Details of Disease

General Information of Disease (ID: DIS8OCOC)

• Disease Name: HIV-associated dementia
• Synonyms: ADC - Acquired immune deficiency syndrome dementia complex; HIV Encephalopathy; AIDS related Dementia Complex; Dementias, HIV; Complex, AIDS Dementia; AIDS Encephalopathies; HIV 1 Cognitive and Motor Complex; HIV-1-Associated Cognitive Motor Complex; Acquired immune deficiency syndrome-related dementia; HIV encephalitis; HIV associated cognitive and motor complex; DEMENTIA COMPLEX ACQUIRED IMMUNE DEFIC SYNDROME; Encephalopathy, AIDS; Acquired-Immune Deficiency Syndrome Dementia Complex; DEMENTIA COMPLEX AIDS RELAT; Encephalopathy, HIV; acquired immune deficiency syndrome-related dementia; HIV Dementias; Dementia Complex, AIDS-related; acquired immune deficiency syndrome dementia complex; Encephalopathies, HIV; Encephalopathies, AIDS; AIDS Dementia Complex; ADC; AIDS Encephalopathy; AIDS - Acquired immune deficiency syndrome dementia complex; HIV ASSOC COGNITIVE MOTOR COMPLEX; Dementia Complex, AIDS related; Dementia associated with acquired immunodeficiency syndrome; AIDS related cognitive impairment; Dementia associated with AIDS; Complex, AIDS-related Dementia; HIV Encephalopathies; HIV 1 Associated Cognitive Motor Complex; AIDS Dementia; HIV Associated Cognitive Motor Complex; Acquired immune deficiency syndrome dementia complex; Dementia Complex, Acquired Immune Deficiency Syndrome; AIDS RELAT DEMENTIA COMPLEX; HIV-associated dementia; Dementia Complex, AIDS; Dementia, HIV; AIDS with dementia (disorder); HIV-Associated Cognitive Motor Complex; AIDS-related Dementia Complex; HIV-1 Cognitive and Motor Complex; HIV Dementia; AIDS dementia complex; AIDS dementia
• Disease Class: 6D80-6D8Z: Dementia
• Definition: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
• Disease Hierarchy:
  DISXL1WY: Dementia
  DISU6QAV: Post-viral disorder
  DIS8OCOC: HIV-associated dementia
• ICD Code:
  ICD-11: ICD-11: 6D85.3
  ICD-10: ICD-10: B20
• Disease Identifiers:
  MONDO ID: MONDO_0020689
  MESH ID: D015526
  UMLS CUI: C0001849
  MedGen ID: 177
  SNOMED CT ID: 421529006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
INP-02	DMHBM67	Investigative	NA	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SLC8A1	TTCF82X	Limited	Genetic Variation	[2]
ADRB2	TTG8ZWP	moderate	Biomarker	[3]
OPRM1	TTKWM86	moderate	Biomarker	[3]
HCK	TT42OGM	Strong	Altered Expression	[4]

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
NALCN	OTWY7DS0	Limited	Genetic Variation	[2]
ITIH4	OT460OO1	Strong	Biomarker	[5]
RRP8	OTGZHVVW	Strong	Genetic Variation	[6]

References

• [1] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [2] Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults.Am J Med Genet B Neuropsychiatr Genet. 2012 Sep;159B(6):669-83. doi: 10.1002/ajmg.b.32071. Epub 2012 May 24.
• [3] -Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization.J Neurovirol. 2016 Dec;22(6):866-870. doi: 10.1007/s13365-016-0464-1. Epub 2016 Jul 11.
• [4] Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia.J Virol. 2006 Jan;80(1):62-72. doi: 10.1128/JVI.80.1.62-72.2006.
• [5] HIV-1B gp120 genes from one patient with AIDS dementia complex can affect the secretion of tumor necrosis factor and interleukin 1 in glial cells.Chin Med J (Engl). 2011 Dec;124(24):4217-22.
• [6] Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain.Ann Neurol. 1997 Nov;42(5):689-98. doi: 10.1002/ana.410420504.