Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTUNARX)

• DTT Name: Carbonic anhydrase (CA) DTT Info
• Gene Name: CA

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quinethazone	DMWCOSR	Hypertension	BA00-BA04	Approved	[1]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[2]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[3]

5 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[4]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[5]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[4]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[6]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[7]

6 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[5]
Imatinib and nilotinib derivative 1	DMMJTUW	Cas mediated disorder	N.A.	Patented	[8]
Imatinib and nilotinib derivative 2	DM34NZ8	Cas mediated disorder	N.A.	Patented	[8]
PMID30074415-Compound-19	DM06PX4	N. A.	N. A.	Patented	[8]
PMID30074415-Compound-20	DMX9LGW	N. A.	N. A.	Patented	[8]
PMID30074415-Compound-21	DM3NPOU	N. A.	N. A.	Patented	[8]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CLIOQUINOL	DM746BZ	N. A.	N. A.	Withdrawn from market	[2]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[9]

106 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(2-bromophenyl)difluoromethanesulfonamide	DMFX9H8	Discovery agent	N.A.	Investigative	[10]
(4-bromophenyl)difluoromethanesulfonamide	DMOCYZJ	Discovery agent	N.A.	Investigative	[10]
1-(3,4-dichlorophenyl)-3-hydroxyurea	DMVOJ7K	Discovery agent	N.A.	Investigative	[11]
2,3-dihydro-1H-indene-5-sulfonamide	DM46MKY	Discovery agent	N.A.	Investigative	[12]
2,4-Disulfamyltrifluoromethylaniline	DM2AW0Z	Discovery agent	N.A.	Investigative	[3]
2,5-difluorophenol	DMIGFX6	Discovery agent	N.A.	Investigative	[13]
2-acetamido-2,3-dihydro-1H-indene-5-sulfonic acid	DMIQM4O	Discovery agent	N.A.	Investigative	[12]
2-amino-2,3-dihydro-1H-indene-5-sulfonamide	DMQOCAY	Discovery agent	N.A.	Investigative	[12]
2-Amino-benzenesulfonamide	DMEMANH	Discovery agent	N.A.	Investigative	[3]
2-Amino-indan-5-sulfonic acid	DMCUSH1	Discovery agent	N.A.	Investigative	[12]
2-hydrazinylbenzenesulfonamide	DMCNXZM	Discovery agent	N.A.	Investigative	[3]
2-oxo-2H-chromene-3-carboxylic acid	DMFN769	Discovery agent	N.A.	Investigative	[14]
2-oxo-2H-thiochromene-3-carboxylic acid	DMZTCOM	Discovery agent	N.A.	Investigative	[14]
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[15]
3,5-difluorophenol	DM4VT0Q	Discovery agent	N.A.	Investigative	[2]
3-(4-sulfamoylphenyl)propanoic acid	DMBDW8P	Discovery agent	N.A.	Investigative	[16]
3-Amino-benzenesulfonamide	DME0TNA	Discovery agent	N.A.	Investigative	[17]
3-bromophenyl-difluoromethanesulfonamide	DMXZW3R	Discovery agent	N.A.	Investigative	[10]
3-Nitro-benzenesulfonamide	DMAY4OZ	Discovery agent	N.A.	Investigative	[18]
4-(2-AMINOETHYL)BENZENESULFONAMIDE	DMEK6WX	Discovery agent	N.A.	Investigative	[19]
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide	DMWG706	Discovery agent	N.A.	Investigative	[3]
4-(2-Hydroxy-ethyl)-benzenesulfonamide	DM1C5U6	Discovery agent	N.A.	Investigative	[3]
4-(2-Phenylacetamido)-3-bromobenzenesulfonamide	DMZ62L3	Discovery agent	N.A.	Investigative	[20]
4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide	DM9GOTA	Discovery agent	N.A.	Investigative	[20]
4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide	DMCOD4N	Discovery agent	N.A.	Investigative	[20]
4-(2-Phenylacetamido)benzenesulfonamide	DMFYR6H	Discovery agent	N.A.	Investigative	[20]
