GDSC2; CTRP2 2.8218 9.8759 1.7665 37.7799
T3M-10 CTRP2; CTRP1; CCLE 2.953 11.9748 1.0899 35.426
COR-L105 GDSC1; GDSC2; CTRP2; CCLE 2.9615 10.8985 1.5324 34.4337
NCI-H2135 GDSC1; GDSC2 3.1342 7.3572 1.1458 14.2152
PC-14 GDSC1; GDSC2; CTRP2; CCLE 3.1379 6.317 3.0456 29.8155
NCI-H1993 GDSC1; GDSC2 3.3197 5.6139 2.174 7.2735
NCI-H1304 GDSC1 3.5573 5.152 1.4557 1.0037
EMC-BAC-1 GDSC1; GDSC2 3.6295 9.5207 0.475 16.5739
Hs 229.T CCLE 3.7831 6.8686 1.6731 5.4581
NCI-H290 GDSC1; GDSC2 3.8022 7.1691 1.7824 8.4205
Calu-3 GDSC1; GDSC2; CTRP2; CCLE 3.8067 8.1205 3.4048 26.7805
NCI-H3122 GDSC1; GDSC2 3.8644 10.1567 0.3454 16.6029
SK-MES-1 GDSC1; GDSC2; CTRP2; CCLE 3.8777 8.5821 3.3469 26.7616
HCC4006 CTRP2; CTRP1; CCLE 3.9 7.6377 3.6305 25.8113
SBC-3 GDSC1; GDSC2 3.9 5.7825 2.5337 3.5395
LK-2 GDSC1; GDSC2 3.9395 5.7676 2.5676 3.2506
NCI-H23 GDSC1; GDSC2; CTRP2; CCLE 3.9424 9.5217 3.1016 27.3413
HCC1195 CTRP2; CTRP1 3.9748 12.9991 1.7078 34.0249
NCI-H1734 GDSC2 3.981 7.5806 1.7138 8.3937
NCI-H187 GDSC1 3.986 5.8015 1.3907 0.8938
RERF-LC-Sq1 GDSC1; GDSC2 4.0284 10.4972 0.3048 16.3683
HOP-92 GDSC1; GDSC2; CTRP2 4.0747 7.679 3.8111 27.4412
HOP-62 GDSC1; GDSC2; CTRP2 4.1284 12.3188 2.1648 32.4255
NCI-H2073 CTRP1 4.1723 13.0411 1.8823 52.2533
NCI-H1792 GDSC1; GDSC2; CTRP2; CCLE 4.1764 10.3659 3.0326 26.9152
A-427 GDSC1; GDSC2 4.1821 11.4872 -0.0679 17.8267
NCI-H847 GDSC1; GDSC2 4.2131 5.9407 2.6596 2.202
COR-L32 GDSC1; GDSC2 4.2974 10.1226 0.6963 13.5687
SW1573 GDSC1; GDSC2; CCLE 4.3207 10.9769 0.2916 13.3693
Lu-134-A GDSC1; GDSC2 4.3272 7.6877 1.9094 6.3968
NCI-H1975 GDSC1; GDSC2; CCLE 4.333 8.843 1.3519 8.1498
NCI-H322M GDSC1; GDSC2 4.3372 14.588 -1.489 23.3837
LC-2/ad GDSC1; GDSC2 4.353 7.5827 1.9775 5.7285
NCI-H2228 GDSC1; GDSC2; CTRP2; CCLE 4.3829 8.025 4.0596 23.1018
EKVX GDSC1; GDSC2; CTRP2 4.3833 12.8701 2.1808 31.6112
NCI-H835 GDSC1; GDSC2 4.4355 6.8765 2.3647 3.4847
NCI-H2810 GDSC1; GDSC2 4.5118 10.2086 0.8128 12.3939
NCI-H2066 GDSC1; GDSC2 4.5705 6.854 2.456 2.7421
NCI-H1688 GDSC1; GDSC2 4.5804 8.5975 1.6449 7.4292
NCI-H1963 GDSC2; CTRP1 4.5876 7.157 4.4732 24.0091
NCI-H513 GDSC1; GDSC2 4.6085 7.4972 2.1842 4.207
LCLC-97TM1 GDSC1; GDSC2; CTRP2 4.622 16.961 0.5063 34.6632
NCI-H2227 GDSC1; GDSC2 4.6361 7.6587 2.1264 4.4893
NCI-H3255 GDSC1; GDSC2; CTRP1; CCLE 4.6395 9.1862 3.9682 22.6238
HCC33 GDSC2 4.6737 9.0064 1.5121 8.0103
NCI-H1770 GDSC1; GDSC2 4.6932 7.1297 2.403 2.8363
COR-L311 GDSC2 4.6942 6.6853 2.5992 1.808
NCI-H1944 GDSC1; GDSC2; CTRP2; CCLE 4.7718 12.2209 2.8659 25.8721
NCI-H2461 GDSC1; GDSC2 4.7754 11.5975 0.3241 14.3721
COR-L279 GDSC1; GDSC2 4.8558 6.4944 2.7588 0.9003
NCI-H748 GDSC2 4.8581 7.502 2.3307 2.9704
NCI-H1915 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 4.8724 12.4963 2.844 25.6863
NCI-H2171 GDSC2 4.8742 8.4959 1.8858 5.4311
NCI-H1048 GDSC1; GDSC2; CCLE 4.9138 6.7643 2.6768 0.9902
NCI-H345 GDSC1; GDSC2 4.9233 5.8186 3.0355 0.0795
RERF-LC-MS GDSC1; GDSC2; CTRP2 4.9313 14.8065 1.8311 30.9417
SK-LU-1 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 4.9741 15.2236 1.675 28.6642
NCI-H2731 GDSC1; GDSC2 5.0339 10.5137 1.0334 9.9728
GLC-82 CCLE 5.0908 8.4837 1.7422 3.0443
NCI-H2803 GDSC1; GDSC2 5.1031 12.3515 0.1917 14.2735
NCI-H1693 GDSC1; GDSC2; CTRP2; CCLE 5.1127 12.5794 3.0479 24.4736
NCI-H720 GDSC1; GDSC2 5.1306 6.5373 2.8595 0.3701
NCI-H510A GDSC1; GDSC2; CTRP2 5.1423 12.822 2.9662 27.1622
NCI-H1648 GDSC1; GDSC2; CCLE 5.1553 12.0321 0.384 11.2588
COR-L321 GDSC1; GDSC2 5.1628 6.7281 2.8017 0.5202
NCI-H1573 GDSC1; GDSC2; CTRP2; CCLE 5.23 16.6484 1.2365 29.1258
NCI-H1436 GDSC1; GDSC2 5.2413 6.6375 2.8662 0.3037
NCI-H82 GDSC1; GDSC2 5.2426 6.7849 2.813 0.4424
Lu-165 GDSC1; GDSC2 5.2799 6.5691 2.9049 0.2057
SW900 CCLE 5.2843 7.5387 2.2349 0.9031
NCI-H524 GDSC1; GDSC2 5.3366 7.3837 2.624 1.0181
Lu-135 GDSC1; GDSC2 5.3576 7.572 2.5586 1.2598
DMS 79 GDSC1; GDSC2 5.3601 7.2387 2.6907 0.7567
NCI-H64 GDSC1; GDSC2 5.3903 6.594 2.9359 0.1246
COR-L303 GDSC2 5.4398 7.2492 2.7202 0.6084
CPC-N GDSC1; GDSC2 5.5053 7.289 2.7321 0.5352
