Details of Disease

General Information of Disease (ID: DISJS4LS)

• Disease Name: Agranulocytosis
• Synonyms: granulocytopenia; Granulopenia; Granulocytopenic disorder
• Definition: A decrease in the number of mature granulocytes (neutrophils, eosinophils, and basophils) in the peripheral blood.
• Disease Hierarchy:
  DISJMBMM: Leukopenia
  DISJS4LS: Agranulocytosis
• Disease Identifiers:
  MONDO ID: MONDO_0001609
  MESH ID: D000380
  UMLS CUI: C0001824
  MedGen ID: 7932
  HPO ID: HP:0012234
  SNOMED CT ID: 17182001

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CNP	TT71P0H	Disputed	Biomarker	[1]
CSF2	TTNYZG2	Strong	Biomarker	[2]
CSF3	TT5TQ2W	Strong	Biomarker	[3]
GADD45B	TTMDW9L	Strong	Genetic Variation	[4]
NQO2	TTJLP0R	Strong	Biomarker	[5]

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
FMO3	DEP76YL	Strong	Genetic Variation	[6]
TPMT	DEFQ8VO	Strong	Genetic Variation	[7]

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ASF1A	OT4S44GP	Disputed	Genetic Variation	[8]
ITPA	OTQ47WVR	Disputed	Genetic Variation	[7]
NCOA5	OTOGWTWB	Disputed	Genetic Variation	[8]
NOX3	OT0FFJH8	Disputed	Genetic Variation	[9]
NUDT15	OTX8SZOT	moderate	Genetic Variation	[10]
HSPA2	OTSDET7B	Strong	Genetic Variation	[11]
NFYB	OTXSE7KW	Strong	Biomarker	[6]
TCN2	OT41D0L3	Strong	Biomarker	[12]

References

• [1] Myeloprotective effects of C-type natriuretic peptide on cisplatin-induced bone marrow granulocytopenia in mice.Cancer Chemother Pharmacol. 2017 Feb;79(2):363-368. doi: 10.1007/s00280-016-3221-5. Epub 2017 Jan 18.
• [2] Full-dose CHOP chemotherapy combined with granulocyte colony-stimulating factor for aggressive non-Hodgkin's lymphoma in elderly patients: a prospective study.Ann Hematol. 2001 Oct;80(10):602-6. doi: 10.1007/s002770100358.
• [3] Granulocyte-Colony-Stimulating Factor Effectively Shortens Recovery Duration in Anti-Thyroid-Drug-Induced Agranulocytosis: A Systematic Review and Meta-Analysis.Front Endocrinol (Lausanne). 2019 Nov 22;10:789. doi: 10.3389/fendo.2019.00789. eCollection 2019.
• [4] Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer.Oncotarget. 2016 May 3;7(18):25291-303. doi: 10.18632/oncotarget.8052.
• [5] Reduction and scavenging of chemically reactive drug metabolites by NAD(P)H:quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 and variability in hepatic concentrations. Chem Res Toxicol. 2018 Feb 19;31(2):116-126.
• [6] Novel Association between Flavin-Containing Monooxygenase 3 Gene Polymorphism and Antithyroid Drug-Induced Agranulocytosis in the Han Population.Ann Nutr Metab. 2019;74(3):200-206. doi: 10.1159/000497314. Epub 2019 Feb 27.
• [7] Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment.J Gastroenterol. 2009;44(3):197-203. doi: 10.1007/s00535-008-2307-1. Epub 2009 Feb 13.
• [8] Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case study.PLoS Comput Biol. 2011 Mar;7(3):e1002016. doi: 10.1371/journal.pcbi.1002016. Epub 2011 Mar 31.
• [9] Rare NOX3 Variants Confer Susceptibility to Agranulocytosis During Thyrostatic Treatment of Graves' Disease.Clin Pharmacol Ther. 2017 Dec;102(6):1017-1024. doi: 10.1002/cpt.733. Epub 2017 Jul 10.
• [10] Severe thiopurine-induced leukocytopenia and hair loss in Japanese patients with defective NUDT15 variant: Retrospective case-control study.J Dermatol. 2018 Oct;45(10):1160-1165. doi: 10.1111/1346-8138.14588. Epub 2018 Aug 13.
• [11] The major histocompatibility complex region marked by HSP70-1 and HSP70-2 variants is associated with clozapine-induced agranulocytosis in two different ethnic groups.Blood. 1995 Nov 15;86(10):3835-40.
• [12] TC II deficiency: avoidance of false-negative molecular genetics by RNA-based investigations.J Hum Genet. 2009 Jun;54(6):331-4. doi: 10.1038/jhg.2009.34. Epub 2009 Apr 17.