4-(2-Phenylacetamidoethyl)benzenesulfonamide	DM1JL03	Discovery agent	N.A.	Investigative	[20]
4-(2-Phenylacetamidomethyl)benzenesulfonamide	DMDYHXE	Discovery agent	N.A.	Investigative	[20]
4-(2-Pyridin-2-ylacetamido)benzenesulfonamide	DM9LKMP	Discovery agent	N.A.	Investigative	[20]
4-(2-Pyridin-4-ylacetamido)benzenesulfonamide	DMD6AYQ	Discovery agent	N.A.	Investigative	[20]
4-(hydroxymethyl)benzenesulfonamide	DMR6VWL	Discovery agent	N.A.	Investigative	[3]
4-amino-3,5-dibromobenzenesulfonamide	DMDCQAX	Discovery agent	N.A.	Investigative	[21]
4-Amino-3-bromo-benzenesulfonamide	DMVUCZK	Discovery agent	N.A.	Investigative	[3]
4-Amino-3-chloro-benzenesulfonamide	DMERTQ4	Discovery agent	N.A.	Investigative	[3]
4-amino-3-fluoro-5-iodobenzenesulfonamide	DMR9M6H	Discovery agent	N.A.	Investigative	[21]
4-Amino-3-fluoro-benzenesulfonamide	DMIQ3VR	Discovery agent	N.A.	Investigative	[3]
4-Amino-3-iodo-benzenesulfonamide	DMCOYHR	Discovery agent	N.A.	Investigative	[3]
4-amino-6-chlorobenzene-1,3-disulfonamide	DMIWGZS	Discovery agent	N.A.	Investigative	[3]
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	DMJZNX6	Discovery agent	N.A.	Investigative	[3]
4-AMINOPHENOL	DMYC1T6	Discovery agent	N.A.	Investigative	[13]
4-azidobenzenesulfonamide	DM7EQ06	Discovery agent	N.A.	Investigative	[22]
4-bromophenylboronic acid	DM2YN37	Discovery agent	N.A.	Investigative	[23]
4-butylphenylboronic acid	DMD9FZW	Discovery agent	N.A.	Investigative	[23]
4-CYANOPHENOL	DMN12EX	Discovery agent	N.A.	Investigative	[13]
4-Hydrazino-benzenesulfonamide	DM49B18	Discovery agent	N.A.	Investigative	[3]
4-methoxyphenylboronic acid	DMP5YFQ	Discovery agent	N.A.	Investigative	[23]
4-methylphenyl-difluoromethanesulfonamide	DMR5NLM	Discovery agent	N.A.	Investigative	[10]
4-Nitro-benzenesulfonamide	DMZY8UW	Discovery agent	N.A.	Investigative	[18]
4-nitrophenyl phosphate	DMBX4UJ	Discovery agent	N.A.	Investigative	[24]
4-nitrophenyl-difluoromethanesulfonamide	DM9ETMD	Discovery agent	N.A.	Investigative	[10]
4-phenoxyphenylboronic acid	DMMWYI9	Discovery agent	N.A.	Investigative	[23]
4-Thiocyanato-benzenesulfonamide	DMUGMVI	Discovery agent	N.A.	Investigative	[18]
4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide	DMH3UPO	Discovery agent	N.A.	Investigative	[20]
4-[2-(2-Thienyl)acetamido]benzenesulfonamide	DMYESXB	Discovery agent	N.A.	Investigative	[20]
6-(aminomethyl)-2H-chromen-2-one	DMJU9TG	Discovery agent	N.A.	Investigative	[14]
6-(hydroxymethyl)-2H-chromen-2-one	DM5TOX2	Discovery agent	N.A.	Investigative	[14]
6-Hydroxy-benzothiazole-2-sulfonic acid amide	DM2B4S5	Discovery agent	N.A.	Investigative	[3]
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid	DM7WH82	Discovery agent	N.A.	Investigative	[14]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid	DMZ6HQL	Discovery agent	N.A.	Investigative	[14]
7-(benzyloxy)-2H-chromen-2-one	DMTKFPW	Discovery agent	N.A.	Investigative	[14]
7-butoxy-2H-chromen-2-one	DM78C5A	Discovery agent	N.A.	Investigative	[14]
7-methoxy-2-oxo-2H-chromene-4-carboxylic acid	DMJITU0	Discovery agent	N.A.	Investigative	[14]
7-phenethoxy-2H-chromen-2-one	DM8Q267	Discovery agent	N.A.	Investigative	[14]
7-propoxy-2H-chromen-2-one	DMD5CB6	Discovery agent	N.A.	Investigative	[14]
8-methoxy-2-oxo-2H-chromene-3-carboxylic acid	DMHCWY8	Discovery agent	N.A.	Investigative	[14]
BENZOLAMIDE	DME5QPX	Discovery agent	N.A.	Investigative	[3]
Benzothiazole-2-sulfonic acid amide	DMROP5Q	Discovery agent	N.A.	Investigative	[19]
