Details of Disease

Disease Name

Streptococcal toxic-shock syndrome

streptococcal TSS; Streptococcus toxic shock syndrome; Streptococcus caused toxic shock syndrome

Definition

Streptococcal toxic-shock syndrome (streptococcal TSS) is an acute disease mediated by the production of superantigenic toxins characterized by the sudden onset of fever and other febrile symptoms, pain, multisystem organ involvement and potentially leading to coma, shock and death due to a Streptococcus pyogenes infection.

Disease Hierarchy

DIS04U9T: Streptococcus infection

DISX5S53: Toxic shock syndrome

DISCVXCW: Streptococcal toxic-shock syndrome

Disease Identifiers

MONDO ID

MONDO_0020544

UMLS CUI

C0343532

MedGen ID

575664

Orphanet ID

99918

SNOMED CT ID

240451000

General Information of Disease (ID: DISCVXCW)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benzylpenicillin	DMS9503	Phase 3	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
KCNMA1	TTE87WJ	Limited	Biomarker	[2]
GALNS	TTT9YPO	Strong	Biomarker	[3]
GAST	TT4LRVO	Strong	Biomarker	[3]
LRRC32	TT0FAYT	Strong	Biomarker	[4]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PAGR1	OTXR5PQ8	Strong	Biomarker	[3]
RAB3IL1	OT18H5HD	Definitive	Biomarker	[5]
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References

1	[Beta-hemolytic streptococcal bacteremia in adults]. Duodecim. 2013;129(14):1477-84.
2	Correlation of virulence genes to clinical manifestations and outcome in patients with Streptococcus dysgalactiae subspecies equisimilis bacteremia.J Microbiol Immunol Infect. 2014 Dec;47(6):462-8. doi: 10.1016/j.jmii.2013.08.019. Epub 2013 Nov 7.
3	T serotyping of group a streptococcus isolated from patients with pharyngitis or streptococcal toxic shock syndrome in Japan between 2005 and 2017.J Infect Chemother. 2020 Feb;26(2):157-161. doi: 10.1016/j.jiac.2019.10.010. Epub 2019 Nov 15.
4	Heterogeneity in FoxP3- and GARP/LAP-Expressing T Regulatory Cells in an HLA Class II Transgenic Murine Model of Necrotizing Soft Tissue Infections by Group A Streptococcus.Infect Immun. 2018 Nov 20;86(12):e00432-18. doi: 10.1128/IAI.00432-18. Print 2018 Dec.
5	Low antibody levels against cell wall-attached proteins of Streptococcus pyogenes predispose for severe invasive disease.J Infect Dis. 2004 Mar 1;189(5):797-804. doi: 10.1086/381982. Epub 2004 Feb 18.