Details of Disease

General Information of Disease (ID: DISCCHZN)

• Disease Name: Sarcomatoid mesothelioma
• Synonyms: sarcomatoid mesothelioma; malignant fibrous mesothelioma; sarcomatoid mesothelioma (morphologic abnormality); spindled mesothelioma; malignant fibrous mesothelioma (morphologic abnormality)
• Definition: A diffuse malignant mesothelioma arising from the pleura and less often the peritoneum. It is characterized by the presence of spindle cells. Anaplastic morphologic features and multinucleated malignant cells may also be seen.
• Disease Hierarchy:
  DISTHJGH: Malignant mesothelioma
  DISCCHZN: Sarcomatoid mesothelioma
• Disease Identifiers:
  MONDO ID: MONDO_0006407
  UMLS CUI: C0334513
  MedGen ID: 137774
  SNOMED CT ID: 399477001

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cisplatin	DMRHGI9	Approved	Small molecular drug	[1]
Pemetrexed	DMMX2E6	Approved	Small molecular drug	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CDKN2A	TTFTWQ8	Strong	Biomarker	[3]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CALB2	OTSNMCG9	Strong	Altered Expression	[4]

References

• [1] Cisplatin FDA Label
• [2] Pemetrexed FDA Label
• [3] Diagnostic usefulness of p16/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis.Am J Clin Pathol. 2013 Jan;139(1):39-46. doi: 10.1309/AJCPT94JVWIHBKRD.
• [4] MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma.Mod Pathol. 2017 May;30(5):672-681. doi: 10.1038/modpathol.2016.181. Epub 2017 Jan 27.