Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DTQ3ZHF)

• DTP Name: Multidrug resistance-associated protein 3 (ABCC3) DTP Info
• Gene Name: MRP3

Molecule-Related Drug & Molecule List

16 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[1]
Dehydroepiandrosterone sulfate	DM4Q80H	N. A.	N. A.	Approved	[2]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[3]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[4]
Etravirine	DMGV8QU	Human immunodeficiency virus-1 infection	1C62	Approved	[5]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[6]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[8]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[9]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[10]
Leucovorin	DMUAZWG	Colon adenocarcinoma		Approved	[9]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[11]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[12]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[13]
Technetium (99MTC) mebrofenin	DMUEWM3	N. A.	N. A.	Approved	[14]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[15]

5 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GLYCYRRHIZIN	DM8M2N3	Influenza virus infection	1E30-1E32	Phase 3	[16]
Cholyl lysyl fluorescein	DMALN2M	N. A.	N. A.	Phase 2	[17]
Glutathione-S-S-glutathione	DMJ85FS	N. A.	N. A.	Phase 2	[18]
Sodium taurocholate	DM3GO0J	Type-2 diabetes	5A11	Phase 1/2	[19]
Taurocholic Acid	DM2LZ8F	Type-2 diabetes	5A11	Phase 1/2	[19]

3 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epipodophyllotoxins	DMVNR20	N. A.	N. A.	Preclinical	[15]
Monomethyl-auristatin-E	DMG2UJS	N. A.	N. A.	Preclinical	[13]
Scutellarin	DMJT1E5	N. A.	N. A.	Preclinical	[20]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
glycocholic acid	DM0SXNM	Discovery agent	N.A.	Investigative	[21]
[3H]estradiol-17beta-glucuronide	DM3KJ45	Discovery agent	N.A.	Investigative	[19]

References

• [1] Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21.
• [2] Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites. Eur J Pharm Sci. 2006 Apr;27(5):447-86.
• [3] Induction of multiple drug transporters by efavirenz. J Pharmacol Sci. 2009 Feb;109(2):242-50.
• [4] Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. Biochemistry. 2009 May 26;48(20):4423-30.
• [5] Interaction potential of etravirine with drug transporters assessed in vitro. Antimicrob Agents Chemother. 2011 Mar;55(3):1282-4.
• [6] Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009 Aug;37(8):1698-702.
• [7] Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Mol Pharmacol. 2008 May;73(5):1474-83.
• [8] ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
• [9] Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32.
• [10] Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102.
• [11] Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13;42(18):5429-37.
• [12] Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch. 2007 Feb;453(5):661-73.
• [13] Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer. Cancer Res. 2008 Jul 1;68(13):5380-9.
• [14] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
• [15] Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7.
• [16] The combination of glycyrrhizin and lamivudine can reverse the cisplatin resistance in hepatocellular carcinoma cells through inhibition of multidrug resistance-associated proteins. Int J Oncol. 2007 Dec;31(6):1465-72.
• [17] The emerging role of transport systems in liver function tests. Eur J Pharmacol. 2012 Jan 30;675(1-3):1-5.
• [18] MRP2 and 3 in health and disease. Cancer Lett. 2006 Mar 8;234(1):51-61.
• [19] Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3. Biochemistry. 2003 Aug 26;42(33):9989-10000.
• [20] Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics. Drug Metab Dispos. 2012 Oct;40(10):2009-20.
• [21] Measurement of transport activities of bile acids in human multidrug resistance-associated protein 3 using liquid chromatography-tandem mass spectrometry. Anal Sci. 2010;26(3):317-23.