Beta-naphthylboronic acid	DMZ8Y67	Discovery agent	N.A.	Investigative	[23]
Biphenyl-4-ylboronic acid	DMIHMP5	Discovery agent	N.A.	Investigative	[23]
Carzenide	DMVD481	Discovery agent	N.A.	Investigative	[3]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[4]
CATECHOL	DML0YEK	Discovery agent	N.A.	Investigative	[5]
CL-5343	DM9AFZ3	Solid tumour/cancer	2A00-2F9Z	Investigative	[25]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[14]
Decane-1,10-diyl disulfamate	DM1ESVR	Discovery agent	N.A.	Investigative	[26]
Decyl sulfamate	DMIERWO	Discovery agent	N.A.	Investigative	[26]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[5]
ETHOXYCOUMARIN	DMSKU4M	Discovery agent	N.A.	Investigative	[14]
Ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate	DMWIB0V	Discovery agent	N.A.	Investigative	[14]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[5]
HERNIARIN	DM9UASM	Discovery agent	N.A.	Investigative	[14]
Hexane-1,6-diamine	DMSHF0K	Discovery agent	N.A.	Investigative	[9]
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide	DMNQDLC	Discovery agent	N.A.	Investigative	[27]
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide	DMA21WB	Discovery agent	N.A.	Investigative	[27]
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide	DM5E7OC	Discovery agent	N.A.	Investigative	[27]
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide	DMSI4PE	Discovery agent	N.A.	Investigative	[27]
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide	DMXLJGR	Discovery agent	N.A.	Investigative	[27]
N1-(2-aminoethyl)ethane-1,2-diamine	DM6HM5S	Discovery agent	N.A.	Investigative	[9]
N1-(naphthalen-1-yl)ethane-1,2-diamine	DMYGCSV	Discovery agent	N.A.	Investigative	[9]
Octane-1,8-diyl disulfamate	DMBQMGH	Discovery agent	N.A.	Investigative	[26]
Octyl sulfamate	DM40ZCA	Discovery agent	N.A.	Investigative	[26]
P-Coumaric Acid	DMGJSVD	Discovery agent	N.A.	Investigative	[5]
P-toluenesulfonamide	DMPEKTO	Discovery agent	N.A.	Investigative	[3]
P-tolylboronic acid	DM8MZF4	Discovery agent	N.A.	Investigative	[23]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[24]
Pentane-1,5-diamine	DMVPZG9	Discovery agent	N.A.	Investigative	[9]
Phenyl Boronic acid	DMFZH49	Discovery agent	N.A.	Investigative	[28]
Phenylarsonic acid	DMFRA1Y	Discovery agent	N.A.	Investigative	[28]
PHENYLDIFLUOROMETHANESULFONAMIDE	DME75VC	Discovery agent	N.A.	Investigative	[10]
PHENYLMETHANESULFONAMIDE	DMGLDFI	Discovery agent	N.A.	Investigative	[10]
PRONTOCIL	DMIUV25	Discovery agent	N.A.	Investigative	[21]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[13]
SACCHARIN	DMRA736	Discovery agent	N.A.	Investigative	[29]
Sodium maleate	DM2WUZA	Discovery agent	N.A.	Investigative	[30]
SULFAMATE	DMF1589	Discovery agent	N.A.	Investigative	[28]
Syringic Acid	DM802V7	Discovery agent	N.A.	Investigative	[5]

References

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• [12] Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60.
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• [14] Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44.
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• [22] Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7.
• [23] Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5.
• [24] Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of - but not of -, - and -carbonic anhydrases. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12.
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