Details of Disease

General Information of Disease (ID: DISAB237)

• Disease Name: Cerebrovascular disease
• Synonyms: CVA; cerebrovascular accident; CVA (cerebral vascular accident); stroke; cerebral infarction; cerebrovascular disorder; cerebrovascular disease
• Disease Class: 8B22-8B2Z: Cerebrovascular disease
• Definition: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.
• Disease Hierarchy:
  DIS1GZDX: Neurovascular disorder
  DIS6ZC3X: Brain disease
  DISAB237: Cerebrovascular disease
• ICD Code:
  ICD-11: ICD-11: 8B2Z
  ICD-10: ICD-10: I60-I69
• Disease Identifiers:
  MONDO ID: MONDO_0011057
  MESH ID: D002561
  UMLS CUI: C0007820
  MedGen ID: 858
  SNOMED CT ID: 62914000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Mesoglycan	DM5TWQR	Approved	NA	[1]
Tolazoline	DMI40NL	Approved	Small molecular drug	[2]
Vincamine	DMK1ZOR	Approved	Small molecular drug	[3]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Nicaraven	DMFBNA3	Phase 3	Small molecular drug	[4]

This Disease is Treated as An Indication in 3 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Isoxsuprine	DMURMY1	Withdrawn from market	Small molecular drug	[1]
97-139	DMG0I6L	Discontinued in Phase 2	NA	[5]
Rovelizumab	DM4VCJI	Terminated	Antibody	[6]

This Disease is Treated as An Indication in 2 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
NBI-18	DMWIOJ8	Investigative	NA	[7]
SIM-071201	DMCD4F1	Investigative	NA	[7]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 30 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CETP	TTFQAYR	Limited	Genetic Variation	[8]
LPA	TTU9LGY	Limited	Genetic Variation	[9]
LPL	TTOF3WZ	Limited	Genetic Variation	[10]
OLR1	TTKSND3	Limited	Genetic Variation	[11]
PROC	TTZUXYS	Limited	Biomarker	[12]
SELPLG	TTS5K8U	Limited	Biomarker	[13]
PDE4D	TTSKMI8	Disputed	Biomarker	[14]
VKORC1	TTEUC8H	Disputed	Genetic Variation	[15]
NOTCH3	TTVX7IA	moderate	Biomarker	[16]
ACTG1	TTGAZF9	Strong	Genetic Variation	[17]
ADM2	TTM642F	Strong	Biomarker	[18]
APOL1	TTDB8PW	Strong	Genetic Variation	[19]
EDN1	TTJR60Z	Strong	Biomarker	[20]
LTC4S	TTW7OTG	Strong	Genetic Variation	[21]
NPR3	TTWVLS6	Strong	Genetic Variation	[22]
PAK4	TT7Y3BZ	Strong	Biomarker	[23]
PLAU	TTGY7WI	Strong	Therapeutic	[24]
PSEN2	TTWN3F4	Strong	Biomarker	[25]
TARDBP	TT9RZ03	Strong	Biomarker	[26]
YY1AP1	TTYED1Q	Strong	Biomarker	[27]
ALOX5AP	TTDMBF5	Definitive	Genetic Variation	[28]
APOA4	TTNC3WS	Definitive	Genetic Variation	[29]
APOB	TTN1IE2	Definitive	Biomarker	[30]
BACE1	TTJUNZF	Definitive	Biomarker	[31]
CYP2C19	TTZ58XG	Definitive	Genetic Variation	[32]
CYP46A1	TT4EB85	Definitive	Biomarker	[33]
F13A1	TTXI2RA	Definitive	Genetic Variation	[34]
FABP2	TTS4YLO	Definitive	Genetic Variation	[35]
GLA	TTIS03D	Definitive	Genetic Variation	[36]
LDLR	TTH0DUS	Definitive	Biomarker	[37]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCD1	DTKM9DZ	Strong	Genetic Variation	[38]

This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP4A11	DE2XQGW	Strong	Genetic Variation	[39]
CYP4F2	DE3GT9C	Strong	Genetic Variation	[40]
CHDH	DEAHED0	Definitive	Biomarker	[41]

This Disease Is Related to 36 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
COL4A1	OTL6D1YE	Limited	Genetic Variation	[42]
DSC3	OTYG47F8	Disputed	Biomarker	[43]
MCIDAS	OTK1JVAH	Disputed	Biomarker	[44]
SERPINA3	OT9BP2S0	moderate	Genetic Variation	[17]
ACOT7	OT7C68YV	Strong	Genetic Variation	[17]
ACTA2	OTEDLG8E	Strong	Biomarker	[45]
ACTBL2	OTD6B81U	Strong	Genetic Variation	[17]
ACTG2	OTRDWUO0	Strong	Genetic Variation	[17]
C1QTNF9	OTLI3VA3	Strong	Biomarker	[46]
CLDND1	OTGECYGG	Strong	Altered Expression	[47]
CYBA	OT16N9ZO	Strong	Genetic Variation	[48]
FGA	OTMIHY80	Strong	Biomarker	[49]
FHL5	OT6C00Z1	Strong	Genetic Variation	[17]
INSIG2	OTX4VY51	Strong	Genetic Variation	[50]
KRIT1	OT58AP1I	Strong	Genetic Variation	[51]
LOXL1	OTA0NEJU	Strong	Genetic Variation	[52]
NANOS3	OTGX9IQU	Strong	Biomarker	[53]
PCNT	OTW4Z65J	Strong	Biomarker	[54]
PICALM	OTQVRPMQ	Strong	Genetic Variation	[25]
POTEM	OT7L2HGH	Strong	Genetic Variation	[17]
RNF213	OT4OVE9O	Strong	Biomarker	[55]
SAMD9	OTDG48P0	Strong	Genetic Variation	[56]
SAMHD1	OTBCIBC7	Strong	Genetic Variation	[57]
SMARCAL1	OTTKXLUZ	Strong	Genetic Variation	[27]
SORL1	OTQ8FFNS	Strong	Genetic Variation	[56]
SRXN1	OTYDBO4L	Strong	Genetic Variation	[58]
STAC3	OTPY3BGK	Strong	Biomarker	[59]
TPSG1	OTDESHKT	Strong	Biomarker	[60]
COL4A2	OTJK1LKN	Definitive	Genetic Variation	[61]
FGB	OT6RKLI9	Definitive	Genetic Variation	[62]
JPH3	OTHTJO2I	Definitive	Biomarker	[63]
LIPC	OTZY5SC9	Definitive	Genetic Variation	[63]
LYPD4	OTYNO8BS	Definitive	Biomarker	[64]
ND2	OTG9OHOX	Definitive	Genetic Variation	[65]
SELENOS	OTUEWIU9	Definitive	Genetic Variation	[66]
TCN2	OT41D0L3	Definitive	Genetic Variation	[67]

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