Details of Disease

Disease Name

typhus exanthematique; shop typhus; ship fever; rat flea typhus; prison fever; petechial fever; murine typhus; louse-borne typhus; louse-borne rickettsiosis; jail fever; hospital fever; gaol fever; flea-borne typhus; flea-borne rickettsiosis; famine fever; exanthematous typhus; epidemic louse-borne typhus fever due to Rickettsia prowazekii; epidemic (louse-borne) typhus; classical typhus (fever); classical typhus; Urban typhus; Moscow typhus; Mexican typhus; European typhus; murine [endemic] typhus; louse-borne [epidemic] typhus; flea typhus; exanthematic typhus fever; epidemic louse-borne typhus; endemic typhus fever; endemic flea-borne typhus; typhus-group rickettsiosis; typhus-group rickettsiae disease; typhus fever

Definition

A group of infectious diseases that include epidemic typhus, scrub typhus and murine typhus.

Disease Hierarchy

DISLJN3G: Rickettsiaceae infectious disease

DISGFCIX: Vector-borne disease

DISJ5JX1: Typhus

Disease Identifiers

MONDO ID

MONDO_0001246

UMLS CUI

C0041471

MedGen ID

11976

Orphanet ID

102023

General Information of Disease (ID: DISJ5JX1)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 7 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Demeclocycline	DMZEPFJ	Approved	Small molecular drug	[2]
Doxycycline	DM7ICNU	Approved	Small molecular drug	[3]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[4]
Minocycline	DMVN5OH	Approved	Small molecular drug	[5]
Oxytetracycline	DMOVH1M	Approved	Small molecular drug	[6]
Tetracycline	DMZA017	Approved	Small molecular drug	[7]
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⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CS	TTZA6B3	Limited	Genetic Variation	[8]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
P3H3	OTRC8QCM	Strong	Genetic Variation	[9]
TRIT1	OTCU9FS5	Strong	Biomarker	[10]
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References

1	Amphotericin B FDA Label
2	Demeclocycline FDA Label
3	Doxycycline FDA Label
4	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
5	Minocycline FDA Label
6	Oxytetracycline FDA Label
7	Tetracycline FDA Label
8	Development of a duplex real-time PCR for the detection of Rickettsia spp. and typhus group rickettsia in clinical samples.FEMS Immunol Med Microbiol. 2012 Feb;64(1):92-7. doi: 10.1111/j.1574-695X.2011.00910.x. Epub 2011 Dec 12.
9	Phylogenetic analysis of the rompB genes of Rickettsia felis and Rickettsia prowazekii European-human and North American flying-squirrel strains.Am J Trop Med Hyg. 2000 May;62(5):598-603. doi: 10.4269/ajtmh.2000.62.598.
10	Molecular epidemic survey on co-prevalence of scrub typhus and marine typhus in Yuxi city, Yunnan province of China.Chin Med J (Engl). 2007 Aug 5;120(15):1314-8.