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Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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ClinicalTrials.gov (NCT02580747) Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART-meso
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| 3 |
Differential susceptibility of human pleural and peritoneal mesothelial cells to asbestos exposure. J Cell Biochem. 2015 Aug;116(8):1540-52.
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| 4 |
Downregulation of TBXAS1 in an iron-induced malignant mesothelioma model.Cancer Sci. 2015 Oct;106(10):1296-302. doi: 10.1111/cas.12752. Epub 2015 Sep 19.
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| 5 |
Expression of V-set immunoregulatory receptor in malignant mesothelioma.Mod Pathol. 2020 Feb;33(2):263-270. doi: 10.1038/s41379-019-0328-3. Epub 2019 Jul 30.
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Methylation profiling of mesothelioma using real-time methylation-specific PCR: a pilot study.Diagn Cytopathol. 2007 Aug;35(8):498-502. doi: 10.1002/dc.20692.
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| 7 |
CAR T-cell immunotherapy of MET-expressing malignant mesothelioma.Oncoimmunology. 2017 Aug 14;6(12):e1363137. doi: 10.1080/2162402X.2017.1363137. eCollection 2017.
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| 8 |
Usefulness of methylthioadenosine phosphorylase and BRCA-associated protein 1 immunohistochemistry in the diagnosis of malignant mesothelioma in effusion cytology specimens.Cancer Cytopathol. 2020 Feb;128(2):126-132. doi: 10.1002/cncy.22221. Epub 2019 Dec 10.
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Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism.J Biol Chem. 2011 Jun 3;286(22):19478-88. doi: 10.1074/jbc.M110.217331. Epub 2011 Apr 12.
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High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma.Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13432-13437. doi: 10.1073/pnas.1612074113. Epub 2016 Nov 9.
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| 11 |
Biological and immunological aspects of malignant mesothelioma.Eur Respir J. 1995 Apr;8(4):643-50.
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| 12 |
Differential regulation of the sphere formation and maintenance of cancer-initiating cells of malignant mesothelioma via CD44 and ALK4 signaling pathways.Oncogene. 2018 Dec;37(49):6357-6367. doi: 10.1038/s41388-018-0405-y. Epub 2018 Jul 30.
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| 13 |
Identification of a tumour associated antigen in lung cancer patients with asbestos exposure.Anticancer Res. 2010 Jul;30(7):2631-9.
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| 14 |
Early detection of malignant pleural mesothelioma in asbestos-exposed individuals with a noninvasive proteomics-based surveillance tool.PLoS One. 2012;7(10):e46091. doi: 10.1371/journal.pone.0046091. Epub 2012 Oct 3.
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| 15 |
Genetic polymorphisms in aquaporin 1 as risk factors for malignant mesothelioma and biomarkers of response to cisplatin treatment.Radiol Oncol. 2019 Mar 3;53(1):96-104. doi: 10.2478/raon-2019-0009.
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| 16 |
Can novel adipokines, asprosin and meteorin-like, be biomarkers for malignant mesothelioma?.Biotech Histochem. 2020 Apr;95(3):171-175. doi: 10.1080/10520295.2019.1656344. Epub 2019 Oct 1.
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| 17 |
Biallelic germline and somatic mutations in malignant mesothelioma: multiple mutations in transcription regulators including mSWI/SNF genes.Int J Cancer. 2015 Feb 1;136(3):560-71. doi: 10.1002/ijc.29015. Epub 2014 Jun 19.
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| 18 |
Increased levels of C-C chemokine RANTES in asbestos exposed workers and in malignant mesothelioma patients from an hyperendemic area.PLoS One. 2014 Aug 27;9(8):e104848. doi: 10.1371/journal.pone.0104848. eCollection 2014.
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MicroRNA and mRNA features of malignant pleural mesothelioma and benign asbestos-related pleural effusion.Biomed Res Int. 2015;2015:635748. doi: 10.1155/2015/635748. Epub 2015 Feb 1.
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| 20 |
The influence of gemcitabine pathway polymorphisms on treatment outcome in patients with malignant mesothelioma.Pharmacogenet Genomics. 2012 Jan;22(1):58-68. doi: 10.1097/FPC.0b013e32834e3572.
