Details of Disease

General Information of Disease (ID: DISMBYB0)

• Disease Name: Chronic urticaria
• Definition: An urticaria that is characterized by the presence of urticaria for a period exceeding 6 weeks, assuming symptoms for most days of the week.
• Disease Hierarchy:
  DIS9WQAI: Urticaria
  DISMBYB0: Chronic urticaria
• Disease Identifiers:
  MONDO ID: MONDO_0850230
  MESH ID: D000080223
  UMLS CUI: C0263338
  MedGen ID: 537829
  SNOMED CT ID: 51611005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Miltefosine	DMND304	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
HNMT	TT2B6EV	Limited	Genetic Variation	[2]
MRGPRX2	TT3YV20	Limited	Biomarker	[3]
PTGDR2	TTQDMX5	Limited	Genetic Variation	[4]
TPT1	TT3PTB6	Limited	Biomarker	[5]
HDC	TTV9GOF	Strong	Altered Expression	[6]

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CRISPLD2	OTVSFHTL	Limited	Biomarker	[7]
FCER1A	OTIRUOHF	Limited	Genetic Variation	[8]
SIGLEC8	OTQ5TRRV	Limited	Biomarker	[9]
TFIP11	OT7NVSWU	Limited	Altered Expression	[10]

References

• [1] Miltefosine FDA Label
• [2] Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria.Allergy. 2009 Feb;64(2):213-21. doi: 10.1111/j.1398-9995.2008.01795.x.
• [3] Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria.J Allergy Clin Immunol. 2014 Sep;134(3):622-633.e9. doi: 10.1016/j.jaci.2014.05.004. Epub 2014 Jun 19.
• [4] Association of CRTH2 gene polymorphisms with the required dose of antihistamines in patients with chronic urticaria.Pharmacogenomics. 2009 Mar;10(3):375-83. doi: 10.2217/14622416.10.3.375.
• [5] Dimerized, Not Monomeric, Translationally Controlled Tumor Protein Induces Basophil Activation and Mast Cell Degranulation in Chronic Urticaria.Immune Netw. 2019 Apr 16;19(3):e20. doi: 10.4110/in.2019.19.e20. eCollection 2019 Jun.
• [6] Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria.J Invest Dermatol. 2005 Nov;125(5):952-5. doi: 10.1111/j.0022-202X.2005.23913.x.
• [7] Protease inhibitor profiles in urticaria and angio-oedema.Br J Dermatol. 1980 Jul;103(1):33-9. doi: 10.1111/j.1365-2133.1980.tb15835.x.
• [8] Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population.Hum Immunol. 2012 Mar;73(3):301-5. doi: 10.1016/j.humimm.2011.12.001. Epub 2011 Dec 11.
• [9] New treatments for chronic urticaria.Ann Allergy Asthma Immunol. 2020 Jan;124(1):2-12. doi: 10.1016/j.anai.2019.08.014. Epub 2019 Aug 23.
• [10] Neurotensin serum levels and skin gene expression are increased in atopic dermatitis.Br J Dermatol. 2013 Sep;169(3):695-9. doi: 10.1111/bjd.12413.