Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMODA2X)

• Drug Name: Bardoxolone methyl Drug Info
• Synonyms: BARD; WPTTVJLTNAWYAO-OYWPANLISA-N; 218600-53-4

Indication

Disease Entry	ICD 11	Status	REF
Mixed connective tissue disease	4A43.3	Phase 3	[1]
Pulmonary arterial hypertension	BB01.0	Phase 2	[2]
Pulmonary hypertension	BB01	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 400769
  CAS Number: CAS 218600-53-4
  TTD Drug ID: DMODA2X
  VARIDT Drug ID: DR00793

Molecule-Related Drug Atlas

Drug(s) Targeting PPAR-gamma messenger RNA (PPARG mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AD-5075	DM1SLJ9	Type-2 diabetes	5A11	Terminated	[7]
2-chloro-5-nitro-N-phenylbenzamide	DMUGQIV	Discovery agent	N.A.	Investigative	[8]
L-783483	DM6OTGE	Discovery agent	N.A.	Investigative	[9]
LG100754	DMEK4FY	Discovery agent	N.A.	Investigative	[10]
L-796449	DMWTGQM	Discovery agent	N.A.	Investigative	[11]
L-165461	DMKBSGN	Discovery agent	N.A.	Investigative	[11]
AD-5061	DM5WV13	Discovery agent	N.A.	Investigative	[12]
TZD18	DMVCHOX	Discovery agent	N.A.	Investigative	[13]
(9Z,12E)-12-nitrooctadeca-9,12-dienoic acid	DM2REIN	Discovery agent	N.A.	Investigative	[14]
reglitazar	DMQ3ER0	Discovery agent	N.A.	Investigative	[15]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[20]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[25]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[32]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[36]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[39]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[43]

Drug(s) Affected By Muscarinic acetylcholine receptor M2 (CHRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[44]
Gallamine Triethiodide	DMPO0MS	Stabilize muscle contraction	FB3Z	Approved	[44]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[47]
Omadacycline	DMR2J95	Acute bacterial skin infection	1C41	Approved	[48]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[49]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[50]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[52]

Drug(s) Affected By Muscarinic acetylcholine receptor M1 (CHRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pirenzepine	DMP6M1N	Peptic ulcer	DA61	Approved	[53]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[55]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[56]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[57]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[58]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[59]
Gallamine Triethiodide	DMPO0MS	Stabilize muscle contraction	FB3Z	Approved	[60]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[56]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[50]

Drug(s) Affected By D(2) dopamine receptor (DRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Droperidol	DM0DXA8	Nausea	MD90	Approved	[54]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[54]
Zuclopenthixol	DMKYD5N	Schizophrenia	6A20	Approved	[54]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[61]
Sulpiride	DMF54ZG	Schizophrenia	6A20	Approved	[62]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[63]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[64]
Methamphetamine	DMPM4SK	Anxiety		Approved	[65]
Bromocriptine	DMVE3TK	Acromegaly	5A60.0	Approved	[66]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[67]

Drug(s) Affected By Alpha-2C adrenergic receptor (ADRA2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[71]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[74]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[75]
Xylometazoline	DMKV32D	Allergic rhinitis	CA08.0	Phase 4	[69]

Drug(s) Affected By D(1A) dopamine receptor (DRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[54]
Haloperidol	DM96SE0	Delirium		Approved	[76]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[77]
Pergolide mesylate	DM5GKOV	N. A.	N. A.	Approved	[78]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[76]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[80]
Methamphetamine	DMPM4SK	Anxiety		Approved	[81]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[82]

Drug(s) Affected By Substance-P receptor (TACR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[84]
SU5402	DM9JON3	Multiple myeloma	2A83	Investigative	[85]
Manganese	DMKT129	N. A.	N. A.	Investigative	[86]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[87]

Drug(s) Affected By 5-hydroxytryptamine receptor 2A (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[54]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[67]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[88]
Haloperidol	DM96SE0	Delirium		Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[89]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[90]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[91]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[92]

Drug(s) Affected By 5-hydroxytryptamine receptor 2C (HTR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[93]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[93]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[93]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By Histamine H1 receptor (HRH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[100]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[100]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[102]

Drug(s) Affected By Alpha-1B adrenergic receptor (ADRA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[103]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[69]
Terbutaline	DMD4381	Asthma	CA23	Approved	[105]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[103]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[91]

Drug(s) Affected By Mu-type opioid receptor (OPRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alvimopan	DMHR8KW	Gastrointestinal disease	DE2Z	Approved	[107]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[108]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[112]
Oliceridine	DM6MDCF	Acute pain	MG31	Approved	[108]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[114]

Drug(s) Affected By Vasopressin V1a receptor (AVPR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[116]
Vasopressin	DMQ2FPC	Diabetes insipidus	5A61.5	Approved	[80]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[118]
Insulin	DMB7CE0	Diabetic complication	5A2Y	Approved	[54]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[54]
Alprostadil	DMWH7NQ	Aorta coarctation		Approved	[54]
Dinoprost Tromethamine	DMXQKSL	Abortion	JA00	Approved	[54]

Drug(s) Affected By Kappa-type opioid receptor (OPRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[120]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[121]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[122]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[119]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[123]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[54]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[128]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[102]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[129]

Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[130]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[132]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[133]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[49]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[134]

