Details of Disease

General Information of Disease (ID: DISQABAA)

• Disease Name: Meningitis
• Synonyms: meninx inflammation; meningitis; inflammation of meninx; meningitis (disease)
• Disease Class: 1D01: Infectious meningitis
• Definition: A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord.
• Disease Hierarchy:
  DISB3X5A: Nervous system inflammation
  DISWD40R: Disease
  DISQABAA: Meningitis
• ICD Code:
  ICD-11: ICD-11: 1D01
  ICD-10: ICD-10: G00-G03
  ICD-9: ICD-9: 320-322
  Expand ICD-11: 'XA0AK4
  Expand ICD-9: 320321322
• Disease Identifiers:
  MONDO ID: MONDO_0021108
  MESH ID: D008581
  UMLS CUI: C0025289
  MedGen ID: 6298
  HPO ID: HP:0001287
  SNOMED CT ID: 7180009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Trumenba	DMDHCK9	Approved	Vaccine	[1]

This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Hib-MenCY-TT vaccine	DM4JL1R	Phase 3	NA	[2]
Meninge B	DM5QZIW	Phase 1	NA	[3]
Meningitis ACYW conj.	DM9AXFJ	Phase 1	NA	[4]
Streptococcus pneumoniae vaccine	DM3136S	Phase 1	NA	[5]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 17 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AADAT	TTT3IXG	Limited	Genetic Variation	[6]
CD248	TTYJWT7	Limited	Biomarker	[7]
CYBB	TT5T8MR	Limited	Biomarker	[8]
GALNS	TTT9YPO	Limited	Biomarker	[9]
GAST	TT4LRVO	Limited	Biomarker	[9]
HLA-B	TTGS10J	Limited	Biomarker	[10]
PDE7A	TT1BC3A	Limited	Biomarker	[11]
SLC46A1	TTY8Z2E	Limited	Biomarker	[11]
BPI	TTXCSDR	Strong	Biomarker	[12]
BTK	TTGM6VW	Strong	Genetic Variation	[13]
CRP	TTWRN6M	Strong	Biomarker	[14]
CXCL11	TTWG0RE	Strong	Biomarker	[15]
HCN1	TTNB6UQ	Strong	Biomarker	[16]
HCN2	TT9EUT4	Strong	Biomarker	[16]
IRAK4	TTILUKB	Strong	Genetic Variation	[17]
MBL2	TTMQDZ5	Strong	Biomarker	[18]
LAMC2	TTNS7H3	Definitive	Biomarker	[19]

This Disease Is Related to 25 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ARHGEF28	OT3F32IU	Limited	Altered Expression	[20]
BATF	OT9VSD2D	Limited	Genetic Variation	[21]
C4BPA	OTHNH6Y8	Limited	Biomarker	[22]
CARD14	OTADQHOV	Limited	Biomarker	[22]
CDS1	OT2F591M	Limited	Biomarker	[23]
CNTNAP1	OT5Y03EU	Limited	Biomarker	[24]
GYPC	OTOEDR7O	Limited	Biomarker	[25]
IL2RG	OTRZ3OMY	Limited	Biomarker	[26]
MARCHF9	OTWF84QT	Limited	Biomarker	[27]
MARCO	OT0NW2Q0	Limited	Altered Expression	[28]
NCOA6	OTOMIGTV	Limited	Biomarker	[29]
OAS2	OT64CCTM	Limited	Genetic Variation	[30]
OAS3	OT6E5FYS	Limited	Genetic Variation	[30]
OMP	OT7JH0DY	Limited	Genetic Variation	[31]
PAGR1	OTXR5PQ8	Limited	Biomarker	[9]
PRF1	OTFVXD7H	Limited	Biomarker	[32]
SAMM50	OTRYFYIU	Limited	Biomarker	[33]
TCF12	OTZVONNU	Limited	Biomarker	[26]
C8A	OTIJ65J4	Strong	Biomarker	[34]
C8B	OTGDJJOK	Strong	Biomarker	[35]
CADM1	OTRWG9QS	Strong	Biomarker	[36]
DDX56	OTGURA53	Strong	Altered Expression	[37]
ENOSF1	OT65D3ZK	Strong	Biomarker	[38]
RECQL4	OT59LSW7	Strong	Biomarker	[38]
SUMF2	OT37I8JL	Strong	Genetic Variation	[39]

