Details of Disease

General Information of Disease (ID: DIS140OB)

• Disease Name: Gastrointestinal mucositis
• Synonyms: mucositis; inflammation of gastrointestinal system mucosa; gastrointestinal system mucosaitis; gastrointestinal system mucosa inflammation
• Definition: Inflammation of the mucous membranes lining the gastrointestinal tract.
• Disease Hierarchy:
  DISWD40R: Disease
  DIS7JDYJ: Gastrointestinal disease
  DIS3FXDI: Mucositis
  DIS140OB: Gastrointestinal mucositis
• Disease Identifiers:
  MONDO ID: MONDO_0000888
  UMLS CUI: C0521585
  MedGen ID: 636691
  SNOMED CT ID: 95518006

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FGF7	TTFY134	Limited	Biomarker	[1]
GCG	TT6Y4PN	Limited	Biomarker	[2]
CDA	TTQ12RK	Strong	Genetic Variation	[3]
GLP2R	TT1YWO5	Strong	Biomarker	[4]
HRH2	TTQHJ1K	Strong	Biomarker	[5]
IL31RA	TT9HPX0	Strong	Biomarker	[6]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CBR3	DEIVKZ8	Strong	Genetic Variation	[7]

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MTX1	OTLSDNZO	Limited	Biomarker	[8]
KLRB1	OTQ2959Y	moderate	Biomarker	[9]
HLA-DRB5	OTUX5TWM	Strong	Biomarker	[10]
LY6G6C	OTV7F59X	Strong	Biomarker	[11]
RAB8A	OTPB54Y3	Strong	Biomarker	[12]
RPTOR	OT4TQZ9F	Strong	Genetic Variation	[13]
CHPT1	OT4FJ0K3	Definitive	Biomarker	[14]
DHDDS	OTVLYBUS	Definitive	Biomarker	[14]

References

• [1] Dimethyl Sulfoxide Prevents Radiation-Induced Oral Mucositis Through Facilitating DNA Double-Strand Break Repair in Epithelial Stem Cells.Int J Radiat Oncol Biol Phys. 2018 Dec 1;102(5):1577-1589. doi: 10.1016/j.ijrobp.2018.07.2010. Epub 2018 Aug 6.
• [2] Potentiation of Glucagon-Like Peptide-2 Dynamics by Methotrexate Administration in Rat Small Intestine.Biol Pharm Bull. 2019;42(10):1733-1740. doi: 10.1248/bpb.b19-00464.
• [3] Influence of cytarabine metabolic pathway polymorphisms in acute myeloid leukemia induction treatment.Leuk Lymphoma. 2017 Dec;58(12):2880-2894. doi: 10.1080/10428194.2017.1323267. Epub 2017 Jun 2.
• [4] Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells.Cancer Res. 2008 Oct 1;68(19):7897-904. doi: 10.1158/0008-5472.CAN-08-0029.
• [5] Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neurons.J Physiol Pharmacol. 2017 Feb;68(1):79-90.
• [6] Folate-producing lactic acid bacteria reduce inflammation in mice with induced intestinal mucositis.J Appl Microbiol. 2018 Nov;125(5):1494-1501. doi: 10.1111/jam.14038. Epub 2018 Aug 19.
• [7] Impact of protocol change on individual factors related to course of adverse reactions to chemotherapy for breast cancer.Support Care Cancer. 2020 Jan;28(1):395-403. doi: 10.1007/s00520-019-04841-x. Epub 2019 May 6.
• [8] MTHFR variant is associated with high-dose methotrexate-induced toxicity in the Chinese osteosarcoma patients.J Bone Oncol. 2018 Nov 1;13:143-147. doi: 10.1016/j.jbo.2018.10.002. eCollection 2018 Nov.
• [9] Circulating CD3(+)CD4(+)CD161(+) Cells Are Associated with Early Complications after Autologous Stem Cell Transplantation in Multiple Myeloma.Biomed Res Int. 2018 Jan 1;2018:5097325. doi: 10.1155/2018/5097325. eCollection 2018.
• [10] Molecular Characteristics of High-Dose Melphalan Associated Oral Mucositis in Patients with Multiple Myeloma: A Gene Expression Study on Human Mucosa.PLoS One. 2017 Jan 4;12(1):e0169286. doi: 10.1371/journal.pone.0169286. eCollection 2017.
• [11] Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma.PLoS One. 2018 Jan 16;13(1):e0190709. doi: 10.1371/journal.pone.0190709. eCollection 2018.
• [12] Evaluating the adverse effects of melphalan formulations.J Oncol Pharm Pract. 2019 Oct;25(7):1631-1637. doi: 10.1177/1078155218804042. Epub 2018 Oct 18.
• [13] Polymorphisms associated with everolimus pharmacokinetics, toxicity and survival in metastatic breast cancer. PLoS One. 2017 Jul 20;12(7):e0180192.
• [14] Preventative effects of selenium-enriched Bifidobacterium longum on irinotecan-induced small intestinal mucositis in mice.Benef Microbes. 2019 May 28;10(5):569-577. doi: 10.3920/BM2018.0096. Epub 2019 Apr 9.