Details of Disease

General Information of Disease (ID: DISAJWJL)

Disease Name	Amoebiasis
Synonyms	chronic intestinal amebiasis; entamoebiasis; amoebiasis
Disease Class	1A36: Amoebiasis
Definition	A parasitic infectious disorder caused by amoebas. The parasite may cause colitis which is manifested with bloody diarrhea, abdominal pain, nausea and fever. In rare cases it may spread to the liver, brain and lungs.
Disease Hierarchy	DIS57EB5: Protozoa infectious disease DISAJWJL: Amoebiasis
ICD Code	ICD-11 ICD-11: 1A36 ICD-10 ICD-10: A06, A06.9 ICD-9 ICD-9: 6 Expand ICD-11 '1A36 Expand ICD-10 'A06; 'A06.9 Expand ICD-9 6
Disease Identifiers	MONDO ID MONDO_0005644 MESH ID D000562 UMLS CUI C0002438 MedGen ID 1857 SNOMED CT ID 105637008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 6 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Iodoquinol	DMUIK80	Approved	Small molecular drug	[1]
Metronidazole	DMTIVEN	Approved	Small molecular drug	[2]
Ornidazole	DM6QHDJ	Approved	Small molecular drug	[1]
Paromomycin	DM1AGXN	Approved	Small molecular drug	[3]
Secnidazole	DMJ18YL	Approved	Small molecular drug	[1]
Sulfacetamide	DMZ6VEY	Approved	Small molecular drug	[4]
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⏷ Show the Full List of 6 Drug(s)

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
WRR605	DMPYGMO	Investigative	NA	[5]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
LAMA2	OTFROQWE	Strong	Altered Expression	[6]
MEIS2	OTG4ADLM	Strong	Genetic Variation	[6]
MEOX2	OTKZCJCB	Strong	Genetic Variation	[6]
NR2E1	OTW47GKM	Strong	Genetic Variation	[6]
TFAP2B	OTR1T8E9	Strong	Genetic Variation	[6]
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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018517.
3	Paromomycin FDA Label
4	Sulfacetamide FDA Label
5	A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J Biol Chem. 2010 Jun 11;285(24):18516-27.
6	Molecular mechanisms underlying gliomas and glioblastoma pathogenesis revealed by bioinformatics analysis of microarray data.Med Oncol. 2017 Sep 26;34(11):182. doi: 10.1007/s12032-017-1043-x.