PaCa-3 GDSC1; GDSC2 5.5267 10.3702 1.4219 6.8401
LC-1F CTRP2 5.5336 10.9515 4.2064 21.8272
SBC-1 GDSC1; GDSC2 5.554 7.1547 2.8001 0.3337
UMC-11 GDSC1; GDSC2 5.5575 7.4012 2.7116 0.5473
LC-1/sq GDSC1; GDSC2 5.5809 11.2269 1.0562 8.7334
NCI-H2444 GDSC1; GDSC2; CTRP2; CCLE 5.61 11.66 3.9664 20.298
NCI-H596 GDSC1; GDSC2; CTRP1 5.6473 13.7271 3.0291 25.991
NCI-H2369 GDSC1; GDSC2 5.6487 11.8032 0.8283 9.8194
IST-SL1 GDSC1; GDSC2 5.6494 7.2656 2.7967 0.3054
EPLC-272H GDSC1; GDSC2; CTRP2 5.6873 18.7285 0.6486 31.6879
NCI-H1651 GDSC1; GDSC2; CCLE 5.7013 8.1264 2.4948 1.1755
NCI-H250 GDSC2 5.7033 7.3992 2.7695 0.3462
IST-SL2 GDSC1; GDSC2 5.7499 7.8313 2.6295 0.7057
NCI-H2085 GDSC1; GDSC2; CTRP2; CCLE 5.8043 12.3877 3.8237 20.3315
Ms-1 GDSC1; GDSC2 5.8135 7.4815 2.7816 0.2809
LB647-SCLC GDSC1; GDSC2 5.8145 7.6061 2.7378 0.376
CAL-12T CTRP1; CCLE; GDSC1; GDSC2; CTRP2 5.8721 19.9934 0.1943 29.9778
NCI-H146 GDSC1; GDSC2 5.9039 11.9164 0.9386 8.7486
NCI-H322 CTRP2; CCLE 5.9512 14.1591 3.1228 22.2898
HCC15 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 5.9689 16.4878 2.0072 25.5158
COR-L23 GDSC1; GDSC2; CTRP1; CCLE 6.0661 9.6411 5.314 14.4393
NCI-H740 GDSC2 6.0728 8.916 2.35 1.463
NCI-H2869 GDSC1; GDSC2 6.1303 13.3294 0.4204 10.9707
NCI-H2595 GDSC1; GDSC2 6.198 13.3448 0.4567 10.6615
SCLC-21H CTRP1 6.2014 7.5944 6.137 27.0047
NCI-H1755 GDSC1; GDSC2; CTRP2; CTRP1 6.3381 13.1135 3.9949 20.5427
NCI-H1341 GDSC1; GDSC2; CTRP2; CCLE 6.3538 8.3325 6.1209 11.0462
HCC2935 CTRP2; CTRP1; CCLE 6.3617 16.6688 2.2793 23.9189
NCI-H2373 GDSC1; GDSC2 6.3822 18.1295 -1.7125 19.5019
LXF 289 GDSC1; GDSC2; CTRP2; CTRP1 6.3842 13.3538 3.9224 20.696
NCI-H2722 GDSC1; GDSC2 6.4072 11.7034 1.3374 5.8265
NCI-H2591 GDSC1; GDSC2 6.4136 18.4095 -1.8264 19.4299
EMC-BAC-2 GDSC1; GDSC2 6.4324 16.2407 -0.7651 15.7767
NCI-H1836 GDSC1; GDSC2; CTRP1 6.4389 8.9278 5.9959 12.6718
RERF-LC-KJ GDSC1; GDSC2; CTRP1 6.5354 12.5743 2.4494 10.6145
COR-L51 CTRP2; CTRP1 6.557 10.5164 5.4383 14.4004
NCI-H211 GDSC1; GDSC2; CTRP2; CCLE 6.5696 12.7601 4.385 16.7065
NCI-H647 GDSC1; GDSC2; CTRP2; CCLE 6.5898 14.4073 3.6005 19.3649
HCC2108 CTRP2; CTRP1 6.5925 16.611 2.5173 24.8564
NCI-H2804 GDSC1; GDSC2 6.6316 15.8861 -0.4622 13.7506
NCI-H2818 GDSC1; GDSC2 6.6575 16.7324 -0.8485 15.6738
RERF-LC-Ad2 CTRP2 6.6868 22.1485 -0.1485 31.0148
NCI-H1930 CTRP1 6.7303 8.3568 4.5081 1.0516
NCI-H1838 GDSC1; GDSC2; CTRP2 6.8219 10.669 5.6288 12.9823
HCC827 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 6.8641 15.7014 3.212 20.0685
ABC-1 GDSC1; GDSC2 6.8696 16.0128 -0.3665 13.2359
NCI-H661 GDSC1; GDSC2; CTRP2; CCLE 7.0628 11.4146 5.5024 11.6225
DMS 53 GDSC1; GDSC2; CTRP2 7.1351 10.6734 5.9293 11.0131
NCI-H1694 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 7.1467 10.8194 5.87 10.0917
NCI-H1299 GDSC1; GDSC2; CTRP2; CCLE 7.1533 20.3993 1.13 25.3254
NCI-H1781 GDSC1; GDSC2; CTRP1 7.2509 11.357 5.6961 11.8457
NCI-H2141 GDSC1; GDSC2; CTRP2; CTRP1 7.2941 13.2108 4.8315 15.1262
KNS-62 GDSC1; GDSC2; CTRP2; CCLE 7.2948 18.1557 2.3717 21.769
DMS 454 CTRP2 7.3358 11.3802 5.7732 11.199
NCI-H1373 CTRP2; CCLE 7.4126 14.6038 4.2445 15.5098
NCI-H1184 CTRP2; CCLE 7.5314 9.0536 7.083 4.8159
NCI-H446 GDSC1; GDSC2; CTRP2 7.5336 8.4872 7.3373 4.3419
NCI-H1876 GDSC1; GDSC2; CTRP1 7.5347 8.6746 7.2509 4.661
SHP-77 GDSC1; GDSC2; CTRP2; CCLE 7.5374 14.1812 4.5642 14.1341
NCI-H2110 GDSC1; GDSC2; CTRP2; CTRP1 7.5487 15.8156 3.759 18.6511
NCI-H2196 GDSC2; CTRP2 7.5537 10.1333 6.5856 7.3493
MOR/CPR CTRP2; CCLE 7.5996 11.7731 5.8174 9.3881
HCC1359 CTRP1 7.691 8.1937 7.6139 5.8528
HCC366 GDSC1; GDSC2; CTRP2 7.7114 15.8578 3.8778 17.8816
COR-L88 GDSC1; GDSC2; CTRP2 7.813 14.9325 4.4268 15.6185
NCI-H1105 GDSC1; GDSC2; CTRP2; CTRP1 7.8205 10.1343 6.8273 5.7632
NCI-H810 GDSC1; GDSC2; CTRP2; CCLE 7.8452 9.5284 7.15 3.9206
NCI-H1092 GDSC1; GDSC2; CTRP2; CCLE 7.9193 9.4596 7.2502 3.4033
HCC2279 CTRP2 7.9559 16.4332 3.7975 17.6709
Lu-139 GDSC1; GDSC2 7.9793 17.4583 -0.3452 11.2259
NCI-H2029 GDSC1; GDSC2; CTRP2 7.9821 12.6486 5.7115 10.104
ChaGo-K-1 GDSC1; GDSC2; CTRP2 8.0043 10.1167 6.9958 4.6812