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| 21 |
p53, p21 and metallothionein immunoreactivities in patients with malignant pleural mesothelioma: correlations with the epidemiological features and prognosis of mesotheliomas with environmental asbestos exposure.Respir Med. 2001 Jul;95(7):588-93. doi: 10.1053/rmed.2001.1108.
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Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma.Oncogene. 2017 Nov 16;36(46):6501-6507. doi: 10.1038/onc.2017.266. Epub 2017 Jul 31.
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| 23 |
Targeting CD26 suppresses proliferation of malignant mesothelioma cell via downmodulation of ubiquitin-specific protease 22.Biochem Biophys Res Commun. 2018 Oct 2;504(2):491-498. doi: 10.1016/j.bbrc.2018.08.193. Epub 2018 Sep 6.
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| 24 |
ENOX2-based early detection (ONCOblot) of asbestos-induced malignant mesothelioma 4-10years in advance of clinical symptoms.Clin Proteomics. 2016 Jan 22;13:2. doi: 10.1186/s12014-016-9103-3. eCollection 2016.
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EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene.Cancer Gene Ther. 2011 Nov;18(11):806-16. doi: 10.1038/cgt.2011.50. Epub 2011 Aug 26.
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| 26 |
Expression of the folate receptor genes FOLR1 and FOLR3 differentiates ovarian carcinoma from breast carcinoma and malignant mesothelioma in serous... Hum Pathol. 2009 Oct;40(10):1453-60.
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| 27 |
Iron signature in asbestos-induced malignant pleural mesothelioma: A population-based autopsy study.J Toxicol Environ Health A. 2016;79(3):129-41. doi: 10.1080/15287394.2015.1123452. Epub 2016 Jan 28.
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Structure and refinement of the physical mapping of the gamma- glutamylcysteine ligase regulatory subunit (GLCLR) gene to chromosome 1p22.1 within the critically deleted region of human malignant mesothelioma.Cytogenet Cell Genet. 1998;82(1-2):91-4. doi: 10.1159/000015072.
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Epigenetic modulation enhances the therapeutic effect of anti-IL-13R(alpha)2 antibody in human mesothelioma xenografts.Clin Cancer Res. 2011 May 1;17(9):2819-29. doi: 10.1158/1078-0432.CCR-10-2986. Epub 2011 Feb 28.
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Serum concentration of integrin-linked kinase in malignant pleural mesothelioma and after asbestos exposure.Eur J Cardiothorac Surg. 2013 May;43(5):940-5. doi: 10.1093/ejcts/ezs521. Epub 2012 Oct 7.
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| 31 |
Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis.Cancer Lett. 2017 Jan 28;385:215-224. doi: 10.1016/j.canlet.2016.10.020. Epub 2016 Oct 20.
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Extracellular signal-regulated kinase 5 and cyclic AMP response element binding protein are novel pathways inhibited by vandetanib (ZD6474) and doxorubicin in mesotheliomas.Am J Respir Cell Mol Biol. 2014 Nov;51(5):595-603. doi: 10.1165/rcmb.2013-0373TR.
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Two cases of malignant peritoneal mesothelioma without asbestos exposure: cytologic and immunohistochemical features.Ann Diagn Pathol. 2013 Feb;17(1):99-103. doi: 10.1016/j.anndiagpath.2012.05.007. Epub 2012 Jul 10.
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Midkine is a potential novel marker for malignant mesothelioma with different prognostic and diagnostic values from mesothelin.BMC Cancer. 2017 Mar 23;17(1):212. doi: 10.1186/s12885-017-3209-5.
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Prediagnostic detection of mesothelioma by circulating calretinin and mesothelin - a case-control comparison nested into a prospective cohort of asbestos-exposed workers.Sci Rep. 2018 Sep 25;8(1):14321. doi: 10.1038/s41598-018-32315-3.
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Induction of IL-17 production from human peripheral blood CD4+ cells by asbestos exposure.Int J Oncol. 2017 Jun;50(6):2024-2032. doi: 10.3892/ijo.2017.3991. Epub 2017 May 9.
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Molecular Analysis of a Patient With Neurofibromatosis 2 (NF2) and Peritoneal Malignant Mesothelioma.Am J Surg Pathol. 2020 Feb;44(2):288-292. doi: 10.1097/PAS.0000000000001359.
