Details of Disease

Disease Name

Intrinsic asthma

Definition

An asthma that is triggered by factors not related to allergies such as anxiety, stress, exercise, cold air, dry air, hyperventilation, smoke, viruses, chemical irritants, autonomic imbalance, hormonal deficiencies and psychogenic influences. It is characterized by airway obstruction and inflammation that is at least partially reversible with medication. The symptoms include coughing, wheezing, shortness of breath or rapid breathing, and chest tightness.

Disease Hierarchy

DISW9QNS: Asthma

DIS2U1Q9: Intrinsic asthma

Disease Identifiers

MONDO ID

MONDO_0004765

UMLS CUI

C0155880

MedGen ID

510123

SNOMED CT ID

266361008

General Information of Disease (ID: DIS2U1Q9)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 6 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Fluticasone propionate	DMRWLB2	Approved	NA	[1]
Formoterol	DMSOURV	Approved	Small molecular drug	[2]
Mometasone	DM45OJN	Approved	Small molecular drug	[3]
Montelukast	DMD157S	Approved	Small molecular drug	[4]
Salmeterol	DMIEU69	Approved	Small molecular drug	[5]
Zileuton	DMVRIC2	Approved	Small molecular drug	[6]
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⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CSF2RA	TT6MP2Z	Limited	Altered Expression	[7]
CYP2J2	TTNE1C7	Limited	Genetic Variation	[8]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CD48	OT83ZNPP	Limited	Biomarker	[9]
STATH	OTQHBHM9	Limited	Genetic Variation	[10]
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References

1	Fluticasone propionate FDA Label
2	Formoterol FDA Label
3	Mometasone FDA Label
4	Montelukast FDA Label
5	Salmeterol FDA Label
6	Zileuton FDA Label
7	Upregulation of alpha GM-CSF-receptor in nonatopic asthma but not in atopic asthma.J Allergy Clin Immunol. 1997 May;99(5):666-72. doi: 10.1016/s0091-6749(97)70029-0.
8	Promoter polymorphism G-50T of a human CYP2J2 epoxygenase gene is associated with common susceptibility to asthma.Chest. 2007 Jul;132(1):120-6. doi: 10.1378/chest.07-0371. Epub 2007 May 2.
9	Evaluation of Soluble CD48 Levels in Patients with Allergic and Nonallergic Asthma in Relation to Markers of Type 2 and Non-Type 2 Immunity: An Observational Study.J Immunol Res. 2018 Sep 16;2018:4236263. doi: 10.1155/2018/4236263. eCollection 2018.
10	Discovery of genetic difference between asthmatic children with high IgE level and normal IgE level by whole genome linkage disequilibrium mapping using 763 autosomal STR markers.J Hum Genet. 2005;50(5):249-258. doi: 10.1007/s10038-005-0248-6. Epub 2005 May 21.