LK2 CTRP2 8.0899 8.7898 7.7312 1.4263
NCI-H1650 GDSC1; GDSC2; CTRP2; CCLE 8.0942 14.3213 4.969 11.6506
VMRC-LCD GDSC1; GDSC2; CTRP2; CCLE 8.0946 11.7769 6.2416 6.8938
Sq-1 CTRP1; CCLE 8.1446 14.9428 4.6881 12.5036
NCI-H2081 GDSC1; GDSC2; CTRP2; CTRP1 8.1447 9.1709 7.5853 1.9369
NCI-H1563 GDSC1; GDSC2; CTRP2; CCLE 8.1465 9.079 7.6325 1.5596
NCI-H1395 CTRP2 8.1703 21.6846 1.3506 24.7029
IA-LM GDSC1; GDSC2; CTRP2; CCLE 8.1924 14.9495 4.7363 12.3292
HCC95 CTRP2 8.2689 17.8367 3.356 18.5898
NCI-H2286 CTRP2; CTRP1; CCLE 8.295 21.5628 1.5148 22.2641
NCI-H292 GDSC1; GDSC2; CTRP2 8.3005 30.627 -3.0124 32.5237
NCI-H1355 GDSC1; GDSC2; CTRP2; CCLE 8.3156 20.724 1.9511 21.0682
COR-L95 GDSC1; GDSC2; CTRP2 8.3194 9.9959 7.3112 2.7767
LC-1/sq-SF CTRP2; CCLE 8.3455 12.707 5.9817 7.4501
NCI-H522 GDSC1; GDSC2; CTRP2; CCLE 8.3458 15.3363 4.6687 12.3103
NCI-H650 GDSC1; GDSC2; CTRP2; CCLE 8.4623 16.274 4.2949 13.4442
NCI-H889 CTRP2 8.4695 10.4691 7.1901 3.0316
NCI-H1435 GDSC1; GDSC2; CTRP2; CTRP1 8.5082 17.6495 3.645 17.129
NCI-H2170 GDSC1; GDSC2; CTRP2; CCLE 8.5293 10.0287 7.4474 1.696
NCI-H520 GDSC1; GDSC2; CTRP2; CCLE 8.5824 11.7137 6.6606 4.5291
NCI-H841 GDSC1; GDSC2; CTRP2; CTRP1 8.6319 15.2103 4.9614 11.9415
NCI-H2342 GDSC1; GDSC2; CTRP2; CTRP1 8.6603 15.3272 4.9257 12.0319
LOU-NH91 GDSC1; GDSC2; CTRP2; CCLE 8.7997 19.259 3.0761 16.9336
RERF-LC-Ad1 CTRP2 8.8274 14.6688 5.3835 9.896
NCI-H1703 GDSC1; GDSC2; CTRP2; CCLE 8.9638 16.7326 4.4641 12.026
LUDLU-1 CTRP2; CCLE 8.9804 18.7759 3.4604 15.4087
NCI-H226 GDSC1; GDSC2; CTRP2; CCLE 9.0208 17.0309 4.3601 12.3011
DMS 114 GDSC1; GDSC2; CTRP2; CCLE 9.0292 13.6453 6.0409 6.1784
BEN GDSC1; GDSC2; CTRP2 9.0426 10.0364 7.7373 0.3352
NCI-H2023 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 9.0672 17.2706 4.2769 12.5181
NCI-H209 GDSC1; GDSC2; CTRP2 9.1582 17.0002 4.4812 12.8791
NCI-H1581 GDSC1; GDSC2; CTRP2; CCLE 9.1786 17.8127 4.0938 12.9746
DMS 273 GDSC1; GDSC2; CTRP2 9.2505 16.5369 4.7806 11.5705
NCI-H1869 GDSC1; GDSC2; CTRP2; CCLE 9.3033 24.367 0.9299 22.029
NCI-H1623 GDSC1; GDSC2; CTRP2 9.3832 21.3533 2.4934 19.2797
NCI-H838 GDSC1; GDSC2; CTRP2 9.4352 16.1423 5.1126 9.966
SBC-5 GDSC1; GDSC2; CTRP2; CCLE 9.4567 10.5245 7.726 0.1651
COLO 668 GDSC1; GDSC2; CTRP2; CTRP1 9.5374 23.195 1.6978 21.2819
NCI-H196 GDSC1; GDSC2; CTRP2 9.6505 15.7013 5.4831 8.1343
NCI-H1568 GDSC1; GDSC2; CTRP2; CCLE 9.9335 24.3487 1.4317 19.79
NCI-H2126 CTRP2 9.9569 21.8251 2.6998 17.6652
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2; CTRP2; CCLE 10.0837 16.8199 5.2437 7.6321
NCI-H441 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 10.089 28.839 -0.6788 24.3247
RERF-LC-A1 CTRP2; CCLE 10.0945 23.566 1.9428 18.1906
NCI-H526 GDSC1; GDSC2; CTRP2 10.1145 11.5791 7.5993 0.2039
NCI-H69 GDSC1; GDSC2; CTRP2 10.1301 11.9797 7.4574 0.4686
LCLC-103H GDSC1; GDSC2; CTRP2; CCLE 10.1495 11.3985 7.6754 0.0876
HCC1438 CTRP2 10.1798 22.9344 2.3195 18.4422
HCC78 GDSC1; GDSC2; CTRP2; CCLE 10.1816 19.6512 3.9362 12.0086
NCI-H1155 GDSC1; GDSC2; CTRP2; CCLE 10.1822 20.8348 3.3561 13.8895
NCI-H2172 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 10.2261 17.5205 5.004 8.2902
NCI-H1339 CTRP2; CCLE 11.0421 22.8672 2.9835 13.8297
NCI-H2030 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 12.1409 35.5609 -2.4428 24.7048
NCI-H1793 GDSC1; GDSC2; CTRP2; CCLE 12.5798 33.6363 -1.172 21.8895
COLO 699 CTRP2; CTRP1; CCLE 12.8373 26.0428 2.6841 12.4334
NCI-H460 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 13.1958 22.1232 4.7216 5.9562
Calu-1 CTRP2; CCLE 13.9228 37.198 -1.9461 21.7017
Hs 888.Lu CTRP2 7.2246 13.1094 4.8192 15.3273
⏷ Show the Full List of 229 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 5.5588 7.4058 2.7104 0.5698
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 6.2451 18.9369 1.0538 29.4952
Aska-SS CTRP2 7.0142 16.2648 3.0668 22.1828
Hs 633.T GDSC1; GDSC2 0.5259 10.0835 -2.6001 38.0174
SW872 GDSC1; GDSC2 1.1045 5.7487 -0.0177 27.1942
TE 617.T CTRP2; CCLE 3.5637 12.7442 1.3983 32.9856