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Malignant Pleural Mesothelioma, Biphasic Type: An Unusual and Insidious Case of Rapidly Progressive Small Blue Cell Tumor.Cureus. 2018 Jun 6;10(6):e2749. doi: 10.7759/cureus.2749.
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| 39 |
Evaluation of New Biomarkers in the Prediction of Malignant Mesothelioma in Subjects with Environmental Asbestos Exposure.Lung. 2016 Jun;194(3):409-17. doi: 10.1007/s00408-016-9868-1. Epub 2016 Mar 31.
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Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations.Nat Genet. 2016 Apr;48(4):407-16. doi: 10.1038/ng.3520. Epub 2016 Feb 29.
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| 41 |
Delivery of expression constructs of secreted frizzled-related protein 4 and its domains by chitosan-dextran sulfate nanoparticles enhances their expression and anti-cancer effects.Mol Cell Biochem. 2018 Jun;443(1-2):205-213. doi: 10.1007/s11010-017-3225-4. Epub 2017 Nov 28.
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| 42 |
Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung.Lung Cancer. 2005 Feb;47(2):193-204. doi: 10.1016/j.lungcan.2004.08.003.
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| 43 |
Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations.Int J Hyg Environ Health. 2006 Jul;209(4):393-8. doi: 10.1016/j.ijheh.2006.03.002. Epub 2006 May 11.
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| 44 |
LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade.Oncogene. 2015 Jan 2;34(1):73-83. doi: 10.1038/onc.2013.528. Epub 2013 Dec 16.
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| 45 |
Soluble CD157 in pleural effusions: a complementary tool for the diagnosis of malignant mesothelioma.Oncotarget. 2018 Apr 27;9(32):22785-22801. doi: 10.18632/oncotarget.25237. eCollection 2018 Apr 27.
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| 46 |
Malignant pleural mesothelioma-targeted CREBBP/EP300 inhibitory protein 1 promoter system for gene therapy and virotherapy.Cancer Res. 2008 Sep 1;68(17):7120-9. doi: 10.1158/0008-5472.CAN-08-0047.
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Latent TGF- binding proteins (LTBPs) 1 and 3 differentially regulate transforming growth factor- activity in malignant mesothelioma.Hum Pathol. 2011 Feb;42(2):269-78. doi: 10.1016/j.humpath.2010.07.005. Epub 2010 Nov 24.
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Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies.Int J Cancer. 2005 Feb 10;113(4):600-4. doi: 10.1002/ijc.20622.
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| 49 |
Expression of plakophilin 3 in diffuse malignant pleural mesothelioma.Histol Histopathol. 2018 Sep;33(9):995-1004. doi: 10.14670/HH-11-996. Epub 2018 May 3.
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| 50 |
Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent.Eur J Cancer. 2012 May;48(7):1096-107. doi: 10.1016/j.ejca.2011.11.009. Epub 2011 Dec 10.
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Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology.Chest. 2010 Jul;138(1):137-44. doi: 10.1378/chest.09-1951. Epub 2010 Feb 5.
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Therapeutic efficacy evaluation of radioimmunotherapy with (90) Y-labeled anti-podoplanin antibody NZ-12 for mesothelioma.Cancer Sci. 2019 May;110(5):1653-1664. doi: 10.1111/cas.13979. Epub 2019 Mar 12.
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Tenascin XB Is a Novel Diagnostic Marker for Malignant Mesothelioma.Anticancer Res. 2019 Feb;39(2):627-633. doi: 10.21873/anticanres.13156.
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| 54 |
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.Mod Pathol. 2019 Jan;32(1):88-99. doi: 10.1038/s41379-018-0127-2. Epub 2018 Aug 31.
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Gene-asbestos interaction in malignant pleural mesothelioma susceptibility.Carcinogenesis. 2015 Oct;36(10):1129-35. doi: 10.1093/carcin/bgv097. Epub 2015 Jul 2.
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| 56 |
Development and Evaluation of Antibody Proteomics Technology for Rapid and Comprehensive Identification of Potential Biomarkers and Therapeutic Targets.Biol Pharm Bull. 2018;41(5):663-669. doi: 10.1248/bpb.b17-01041.
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A Subset of Malignant Mesotheliomas in Young Adults Are Associated With Recurrent EWSR1/FUS-ATF1 Fusions.Am J Surg Pathol. 2017 Jul;41(7):980-988. doi: 10.1097/PAS.0000000000000864.
