Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DE3GT9C)

• DME Name: Cytochrome P450 4F2 (CYP4F2) DME Info
• Gene Name: CYP4F2

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[1]
Fingolimod	DM5JVAN	Multiple sclerosis	8A40	Approved	[2]
Ebastine	DMH21D9	N. A.	N. A.	Phase 4	[3]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pafuramidine	DMFKOR9	Malaria	1F40-1F45	Phase 3	[4]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[5]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[6]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[7]

References

• [1] Cloning and characterization of CYP4F21: a prostaglandin E2 20-hydroxylase of ram seminal vesicles. Arch Biochem Biophys. 2001 May 1;389(1):123-9.
• [2] CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis. Drug Metab Dispos. 2011 Feb;39(2):191-8.
• [3] cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine. Biochem Biophys Res Commun. 2001 Feb 2;280(4):1135-41.
• [4] Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. Drug Metab Dispos. 2007 Nov;35(11):2067-75.
• [5] Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism. Ann N Y Acad Sci. 2004 Dec;1031:13-21.
• [6] Product information - Gilenya.
• [7] Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. Biochim Biophys Acta. 2011 Jan;1814(1):210-22.