RD GDSC1; GDSC2; CTRP2; CCLE 3.7276 12.3543 1.7363 31.7282
STS-0421 GDSC1; GDSC2 4.5294 8.3458 1.7311 7.0279
G-401 GDSC1; GDSC2; CTRP2; CCLE 4.5315 10.1091 3.511 24.4751
MFH-ino GDSC1; GDSC2 4.6364 16.0078 -1.9616 24.256
HT-1080 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 4.8291 11.3375 3.3133 24.3432
SW684 GDSC1; GDSC2 4.9881 11.6667 0.4434 13.2569
Rh30 GDSC1; GDSC2; CCLE 5.1826 7.8371 2.3615 1.9608
VA-ES-BJ GDSC1; GDSC2 5.4577 11.4 0.8941 9.8506
EW-8 GDSC1; GDSC2 5.5028 6.873 2.8803 0.1867
Rh18 GDSC1; CTRP2 5.9677 8.4366 5.6677 15.1025
MES-SA GDSC1; GDSC2; CTRP2; CCLE 6.149 11.0015 4.8078 16.1236
RKN CTRP1; CCLE; GDSC1; GDSC2; CTRP2 6.315 15.3028 2.9078 22.1651
TTC-709 CTRP2 6.5574 11.5117 4.9727 16.2572
A-204 GDSC1; GDSC2; CTRP2; CCLE 7.0289 12.4954 4.9432 13.7473
SK-LMS-1 GDSC1; GDSC2; CTRP2; CCLE 7.1929 14.5342 4.0848 16.4943
Rh41 GDSC1; GDSC2; CTRP2 7.3231 11.5812 5.6627 11.6828
G-402 GDSC1; GDSC2; CTRP2; CCLE 7.4287 16.4014 3.3628 18.4709
TE 441.T GDSC2; CTRP2 7.4592 9.703 6.7053 7.0726
Hs 729.T CTRP2; CCLE 7.4988 11.1618 6.0296 8.7877
Tm87-16 CTRP2 7.5376 17.6826 2.8175 21.8419
BT-16 CTRP2 9.6246 12.5223 6.9731 2.365
BT-12 CTRP2 9.9985 24.2153 1.5478 20.8991
KYM-1 GDSC1; GDSC2; CTRP2; CCLE 10.0537 17.0126 5.13 8.0737
GCT GDSC1; GDSC2; CTRP2; CCLE 11.3964 24.3344 2.5209 14.7121
SK-UT-1 GDSC1; GDSC2; CTRP2 12.0469 23.816 3.2194 12.8797
SW982 GDSC1; GDSC2; CTRP2 12.7469 27.3355 2.0066 15.5488
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 6.9065 13.1624 4.5032 17.2815
ES-2 GDSC1; GDSC2; CCLE 1.0275 6.2694 -0.3272 25.2855
OV-90 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 1.5065 6.3235 1.2978 39.8061
SNU-8 CTRP2 2.1572 8.7584 1.4184 41.0657
OVCAR-5 GDSC1; GDSC2; CTRP2 2.513 16.6053 -1.3978 43.2061
MCAS CTRP2; CCLE 2.8125 7.7057 2.4286 32.6038
A2780 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 3.1176 12.8686 0.884 35.3587
Caov-4 GDSC1; GDSC2 3.2172 8.8207 0.4848 17.7397
OVKATE GDSC1; GDSC2; CTRP1 3.3259 6.3941 3.2348 32.5003
COV504 CCLE 3.8107 8.8203 0.7347 10.3164
TYK-nu CTRP1; CCLE; GDSC1; GDSC2; CTRP2 3.8188 11.9666 1.9971 30.8187
OVK18 GDSC1; GDSC2; CTRP2; CTRP1 3.8496 11.6698 2.1549 33.3262
HEY A8 CTRP2; CCLE 3.8634 11.4445 2.2639 29.9883
OC 315 CCLE 3.9087 6.3202 2.0224 3.417
OC 316 CCLE 4.3283 6.8269 2.0474 2.6443
IGROV-1 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 4.4545 11.8504 2.7046 27.1622
FU-OV-1 GDSC1; GDSC2; CTRP2; CCLE 4.9783 18.1365 0.2781 31.7705
OVCAR-3 GDSC1; GDSC2; CCLE 5.038 10.005 1.2797 7.209
SNU-119 CTRP2 5.4449 17.3274 1.1093 31.2962
RMG-I GDSC1; GDSC2; CTRP2; CTRP1 5.502 22.0056 -1.1347 35.2293
JHOS-4 GDSC1; GDSC2; CTRP1; CCLE 5.7151 10.8366 2.697 9.5284
OVCAR-4 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 6.0434 11.1673 4.6262 17.0076
RMUG-S CTRP1 6.295 12.3751 4.2988 36.4247
OV7 CTRP2; CTRP1 6.3584 20.8548 0.2047 31.0411
COV318 CTRP1; CCLE 6.3772 7.5402 4.6705 0.3074
OVMANA CTRP1; CCLE 6.9255 8.2484 4.6281 0.1935
EFO-21 GDSC1; GDSC2; CTRP2; CCLE 7.0992 15.0323 3.7541 17.814
OVCAR-8 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 7.2044 13.9874 4.3663 15.4816
COV644 CTRP2; CTRP1 7.2821 21.417 0.7334 27.9562
TOV-21G GDSC1; GDSC2; CTRP2; CCLE 7.2966 14.3353 4.2758 15.6225
COV434 CTRP2; CTRP1 7.3148 18.833 2.0512 24.588
COV362 CTRP2; CTRP1 7.3481 12.7611 5.1027 13.9197
ONCO-DG-1 CTRP2; CCLE 7.4225 14.8313 4.1399 15.8582
OAW42 GDSC1; GDSC2; CTRP2; CTRP1 7.6204 8.1913 7.5434 3.3129
JHOS-2 GDSC1; GDSC2; CTRP2; CCLE 7.835 19.07 2.3774 20.7338
OVSAHO CTRP2; CCLE 7.8615 23.7246 0.0728 26.3971
JHOM-1 CTRP2; CTRP1 7.99 9.5307 7.2763 3.5328
ES2 CTRP2 8.2464 18.3045 3.1036 19.4765
OV56 GDSC1; GDSC2; CTRP2 8.2968 17.4792 3.5577 17.842
OVTOKO GDSC1; GDSC2; CTRP2; CCLE 8.3435 16.6408 4.0149 14.6213
Kuramochi GDSC1; GDSC2; CTRP2; CCLE 8.3938 19.9056 2.4245 19.5957
TOV-112D GDSC1; GDSC2; CTRP2; CCLE 8.6122 15.9947 4.5547 12.2733
JHOC-5 CTRP2; CTRP1 9.1895 18.098 3.9606 14.7555
SK-OV-3 GDSC1; GDSC2; CTRP2; CCLE 9.2794 15.9647 5.0847 9.3197
OC 314 GDSC1; GDSC2; CTRP2; CCLE 9.5136 17.2751 4.6133 10.6575
