Details of Disease

General Information of Disease (ID: DISRP9SL)

• Disease Name: Bacterial meningitis
• Synonyms: meningitis, bacterial; Bacteria infectious meningitis; Bacteria caused infectious meningitis
• Definition: Inflammation of the membranes surrounding the brain and spinal cord due to a bacterial infection.
• Disease Hierarchy:
  DISQ4DO4: Infectious meningitis
  DIS5QJ9S: Bacterial infection
  DISRP9SL: Bacterial meningitis
• Disease Identifiers:
  MONDO ID: MONDO_0006670
  MESH ID: D016920
  UMLS CUI: C0085437
  MedGen ID: 39048
  SNOMED CT ID: 95883001

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 10 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AADAT	TTT3IXG	Limited	Genetic Variation	[1]
C3AR1	TTI6B3F	Limited	Biomarker	[2]
BDNF	TTSMLOH	Strong	Biomarker	[3]
KMO	TTIY56R	Strong	Biomarker	[4]
KYNU	TTWQM3J	Strong	Altered Expression	[4]
LAMC2	TTNS7H3	Strong	Biomarker	[5]
LTA4H	TTXZEAJ	Strong	Genetic Variation	[6]
NGF	TTDN3LF	Strong	Biomarker	[7]
TACR1	TTZPO1L	Strong	Biomarker	[8]
TLR9	TTSHG0T	Strong	Genetic Variation	[9]

This Disease Is Related to 15 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCDC33	OTOIFZ4R	Limited	Genetic Variation	[10]
MARCO	OT0NW2Q0	Limited	Biomarker	[11]
PAGR1	OTXR5PQ8	Limited	Genetic Variation	[12]
SAMM50	OTRYFYIU	Limited	Biomarker	[13]
APH1A	OT97F1TU	Strong	Biomarker	[14]
AZU1	OTHXU264	Strong	Genetic Variation	[15]
C1QTNF4	OTHD4Y9D	Strong	Altered Expression	[16]
FAM20C	OTW5YZ7X	Strong	Biomarker	[17]
GBP1	OTUM7RPJ	Strong	Biomarker	[18]
HDLBP	OTKDEEYX	Strong	Altered Expression	[19]
HEBP1	OTR9MPDX	Strong	Altered Expression	[19]
SFPQ	OTLCIAPJ	Strong	Biomarker	[14]
SLBP	OTVYYQRT	Strong	Altered Expression	[19]
STAM2	OT9OBWPH	Strong	Altered Expression	[19]
SUMF2	OT37I8JL	Strong	Biomarker	[20]

References

• [1] Association of kynurenine aminotransferase II gene C401T polymorphism with immune response in patients with meningitis.BMC Med Genet. 2011 Apr 7;12:51. doi: 10.1186/1471-2350-12-51.
• [2] The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: analysis in multiple sclerosis and bacterial meningitis.J Immunol. 1998 Apr 1;160(7):3543-54.
• [3] Brain-derived neurotrophic factor reduces inflammation and hippocampal apoptosis in experimental Streptococcus pneumoniae meningitis.J Neuroinflammation. 2017 Aug 4;14(1):156. doi: 10.1186/s12974-017-0930-6.
• [4] The cerebral protective effect and mechanism of action of vitamin B6 adjuvant ceftriaxone in experimental pneumococcal meningitis.Brain Res. 2018 Sep 15;1695:53-64. doi: 10.1016/j.brainres.2018.05.031. Epub 2018 May 22.
• [5] Correlation between vancomycin penetration into cerebrospinal fluid and protein concentration in cerebrospinal fluid/serum albumin ratio.J Infect Chemother. 2019 Feb;25(2):124-128. doi: 10.1016/j.jiac.2018.10.013. Epub 2018 Nov 10.
• [6] LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome.PLoS One. 2015 Mar 23;10(3):e0118789. doi: 10.1371/journal.pone.0118789. eCollection 2015.
• [7] Evaluation of the brain-derived neurotrophic factor, nerve growth factor and memory in adult rats survivors of the neonatal meningitis by Streptococcus agalactiae.Brain Res Bull. 2013 Mar;92:56-9. doi: 10.1016/j.brainresbull.2012.05.014. Epub 2012 Jun 7.
• [8] Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis.J Neuroinflammation. 2017 Feb 15;14(1):37. doi: 10.1186/s12974-017-0813-x.
• [9] Polymorphisms of toll-like receptors 2 and 9 and severity and prognosis of bacterial meningitis in Chinese children.Sci Rep. 2017 Feb 16;7:42796. doi: 10.1038/srep42796.
• [10] Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis.Nat Commun. 2019 May 15;10(1):2176. doi: 10.1038/s41467-019-09976-3.
• [11] The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis.J Neuroinflammation. 2011 Feb 7;8(1):11. doi: 10.1186/1742-2094-8-11.
• [12] Group A streptococcal meningitis: a case report.New Microbiol. 2013 Oct;36(4):419-22. Epub 2013 Oct 1.
• [13] Omp85 genosensor for detection of human brain bacterial meningitis.Biotechnol Lett. 2013 Jun;35(6):929-35. doi: 10.1007/s10529-013-1161-2. Epub 2013 Mar 8.
• [14] Vimentin and PSF act in concert to regulate IbeA+ E. coli K1 induced activation and nuclear translocation of NF-B in human brain endothelial cells.PLoS One. 2012;7(4):e35862. doi: 10.1371/journal.pone.0035862. Epub 2012 Apr 20.
• [15] Meningococcal Antigen Typing System (MATS)-Based Neisseria meningitidis Serogroup B Coverage Prediction for the MenB-4C Vaccine in the United States.mSphere. 2017 Nov 15;2(6):e00261-17. doi: 10.1128/mSphere.00261-17. eCollection 2017 Nov-Dec.
• [16] C1Q/TNF-related protein 4 expression correlates with herpes simplex encephalitis progression.Ann Transl Med. 2019 Jun;7(11):235. doi: 10.21037/atm.2019.05.01.
• [17] Protein Oxidation Biomarkers and Myeloperoxidase Activation in Cerebrospinal Fluid in Childhood Bacterial Meningitis.Antioxidants (Basel). 2019 Oct 1;8(10):441. doi: 10.3390/antiox8100441.
• [18] Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis.Am J Pathol. 2006 Sep;169(3):1088-99. doi: 10.2353/ajpath.2006.060244.
• [19] Accuracy of heparin binding protein: as a new marker in prediction of acute bacterial meningitis.Braz J Microbiol. 2018 Nov;49 Suppl 1(Suppl 1):213-219. doi: 10.1016/j.bjm.2018.05.007. Epub 2018 Aug 17.
• [20] Phenotypic and molecular characterization of serogroup C Neisseria meningitidis associated with an outbreak in Bahia, Brazil.Enferm Infecc Microbiol Clin. 2012 Feb;30(2):56-9. doi: 10.1016/j.eimc.2011.07.022. Epub 2011 Nov 9.