Details of Disease

General Information of Disease (ID: DISKWPS1)

• Disease Name: Neuroblastic tumor
• Synonyms: neuroblastic tumor
• Definition: A group of nervous system tumors which display neuronal differentiation. It includes tumors that are composed of immature round cells and tumors that display advanced differentiation and the formation of ganglion cells.
• Disease Hierarchy:
  DISFHXHA: Primitive neuroectodermal tumor
  DISKWPS1: Neuroblastic tumor
• Disease Identifiers:
  MONDO ID: MONDO_0006316
  UMLS CUI: C1334953
  MedGen ID: 233228
  HPO ID: HP:0004376

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ASPH	TT2KHP7	Limited	Altered Expression	[1]
DAPK3	TTERVQN	Limited	Altered Expression	[2]
ITGAV	TTT1R2L	Limited	Altered Expression	[3]
GAL	TTXZAJ5	moderate	Biomarker	[4]
MYCN	TT9JBY5	Strong	Biomarker	[5]

This Disease Is Related to 12 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AGAP3	OT8C6PKL	Limited	Biomarker	[6]
CENPF	OT7AG0SW	Limited	Altered Expression	[7]
CHD5	OTS5EVHH	Limited	Altered Expression	[8]
MAP3K12	OT5HODDD	Limited	Altered Expression	[2]
MAX	OTKZ0YKM	Limited	Biomarker	[6]
SAMD1	OT2LK4JW	Limited	Biomarker	[6]
STMN2	OT0FUHLH	Limited	Altered Expression	[9]
INSM1	OTG8RV8E	moderate	Altered Expression	[10]
CCM2	OT2I5DOW	Strong	Biomarker	[11]
GALP	OTW25XLK	Strong	Altered Expression	[4]
RASSF5	OT6Q41I2	Strong	Altered Expression	[12]
RPS27A	OTIIGGZ2	Strong	Altered Expression	[13]

References

• [1] Differential growth factor regulation of aspartyl-(asparaginyl)-beta-hydroxylase family genes in SH-Sy5y human neuroblastoma cells.BMC Cell Biol. 2006 Dec 7;7:41. doi: 10.1186/1471-2121-7-41.
• [2] Differential expression of delta-like gene and protein in neuroblastoma, ganglioneuroblastoma and ganglioneuroma.Mod Pathol. 2005 May;18(5):656-62. doi: 10.1038/modpathol.3800335.
• [3] Vitronectin expression in differentiating neuroblastic tumors: integrin alpha v beta 5 mediates vitronectin-dependent adhesion of retinoic-acid-differentiated neuroblastoma cells.Am J Pathol. 1997 May;150(5):1631-46.
• [4] Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene.J Mol Neurosci. 2006;29(2):145-52. doi: 10.1385/JMN:29:2:145.
• [5] Comparative genetic study of intratumoral heterogenous MYCN amplified neuroblastoma versus aggressive genetic profile neuroblastic tumors.Oncogene. 2016 Mar 17;35(11):1423-32. doi: 10.1038/onc.2015.200. Epub 2015 Jun 29.
• [6] Exome sequencing identifies predisposing and fusion gene in ganglioneuroma, ganglioneuroblastoma and neuroblastoma.Math Biosci Eng. 2019 Aug 8;16(6):7217-7229. doi: 10.3934/mbe.2019362.
• [7] Identification of low intratumoral gene expression heterogeneity in neuroblastic tumors by genome-wide expression analysis and game theory.Cancer. 2008 Sep 15;113(6):1412-22. doi: 10.1002/cncr.23720.
• [8] Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma.Mol Cancer. 2010 Oct 15;9:277. doi: 10.1186/1476-4598-9-277.
• [9] Kidins220/ARMS depletion is associated with the neural-to Schwann-like transition in a human neuroblastoma cell line model.Exp Cell Res. 2013 Mar 10;319(5):660-9. doi: 10.1016/j.yexcr.2012.12.027. Epub 2013 Jan 16.
• [10] INSM1 Expression in Peripheral Neuroblastic Tumors and Other Embryonal Neoplasms.Pediatr Dev Pathol. 2019 Oct;22(5):440-448. doi: 10.1177/1093526619843725. Epub 2019 Apr 11.
• [11] CCM2 mediates death signaling by the TrkA receptor tyrosine kinase.Neuron. 2009 Sep 10;63(5):585-91. doi: 10.1016/j.neuron.2009.08.020.
• [12] Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma.Int J Cancer. 2008 Jul 15;123(2):389-394. doi: 10.1002/ijc.23533.
• [13] The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation.J Exp Clin Cancer Res. 2018 Oct 25;37(1):258. doi: 10.1186/s13046-018-0931-z.