OVISE GDSC1; GDSC2; CTRP2 9.724 11.0418 7.6422 0.2482
SNU-840 CTRP2; CTRP1 9.8628 30.2999 -1.5836 27.8458
DOV13 GDSC1; GDSC2; CTRP2; CCLE 10.2271 11.902 7.5261 0.2638
EFO-27 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 10.4015 23.0126 2.4466 16.3196
Caov-3 GDSC2; CTRP2; CTRP1 10.983 23.4516 2.6562 16.1637
OAW28 GDSC1; GDSC2; CTRP2 14.1215 33.2214 0.1156 18.4691
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 9.845 11.1434 7.6526 0.2218
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 10.0816 17.2732 5.0233 9.3145
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC1; GDSC2; CTRP2; CCLE 3.8578 10.7735 2.5328 29.2572
MSTO-211H GDSC1; GDSC2; CTRP2; CCLE 3.9056 9.2745 3.1493 27.2968
IST-Mes2 CCLE 4.3202 6.6449 2.1247 2.2934
NCI-H2052 GDSC1; GDSC2; CCLE 5.6753 7.5898 2.6892 0.4732
IST-Mes1 GDSC1; GDSC2; CTRP2; CCLE 6.6268 10.8459 5.3544 13.0917
NCI-H2452 GDSC1; GDSC2; CTRP2; CCLE 6.9177 15.6474 3.2869 19.7199
MPP 89 GDSC1; GDSC2; CTRP2; CCLE 6.9254 9.8263 6.1231 9.6443
JL-1 CTRP2 7.6785 13.9733 4.7904 14.4733
ACC-MESO-1 CTRP2 8.3149 9.7439 7.4324 2.2803
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 GDSC1; GDSC2; CTRP2; CCLE 5.097 20.0806 -0.5591 33.0414
PC-3 GDSC1; GDSC2; CCLE 6.4705 10.0922 2.0617 1.9006
LNCaP clone FGC GDSC1; GDSC2; CTRP2 7.7154 9.3821 7.103 4.8443
VCaP GDSC1; GDSC2; CTRP2 8.3932 9.6934 7.5146 1.8163
PaCa-3 CTRP2; CTRP1 8.4422 10.6588 7.0762 3.5478
DU145 GDSC1; GDSC2; CTRP2; CCLE 9.0277 14.517 5.6107 7.7694
NCI-H660 GDSC2; CTRP2 9.777 13.3108 6.7044 3.192
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 3.5826 17.4392 -0.7275 39.4191
A-253 GDSC1; GDSC2; CTRP2; CCLE 6.2308 13.2775 3.8139 19.4136
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 4.3756 7.0383 2.2514 4.2556
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-620 CTRP2 -4.4784 2.6674 -4.6126 75.7056
OCUM-1 GDSC1; GDSC2; CTRP2; CCLE -3.092 2.9931 -3.1885 64.9944
NUGC-4 GDSC1; GDSC2; CTRP2; CCLE -0.2712 9.5357 -1.4701 49.946
AGS GDSC1; GDSC2; CTRP2; CTRP1 1.1077 5.5928 0.9776 46.5645
NCC-StC-K140 CTRP2 1.3896 6.2361 1.1864 44.8687
GSU CTRP2 1.625 5.0087 1.579 43.0564
SNU-5 GDSC1; GDSC2; CTRP2 3.0767 11.7426 1.3155 37.7999
AZ-521 CCLE 3.539 11.7496 -0.9341 18.805
HSC-39 GDSC1; GDSC2 3.6425 5.5111 2.4817 4.4572
MKN28 GDSC1; GDSC2 3.7347 6.1267 2.2469 5.6957
SNU-668 CTRP2 4.0018 21.0333 -2.0471 39.8398
TGBC11TKB GDSC1; GDSC2 4.052 11.2881 -0.0703 18.1865
SCH GDSC1; GDSC2 4.3059 6.1824 2.6047 2.3531
TMK-1 GDSC1; GDSC2 4.327 11.6727 -0.0483 17.3516
GCIY GDSC1; GDSC2; CCLE 4.3469 12.4173 -0.4024 16.411
SNU-601 CTRP2 4.5145 12.7703 2.3586 30.743
SNU-1 GDSC1; GDSC2; CTRP2; CCLE 4.5836 11.4533 3.0097 25.9143
Hs 746.T GDSC1; GDSC2; CTRP2; CCLE 4.6524 13.0938 2.3513 27.6659
ECC10 GDSC1; GDSC2; CTRP2 5.1213 9.1087 4.5206 21.8193
Fu97 GDSC1; GDSC2; CTRP2; CCLE 5.2484 12.7451 3.1073 23.9616
SK-GT-2 GDSC1; GDSC2 5.2834 10.3879 1.2594 8.1988
GSS CTRP2 5.3154 11.1387 3.9004 23.5375
RERF-GC-1B GDSC1; GDSC2; CCLE 5.3707 18.6372 -2.7025 22.4126
RF-48 GDSC1; GDSC2 5.4255 7.6037 2.5771 1.1256
NUGC-3 GDSC1; GDSC2; CTRP2; CCLE 5.6317 16.3133 1.7778 26.8715
BGC-823 CCLE 5.7901 8.3229 2.1509 0.843
IM95 GDSC1; GDSC2; CTRP2; CCLE 5.8709 15.9749 2.1666 25.2959
23132/87 GDSC1; GDSC2; CTRP2 5.94 9.8318 5.1091 17.3005
SNU-16 GDSC1; GDSC2; CTRP2; CCLE 6.5681 10.2847 5.5554 12.4966
MKN74 CTRP2; CTRP1; CCLE 6.6084 15.3582 3.1501 20.79
NCI-N87 GDSC1; GDSC2; CTRP2; CCLE 6.7776 16.4868 2.7455 21.6935
HuG1-N CTRP2 7.2025 27.7528 -2.4989 33.7342
ECC12 GDSC2; CTRP2 7.5582 11.3687 5.9809 9.8523
KATO III GDSC1; GDSC2; CTRP2 7.8248 10.2305 6.7833 5.9383
HGC-27 GDSC1; GDSC2; CTRP2; CCLE 7.9239 8.9195 7.5221 2.3741
SH-10-TC CTRP2; CCLE 7.9914 10.28 6.9033 4.5785
KE-39 CTRP2; CCLE 8.195 23.199 0.614 24.6268
MKN7 GDSC1; GDSC2; CTRP2; CCLE 8.7674 20.3678 2.4969 18.7426
MKN45 GDSC1; GDSC2; CTRP2; CCLE 8.7717 16.5915 4.3838 12.6178
MKN1 GDSC1; GDSC2; CTRP2 9.0985 21.8907 2.0017 21.2212
SNU-216 CTRP2 10.5534 31.289 -1.5354 26.7005
LMSU CTRP2 10.634 18.4247 4.8476 9.1849
SNU-1077 CTRP2 5.7825 8.6037 5.4116 16.5929