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Absence of post-transcriptional RNA modifications of BCL10 in human malignant mesothelioma and colorectal cancer.Genes Chromosomes Cancer. 2001 Jan;30(1):96-8. doi: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1059>3.0.co;2-7.
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Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related Ca(2+)-Binding Proteins Calbindin-D28k and Parvalbumin.Int J Mol Sci. 2018 Dec 12;19(12):4015. doi: 10.3390/ijms19124015.
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| 60 |
The role of apoptosis defects in malignant mesothelioma pathogenesis with an impact on prognosis and treatment.Cancer Chemother Pharmacol. 2019 Aug;84(2):241-253. doi: 10.1007/s00280-019-03878-3. Epub 2019 May 22.
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Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines.Cancer Genet. 2013 May;206(5):191-205. doi: 10.1016/j.cancergen.2013.04.006. Epub 2013 Jul 5.
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Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing.Lung. 2016 Feb;194(1):125-35. doi: 10.1007/s00408-015-9814-7.
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A genome-wide association study for malignant mesothelioma risk.Lung Cancer. 2013 Oct;82(1):1-8. doi: 10.1016/j.lungcan.2013.04.018. Epub 2013 Jul 1.
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Fibulin-3 as biomarker of malignant mesothelioma.Biomark Med. 2019 Jul;13(10):875-886. doi: 10.2217/bmm-2018-0285. Epub 2019 Jun 25.
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Expression of the Ets transcription factor EHF in serous ovarian carcinoma effusions is a marker of poor survival.Hum Pathol. 2012 Apr;43(4):496-505. doi: 10.1016/j.humpath.2011.05.023. Epub 2011 Aug 19.
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Expression of Snail, Slug and Sip1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression.Lung Cancer. 2006 Dec;54(3):309-17. doi: 10.1016/j.lungcan.2006.08.010. Epub 2006 Sep 25.
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Homozygous deletions within 9p21-p22 identify a small critical region of chromosomal loss in human malignant mesotheliomas.Cancer Res. 1993 Oct 15;53(20):4761-3.
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CD146 and insulin-like growth factor 2 mRNA-binding protein 3 predict prognosis of asbestos-induced rat mesothelioma.Cancer Sci. 2013 Aug;104(8):989-95. doi: 10.1111/cas.12185. Epub 2013 May 26.
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PINCH-2 expression in cancers involving serosal effusions using quantitative PCR.Cytopathology. 2011 Feb;22(1):22-9. doi: 10.1111/j.1365-2303.2010.00757.x.
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Pro-tumorigenic effects of miR-31 loss in mesothelioma.J Biol Chem. 2010 Jul 23;285(30):22809-17. doi: 10.1074/jbc.M110.100354. Epub 2010 May 12.
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Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells.Redox Biol. 2014;3:79-87. doi: 10.1016/j.redox.2014.11.003. Epub 2014 Nov 18.
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Inflammation-Related IL1/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma.Cancer Prev Res (Phila). 2016 May;9(5):406-414. doi: 10.1158/1940-6207.CAPR-15-0347. Epub 2016 Mar 2.
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YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes.Oncogene. 2012 Dec 6;31(49):5117-22. doi: 10.1038/onc.2012.5. Epub 2012 Jan 30.
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Frequent deletion of 3p21.1 region carrying semaphorin 3G and aberrant expression of the genes participating in semaphorin signaling in the epithelioid type of malignant mesothelioma cells.Int J Oncol. 2011 Dec;39(6):1365-74. doi: 10.3892/ijo.2011.1158. Epub 2011 Aug 12.
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Assessing the completeness and correctness of the registration of malignant mesothelioma in Belgium.Lung Cancer. 2018 Aug;122:38-43. doi: 10.1016/j.lungcan.2018.05.018. Epub 2018 May 21.
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Mutational analysis of hedgehog signaling pathway genes in human malignant mesothelioma.PLoS One. 2013 Jun 24;8(6):e66685. doi: 10.1371/journal.pone.0066685. Print 2013.
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Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma.J Clin Oncol. 2018 Oct 1;36(28):2863-2871. doi: 10.1200/JCO.2018.78.5204. Epub 2018 Aug 16.
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Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types.Int J Cancer. 2004 May 1;109(5):786-92. doi: 10.1002/ijc.20041.
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