References

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• [2] ClinicalTrials.gov (NCT01978093) Immunogenicity, Safety and Reactogenicity Study of GlaxoSmithKline (GSK) Biologicals' Hib-MenCY-TT Vaccine Compared to Merck & Co, Inc. PedvaxHIB Vaccine in Healthy Infants and Toddlers 12 to 15 Months of Age. U.S. National Institutes of Health.
• [3] Vaccines, Stanley A, Plotkin,Walter A, Orenstein,Paul A. Offit. Page(42).
• [4] Clinical pipeline report, company report or official report of Sanofi Pasteur.
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• [24] Caspr1 is a host receptor for meningitis-causing Escherichia coli.Nat Commun. 2018 Jun 12;9(1):2296. doi: 10.1038/s41467-018-04637-3.
• [25] Proton NMR metabolic profiling of CSF reveals distinct differentiation of meningitis from negative controls.Clin Chim Acta. 2017 Jun;469:42-52. doi: 10.1016/j.cca.2017.03.015. Epub 2017 Mar 15.
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• [28] The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis.J Neuroinflammation. 2011 Feb 7;8(1):11. doi: 10.1186/1742-2094-8-11.
• [29] Comparison of clinical and laboratory characteristics during two major paediatric meningitis outbreaks of echovirus 30 and other non-polio enteroviruses in Germany in 2008 and 2013.Eur J Clin Microbiol Infect Dis. 2017 Sep;36(9):1651-1660. doi: 10.1007/s10096-017-2979-7. Epub 2017 Apr 13.
• [30] Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.J Infect Dis. 2010 Dec 15;202(12):1813-8. doi: 10.1086/657418. Epub 2010 Nov 4.
• [31] Clonal analysis of Haemophilus influenzae type b isolates in the United Kingdom.J Med Microbiol. 1995 Jul;43(1):45-9. doi: 10.1099/00222615-43-1-45.
• [32] Quercetin reduces Streptococcus suis virulence by inhibiting suilysin activity and inflammation.Int Immunopharmacol. 2019 Apr;69:71-78. doi: 10.1016/j.intimp.2019.01.017. Epub 2019 Jan 23.
• [33] Omp85 genosensor for detection of human brain bacterial meningitis.Biotechnol Lett. 2013 Jun;35(6):929-35. doi: 10.1007/s10529-013-1161-2. Epub 2013 Mar 8.
• [34] Genetic basis of human complement C8 alpha-gamma deficiency.J Immunol. 1998 Oct 1;161(7):3762-6.
• [35] Genetic basis of human complement C8 beta deficiency.J Immunol. 1993 Jun 1;150(11):4943-7.
• [36] Molecular Characteristics and Antimicrobial Resistance of Group B Streptococcus Strains Causing Invasive Disease in Neonates and Adults.Front Microbiol. 2019 Feb 18;10:264. doi: 10.3389/fmicb.2019.00264. eCollection 2019.
• [37] Comparison of real-time florescence quantitative PCR measurements of VAD1 mRNA with three conventional methods in diagnosis and follow-up treatment of Cryptococcus neoformans infection.Mycoses. 2012 Jul;55(4):326-32. doi: 10.1111/j.1439-0507.2011.02100.x. Epub 2011 Sep 5.
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• [39] Recurrent infection with genetically identical pneumococcal isolates in a patient with interleukin-1 receptor-associated kinase-4 deficiency.J Med Microbiol. 2007 Jun;56(Pt 6):863-865. doi: 10.1099/jmm.0.47046-0.