Details of Disease

Disease Name

trachoma dubium; active stage trachoma

Definition

A chronic infection of the conjunctiva and cornea caused by chlamydia trachomatis.

Disease Hierarchy

DISJFHYP: Chlamydia trachomatis infectious disease

DIS2WZUR: Trachoma

Disease Identifiers

MONDO ID

MONDO_0001249

MESH ID

D014141

UMLS CUI

C0040592

MedGen ID

52801

SNOMED CT ID

2576002

General Information of Disease (ID: DIS2WZUR)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 10 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Chlortetracycline	DMCQ6C4	Approved	Small molecular drug	[2]
Demeclocycline	DMZEPFJ	Approved	Small molecular drug	[3]
Doxycycline	DM7ICNU	Approved	Small molecular drug	[4]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[5]
Minocycline	DMVN5OH	Approved	Small molecular drug	[6]
Oxytetracycline	DMOVH1M	Approved	Small molecular drug	[7]
Sulfacetamide	DMZ6VEY	Approved	Small molecular drug	[8]
Sulfisoxazole	DMXLT8C	Approved	Small molecular drug	[9]
Tetracycline	DMZA017	Approved	Small molecular drug	[10]
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⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IL13RA1	TTNEAMG	Strong	Biomarker	[11]
KIR2DL2	TTU0P73	Strong	Genetic Variation	[12]
KIR2DL3	TTEX3SI	Strong	Biomarker	[12]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SEPTIN1	OT4GVSU3	Strong	Biomarker	[13]
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References

1	Amphotericin B FDA Label
2	Chlortetracycline FDA Label
3	Demeclocycline FDA Label
4	Doxycycline FDA Label
5	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
6	Minocycline FDA Label
7	Oxytetracycline FDA Label
8	Sulfacetamide FDA Label
9	Sulfisoxazole FDA Label
10	Tetracycline FDA Label
11	Role of secreted conjunctival mucosal cytokine and chemokine proteins in different stages of trachomatous disease.PLoS Negl Trop Dis. 2008 Jul 16;2(7):e264. doi: 10.1371/journal.pntd.0000264.
12	Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3.PLoS Negl Trop Dis. 2014 Mar 20;8(3):e2744. doi: 10.1371/journal.pntd.0002744. eCollection 2014 Mar.
13	Feasibility and safety of mass drug coadministration with azithromycin and ivermectin for the control of neglected tropical diseases: a single-arm intervention trial.Lancet Glob Health. 2018 Oct;6(10):e1132-e1138. doi: 10.1016/S2214-109X(18)30397-8.