SNG-M CTRP1; CCLE; GDSC1; GDSC2; CTRP2 7.2379 14.9906 3.8981 17.0515
SNU-685 CTRP2 7.9475 10.9062 6.553 6.6524
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMH-2 GDSC1; GDSC2 -1.7921 3.1672 -2.2177 51.0585
HTC-C3 GDSC1; GDSC2 -0.7968 6.0081 -2.1119 43.1463
BHT-101 GDSC1; GDSC2 -0.6161 3.5252 -1.0329 40.9678
IHH-4 GDSC1; GDSC2 -0.2351 4.7381 -1.0215 38.6813
K5 GDSC1; GDSC2 0.0878 13.3185 -4.5742 43.1695
8305C GDSC1; GDSC2; CTRP2; CCLE 3.0394 13.9971 0.3106 36.6535
ASH-3 GDSC1; GDSC2 3.2358 13.6691 -1.9236 27.8561
TT2609-C02 GDSC1; GDSC2; CTRP2; CCLE 4.2249 14.8951 1.0957 31.8934
8505C GDSC1; GDSC2; CTRP2; CCLE 5.2029 15.6091 1.7113 28.0286
B-CPAP GDSC1; GDSC2; CTRP2; CCLE 5.5269 17.0693 1.3117 28.2698
SW579 CTRP2; CCLE 5.7133 8.1039 5.49 14.8374
ML-1 [Human leukemia] GDSC1; GDSC2; CTRP2 5.8421 11.5926 4.2299 20.9215
CGTH-W-1 GDSC1; GDSC2; CTRP2 5.9787 8.6895 5.5948 15.3408
TT GDSC1; GDSC2; CTRP2 6.0274 16.6409 1.9863 27.7036
CAL-62 GDSC1; GDSC2; CTRP2 7.5145 18.6908 2.2942 23.4107
WRO GDSC1; GDSC2 7.7383 21.0239 -2.1741 18.4796
FTC-133 GDSC1; GDSC2; CTRP2 7.9339 9.5694 7.2083 3.9324
FTC-238 CTRP2 8.7204 16.1696 4.5535 13.3796
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 -5.8213 15.7588 -9.7103 65.0479
HO-1-N-1 GDSC1; GDSC2 0.5904 6.1425 -0.7184 33.4104
UPCI-SCC-090 GDSC1; GDSC2 0.7776 9.1626 -1.9184 36.2805
DOK GDSC1; GDSC2 0.8258 15.8107 -5.1078 40.7744
BB30-HNC GDSC1; GDSC2 1.0013 7.0902 -0.7268 31.5799
BB49-HNC GDSC1; GDSC2 1.7181 26.2953 -9.5272 42.6243
Ca9-22 GDSC1; GDSC2 1.7924 8.9318 -0.8412 28.8257
SNU-1214 CTRP2 1.8894 11.4676 0.1694 43.8772
PCI-38 GDSC1 2.0328 13.8902 -3.9178 32.8239
SNU-899 CTRP2 2.2147 14.1132 -0.5866 43.4392
PCI-15A GDSC1; GDSC2 2.5695 5.6097 1.5032 13.8892
BICR 78 GDSC1; GDSC2 2.746 10.8814 -0.9479 25.9245
JHU-029 GDSC1; GDSC2 3.0874 8.1172 0.7262 16.8045
SAS GDSC1; GDSC2 3.1125 14.121 -2.2531 29.2059
SCC-25 GDSC1; GDSC2; CTRP2; CCLE 3.1871 9.3295 2.3526 31.6834
JHU-011 GDSC1; GDSC2 3.2941 10.136 -0.1084 20.5405
KOSC-2 GDSC1; GDSC2 3.4386 12.3109 -1.0757 24.299
PCI-04B GDSC1; GDSC2 3.662 10.3513 0.0865 18.4998
BICR 56 CTRP2 3.6961 31.3644 -7.3928 43.989
JHU-022 GDSC1; GDSC2 3.7065 14.8697 -2.1347 27.1971
PE/CA-PJ41 (clone D2) CTRP2 4.0051 16.7944 -0.0109 37.2331
SAT [Human HNSCC] GDSC1; GDSC2 4.0087 17.0379 -2.9724 28.766
SNU-1076 CTRP2 4.1044 21.522 -2.1879 39.7401
Hs 840.T CCLE 4.3153 9.8116 0.6184 9.8563
BICR 22 GDSC1; GDSC2; CTRP2 4.3472 10.1027 3.3174 28.3527
KON GDSC1; GDSC2 4.4522 17.1041 -2.6513 26.8046
PE/CA-PJ34 (clone C12) CTRP2 4.483 12.4097 2.4878 30.4764
HO-1-u-1 GDSC1; GDSC2 4.7306 8.5924 1.7479 6.51
PCI-06A GDSC1; GDSC2 4.8991 11.5768 0.4237 13.5651
CAL-27 GDSC1; GDSC2; CTRP2; CCLE 4.9246 14.7966 1.8293 28.3914
OSC-19 GDSC1; GDSC2 4.974 12.3563 0.0967 15.0438
BHY GDSC1; GDSC2; CTRP2 5.0163 12.7253 2.8847 27.6809
SCC-15 GDSC1; GDSC2 5.0715 14.9345 -1.0986 20.0978
OSC-20 GDSC1; GDSC2 5.1322 11.7452 0.507 12.2277
NCI-H3118 GDSC1; GDSC2 5.3663 15.8956 -1.3532 20.3893
BICR 31 GDSC2; CTRP2 5.4083 14.6332 2.3756 28.2023
LB771-HNC GDSC1; GDSC2 5.4166 8.5963 2.158 3.0638
PCI-30 GDSC1; GDSC2 5.6247 11.7549 0.8355 9.829
BICR 10 GDSC1; GDSC2 5.9228 14.7263 -0.3852 15.1912
SKN-3 GDSC1; GDSC2 6.0604 14.5746 -0.2182 14.1533
HSC-4 GDSC1; GDSC2; CTRP2 6.4571 17.6871 1.8631 27.0101
BICR 18 CTRP2 6.7162 12.3538 4.7203 16.8752
YD-8 CTRP2 6.8821 12.0713 5.0136 15.3238
SCC-4 GDSC1; GDSC2; CTRP2 7.0479 19.0418 1.7149 26.073
HSC-2 GDSC1; GDSC2; CTRP2; CCLE 7.1391 12.3219 5.1298 12.8418
PE/CA-PJ49 CTRP2 7.1946 17.3616 2.6802 23.0064
PE/CA-PJ15 GDSC1; GDSC2; CTRP2 7.3073 22.3042 0.3121 28.8162
CAL-33 GDSC1; GDSC2; CTRP2 7.9621 21.7708 1.134 25.6477
Detroit 562 GDSC1; GDSC2; CTRP2; CCLE 8.1206 22.1504 1.0765 23.6694
SCC-9 CTRP1; CCLE; GDSC1; GDSC2; CTRP2 8.3925 24.5255 0.114 25.3886
BICR 6 CTRP2 8.6316 18.9291 3.1058 18.7265
SNU-1041 CTRP2 8.6459 25.8415 -0.3359 27.5874
FaDu GDSC1; GDSC2; CTRP2; CCLE 9.2483 17.8983 4.1049 12.8278
HSC-3 GDSC1; GDSC2; CTRP2 9.2923 21.9855 2.1077 20.5735
SNU-46 CTRP2 10.1458 22.8132 2.3538 18.397
