Details of Disease

General Information of Disease (ID: DIS3OT4T)

Disease Name Tropical pancreatitis
Synonyms tropical calcific pancreatitis; fibrocalculous pancreatic diabetes, susceptibility to; tropical calcific chronic pancreatitis; TCP
Definition
Tropical pancreatitis is a rare pancreatic disease of juvenile onset occurring mainly in tropical developing countries and characterized by chronic non-alcoholic pancreatitis manifesting with abdominal pain, steatorrhea and fibrocalculous pancreatopathy. It is also commonly associated with the development of pancreatic calculi and pancreatic cancer at a much higher frequency than seen in ordinary chronic pancreatitis.
Disease Hierarchy
DISF0J1Q: Hereditary chronic pancreatitis
DIS3OT4T: Tropical pancreatitis
Disease Identifiers
MONDO ID
MONDO_0011986
UMLS CUI
C1842402
OMIM ID
608189
MedGen ID
334069
Orphanet ID
103918
SNOMED CT ID
724540009

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 3 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CPA1 TT3LJ6G moderate Biomarker [1]
PRSS1 TT2WR1T moderate Genetic Variation [2]
CTRC TT3RMNA Strong SusceptibilityMutation [3]
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This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CRISPLD2 OTVSFHTL moderate Genetic Variation [4]
NIN OTVH3M4Z moderate Genetic Variation [5]
PRSS2 OTOMVUWL moderate Genetic Variation [4]
SPINK1 OTSUVAL2 Strong Autosomal dominant [6]
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References

1 Genetic and phenotypic heterogeneity in tropical calcific pancreatitis.World J Gastroenterol. 2014 Dec 14;20(46):17314-23. doi: 10.3748/wjg.v20.i46.17314.
2 Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis.Gut. 2006 Sep;55(9):1270-5. doi: 10.1136/gut.2005.087403. Epub 2006 Feb 21.
3 Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants.Gut. 2013 Nov;62(11):1602-6. doi: 10.1136/gutjnl-2012-302448. Epub 2012 May 12.
4 Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis.Pancreatology. 2009;9(1-2):145-9. doi: 10.1159/000178885. Epub 2008 Dec 13.
5 Five novel transcription factors as potential regulators of OsNHX1 gene expression in a salt tolerant rice genotype.Plant Mol Biol. 2017 Jan;93(1-2):61-77. doi: 10.1007/s11103-016-0547-7. Epub 2016 Oct 20.
6 Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet. 2000 Jun;25(2):213-6. doi: 10.1038/76088.