Details of Disease

General Information of Disease (ID: DISCQ39I)

• Disease Name: Postherpetic neuralgia
• Synonyms: PHN - post-herpetic neuralgia; post-zoster neuralgia; postherpetic neuralgia
• Disease Class: 1E91: Zoster
• Disease Hierarchy:
  DISMIHUH: Post-infectious neuralgia
  DISCQ39I: Postherpetic neuralgia
• ICD Code:
  ICD-11: ICD-11: 1E91.5
  ICD-10: ICD-10: G53.0
• Disease Identifiers:
  MONDO ID: MONDO_0041052
  UMLS CUI: C0032768
  MedGen ID: 18589
  Orphanet ID: 466673
  SNOMED CT ID: 2177002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 5 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Capsaicin	DMGMF6V	Approved	Small molecular drug	[1]
Gabapentin	DM6T924	Approved	Small molecular drug	[2]
Lidocaine	DML4ZOT	Approved	Small molecular drug	[3]
Pregabalin	DMDVP3B	Approved	Small molecular drug	[4]
VariZIG	DMJ3JEK	Approved	NA	[5]

This Disease is Treated as An Indication in 5 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
EMA-401	DMYOUB6	Phase 2	Small molecular drug	[6]
Gabapentin enacarbil	DMJY2TM	Phase 2	Small molecular drug	[7]
TEM	DMLNFWU	Phase 2	Small molecular drug	[8]
3VM1001	DMRSXGD	Phase 1/2	NA	[9]
ARC-2022	DMXASP4	Phase 1/2	NA	[10]

This Disease is Treated as An Indication in 2 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
DA-5018	DM48ECA	Discontinued in Phase 2	Small molecular drug	[11]
KDS-2000	DMX9M53	Discontinued in Phase 2	NA	[11]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
TDT-077	DMX1AIZ	Investigative	NA	[12]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CPS1	TT42M75	Strong	Genetic Variation	[14]
SCN8A	TT54ERL	Strong	Biomarker	[15]
SCN9A	TT4G2JS	Strong	Biomarker	[15]

References

• [1] Capsaicin FDA Label
• [2] Gabapentin FDA Label
• [3] Lidocaine FDA Label
• [4] Pregabalin FDA Label
• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8374).
• [7] Gabapentin enacarbil FDA Label
• [8] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
• [9] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [10] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027668)
• [11] Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
• [12] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [13] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [14] The comparative efficacy and safety of herpes zoster vaccines: A network meta-analysis.Vaccine. 2019 May 16;37(22):2896-2909. doi: 10.1016/j.vaccine.2019.04.014. Epub 2019 Apr 11.
• [15] Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line.PLoS One. 2013;8(1):e51570. doi: 10.1371/journal.pone.0051570. Epub 2013 Jan 31.