Details of Disease

General Information of Disease (ID: DIS8KHDE)

• Disease Name: Meningeal tuberculosis
• Synonyms: Meningitis, Tuberculous; tubercular meningitis; TBM; TB meningitis; tuberculous meningitis
• Definition: A bacterial infection of the membranes covering the brain and the spinal cord caused by Mycobacterium tuberculosis.
• Disease Hierarchy:
  DISQABAA: Meningitis
  DIS4OUTE: Central nervous system tuberculosis
  DIS2YIMD: Tuberculosis
  DISRP9SL: Bacterial meningitis
  DISFW7FV: Tuberculous salpingitis
  DIS8KHDE: Meningeal tuberculosis
• Disease Identifiers:
  MONDO ID: MONDO_0006042
  MESH ID: D014390
  UMLS CUI: C0041318
  MedGen ID: 21725
  Orphanet ID: 499004
  SNOMED CT ID: 58437007

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Pyrazinamide	DM4IF32	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
LAMC2	TTNS7H3	Limited	Biomarker	[2]
ADA	TTLP57V	Strong	Altered Expression	[3]
HPD	TT8DSFC	Strong	Biomarker	[4]
LTA4H	TTXZEAJ	Strong	Genetic Variation	[5]
RNF34	TTEWDK1	Strong	Biomarker	[6]

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BBS9	OT23V9YF	Limited	Genetic Variation	[7]
THEMIS	OTXODBXJ	moderate	Biomarker	[8]
ADSL	OTSNJALL	Strong	Biomarker	[9]
C1QTNF4	OTHD4Y9D	Strong	Altered Expression	[10]
CCN6	OTRFHQ2Z	Strong	Biomarker	[4]
NCAPG2	OTZYENKO	Strong	Biomarker	[11]
RHOF	OTPA3F8Q	Strong	Biomarker	[6]
SIGLEC14	OT2JGGXD	Definitive	Genetic Variation	[12]

References

• [1] Pyrazinamide FDA Label
• [2] Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis.J Pediatric Infect Dis Soc. 2020 Feb 28;9(1):82-86. doi: 10.1093/jpids/piy141.
• [3] Diagnostic Usefulness of Cytokine and Chemokine Levels in the Cerebrospinal Fluid of Patients with Suspected Tuberculous Meningitis.Am J Trop Med Hyg. 2019 Aug;101(2):343-349. doi: 10.4269/ajtmh.18-0947.
• [4] DNA polymorphism of Mycobacterium tuberculosis PE_PGRS33 gene among clinical isolates of pediatric TB patients and its associations with clinical presentation.Tuberculosis (Edinb). 2011 Jul;91(4):287-92. doi: 10.1016/j.tube.2011.05.001. Epub 2011 Jun 12.
• [5] Do Intracerebral Cytokine Responses Explain the Harmful Effects of Dexamethasone in Human Immunodeficiency Virus-associated Cryptococcal Meningitis?.Clin Infect Dis. 2019 Apr 24;68(9):1494-1501. doi: 10.1093/cid/ciy725.
• [6] Xpert MTB/RIF Ultra improved the diagnosis of paucibacillary tuberculosis: A prospective cohort study.J Infect. 2019 Apr;78(4):311-316. doi: 10.1016/j.jinf.2019.02.010. Epub 2019 Feb 21.
• [7] Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study.Lancet Infect Dis. 2018 May;18(5):526-535. doi: 10.1016/S1473-3099(18)30053-7. Epub 2018 Feb 3.
• [8] Evaluation of a New IFN- Release Assay for Rapid Diagnosis of Active Tuberculosis in a High-Incidence Setting.Front Cell Infect Microbiol. 2017 Apr 11;7:117. doi: 10.3389/fcimb.2017.00117. eCollection 2017.
• [9] Nucleotide degradation products in cerebrospinal fluid (CSF) in inherited and acquired pathologies.Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1185-7. doi: 10.1081/NCN-200027451.
• [10] C1Q/TNF-related protein 4 expression correlates with herpes simplex encephalitis progression.Ann Transl Med. 2019 Jun;7(11):235. doi: 10.21037/atm.2019.05.01.
• [11] Diagnostic usefulness of Xpert MTB/RIF assay for detection of tuberculous meningitis using cerebrospinal fluid.J Infect. 2017 Aug;75(2):125-131. doi: 10.1016/j.jinf.2017.04.010. Epub 2017 May 10.
• [12] The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes.Tuberculosis (Edinb). 2017 May;104:38-45. doi: 10.1016/j.tube.2017.02.005. Epub 2017 Feb 21.