Details of Disease

General Information of Disease (ID: DIS532UM)

Disease Name	Vasospasm
Disease Class	9B74: Retinal vascular occlusion
Definition	Constriction of arteries in the skull due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and brain ischemia that may lead to hypoxic-ischemic brain injury (hypoxia-ischemia, brain).
Disease Hierarchy	DISAB237: Cerebrovascular disease DIS532UM: Vasospasm
ICD Code	ICD-11 ICD-11: 9B74.0 Expand ICD-9 430,728.85,852.0,852.1
Disease Identifiers	MONDO ID MONDO_0006812 MESH ID D020301 UMLS CUI C0751895 MedGen ID 199760 HPO ID HP:0025637 SNOMED CT ID 71772004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Clazosentan	DMQSBX4	Phase 3	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PLAT	TTXAGYU	Strong	Therapeutic	[2]
S100A4	TTPR5SX	Strong	Biomarker	[3]
S100A6	TT716MY	Strong	Biomarker	[3]
S100B	TTQ0V86	Strong	Biomarker	[3]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
S100A1	OT1F2G4J	Strong	Biomarker	[3]
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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017374)
2	Treatment of cerebral vasospasm with biocompatible controlled-release systems for intracranial drug delivery.Neurosurgery. 2008 Dec;63(6):1011-9; discussion 1019-21. doi: 10.1227/01.NEU.0000327574.32000.9A.
3	Expression of members of the calcium-binding S-100 protein family in a rat model of cerebral basilar artery vasospasm.J Neurosurg. 2002 Aug;97(2):408-15. doi: 10.3171/jns.2002.97.2.0408.