Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DE2GB8N)

• DME Name: UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
• Gene Name: UGT1A8

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Darolutamide	DMV7YFT	Prostate cancer	2C82.0	Approved	[1]
Empagliflozin	DMRF9YK	Type-1 diabetes	5A10	Approved	[2]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[3]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[4]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[5]

1 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[4]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anthraflavic acid	DMN1YFU	N. A.	N. A.	Investigative	[4]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[4]
Cis-4-hydroxytamoxifen	DMRFTB5	N. A.	N. A.	Investigative	[5]
phloretin	DMYA50U	Discovery agent	N.A.	Investigative	[4]

References

• [1] Drug-drug interaction potential of darolutamide: in vitro and clinical studies. Eur J Drug Metab Pharmacokinet. 2019 Dec;44(6):747-759.
• [2] Empagliflozin (Jardiance): a novel SGLT2 inhibitor for the treatment of type-2 diabetes. P T. 2015 Jun;40(6):364-8.
• [3] Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy. Future Oncol. 2010 Apr;6(4):563-85.
• [4] Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41.
• [5] Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2006-14.