Drug(s) Affected By Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[137]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[140]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[141]

Drug(s) Affected By NF-kappa-B inhibitor epsilon (NFKBIE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[146]
Bortezomib	DMNO38U	Leukemia		Approved	[147]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[148]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[140]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]

Drug(s) Affected By SH3 domain-binding protein 5 (SH3BP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[98]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[155]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[156]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[158]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[159]

Drug(s) Affected By Dynamin-like 120 kDa protein, mitochondrial (OPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[146]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[163]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]

Drug(s) Affected By Mitofusin-2 (MFN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[146]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[167]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[49]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[169]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[170]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[172]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[140]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[173]

Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[175]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[176]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[179]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[180]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[183]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[184]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[191]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[192]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[193]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[195]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[196]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[141]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, muscle type (PFKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[146]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[200]
Clotrimazole	DMMFCIH	Cutaneous candidiasis	1F23.14	Approved	[199]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[49]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[118]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[202]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[203]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[204]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[205]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[206]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[210]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[212]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[213]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[213]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[214]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[215]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[216]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[217]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Selenium	DM25CGV	N. A.	N. A.	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[222]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[221]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[223]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[224]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[226]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[36]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Selenium	DM25CGV	N. A.	N. A.	Approved	[229]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[230]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[231]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[218]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[232]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[32]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[234]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[235]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[234]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[236]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[237]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[238]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[239]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[241]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[141]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[141]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[141]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[244]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[216]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[247]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[248]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[249]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[251]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[252]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[254]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[255]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[256]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[257]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[258]

Drug(s) Affected By Pyruvate kinase PKM (PKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[264]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[265]

Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[267]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[267]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]

Drug(s) Affected By Beta-1,4-galactosyltransferase 1 (B4GALT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[268]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[146]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[71]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[269]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[269]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[269]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[270]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[271]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[181]

Drug(s) Affected By Glutathione peroxidase 2 (GPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[274]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[276]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[277]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[150]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[280]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[218]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[280]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[5]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[282]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[280]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[283]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[284]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[37]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[292]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[294]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[296]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[297]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[298]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[196]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[197]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[150]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[300]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[301]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[302]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[303]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[37]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[304]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[247]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]

Drug(s) Affected By Lon protease homolog, mitochondrial (LONP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[307]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[307]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[308]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[311]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[312]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[313]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[316]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[284]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[318]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[319]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[320]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[321]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[323]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[324]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[273]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[326]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[327]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[298]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[328]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[329]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[330]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[197]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[331]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[333]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[334]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[335]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[245]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[336]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[337]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[274]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[130]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[340]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[342]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[343]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[345]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[239]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[346]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[347]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[348]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[239]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[239]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[349]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[218]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[350]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[222]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[140]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[351]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[353]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[353]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[354]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[355]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[353]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[353]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[353]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[353]

Drug(s) Affected By Antigen peptide transporter 1 (TAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[239]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[357]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[358]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[359]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[360]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[361]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[362]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[363]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[282]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[284]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[365]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[368]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[141]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[141]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[265]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]

Drug(s) Affected By Neutral amino acid transporter B(0) (SLC1A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[369]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[141]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[146]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[369]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[141]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[369]

Drug(s) Affected By Mitofusin-1 (MFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[163]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[167]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[371]
Bortezomib	DMNO38U	Leukemia		Approved	[372]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[374]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[375]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[376]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[377]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]

Drug(s) Affected By Thyroid hormone-inducible hepatic protein (THRSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[275]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[379]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[275]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[275]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[380]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[380]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]

Drug(s) Affected By Multidrug and toxin extrusion protein 1 (SLC47A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[381]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[382]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[383]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[382]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[384]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[128]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[382]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[386]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[387]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[388]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[389]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[390]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[391]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[196]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[197]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[331]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[301]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]

Drug(s) Affected By Sigma non-opioid intracellular receptor 1 (SIGMAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[146]
Bortezomib	DMNO38U	Leukemia		Approved	[372]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[72]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[392]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[393]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[98]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[393]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[394]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[5]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[141]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[140]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[141]

Drug(s) Affected By Prolyl hydroxylase EGLN3 (EGLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[395]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[49]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[75]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[146]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[396]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[397]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[49]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PPAR-gamma messenger RNA (PPARG mRNA)	TTT2SVW	PPARG_HUMAN	Antagonist	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Gene/Protein Processing	[4]
5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2)	OTHTAM54	AAKG2_HUMAN	Gene/Protein Processing	[5]
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Gene/Protein Processing	[4]
5-hydroxytryptamine receptor 2C (HTR2C)	OT6H8DE0	5HT2C_HUMAN	Gene/Protein Processing	[4]
Alpha-1B adrenergic receptor (ADRA1B)	OTSAYAFD	ADA1B_HUMAN	Gene/Protein Processing	[4]
Alpha-2C adrenergic receptor (ADRA2C)	OT5B9RKP	ADA2C_HUMAN	Gene/Protein Processing	[4]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[5]
AN1-type zinc finger protein 2A	OTTG7P8R	ZFN2A_HUMAN	Gene/Protein Processing	[5]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Gene/Protein Processing	[6]
Antigen peptide transporter 1 (TAP1)	OTJL27PW	TAP1_HUMAN	Gene/Protein Processing	[5]

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