SNU-1066 CTRP2 10.1932 12.66 7.2165 1.0562
BICR 16 CTRP2 10.4205 22.2462 2.8378 16.479
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-BLC1 CTRP2 -2.9006 9.8048 -4.416 62.9168
KU-19-19 GDSC1; GDSC2; CTRP2 0.4675 6.266 0.1876 50.5746
UM-UC-1 CTRP2 1.6426 7.2535 1.2614 43.5622
SW780 GDSC1; GDSC2; CCLE 2.078 10.6867 -1.4424 26.249
BFTC-905 GDSC1; GDSC2; CTRP2 2.8653 8.4525 2.2824 36.3839
SCaBER CTRP2; CCLE 3.1854 13.6608 0.6085 35.6978
VM-CUB-1 CTRP2 3.4005 14.2554 0.5626 38.0888
JMSU-1 CTRP2; CCLE 4.1556 10.1941 3.0779 26.8326
5637 GDSC1; GDSC2; CTRP2; CCLE 4.1981 8.9101 3.5902 25.1114
RT-4 GDSC1; GDSC2; CTRP2; CCLE 4.9506 9.3036 4.266 23.2216
RT-112 GDSC1; GDSC2; CTRP2; CCLE 5.0016 15.6871 1.4806 29.0788
BC-3C CTRP2 5.7904 18.9636 0.6275 31.4858
KMBC-2 CTRP2; CCLE 6.3289 26.494 -2.6261 33.7129
UM-UC-3 GDSC1; GDSC2; CTRP2; CCLE 7.3239 15.5618 3.6898 17.5917
TCCSUP GDSC1; GDSC2; CTRP2; CCLE 7.5668 12.4573 5.4483 10.8299
253J-BV CTRP2 7.6037 10.7286 6.3386 8.2654
647V GDSC1; GDSC2; CTRP2 7.762 14.0274 4.8353 14.1228
SW1710 GDSC1; GDSC2; CTRP2 7.9059 16.2593 3.8423 17.6105
HT-1197 GDSC1; GDSC2; CTRP2; CCLE 8.0558 20.9163 1.6396 22.364
J82 GDSC1; GDSC2; CTRP2; CCLE 8.6207 12.1753 6.4613 5.2158
HT-1376 GDSC1; GDSC2; CTRP2; CCLE 9 20.8432 2.4457 18.5033
639V GDSC1; GDSC2; CTRP2; CCLE 9.1172 13.5968 6.1285 5.7312
CAL-29 GDSC1; GDSC2; CTRP2 9.1875 25.0012 0.5215 24.8124
T24 GDSC1; GDSC2; CTRP2; CCLE 10.2149 26.8823 0.3911 21.8742
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-39 GDSC1; GDSC2 -1.0343 6.0297 -2.3718 45.9241
BPH-1 GDSC1; GDSC2 -0.2816 13.2986 -4.9153 44.0691
HEY GDSC1; GDSC2 0.582 5.1159 -0.2956 31.7485
SW954 GDSC1; GDSC2 1.1937 10.3127 -2.0741 35.0316
OVCA420 GDSC1; GDSC2 1.9166 11.7485 -2.1131 32.5438
OVMIU GDSC1; GDSC2 2.32 13.1774 -2.4638 32.1641
JHOS-3 GDSC1; GDSC2 3.1305 7.4581 1.0922 14.5458
SW962 GDSC1; GDSC2 3.8434 17.788 -3.4813 30.4177
OVCA433 GDSC1; GDSC2 3.8485 12.1295 -0.6511 21.3971
PA-1 GDSC1; GDSC2 3.9389 6.8975 2.0186 6.617
DSH1 GDSC1; GDSC2 4.0369 6.4943 2.2849 4.7546
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 4.0538 7.7407 1.6888 8.3683
DoTc2 4510 GDSC1; GDSC2 4.0778 7.4067 1.8701 6.9543
C-4-I GDSC1; GDSC2 4.1671 6.877 2.1899 5.0489
ACC-OV7 GDSC1; GDSC2 4.1898 10.466 0.4449 15.2049
HT-3 GDSC1; GDSC2 4.2328 9.8744 0.7704 13.3221
NCC-IT GDSC2 4.4321 6.3024 2.6236 2.051
TC-YIK GDSC1; GDSC2 4.4502 10.9968 0.3794 14.8829
KGN GDSC1; GDSC2 4.468 12.9028 -0.5502 19.3049
SKG-IIIa GDSC1; GDSC2 4.5285 7.634 2.0694 5.0264
JEG-3 GDSC1; GDSC2 4.5502 9.5528 1.1613 10.3288
PWR-1E GDSC1; GDSC2 4.6897 7.0343 2.4437 2.6223
NT2-D1 GDSC1; GDSC2 4.7939 6.8385 2.5859 1.6857
C-33 A GDSC1; GDSC2 4.8185 10.3902 0.944 10.9457
UWB1.289 GDSC1; GDSC2 4.8519 9.7426 1.2799 8.9721
LB831-BLC GDSC1; GDSC2 4.9132 7.3665 2.4212 2.4144
SW756 GDSC1; GDSC2 4.9166 16.6819 -2.08 23.9662
HEC-1 GDSC1; GDSC2 5.1486 6.6402 2.8287 0.4471
SiHa GDSC1; GDSC2 5.2314 7.0992 2.6889 0.8578
NEC8 GDSC1; GDSC2 5.3495 6.7969 2.8503 0.2976
JAR GDSC1; GDSC2 5.3974 7.3411 2.6674 0.8116
SKN GDSC1; GDSC2 5.852 8.9099 2.2487 2.0992
SiSo GDSC1; GDSC2 5.9123 7.627 2.767 0.2783
OV17R GDSC1; GDSC2 5.9824 11.9913 0.9529 8.5297
Ca Ski GDSC1; GDSC2 6.3541 12.7443 0.8339 8.4807
MS751 GDSC1; GDSC2 6.3555 13.2794 0.587 9.7209
ME-180 GDSC1; GDSC2 7.1741 20.2308 -2.1774 19.5224
PEO1 GDSC1; GDSC2 7.4331 17.3664 -0.6411 13.3819
HeLa GDSC1; GDSC2; CTRP2 9.043 10.0913 7.7157 0.3936
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Selumetinib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Moderate Increased metabolism of Selumetinib caused by Ivosidenib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [11]
Arn-509 DMT81LZ Major Increased metabolism of Selumetinib caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [11]
Troleandomycin DMUZNIG Major Decreased metabolism of Selumetinib caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [11]
Pexidartinib DMS2J0Z Major Increased metabolism of Selumetinib caused by Pexidartinib mediated induction of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [11]
