Details of Disease

General Information of Disease (ID: DIS1AW2Z)

• Disease Name: Mycoplasma pneumoniae pneumonia
• Synonyms: pneumonia due to Mycoplasma pneumoniae; Mycoplasmal pneumonia; cold agglutinin positive pneumonia; pneumonia due to Eaton's agent; pneumonia due to Mycoplasma pneumoniae (disorder); Mycoplasma pneumonia
• Definition: Interstitial pneumonia caused by extensive infection of the lungs (lung) and bronchi, particularly the lower lobes of the lungs, by mycoplasma pneumoniae in humans. In sheep, it is caused by mycoplasma ovipneumoniae. In cattle, it may be caused by mycoplasma dispar.
• Disease Hierarchy:
  DISPW7PH: Bacterial pneumonia
  DIS1AW2Z: Mycoplasma pneumoniae pneumonia
• Disease Identifiers:
  MONDO ID: MONDO_0005867
  MESH ID: D011019
  UMLS CUI: C0032302
  MedGen ID: 19363
  SNOMED CT ID: 46970008

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 14 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Clarithromycin	DM4M1SG	Approved	Small molecular drug	[1]
Dirithromycin	DM0D9YJ	Approved	Small molecular drug	[2]
Doxycycline	DM7ICNU	Approved	Small molecular drug	[3]
Erythromycin	DM4K7GQ	Approved	Small molecular drug	[4]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[5]
Gatifloxacin	DMSL679	Approved	Small molecular drug	[6]
Gemifloxacin	DMHT34O	Approved	Small molecular drug	[7]
Levofloxacin	DMS60RB	Approved	Small molecular drug	[8]
Moxifloxacin	DMU8V4S	Approved	Small molecular drug	[9]
Norfloxacin	DMIZ6W2	Approved	Small molecular drug	[10]
Ofloxacin	DM0VQN3	Approved	Small molecular drug	[11]
Sparfloxacin	DMB4HCT	Approved	Small molecular drug	[12]
Telithromycin	DMZ4P3A	Approved	Small molecular drug	[13]
Trovafloxacin	DM6AN32	Approved	Small molecular drug	[14]

This Disease is Treated as An Indication in 1 Drugs in Phase 3 Trial

Drug Name	Drug ID	Highest Status	Drug Type	REF
Azithromycin	DMS6UOE	Phase 3 Trial	Small molecular drug	[15]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CD276	TT6CQUM	Limited	Biomarker	[16]

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CLEC5A	OT19WV30	moderate	Biomarker	[17]
MPHOSPH6	OT6E2S48	moderate	Genetic Variation	[18]
MTHFS	OTZ39JNR	moderate	Biomarker	[19]

References

• [1] Clarithromycin FDA Label
• [2] Dirithromycin FDA Label
• [3] Doxycycline FDA Label
• [4] Erythromycin FDA Label
• [5] A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
• [6] Gatifloxacin FDA Label
• [7] Gemifloxacin FDA Label
• [8] Levofloxacin FDA Label
• [9] Moxifloxacin FDA Label
• [10] Norfloxacin FDA Label
• [11] Ofloxacin FDA Label
• [12] Sparfloxacin FDA Label
• [13] Telithromycin FDA Label
• [14] Trovafloxacin FDA Label
• [15] Azithromycin FDA Label
• [16] The role of miR-29c/B7-H3/Th17 axis in children with Mycoplasma pneumoniae pneumonia.Ital J Pediatr. 2019 May 14;45(1):61. doi: 10.1186/s13052-019-0655-5.
• [17] Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency.Hum Genomics. 2017 Mar 16;11(1):4. doi: 10.1186/s40246-017-0101-y.
• [18] Role of E-selectin for diagnosing myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia.Ann Clin Biochem. 2017 Jan;54(1):49-54. doi: 10.1177/0004563216631570. Epub 2016 Sep 28.
• [19] Investigations of Amino Acids in the 5-Formyltetrahydrofolate Binding Site of 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumonia.Protein J. 2019 Aug;38(4):409-418. doi: 10.1007/s10930-019-09861-4.