Details of Disease

Disease Name

endemic treponematoses; Treponema pertenue infection; thymosis; frambosie; frambesia; frambesia tropica; polypapilloma tropicum; Bouba; Treponema pallidum subsp. pertenue caused disease or disorder; Treponema pallidum subsp. pertenue infectious disease; Treponema pallidum subsp. pertenue disease or disorder

Definition

An endemic, infectious, nonvenereal disease in humans that presents mainly in children younger than 15 years. The disease occurs primarily in warm, humid, tropical areas of Africa, Asia, South America, and Oceania, among poor rural populations where conditions of overcrowding and poor sanitation prevail. Infection with Treponema pertenue, a subspecies of Treponema pallidum, causes the disease.

Disease Hierarchy

DISJ73BS: Syphilis

DISEM33Q: Infectious disease

DISLTH3X: Yaws

Disease Identifiers

MONDO ID

MONDO_0006019

MESH ID

D015001

UMLS CUI

C0043388

MedGen ID

12186

SNOMED CT ID

70647001

General Information of Disease (ID: DISLTH3X)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 7 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Demeclocycline	DMZEPFJ	Approved	Small molecular drug	[2]
Doxycycline	DM7ICNU	Approved	Small molecular drug	[3]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[4]
Minocycline	DMVN5OH	Approved	Small molecular drug	[5]
Oxytetracycline	DMOVH1M	Approved	Small molecular drug	[6]
Tetracycline	DMZA017	Approved	Small molecular drug	[7]
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⏷ Show the Full List of 7 Drug(s)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benzylpenicillin	DMS9503	Phase 3	Small molecular drug	[8]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1	Amphotericin B FDA Label
2	Demeclocycline FDA Label
3	Doxycycline FDA Label
4	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
5	Minocycline FDA Label
6	Oxytetracycline FDA Label
7	Tetracycline FDA Label
8	Yaws Osteoperiostitis Treated with Single-Dose Azithromycin. Am J Trop Med Hyg. 2017 May;96(5):1039-1041.