Osilodrostat DMIJC9X Moderate Decreased metabolism of Selumetinib caused by Osilodrostat mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [12]
MK-8228 DMOB58Q Major Decreased metabolism of Selumetinib caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [11]
Eslicarbazepine DMZREFQ Moderate Increased metabolism of Selumetinib caused by Eslicarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [11]
Tazemetostat DMWP1BH Moderate Increased metabolism of Selumetinib caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [11]
MK-1439 DM215WE Moderate Increased metabolism of Selumetinib caused by MK-1439 mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [11]
Brigatinib DM7W94S Moderate Increased metabolism of Selumetinib caused by Brigatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [11]
PF-06463922 DMKM7EW Major Increased metabolism of Selumetinib caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [11]
Fedratinib DM4ZBK6 Major Decreased metabolism of Selumetinib caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [11]
Rucaparib DM9PVX8 Moderate Decreased metabolism of Selumetinib caused by Rucaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [11]
Voxelotor DMCS6M5 Moderate Decreased metabolism of Selumetinib caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [11]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Selumetinib caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [13]
Larotrectinib DM26CQR Moderate Decreased metabolism of Selumetinib caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [11]
Elagolix DMB2C0E Moderate Increased metabolism of Selumetinib caused by Elagolix mediated induction of CYP450 enzyme. Uterine fibroid [2E86] [11]
⏷ Show the Full List of 17 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
FD&C blue no. 2 E00446 2723854 Colorant
Glyceryl monooleate E00473 5283468 Bioadhesive material; Emollient; Emulsifying agent; Emulsion stabilizing agent; Gelling agent; Modified-release agent; Surfactant
Potassium chloride E00074 4873 Tonicity agent
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Ferric oxide black E00522 16211978 Colorant
Hypromellose E00634 Not Available Coating agent
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Tocophersolan E00679 Not Available Antioxidant; Binding agent; Emulsifying agent; Ointment base; Solubilizing agent; Surfactant; Suspending agent
Water E00035 962 Solvent
Haematite red E00236 14833 Colorant
Ammonium hydroxide E00687 Not Available Alkalizing agent
Carrageenan E00714 Not Available Emulsion stabilizing agent; Gelling agent; Microencapsulating agent; Modified-release agent; Suspending agent; Viscosity-controlling agent
Pregelatinized starch E00674 Not Available Binding agent; Diluent; Disintegrant
Shellac E00695 Not Available Coating agent; Film/membrane-forming agent; Microencapsulating agent; Modified-release agent
⏷ Show the Full List of 15 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Selumetinib 25 mg capsule 25 mg Capsule Oral
Selumetinib 10 mg capsule 10 mg Capsule Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 ClinicalTrials.gov (NCT01933932) Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLC (SELECT-1)
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5665).
5 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1479).
7 Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells.Br J Cancer.2012 May 8;106(10):1648-59.
8 Ursonic acid exerts inhibitory effects on matrix metalloproteinases via ERK signaling pathway. Chem Biol Interact. 2020 Jan 5;315:108910. doi: 10.1016/j.cbi.2019.108910. Epub 2019 Nov 29.
9 Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
10 The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition. Br J Cancer. 2012 Apr 10;106(8):1386-94. doi: 10.1038/bjc.2012.70. Epub 2012 Mar 13.
11 Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
12 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
13 Multum Information Services, Inc. Expert Review Panel.