Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT9ISBX)

• DTT Name: HIF-prolyl hydroxylase 2 (HPH-2) DTT Info
• Gene Name: EGLN1

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FG-4592	DM4XSQ2	Anaemia	3A90	Phase 3	[1]

33 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US10100051, Compound 1	DMJKS4X	N. A.	N. A.	Patented	[2]
US10100051, Compound 10	DMQ7ODW	N. A.	N. A.	Patented	[2]
US10100051, Compound 11	DM2DEOA	N. A.	N. A.	Patented	[2]
US10100051, Compound 2	DMWESZ1	N. A.	N. A.	Patented	[2]
US10149841, Compound 1	DMEVGR6	N. A.	N. A.	Patented	[3]
US10149841, Compound 19	DMYSI9J	N. A.	N. A.	Patented	[3]
US10149841, Compound 5	DMBS50K	N. A.	N. A.	Patented	[3]
US10149841, Compound 9	DMS415A	N. A.	N. A.	Patented	[3]
US8536181, A41	DMF9LNO	N. A.	N. A.	Patented	[4]
US8536181, C14	DMZNF59	N. A.	N. A.	Patented	[4]
US8536181, C17	DMRTL63	N. A.	N. A.	Patented	[5]
US8536181, C35	DMAM51Z	N. A.	N. A.	Patented	[4]
US8598210, Table XV, 1	DM9YI3K	N. A.	N. A.	Patented	[6]
US8598210, Table XV, 2	DMDK98P	N. A.	N. A.	Patented	[7]
US8598210, Table XV, 4	DM3XWMO	N. A.	N. A.	Patented	[6]
US8598210, Table XV, 5	DMEU5ST	N. A.	N. A.	Patented	[8]
US8921389, 1	DM34KXF	N. A.	N. A.	Patented	[9]
US8921389, 123	DM8NE12	N. A.	N. A.	Patented	[10]
US8921389, 2	DMX7KDR	N. A.	N. A.	Patented	[9]
US8921389, 210	DME1A80	N. A.	N. A.	Patented	[9]
US8921389, 22	DMIY68N	N. A.	N. A.	Patented	[10]
US9340511, 2	DM0GOCZ	N. A.	N. A.	Patented	[11]
US9340511, 5	DMFQERG	N. A.	N. A.	Patented	[11]
US9340511, 6	DMRL0WA	N. A.	N. A.	Patented	[12]
US9340511, 7	DMC0PUI	N. A.	N. A.	Patented	[11]
US9409892, 136	DMMFC0V	N. A.	N. A.	Patented	[13]
US9409892, 148	DMZJTSP	N. A.	N. A.	Patented	[13]
US9409892, 19	DMHF2OX	N. A.	N. A.	Patented	[13]
US9409892, 59	DMWAL5Q	N. A.	N. A.	Patented	[13]
US9422240, 1-282	DMV4AHL	N. A.	N. A.	Patented	[14]
US9422240, 1-286	DM0S2UK	N. A.	N. A.	Patented	[14]
US9422240, 1-297	DMST6IF	N. A.	N. A.	Patented	[14]
US9422240, 1-298	DMH7DL5	N. A.	N. A.	Patented	[14]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IOX1	DMYG0M5	Discovery agent	N.A.	Investigative	[15]
IOX2	DMQ0X7I	Discovery agent	N.A.	Investigative	[16]
KRH-102053	DMXFBER	Solid tumour/cancer	2A00-2F9Z	Investigative	[17]

References

• [1] Crystalline forms of a prolyl hydroxylase inhibitor. US9115085.
• [2] Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof. US10100051.
• [3] Compound of 3-hydroxyl pyridine, preparation method thereof and pharmaceutical use thereof. US10149841.
• [4] Prolyl hydroxylase inhibitors. US8536181.
• [5] Methods for increasing the stabilization of hypoxia inducible factor-1 alpha. US8778412.
• [6] Prolyl hydroxylase inhibitors and methods of use. US8598210.
• [7] Prolyl hydroxylase inhibitors and methods of use. US9598370.
• [8] Prolyl hydroxylase inhibitors and method of use. US8722895.
• [9] Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase. US9695170.
• [10] Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase. US8921389.
• [11] Process for making isoquinoline compounds. US9708269.
• [12] Process for making isoquinoline compounds. US9340511.
• [13] 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors. US9409892.
• [14] Partially saturated nitrogen-containing heterocyclic compound. US9422240.
• [15] A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71.
• [16] Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96.
• [17] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2833).