Details of Disease

General Information of Disease (ID: DISGX28I)

Disease Name Herpes simplex encephalitis
Synonyms
Herpes simplex virus encephalitis; Herpes simplex neuroinvasion; HSE; Herpes simplex meningo-encephalitis; Simplexvirus infectious encephalitis; HSV encephalitis; herpetic encephalitis; HSVE; Encephalitis, Herpes Simplex; Simplexvirus caused infectious encephalitis
Definition
Herpes simplex virus encephalitis (HSE) is caused by the infection of the central nervous system by Herpes simplex virus (HSV) that could have a devastating clinical course and a potentially fatal outcome particularly with delay or lack of treatment. HSV often involves the frontal and temporal lobes, usually asymmetrically, resulting in personality changes, cognitive impairment, aphasia, seizures, and focal weakness.
Disease Hierarchy
DIS9G09S: Viral encephalitis
DISTC30O: Infectious encephalitis
DIS7K18Z: Herpes simplex virus infection
DISGX28I: Herpes simplex encephalitis
Disease Identifiers
MONDO ID
MONDO_0012521
MESH ID
D020803
UMLS CUI
C0276226
MedGen ID
75794
HPO ID
HP:0012302
Orphanet ID
1930
SNOMED CT ID
428638009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Aciclovir DMYLOVR Approved Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 6 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ACKR1 TTKY2NS Strong Biomarker [2]
CALCA TTVSFJW Strong Therapeutic [3]
CALCR TTLWS2O Strong Therapeutic [3]
IRAK4 TTILUKB Strong Genetic Variation [4]
TLR2 TTY7ZHS Strong Biomarker [5]
TLR4 TTISGCA Strong Biomarker [5]
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⏷ Show the Full List of 6 DTT(s)
This Disease Is Related to 7 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
IKBKG OTNWJWSD Limited Biomarker [6]
IRF9 OTK4MYQJ moderate Genetic Variation [7]
C1QTNF4 OTHD4Y9D Strong Altered Expression [8]
CEBPZ OT11BATG Strong Biomarker [9]
IFNLR1 OTWWWK45 Strong Genetic Variation [10]
LGI1 OTPS77HO Strong Biomarker [11]
TRAF3 OT5TQBGV Strong Biomarker [12]
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⏷ Show the Full List of 7 DOT(s)

References

1 Management of suspected viral encephalitis in adults--Association of British Neurologists and British Infection Association National Guidelines. J Infect. 2012 Apr;64(4):347-73.
2 Analysis of herpes simplex virus type 1 glycoprotein D nucleotide sequence in human herpes simplex encephalitis.J Neurovirol. 1996 Aug;2(4):289-95. doi: 10.3109/13550289609146892.
3 The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.PLoS Pathog. 2012;8(6):e1002753. doi: 10.1371/journal.ppat.1002753. Epub 2012 Jun 28.
4 The role of Toll-like receptor signaling in human immunodeficiencies.Clin Rev Allergy Immunol. 2010 Feb;38(1):11-9. doi: 10.1007/s12016-009-8135-0.
5 Influence of perineurial cells and Toll-like receptors 2 and 9 on Herpes simplex type 1 entry to the central nervous system in rat encephalitis.PLoS One. 2010 Aug 27;5(8):e12350. doi: 10.1371/journal.pone.0012350.
6 Mendelian predisposition to herpes simplex encephalitis.Handb Clin Neurol. 2013;112:1091-7. doi: 10.1016/B978-0-444-52910-7.00027-1.
7 IRF and STAT Transcription Factors - From Basic Biology to Roles in Infection, Protective Immunity, and Primary Immunodeficiencies.Front Immunol. 2019 Jan 8;9:3047. doi: 10.3389/fimmu.2018.03047. eCollection 2018.
8 C1Q/TNF-related protein 4 expression correlates with herpes simplex encephalitis progression.Ann Transl Med. 2019 Jun;7(11):235. doi: 10.21037/atm.2019.05.01.
9 Role of 3D Pseudocontinuous Arterial Spin-Labeling Perfusion in the Diagnosis and Follow-Up in Patients with Herpes Simplex Encephalitis.AJNR Am J Neuroradiol. 2019 Nov;40(11):1901-1907. doi: 10.3174/ajnr.A6279. Epub 2019 Oct 24.
10 Frequently used bioinformatics tools overestimate the damaging effect of allelic variants.Genes Immun. 2019 Jan;20(1):10-22. doi: 10.1038/s41435-017-0002-z. Epub 2017 Dec 4.
11 Postherpes simplex encephalitis: a case series of viral-triggered autoimmunity, synaptic autoantibodies and response to therapy.Ther Adv Neurol Disord. 2018 Apr 23;11:1756286418768778. doi: 10.1177/1756286418768778. eCollection 2018.
12 Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. J Clin Invest. 2011 Dec;121(12):4889-902. doi: 10.1172/JCI59259. Epub 2011 Nov 21.