Details of Disease

General Information of Disease (ID: DIS79FJF)

Disease Name Adult kidney Wilms tumor
Synonyms
adult kidney adenosarcoma; adult renal adenosarcoma; adult renal Wilms' tumor; adult renal Wilms tumor; adult nephroblastoma; adult kidney Wilms tumor; kidney Wilms tumor of adults; kidney Wilms tumour of adults; adult renal Wilms tumour; adenosarcoma of the adult kidney; adult renal Wilms' tumour; adenosarcoma of adult kidney
Definition Wilms tumor of the kidney which occurs in adults.
Disease Hierarchy
DIS7WJYB: Kidney Wilms tumor
DIS79FJF: Adult kidney Wilms tumor
Disease Identifiers
MONDO ID
MONDO_0024675
UMLS CUI
C1332219
MedGen ID
231045

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 4 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Dactinomycin DM2YGNW Approved Small molecular drug [1]
Doxorubicin DMVP5YE Approved Small molecular drug [2]
Etoposide DMNH3PG Approved Small molecular drug [3]
Vincristine DMINOX3 Approved Small molecular drug [4]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
BMP7 TTKOBRA Strong Biomarker [5]
VHL TTEMWSD Strong Biomarker [6]
------------------------------------------------------------------------------------
This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
PAX2 OTKP1N8F Limited Biomarker [7]
------------------------------------------------------------------------------------

References

1 Dactinomycin FDA Label
2 Doxorubicin FDA Label
3 Etoposide FDA Label
4 Vincristine FDA Label
5 Deficient expression of mRNA for the putative inductive factor bone morphogenetic protein-7 in chemically initiated rat nephroblastomas.Mol Carcinog. 1998 Oct;23(2):53-61. doi: 10.1002/(sici)1098-2744(199810)23:2<53::aid-mc1>3.0.co;2-t.
6 Down-regulation of von Hippel-Lindau protein in N-nitroso compound-induced rat non-clear cell renal tumors.Cancer Lett. 2002 May 8;179(1):33-8. doi: 10.1016/s0304-3835(01)00863-1.
7 A rodent model for Wilms tumors: embryonal kidney neoplasms induced by N-nitroso-N'-methylurea.Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9931-5. doi: 10.1073/pnas.91.21.9931.