Details of Disease

General Information of Disease (ID: DIS04U9T)

• Disease Name: Streptococcus infection
• Synonyms: infection, streptococcal; infections, streptococcal; Streptococcus caused disease or disorder; streptococcal infection; Streptococcus disease or disorder; Streptococcus infectious disease
• Disease Class: 1D01: Infectious meningitis
• Definition: Any of the several infectious disorders caused by members of streptococcus, a genus of gram positive bacteria belonging to the family Streptococcaceae. Streptococcal infections are classified into Groups A, B, C, D and G.
• Disease Hierarchy:
  DISZ44JH: Gram-positive bacterial infection
  DISEM33Q: Infectious disease
  DIS04U9T: Streptococcus infection
• ICD Code:
  ICD-11: ICD-11: 1B53
  ICD-10: ICD-10: G00.1, G00.2
• Disease Identifiers:
  MONDO ID: MONDO_0021680
  MESH ID: D013290
  UMLS CUI: C0038395
  MedGen ID: 20963
  SNOMED CT ID: 85769006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 5 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[1]
Lincomycin	DMVTHER	Approved	Small molecular drug	[2]
Pneumococcal 13-valent conjugate vaccine	DMG8MLJ	Approved	NA	[3]
Pneumococcal vaccine	DMWE5VU	Approved	NA	[4]
Synflorix	DMY976H	Phase 4	NA	[5]

This Disease is Treated as An Indication in 7 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benzylpenicillin	DMS9503	Phase 3	Small molecular drug	[6]
PF-06760805	DMQRMW9	Phase 2	NA	[7]
S. pneumococcal next-generation vaccine	DMC72B6	Phase 2	NA	[8]
S. pneumoniae paediatric next generation	DM654NZ	Phase 2	NA	[9]
GSK-2231395A	DMZIGR8	Phase 1	NA	[10]
RASV-Sp	DM4VTX6	Phase 1	Vaccine	[11]
Streptococcus pneumoniae vaccine	DM3136S	Phase 1	NA	[12]

This Disease is Treated as An Indication in 3 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
IC-47	DMZ9JDR	Discontinued in Phase 1	NA	[13]
Streptococcus pneumoniae vaccine, Cytovax	DMLLNZX	Terminated	NA	[14]
Streptococcus vaccines	DMF26I7	Terminated	NA	[15]

This Disease is Treated as An Indication in 4 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
LipoNeu	DMNTCSI	Investigative	NA	[16]
PdB-W433F	DMVYV06	Investigative	NA	[16]
PneuGEM	DM6ND91	Investigative	NA	[16]
PPS14 PCMV	DM42N7T	Investigative	NA	[16]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
RAB9A	TT958S6	Limited	Biomarker	[17]
RPS6KA6	TT3KYWB	Limited	Biomarker	[18]
GALNS	TTT9YPO	Strong	Biomarker	[19]
GAST	TT4LRVO	Strong	Biomarker	[19]

This Disease Is Related to 7 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CFHR5	OT7BMOYE	Limited	Genetic Variation	[20]
RAB23	OTBAKFBR	Limited	Biomarker	[17]
RNF5	OTDQGI37	Limited	Biomarker	[21]
TMEM8B	OTJZWPS6	Limited	Biomarker	[22]
FCN2	OTTHJBKZ	Strong	Genetic Variation	[23]
MYOM2	OTD2UOXW	Strong	Biomarker	[24]
PAGR1	OTXR5PQ8	Strong	Biomarker	[19]

References

• [1] Impetigo: diagnosis and treatment. Am Fam Physician. 2014 Aug 15;90(4):229-35.
• [2] Lincomycin FDA Label
• [3] Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [5] ClinicalTrials.gov (NCT01235949) Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment. U.S. National Institutes of Health.
• [6] Prevalence and treatment of group B streptococcus colonization based on risk factors versus intrapartum culture screening. Eur J Obstet Gynecol Reprod Biol. 2019 Sep;240:178-181.
• [7] Clinical pipeline report, company report or official report of Pfizer.
• [8] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [9] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [10] ClinicalTrials.gov (NCT00849069) Study to Assess the Safety of a New GSK Biologicals' GSK2231395A Candidate Vaccine. U.S. National Institutes of Health.
• [11] Rapid, Sensitive Recovery of Recombinant Attenuated Salmonella enterica Serovar Typhi Vaccine Strains from Human Blood. Clin Vaccine Immunol. 2013 September; 20(9): 1473-1478.
• [12] Safety and immunogenicity of pneumococcal protein vaccine candidates: monovalent choline-binding protein A (PcpA) vaccine and bivalent PcpA-pneumococcal histidine triad protein D vaccine. Vaccine. 2012 Dec 14;30(52):7461-8.
• [13] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024371)
• [14] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016539)
• [15] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010392)
• [16] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [17] The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection.Cell Microbiol. 2012 Aug;14(8):1149-65. doi: 10.1111/j.1462-5822.2012.01792.x. Epub 2012 Apr 17.
• [18] Novel interacting proteins identified by tandem affinity purification coupled to nano LC-MS/MS interact with ribosomal S6 protein kinase 4 (RSK4) and its variant protein (RSK4m).Int J Biol Macromol. 2017 Mar;96:421-428. doi: 10.1016/j.ijbiomac.2016.12.030. Epub 2016 Dec 13.
• [19] The Emergence of Hypervirulent M1T1 Clone of Group A Streptococcus via Genetic Recombination and Host Selection.Curr Issues Mol Biol. 2019;32:435-472. doi: 10.21775/cimb.032.435. Epub 2019 Jun 5.
• [20] Acute presentation and persistent glomerulonephritis following streptococcal infection in a patient with heterozygous complement factor H-related protein 5 deficiency.Am J Kidney Dis. 2012 Jul;60(1):121-5. doi: 10.1053/j.ajkd.2012.02.329. Epub 2012 Apr 13.
• [21] Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection.PLoS Genet. 2012;8(10):e1003007. doi: 10.1371/journal.pgen.1003007. Epub 2012 Oct 18.
• [22] Expression and purification of a rapidly degraded protein, TMEM8B-a, in mammalian cell line.Protein Expr Purif. 2018 Nov;151:38-45. doi: 10.1016/j.pep.2018.06.002. Epub 2018 Jun 8.
• [23] MBL2 and FCN2 gene polymorphisms in a cohort of Italian children with rheumatic fever: A case-control study.Semin Arthritis Rheum. 2017 Oct;47(2):264-268. doi: 10.1016/j.semarthrit.2017.04.006. Epub 2017 Apr 27.
• [24] Safety and immunogenicity of a 30-valent M protein-based group a streptococcal vaccine in healthy adult volunteers: A randomized, controlled phase I study.Vaccine. 2020 Feb 5;38(6):1384-1392. doi: 10.1016/j.vaccine.2019.12.005. Epub 2019 Dec 13.