Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTLSRBZ)

DTT Name Sorbitoldehydrogenase (SORD)
Synonyms SORD; SDH; L-iditol2-dehydrogenase
Gene Name SORD
DTT Type
Literature-reported target
 [1]
BioChemical Class
Short-chain dehydrogenases reductase
UniProt ID
DHSO_HUMAN
TTD ID
T59445
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 1.1.1.-
Sequence
MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNF
IVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFC
ATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCG
AGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQL
GCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRY
CNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
Function Convertssorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.
KEGG Pathway
Pentose and glucuronate interconversions (hsa00040 )
Fructose and mannose metabolism (hsa00051 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Formation of xylulose-5-phosphate (R-HSA-5661270 )
Fructose biosynthesis (R-HSA-5652227 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
CP-470,711 DMS2RHE Discovery agent N.A. Investigative [2]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [1]
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name Sorbitol dehydrogenase (SORD) DME Info
Gene Name SORD
2 Approved Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [3]
Sorbitol DMAN0DE Constipation DD91.1 Approved [4]
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References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Sorbitol dehydrogenase: a novel target for adjunctive protection of ischemic myocardium. FASEB J. 2003 Dec;17(15):2331-3.
3 Isolation, characterization and evaluation of the Pichia pastoris sorbitol dehydrogenase promoter for expression of heterologous proteins. Protein Expr Purif. 2013 Nov;92(1):128-33.
4 Plasma concentration of iditol dehydrogenase (sorbitol dehydrogenase) in ponies treated with aflatoxin B1. Am J Vet Res. 1980 Jun;41(6):925-7.