Details of Disease

General Information of Disease (ID: DISEA4L7)

• Disease Name: Relapsing fever
• Definition: Relapsing fever is an infection caused by bacteria of the genus Borrelia, excluding those responsible for Lyme disease belonging to the Borrelia burgdorferi complex.
• Disease Hierarchy:
  DISGFCIX: Vector-borne disease
  DIS8ZVFW: Primary bacterial infectious disease
  DISKCYB2: Borrelia infectious disease
  DISEA4L7: Relapsing fever
• Disease Identifiers:
  MONDO ID: MONDO_0019633
  MESH ID: D012061
  UMLS CUI: C0035021
  MedGen ID: 48397
  Orphanet ID: 91547

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 7 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Demeclocycline	DMZEPFJ	Approved	Small molecular drug	[2]
Doxycycline	DM7ICNU	Approved	Small molecular drug	[3]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[4]
Minocycline	DMVN5OH	Approved	Small molecular drug	[5]
Oxytetracycline	DMOVH1M	Approved	Small molecular drug	[6]
Tetracycline	DMZA017	Approved	Small molecular drug	[7]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IL1RN	TT6GSR3	Strong	Biomarker	[8]
NLRP3	TT4EN8X	Strong	Biomarker	[9]
NTRK1	TTTDVOJ	Strong	Genetic Variation	[10]
TNFRSF1A	TTG043C	Strong	Biomarker	[11]

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CPVL	OTOJL31C	Strong	Biomarker	[12]
LPIN2	OTRRTMXX	Strong	Genetic Variation	[13]
MEFV	OTRJ6S6K	Definitive	Genetic Variation	[14]
NLRP12	OTGR132Z	Definitive	Biomarker	[15]

References

• [1] Amphotericin B FDA Label
• [2] Demeclocycline FDA Label
• [3] Doxycycline FDA Label
• [4] A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
• [5] Minocycline FDA Label
• [6] Oxytetracycline FDA Label
• [7] Tetracycline FDA Label
• [8] An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med. 2009 Jun 4;360(23):2426-37. doi: 10.1056/NEJMoa0807865.
• [9] Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis.Arthritis Rheum. 2002 Sep;46(9):2445-52. doi: 10.1002/art.10509.
• [10] A novel point mutation affecting the tyrosine kinase domain of the TRKA gene in a family with congenital insensitivity to pain with anhidrosis.J Invest Dermatol. 1999 May;112(5):810-4. doi: 10.1046/j.1523-1747.1999.00569.x.
• [11] A novel mutation (T61I) in the gene encoding tumour necrosis factor receptor superfamily 1A (TNFRSF1A) in a Japanese patient with tumour necrosis factor receptor-associated periodic syndrome (TRAPS) associated with systemic lupus erythematosus.Rheumatology (Oxford). 2004 Oct;43(10):1292-9. doi: 10.1093/rheumatology/keh320. Epub 2004 Jul 27.
• [12] Genome-wide analysis of Borrelia turcica and 'Candidatus Borrelia tachyglossi' shows relapsing fever-like genomes with unique genomic links to Lyme disease Borrelia.Infect Genet Evol. 2018 Dec;66:72-81. doi: 10.1016/j.meegid.2018.09.013. Epub 2018 Sep 18.
• [13] Compound heterozygous LPIN2 pathogenic variants in a patient with Majeed syndrome with recurrent fever and severe neutropenia: case report.BMC Med Genet. 2019 Nov 14;20(1):182. doi: 10.1186/s12881-019-0919-3.
• [14] A novel insertion mutation identified in exon 10 of the MEFV gene associated with Familial Mediterranean Fever.BMC Med Genet. 2014 Jul 1;15:74. doi: 10.1186/1471-2350-15-74.
• [15] The clinical phenotype and genotype of NLRP12-autoinflammatory disease: a Chinese case series with literature review.World J Pediatr. 2020 Oct;16(5):514-519. doi: 10.1007/s12519-019-00294-8. Epub 2019 Dec 9.