Details of Disease

General Information of Disease (ID: DISDAMTJ)

Disease Name Oropharyngeal cancer
Synonyms
oropharyngeal carcinoma; malignant tumor of mesopharynx; oropharyngeal cancer; malignant oropharynx neoplasm; malignant neoplasm of junctional region of oropharynx; malignant oropharyngeal tumour; malignant oropharyngeal tumor; malignant neoplasm of the oropharynx; malignant tumour of the oropharynx; malignant tumor of the oropharynx; malignant neoplasm of lateral wall of oropharynx; malignant neoplasm of posterior wall of oropharynx; malignant oropharyngeal neoplasm; oropharynx cancer; malignant tumour of mesopharynx; cancer of oropharynx; malignant tumor of oropharynx; primary malignant neoplasm of lateral wall of oropharynx; malignant tumor of posterior wall of oropharynx; malignant tumour of posterior wall of oropharynx; malignant tumour of oropharynx; malignant neoplasm of oropharynx
Disease Class 2B6A: Oropharyngeal cancer
Definition A primary or metastatic malignant neoplasm that affects the oropharynx.
Disease Hierarchy
DIS6YM4S: Neoplasm of oropharynx
DISXLF8Z: Pharynx cancer
DISAT1Z9: Advanced cancer
DISDAMTJ: Oropharyngeal cancer
ICD Code
ICD-11
ICD-11: 2B6A
Expand ICD-11
'2B6A.Z
Disease Identifiers
MONDO ID
MONDO_0004608
UMLS CUI
C0153382
MedGen ID
57783
SNOMED CT ID
363392002

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
TT12 DM6XPQ6 Phase 1 NA [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 3 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
GRHL2 TTUGH4C Strong Altered Expression [2]
KCNC4 TTODZF1 Strong Genetic Variation [3]
SIRPA TTBRJS9 Strong Altered Expression [4]
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This Disease Is Related to 2 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ADH1B DEEN9RD Strong Genetic Variation [3]
ADH5 DEIOH6A Strong Genetic Variation [5]
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This Disease Is Related to 8 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
APOBEC3A OTYO6F5P Strong Biomarker [6]
DEFB103B OT8RWY64 Strong Altered Expression [7]
EPB41L3 OTS6CHG2 Strong Genetic Variation [8]
HLA-DQB1 OTVVI3UI Strong Genetic Variation [3]
MED15 OT0D0JVD Strong Biomarker [9]
NEIL2 OTV6JEON Strong Genetic Variation [10]
PEG3 OTHQW98S Strong Posttranslational Modification [11]
SIAH1 OT29A838 Strong Biomarker [12]
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⏷ Show the Full List of 8 DOT(s)

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Human Papillomavirus 16 E6 Induces FoxM1B in Oral Keratinocytes through GRHL2.J Dent Res. 2018 Jul;97(7):795-802. doi: 10.1177/0022034518756071. Epub 2018 Feb 14.
3 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.Nat Genet. 2016 Dec;48(12):1544-1550. doi: 10.1038/ng.3685. Epub 2016 Oct 17.
4 Genetic Mutation and Exosome Signature of Human Papilloma Virus Associated Oropharyngeal Cancer.Sci Rep. 2017 Apr 6;7:46102. doi: 10.1038/srep46102.
5 Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms.Hum Genet. 1997 Mar;99(3):319-25. doi: 10.1007/s004390050365.
6 Expression of estrogen receptor alpha is associated with pathogenesis and prognosis of human papillomavirus-positive oropharyngeal cancer.Int J Cancer. 2019 Sep 15;145(6):1547-1557. doi: 10.1002/ijc.32500. Epub 2019 Jun 22.
7 Human papillomavirus oncogenic E6 protein regulates human -defensin 3 (hBD3) expression via the tumor suppressor protein p53.Oncotarget. 2016 May 10;7(19):27430-44. doi: 10.18632/oncotarget.8443.
8 Methylation of HPV 16 and EPB41L3 in oral gargles: Associations with oropharyngeal cancer detection and tumor characteristics.Int J Cancer. 2020 Feb 15;146(4):1018-1030. doi: 10.1002/ijc.32570. Epub 2019 Jul 26.
9 Promoter Hypermethylation of Tumor-Suppressor Genes p16(INK4a),RASSF1A,TIMP3, and PCQAP/MED15 in Salivary DNA as a Quadruple Biomarker Panel for Early Detection of Oral and Oropharyngeal Cancers.Biomolecules. 2019 Apr 12;9(4):148. doi: 10.3390/biom9040148.
10 Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.Clin Cancer Res. 2008 Jul 1;14(13):4345-52. doi: 10.1158/1078-0432.CCR-07-5282.
11 Hypermethylation of a cluster of Krppel-type zinc finger protein genes on chromosome 19q13 in oropharyngeal squamous cell carcinoma.Am J Pathol. 2011 May;178(5):1965-74. doi: 10.1016/j.ajpath.2011.01.049.
12 Activation of Wnt signaling pathway by human papillomavirus E6 and E7 oncogenes in HPV16-positive oropharyngeal squamous carcinoma cells.Mol Cancer Res. 2010 Mar;8(3):433-43. doi: 10.1158/1541-7786.MCR-09-0345. Epub 2010 Mar 9.