Details of Disease

General Information of Disease (ID: DISH4FJX)

• Disease Name: Malignant pancreatic neoplasm
• Synonyms: pancreatic tumour; pancreas neoplasm; Ca head of pancreas; cancer of pancreas; Ca tail of pancreas; malignant pancreatic neoplasm; Ca body of pancreas; malignant neoplasm of head of pancreas; malignant neoplasm of body of pancreas; malignant pancreas neoplasm; malignant neoplasm of pancreas; malignant neoplasm of the pancreas; pancreas cancer; malignant neoplasm of tail of pancreas; pancreatic cancer
• Definition: A malignant neoplasm involving the pancreas.
• Disease Hierarchy:
  DIS3U0LK: Pancreatic tumour
  DISAT1Z9: Advanced cancer
  DIS3AOQ7: Aerodigestive tract cancer
  DISH4FJX: Malignant pancreatic neoplasm

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ACVR1B	TTPKHTZ	No Known	Unknown	[1]
CDK4	TT0PG8F	Moderate	Autosomal dominant	[2]
MLH1	TTISG27	Moderate	Autosomal dominant	[2]
MSH2	TTCAWRT	Moderate	Autosomal dominant	[2]
PRSS1	TT2WR1T	Moderate	Autosomal dominant	[2]

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACVR1B	OT778HIQ	No Known	Unknown	[1]
FANCC	OTTIDM3P	Limited	Autosomal dominant	[1]
CDK4	OT7EP05T	Moderate	Autosomal dominant	[2]
MLH1	OTG5XDD8	Moderate	Autosomal dominant	[2]
MSH2	OT10H1AB	Moderate	Autosomal dominant	[2]
MSH6	OT46FP09	Moderate	Autosomal dominant	[2]
PMS2	OTNLWTMI	Moderate	Autosomal dominant	[2]
PRSS1	OTA425AX	Moderate	Autosomal dominant	[2]

References

• [1] Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
• [2] Current Approaches to Pancreatic Cancer Screening. Am J Pathol. 2019 Jan;189(1):22-35. doi: 10.1016/j.ajpath.2018.09.013.